{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:39:13Z","timestamp":1791005953758,"version":"4.1.0"},"reference-count":98,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T00:00:00Z","timestamp":1735430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D (VD) is a vital lipophilic secosteroid hormone known for its essential role in maintaining skeletal health and regulating calcium and phosphate metabolism. Recent evidence has begun to illuminate its significance beyond bone health, particularly in relation to thrombosis\u2014a condition characterized by blood clot formation within the vascular system that can lead to serious cardiovascular events such as myocardial infarction and stroke. VD deficiency, defined as a plasma 25-hydroxyVD level below 25 nmol\/L, affects a substantial portion of the global population, with prevalence rates ranging from 8% to 18%. This study systematically explores the relationships between VD levels and the risk of thrombosis, investigating the underlying mechanisms including VD\u2019s anticoagulant properties, influence on inflammatory pathways, and interactions with endothelial cells. Epidemiological data suggest that low serum levels of VD correlate with an increased risk of venous thromboembolism (VTE), although the reported findings remain inconsistent. Mechanisms that potentially link VD to thrombotic risk include modulation of thrombomodulin and tissue factor expression, as well as enhancement of anti-inflammatory cytokines. Given the prevalence of VD insufficiency, particularly among populations with limited exposure to sunlight, this research highlights the urgent need for strategies to increase VD levels through dietary modifications and supplementation in order to prevent thrombotic events.<\/jats:p>","DOI":"10.3390\/nu17010090","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T10:32:26Z","timestamp":1735813946000},"page":"90","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease"],"prefix":"10.3390","volume":"17","author":[{"given":"Amirhossein","family":"Ojaroodi","sequence":"first","affiliation":[{"name":"Hematology and Transfusion Medicine Ward, Department of Medical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Jafarnezhad","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, Ferdowsi University of Mashhad, Mashhad 9177899191, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Eskandari","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Allied Medicine, Bushehr University of Medical Sciences, Bushehr 7518759577, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Keramat","sequence":"additional","affiliation":[{"name":"VAS-European Independent Foundation in Angiology\/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy"},{"name":"Support Association of Patients of Buerger\u2019s Disease, Buerger\u2019s Disease NGO, Mashhad 9183785195, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-9898","authenticated-orcid":false,"given":"Agata","family":"Stanek","sequence":"additional","affiliation":[{"name":"VAS-European Independent Foundation in Angiology\/Vascular Medicine, Via GB Grassi 74, 20157 Milan, Italy"},{"name":"Department of Internal Medicine, Metabolic Diseases and Angiology, Faculty of Health Sciences in Katowice, Medical University of Silesia, Zio\u0142owa 45\/47, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mohammad, S., Mishra, A., and Ashraf, M.Z. 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