{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:27:30Z","timestamp":1791779250977,"version":"4.3.4"},"reference-count":53,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ricerca Corrente Istituto Oncologico Veneto (IOV-IRCCS) 2018\u20132021","award":["RF-2016-02363566"],"award-info":[{"award-number":["RF-2016-02363566"]}]},{"name":"Ricerca Corrente Centro di Riferimento Oncologico di Aviano (CRO-IRCCS) 2021\u20132022","award":["RF-2016-02363566"],"award-info":[{"award-number":["RF-2016-02363566"]}]},{"name":"Ricerca Finalizzata","award":["RF-2016-02363566"],"award-info":[{"award-number":["RF-2016-02363566"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Gastric cancer (GC) incidence remains high worldwide, and the survival rate is poor. GC develops from atrophic gastritis (AG), associated with Helicobacter pylori (Hp) infection, passing through intestinal metaplasia and dysplasia steps. Since Hp eradication does not exclude GC development, further investigations are needed. New data suggest the possible role of unexplored gastric microbiota beyond Hp in the progression from AG to GC. Aimed to develop a score that could be used in clinical practice to stratify GC progression risk, here was investigate gastric microbiota in AG Hp-negative patients with or without high-grade dysplasia (HGD) or GC. Methods: Consecutive patients undergoing upper endoscopy within an endoscopic follow-up for AG were considered. The antrum and corpus biopsies were used to assess the microbiota composition along the disease progression by sequencing the 16S ribosomal RNA gene. Statistical differences between HGD\/GC and AG patients were included in a multivariate analysis. Results: HGD\/GC patients had a higher percentage of Bacillus in the antrum and a low abundance of Rhizobiales, Weeksellaceae and Veillonella in the corpus. These data were used to calculate a multiparametric score (Resident Gastric Microbiota Dysbiosis Test, RGM-DT) to predict the risk of progression toward HGD\/GC. The performance of RGM-DT in discriminating patients with HGD\/GC showed a specificity of 88.9%. Conclusions: The microbiome-based risk prediction model for GC could clarify the role of gastric microbiota as a cancer risk biomarker to be used in clinical practice. The proposed test might be used to personalize follow-up program thanks to a better cancer risk stratification.<\/jats:p>","DOI":"10.3390\/nu17010142","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:00:37Z","timestamp":1735628437000},"page":"142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictive Value of a Gastric Microbiota Dysbiosis Test for Stratifying Cancer Risk in Atrophic Gastritis Patients"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-0325","authenticated-orcid":false,"given":"Alice","family":"Zaramella","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy"},{"name":"Gastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-6513","authenticated-orcid":false,"given":"Diletta","family":"Arcidiacono","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Duci","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, University of Padova, 35128 Padova, Italy"},{"name":"Pediatric Surgery Unit, Division of Women\u2019s and Children\u2019s Health, Padova University Hospital, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9077-2471","authenticated-orcid":false,"given":"Clara","family":"Benna","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5289-9925","authenticated-orcid":false,"given":"Salvatore","family":"Pucciarelli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-9117","authenticated-orcid":false,"given":"Alberto","family":"Fantin","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rosato","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy"},{"name":"UOC Immunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-9373","authenticated-orcid":false,"given":"Valli","family":"De Re","sequence":"additional","affiliation":[{"name":"Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano, National Cancer Institute, IRCCS, 33081 Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-222X","authenticated-orcid":false,"given":"Renato","family":"Cannizzaro","sequence":"additional","affiliation":[{"name":"Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy"},{"name":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-5482","authenticated-orcid":false,"given":"Matteo","family":"Fassan","sequence":"additional","affiliation":[{"name":"Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"},{"name":"Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Via Gabelli 61, 35121 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-7637","authenticated-orcid":false,"given":"Stefano","family":"Realdon","sequence":"additional","affiliation":[{"name":"Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.csbj.2023.11.053","article-title":"The Influence of Helicobacter Pylori, Proton Pump Inhibitor, and Obesity on the Gastric Microbiome in Relation to Gastric Cancer Development","volume":"23","author":"Zhou","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.dld.2024.02.008","article-title":"Gastric Cancer Screening in Western Countries: A Call to Action","volume":"56","author":"Farinati","year":"2024","journal-title":"Dig. Liver Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The Gastric Precancerous Cascade","volume":"13","author":"Correa","year":"2012","journal-title":"J. Dig. