{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:13:51Z","timestamp":1789906431048,"version":"4.0.1"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Western Sydney University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and Objectives: Nutrient supplements are commonly used to improve fertility outcomes by women with infertility trying to conceive spontaneously or utilising medically assisted reproduction (MAR). However, despite their widespread use and perceived safety, there is a lack of clear guidance on the efficacy and safety of these supplements for female infertility. The aim of this umbrella review was to identify the best available and most recent evidence on the efficacy and safety of nutrient supplements for female infertility to provide evidence-based guidance for clinicians and reproductive couples. Methods: Five electronic databases were searched for umbrella reviews, meta-analyses, and systematic reviews of randomised controlled trials on nutrient supplements for female infertility, published from August 2017 to January 2024. The primary outcomes were live birth, and clinical and biochemical pregnancy rates. Secondary outcomes were adverse effects including miscarriage and ectopic or multiple pregnancy. Quality assessment was performed using the A MeaSurement Tool to Assess systematic Reviews Version 2.0 (AMSTAR 2), and the certainty of evidence for outcomes were assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, where possible. Results: Four meta-analyses were included. Multiple micronutrients and antioxidants increased live birth rates in women utilising MAR and\/or trying to conceive spontaneously compared to placebo, standard or no treatment (odds ratio (OR) 2.59 and 1.81 respectively) with very low certainty evidence. L-carnitine, coQ10, melatonin, myo-inositol, NAC and vitamin D increased clinical pregnancy rates in women with PCOS and\/or undergoing MAR compared to placebo, standard or no treatment (odds ratio (OR) 11.14, 2.49, 1.66, relative risk (RR) 1.52, OR 2.15, and 1.49 respectively) with very low certainty evidence. Vitamin D did not increase biochemical pregnancy rates in women utilising MAR with very low certainty evidence. NAC, vitamin D, and pooled antioxidants had no effect on miscarriage rates or multiple pregnancy rates in women trying to conceive spontaneously or utilising MAR, with low to very low certainty evidence. Pooled antioxidants had no effect on ectopic pregnancy rates in women trying to conceive spontaneously or utilising MAR, with low certainty evidence. Conclusions: The available evidence is insufficient to recommend nutrient supplementation to improve female infertility in women trying to conceive naturally and those utilising MAR. However, there is currently no indication that these nutrients pose any risk of significant harm. Registration: PROSPERO (CRD42022365966) 20 October 2022.<\/jats:p>","DOI":"10.3390\/nu17010057","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T09:23:36Z","timestamp":1735291416000},"page":"57","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Role of Nutrient Supplements in Female Infertility: An Umbrella Review and Hierarchical Evidence Synthesis"],"prefix":"10.3390","volume":"17","author":[{"given":"Chhiti","family":"Pandey","sequence":"first","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Maunder","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishnavi","family":"Vaddiparthi","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-1356","authenticated-orcid":false,"given":"Michael F.","family":"Costello","sequence":"additional","affiliation":[{"name":"Women\u2019s Health, University of New South Wales and Royal Hospital for Women and Monash IVF, Sydney, NSW 2031, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-1283","authenticated-orcid":false,"given":"Mahnaz","family":"Bahri-Khomami","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-4523","authenticated-orcid":false,"given":"Aya","family":"Mousa","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation, Monash University, Melbourne, VIC 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3363-9199","authenticated-orcid":false,"given":"Carolyn","family":"Ee","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"ref_1","unstructured":"WHO (2023). Infertility Prevalence Estimates, 1990\u20132021, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: Definition and epidemiology","volume":"62","author":"Wyns","year":"2018","journal-title":"Clin. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/bmj.327.7412.434","article-title":"ABC of subfertility: Extent of the problem","volume":"327","author":"Taylor","year":"2003","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.31887\/DCNS.2018.20.1\/klrooney","article-title":"The relationship between stress and infertility","volume":"20","author":"Rooney","year":"2018","journal-title":"Diag. Clin. