{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:04:04Z","timestamp":1791583444696,"version":"4.3.4"},"reference-count":237,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The substantial evidence supporting the ketogenic diet (KD) in epilepsy management has spurred research into its effects on other neurological and psychiatric conditions. Despite differences in characteristics, symptoms, and underlying mechanisms, these conditions share common pathways that the KD may influence. The KD reverses metabolic dysfunction. Moreover, it has been shown to support neuroprotection through mechanisms such as neuronal energy support, inflammation reduction, amelioration of oxidative stress, and reversing mitochondrial dysfunction. The adequate intake of dietary nutrients is essential for maintaining normal brain functions, and strong evidence supports the role of nutrition in the treatment and prevention of many psychiatric and neurological disorders. Obsessive\u2013compulsive disorder (OCD) is a neuropsychiatric condition marked by persistent, distressing thoughts or impulses (obsessions) and repetitive behaviors performed in response to these obsessions (compulsions). Recent studies have increasingly examined the role of nutrition and metabolic disorders in OCD. This narrative review examines current evidence on the potential role of the KD in the treatment of OCD. We explore research on the KD\u2019s effects on psychiatric disorders to assess its potential relevance for OCD treatment. Additionally, we identify key gaps in the preclinical and clinical research that warrant further study in applying the KD as a metabolic therapy for OCD.<\/jats:p>","DOI":"10.3390\/nu17010031","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:27:46Z","timestamp":1735154866000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ketogenic Diet as a Nutritional Metabolic Intervention for Obsessive\u2013Compulsive Disorder: A Narrative Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Astrid","family":"Lounici","sequence":"first","affiliation":[{"name":"Clinic for Adults, University Psychiatric Clinics Basel, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1079-4460","authenticated-orcid":false,"given":"Ana","family":"Iacob","sequence":"additional","affiliation":[{"name":"P\u00f4le de Psychiatrie et Psychoth\u00e9rapie (PPP), Unit\u00e9 de Psychiatrie de Liaison, H\u00f4pital du Valais, 1950 Sion, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Hongler","sequence":"additional","affiliation":[{"name":"Clinic for Adults, University Psychiatric Clinics Basel, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina A.","family":"M\u00f6lling","sequence":"additional","affiliation":[{"name":"MEDIAN Zentrum f\u00fcr Verhaltensmedizin, 31812 Bad Pyrmont, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Drechsler","sequence":"additional","affiliation":[{"name":"Stiftung f\u00fcr Ganzheitliche Medizin (SGM), Klinik SGM Langenthal, 4900 Langenthal, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Hersberger","sequence":"additional","affiliation":[{"name":"Stiftung f\u00fcr Ganzheitliche Medizin (SGM), Klinik SGM Langenthal, 4900 Langenthal, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shebani","family":"Sethi","sequence":"additional","affiliation":[{"name":"Metabolic Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Undine E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Clinic for Adults, University Psychiatric Clinics Basel, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Liwinski","sequence":"additional","affiliation":[{"name":"Clinic for Adults, University Psychiatric Clinics Basel, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"ref_1","unstructured":"(2024, December 19). 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