{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:25:06Z","timestamp":1787905506674,"version":"build-2784847793"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agricultural Research Development Administration (ARDA, a public organization) Thailand","award":["CRP6405030600"],"award-info":[{"award-number":["CRP6405030600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: UV radiation is a primary cause of skin damage and photoaging. \u03b2-carotene, a potent antioxidant, aids in mitigating UV-induced oxidative stress and enhancing skin photoprotection. This research aimed to evaluate the efficacy of a nutraceutical product designed to prevent photoaging. Methods: The product consists of a blend of hemp seed oil and banana (Musa AA), formulated as a chewable tablet. Healthy male participants aged 35\u201350 years were enrolled in a randomized, parallel, single-blind, placebo-controlled clinical trial. Participants received either the chewable nutraceutical (five tablets after meals in the morning and evening, equivalent to 8 \u00b1 2 mg\/day of \u03b2-carotene and 400 mg\/day of PUFA) or a chewable placebo for 16 weeks. A total of thirty-six participants successfully completed the entire 16-week study. Results: Administration of the nutraceutical resulted in a significant reduction (p &lt; 0.05) in UV solar light stimulator-induced erythema on the dorsal skin at week 4, with a mean value of 3.76 \u00b1 0.46 AU, compared to the initial value of 4.88 \u00b1 0.62 AU at week 0. Additionally, serum \u03b2-carotene concentration significantly increased from 0.45 \u00b1 0.02 \u00b5g\/mL at week 0 to 0.61 \u00b1 0.06 \u00b5g\/mL at week 16 (p &lt; 0.05). Moreover, skin intensity in the sun-exposed arm area also significantly improved at week 16, increasing from 71.33 \u00b1 3.50 at week 0 to 81.80 \u00b1 4.45 (p &lt; 0.05). Conclusions: The results indicate that the developed nutraceutical may offer effective protection against erythema, making it a promising option for preventing photoaging.<\/jats:p>","DOI":"10.3390\/nu17010065","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T13:37:51Z","timestamp":1735738671000},"page":"65","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Natural \u03b2-Carotene Chewable Tablets Derived from Banana (Musa AA) Pulp in Reducing UV-Induced Skin Erythema"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0607-1813","authenticated-orcid":false,"given":"Chatnarong","family":"Putthong","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanasorn","family":"Panmanee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pensri","family":"Charoensit","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-6779","authenticated-orcid":false,"given":"Sukunya","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center of Excellence in Biomaterials, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongaphisith","family":"Tongpoolsomjit","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut\u2019s University of Technology North Bangkok, Bangkok 10800, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarupa","family":"Viyoch","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12033-007-0051-z","article-title":"Carotenoids and Flavonoids Contribute to Nutritional Protection against Skin Damage from Sunlight","volume":"37","author":"Stahl","year":"2007","journal-title":"Mol. 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