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1554023","DOI":"10.1080\/17482631.2018.1554023","article-title":"Lived experience of infertility among Hong Kong Chinese women","volume":"13","author":"Tiu","year":"2018","journal-title":"Int. J. Qual. Stud. Health Well-Being"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Thoma, M., Fledderjohann, J., Cox, C., and Kantum, A.R. (2021). Biological and Social Aspects of Human Infertility: A Global Perspective, Oxford University Press.","DOI":"10.1093\/acrefore\/9780190632366.013.184"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e820","DOI":"10.1016\/S2214-109X(22)00098-5","article-title":"Prevalence of intimate partner violence against infertile women in low-income and middle-income countries: A systematic review and meta-analysis","volume":"10","author":"Wang","year":"2022","journal-title":"Lancet Glob. Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/01443610902803625","article-title":"Prevalence of utero-tubal infertility","volume":"29","author":"Audu","year":"2009","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and Management of Infertility: A Review","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e11010","DOI":"10.1016\/j.heliyon.2022.e11010","article-title":"An update of polycystic ovary syndrome: Causes and therapeutics options","volume":"8","author":"Matani","year":"2022","journal-title":"Heliyon"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: Etiology, pathobiology, and therapeutic prospects","volume":"184","author":"Saunders","year":"2021","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil Steril."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(10)60490-4","article-title":"Endometriosis and infertility: Pathophysiology and management","volume":"376","author":"Borghese","year":"2010","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.12688\/f1000research.26423.1","article-title":"Recent advances in understanding primary ovarian insufficiency","volume":"9","author":"Wesevich","year":"2020","journal-title":"F1000Research"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0002-9378(82)90535-X","article-title":"Clinical staging of acute bacterial salpingitis and its therapeutic ramifications","volume":"143","author":"Monif","year":"1982","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/humupd\/7.2.161","article-title":"Clinical implications of uterine malformations and hysteroscopic treatment results","volume":"7","author":"Grimbizis","year":"2001","journal-title":"Hum. Reprod. Updat."},{"key":"ref_17","unstructured":"Committee Opinion No 589: Female Age-Related Fertility Decline (2024, June 30). American College of Obstetricians and Gynecologists. Available online: https:\/\/www.acog.org\/clinical\/clinical-guidance\/committee-opinion\/articles\/2014\/03\/female-age-related-fertility-decline."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/humupd\/dmad018","article-title":"Assessing the influence of preconception diet on female fertility: A systematic scoping review of observational studies","volume":"29","author":"Alesi","year":"2023","journal-title":"Hum. Reprod. Updat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/s43032-021-00767-0","article-title":"Expectant Management Before In vitro Fertilization in Women Aged 39 or Above and Unexplained Infertility Does Not Decrease Live Birth Rates Compared to Immediate Treatment","volume":"29","author":"Carosso","year":"2022","journal-title":"Reprod. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2147\/IJWH.S51288","article-title":"Low-cost in vitro fertilization: Current insights","volume":"6","author":"Maheshwari","year":"2014","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.rbmo.2016.07.012","article-title":"Socio-economic disparities in access to assisted reproductive technologies in Australia","volume":"33","author":"Harris","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kushnir, V.A., Barad, D.H., Albertini, D.F., Darmon, S.K., and Gleicher, N. (2017). Systematic review of worldwide trends in assisted reproductive technology 2004\u20132013. Reprod. Biol. Endocrinol., 15.","DOI":"10.1186\/s12958-016-0225-2"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fertnstert.2019.09.020","article-title":"Use of exogenous gonadotropins for ovulation induction in anovulatory women: A committee opinion","volume":"113","author":"Penzias","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.rbmo.2017.08.018","article-title":"Effect of micronutrient supplementation on IVF outcomes: A systematic review of the literature","volume":"35","author":"Arhin","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ku, C.W., Ku, C.O., Tay, L.P.C., Xing, H.K., Cheung, Y.B., Godfrey, K.M., Colega, M.T., Teo, C., Tan, K.M.L., and Chong, Y.-S. (2022). Dietary Supplement Intake and Fecundability in a Singapore Preconception Cohort Study. Nutrients, 14.","DOI":"10.3390\/nu14235110"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Looman, M., Berg, C.V.D., Geelen, A., Samlal, R.A.K., Heijligenberg, R., Gunnewiek, J.M.T.K., Balvers, M.G.J., Leendertz-Eggen, C.L., Wijnberger, L.D.E., and Feskens, E.J.M. (2018). Supplement Use and Dietary Sources of Folate, Vitamin D, and n-3 Fatty Acids during Preconception: The GLIMP2 Study. Nutrients, 10.","DOI":"10.3390\/nu10080962"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"McKenna, E., Hure, A., Perkins, A., and Gresham, E. (2017). Dietary Supplement Use during Preconception: The Australian Longitudinal Study on Women\u2019s Health. Nutrients, 9.","DOI":"10.3390\/nu9101119"},{"key":"ref_28","unstructured":"Kermack, A., and Macklon, N. (2014, January 8\u20139). Vitamin supplement usage in 400 women embarking on in vitro fertilization treatment. Proceedings of the British Fertility Society Annual Meeting, Sheffield, UK."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1179562X19843868","DOI":"10.1177\/1179562X19843868","article-title":"The Impact of Preconceptional Multiple-Micronutrient Supplementation on Female Fertility","volume":"12","author":"Schaefer","year":"2019","journal-title":"Clin. Med. Insights Women\u2019s Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2285025","DOI":"10.1080\/01443615.2023.2285025","article-title":"Association between nutrient intake and female infertility: A study based on NHANES database","volume":"43","author":"Ji","year":"2023","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_31","unstructured":"GVR (2024, June 30). Vitamin Supplements Market Size & Trends. Grand_View_Research., Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/vitamin-supplements-market-report."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s11655-016-2748-y","article-title":"Prevalence and Determinants of Traditional, Complementary and Alternative Medicine Provider Use among Adults from 32 Countries","volume":"24","author":"Peltzer","year":"2018","journal-title":"Chin. J. Integr. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1872211313666190503112040","article-title":"Nutraceuticals\u2019 Novel Formulations: The Good, the Bad, the Unknown and Patents Involved","volume":"13","author":"Helal","year":"2019","journal-title":"Recent Patents Drug Deliv. Formul."},{"key":"ref_34","unstructured":"WHO Guidelines Approved by the Guidelines Review Committee (2016). WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience, World Health Organization."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ejcn.2015.131","article-title":"A review of European guidelines on periconceptional folic acid supplementation","volume":"70","author":"Cawley","year":"2015","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_36","first-page":"CD007950","article-title":"Effects and safety of periconceptional oral folate supplementation for preventing birth defects","volume":"2015","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e070849","DOI":"10.1136\/bmj-2022-070849","article-title":"Reporting guideline for overviews of reviews of healthcare interventions: Development of the PRIOR statement","volume":"378","author":"Gates","year":"2022","journal-title":"BMJ"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Fong, C., Alesi, S., Mousa, A., Moran, L.J., Deed, G., Grant, S., Tapia, K., and Ee, C. (2022). Efficacy and Safety of Nutrient Supplements for Glycaemic Control and Insulin Resistance in Type 2 Diabetes: An Umbrella Review and Hierarchical Evidence Synthesis. Nutrients, 14.","DOI":"10.20944\/preprints202205.0100.v1"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Lin, J., Liu, J., O\u2019fee, A., Pandey, C., Benna-Doyle, S., Maunder, A., Rao, V., Alesi, S., Ng, B., and Ee, C. (2024). The effectiveness and safety of lifestyle medicine and integrative therapies in inflammatory arthritis: An umbrella review using a hierarchical evidence gathering approach. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1357914"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jclinepi.2013.11.007","article-title":"Systematic review finds overlapping reviews were not mentioned in every other overview","volume":"67","author":"Pieper","year":"2014","journal-title":"J. Clin. Epidemiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: An emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1515\/jbcpp-2020-0107","article-title":"N-acetyl-cysteine as adjuvant therapy in female infertility: A systematic review and meta-analysis","volume":"32","author":"Devi","year":"2020","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_44","first-page":"CD007807","article-title":"Antioxidants for female subfertility","volume":"2020","author":"Showell","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Meng, X., Zhang, J., Wan, Q., Huang, J., Han, T., Qu, T., and Yu, L.-L. (2023). Influence of Vitamin D supplementation on reproductive outcomes of infertile patients: A systematic review and meta-analysis. Reprod. Biol. Endocrinol., 21.","DOI":"10.1186\/s12958-023-01068-8"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/09513590.2022.2136160","article-title":"Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: Systematic review and meta-analysis","volume":"38","author":"Unanyan","year":"2022","journal-title":"Gynecol. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Sengupta, P., and Durairajanayagam, D. (2018). Role of L-carnitine in female infertility. Reprod. Biol. Endocrinol., 16.","DOI":"10.1186\/s12958-018-0323-4"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1177\/154405910608501001","article-title":"Genetic and Cellular Toxicology of Dental Resin Monomers","volume":"85","author":"Schweikl","year":"2006","journal-title":"J. Dent. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/0022034510363243","article-title":"N-acetyl cysteine alleviates cytotoxicity of bone substitute","volume":"89","author":"Yamada","year":"2010","journal-title":"J. Dent. Res."},{"key":"ref_51","unstructured":"Orlowski, M., and Sarao, M.S. (2024). Physiology, Follicle Stimulating Hormone, StatPearls."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1210\/clinem\/dgad762","article-title":"Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines","volume":"109","author":"Fitz","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/acel.12368","article-title":"Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging","volume":"14","author":"Burstein","year":"2015","journal-title":"Aging Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/1541-4337.12539","article-title":"Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges","volume":"19","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Reiter, R.J., Sharma, R., Romero, A., Manucha, W., Tan, D.-X., Zuccari, D.A.P.d.C., and Chuffa, L.G.d.A. (2023). Aging-Related Ovarian Failure and Infertility: Melatonin to the Rescue. Antioxidants, 12.","DOI":"10.3390\/antiox12030695"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tamura, H., Jozaki, M., Tanabe, M., Shirafuta, Y., Mihara, Y., Shinagawa, M., Tamura, I., Maekawa, R., Sato, S., and Taketani, T. (2020). Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21031135"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e12782","DOI":"10.1111\/jpi.12782","article-title":"Safety of higher doses of melatonin in adults: A systematic review and meta-analysis","volume":"72","author":"Schrire","year":"2021","journal-title":"J. Pineal Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D Deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1530\/EJE-11-0984","article-title":"Vitamin D and fertility: A systematic review","volume":"166","author":"Lerchbaum","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1080\/07315724.2018.1431160","article-title":"The Relationship Between Female Reproductive Functions and Vitamin, D.J","volume":"37","author":"Arslan","year":"2018","journal-title":"Am. Coll. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1210\/me.2004-0336","article-title":"Direct Regulation of HOXA10 by 1,25-(OH)2D3in Human Myelomonocytic Cells and Human Endometrial Stromal Cells","volume":"19","author":"Du","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"a023002","DOI":"10.1101\/cshperspect.a023002","article-title":"The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility","volume":"6","author":"Du","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/a-1206-1064","article-title":"Calcitriol Effect on Outcomes of in Vitro Fertilization in Infertile Women with Vitamin D Deficiency: A Double-Blind Randomized Clinical Trial","volume":"225","author":"Doryanizadeh","year":"2021","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00404-016-4058-1","article-title":"Serum vitamin D status and in vitro fertilization outcomes: A systematic review and meta-analysis","volume":"293","author":"Lv","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40520-020-01678-x","article-title":"Vitamin D supplementation: Upper limit for safety revisited?","volume":"33","author":"Rizzoli","year":"2021","journal-title":"Aging Clin. Exp. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/1\/57\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:01:21Z","timestamp":1760115681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/1\/57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["nu17010057"],"URL":"https:\/\/doi.org\/10.3390\/nu17010057","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]}}}