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/gut.2006.106666","article-title":"Gastritis Staging in Clinical Practice: The OLGA Staging System","volume":"56","author":"Rugge","year":"2007","journal-title":"Gut"},{"key":"ref_6","first-page":"13B","article-title":"Role of Bacterial Overgrowth in the Stomach as an Additional Risk Factor for Gastritis","volume":"17","author":"Naylor","year":"2003","journal-title":"Can. J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ijc.28999","article-title":"Global Burden of Gastric Cancer Attributable to Pylori","volume":"136","author":"Plummer","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Li, T.H., Qin, Y., Sham, P.C., Lau, K.S., Chu, K.-M., and Leung, W.K. (2017). Alterations in Gastric Microbiota After H. Pylori Eradication and in Different Histological Stages of Gastric Carcinogenesis. Sci. Rep., 7.","DOI":"10.1038\/srep44935"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1177\/2050640619852255","article-title":"Composition of the Mucosa-Associated Microbiota along the Entire Gastrointestinal Tract of Human Individuals","volume":"7","author":"Vuik","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.15430\/JCP.2017.22.2.115","article-title":"Analysis of Gastric Body Microbiota by Pyrosequencing: Possible Role of Bacteria Other Than Helicobacter Pylori in the Gastric Carcinogenesis","volume":"22","author":"Sohn","year":"2017","journal-title":"J. Cancer Prev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jcmgh.2021.08.013","article-title":"The Role of Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse?","volume":"13","author":"Smet","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, Z., Gao, X., Zeng, R., Wu, Q., Sun, H., Wu, W., Zhang, X., Sun, G., Yan, B., and Wu, L. (2020). Changes of the Gastric Mucosal Microbiome Associated With Histological Stages of Gastric Carcinogenesis. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00997"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jfma.2022.11.008","article-title":"Evolution of the Correa\u2019s Cascade Steps: A Long-Term Endoscopic Surveillance among Non-Ulcer Dyspepsia and Gastric Ulcer after H. Pylori Eradication","volume":"122","author":"Cheng","year":"2023","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ebiom.2018.12.034","article-title":"Alterations of Gastric Mucosal Microbiota across Different Stomach Microhabitats in a Cohort of 276 Patients with Gastric Cancer","volume":"40","author":"Liu","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1126\/science.1195568","article-title":"Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?","volume":"330","author":"Lee","year":"2010","journal-title":"Science"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nrc3610","article-title":"The Microbiome and Cancer","volume":"13","author":"Schwabe","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/hel.12145","article-title":"Differences in Gastric Mucosal Microbiota Profiling in Patients with Chronic Gastritis, Intestinal Metaplasia, and Gastric Cancer Using Pyrosequencing Methods","volume":"19","author":"Eun","year":"2014","journal-title":"Helicobacter"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/gutjnl-2017-314205","article-title":"Gastric Microbial Community Profiling Reveals a Dysbiotic Cancer-Associated Microbiota","volume":"67","author":"Ferreira","year":"2018","journal-title":"Gut"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2017-314281","article-title":"Mucosal Microbiome Dysbiosis in Gastric Carcinogenesis","volume":"67","author":"Dai","year":"2018","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Aviles-Jimenez, F., Vazquez-Jimenez, F., Medrano-Guzman, R., Mantilla, A., and Torres, J. (2014). Stomach Microbiota Composition Varies between Patients with Non-Atrophic Gastritis and Patients with Intestinal Type of Gastric Cancer. Sci. Rep., 4.","DOI":"10.1038\/srep04202"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1073\/pnas.0506655103","article-title":"Molecular Analysis of the Bacterial Microbiota in the Human Stomach","volume":"103","author":"Bik","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gantuya, B., El-Serag, H.B., Matsumoto, T., Ajami, N.J., Oyuntsetseg, K., Azzaya, D., Uchida, T., and Yamaoka, Y. (2019). Gastric Microbiota in Helicobacter Pylori-Negative and -Positive Gastritis Among High Incidence of Gastric Cancer Area. Cancers, 11.","DOI":"10.3390\/cancers11040504"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zaramella, A., Arcidiacono, D., Nucci, D., Fabris, F., Benna, C., Pucciarelli, S., Fassan, M., Fantin, A., De Re, V., and Cannizzaro, R. (2023). Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett\u2019s Esophagus Patients and Is Linked to Low Adherence to WCRF\/AICR Lifestyle Recommendations. Nutrients, 15.","DOI":"10.3390\/nu15132885"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1007\/s10620-006-9276-0","article-title":"Progression of Atrophic Gastritis and Intestinal Metaplasia Drives Helicobacter Pylori out of the Gastric Mucosa","volume":"51","author":"Kang","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.dld.2021.05.005","article-title":"Gastric Microbiota Composition in Patients with Corpus Atrophic Gastritis","volume":"53","author":"Conti","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s10120-020-01141-w","article-title":"Long-Term Persistence of Gastric Dysbiosis after Eradication of Helicobacter Pylori in Patients Who Underwent Endoscopic Submucosal Dissection for Early Gastric Cancer","volume":"24","author":"Watanabe","year":"2021","journal-title":"Gastric Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Park, J.Y., Seo, H., Kang, C.-S., Shin, T.-S., Kim, J.W., Park, J.-M., Kim, J.G., and Kim, Y.-K. (2022). Dysbiotic Change in Gastric Microbiome and Its Functional Implication in Gastric Carcinogenesis. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-08288-9"},{"key":"ref_29","first-page":"157","article-title":"Gastric Cancer: The Microbiome Beyond Helicobacter Pylori","volume":"444","author":"Ferreira","year":"2023","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mam.2017.06.002","article-title":"Interactions between Gut Bacteria and Bile in Health and Disease","volume":"56","author":"Long","year":"2017","journal-title":"Mol. Asp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e12547","DOI":"10.1111\/hel.12547","article-title":"Evaluation of Gastric Microbiome and Metagenomic Function in Patients with Intestinal Metaplasia Using 16S RRNA Gene Sequencing","volume":"24","author":"Park","year":"2019","journal-title":"Helicobacter"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41564-019-0591-6","article-title":"Dietary L-Serine Confers a Competitive Fitness Advantage to Enterobacteriaceae in the Inflamed Gut","volume":"5","author":"Kitamoto","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13099-021-00403-x","article-title":"Gut Microbiota of Patients with Different Subtypes of Gastric Cancer and Gastrointestinal Stromal Tumors","volume":"13","author":"Sarhadi","year":"2021","journal-title":"Gut Pathog."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Guo, P., Zhang, K., Ma, X., and He, P. (2020). Clostridium Species as Probiotics: Potentials and Challenges. J. Anim. Sci. Biotechnol., 11.","DOI":"10.1186\/s40104-019-0402-1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e0056922","DOI":"10.1128\/msphere.00569-22","article-title":"Diversity and Prevalence of Clostridium Innocuum in the Human Gut Microbiota","volume":"8","author":"Bhattacharjee","year":"2023","journal-title":"mSphere"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/cas.14298","article-title":"Significance of the Gut Microbiome in Multistep Colorectal Carcinogenesis","volume":"111","author":"Mizutani","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gunathilake, M., Lee, J., Choi, I.J., Kim, Y.-I., Yoon, J., Sul, W.J., Kim, J.F., and Kim, J. (2020). Alterations in Gastric Microbial Communities Are Associated with Risk of Gastric Cancer in a Korean Population: A Case-Control Study. Cancers, 12.","DOI":"10.21203\/rs.3.rs-45990\/v1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1038\/s41388-022-02377-9","article-title":"Meta-Analysis of Mucosal Microbiota Reveals Universal Microbial Signatures and Dysbiosis in Gastric Carcinogenesis","volume":"41","author":"Liu","year":"2022","journal-title":"Oncogene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"37871","DOI":"10.1039\/D0RA06129H","article-title":"Isolation, Expression, and Biochemical Characterization: Nitrite Reductase from Bacillus Cereus LJ01","volume":"10","author":"Huang","year":"2020","journal-title":"RSC Adv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gutjnl-2013-305178","article-title":"Gastric Colonisation with a Restricted Commensal Microbiota Replicates the Promotion of Neoplastic Lesions by Diverse Intestinal Microbiota in the Helicobacter Pylori INS-GAS Mouse Model of Gastric Carcinogenesis","volume":"63","author":"Lertpiriyapong","year":"2014","journal-title":"Gut"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1099\/00207713-50-2-679","article-title":"Description of Mogibacterium Pumilum Gen. Nov., Sp. Nov. and Mogibacterium Vescum Gen. Nov., Sp. Nov., and Reclassification of Eubacterium Timidum (Holdeman et al. 1980) as Mogibacterium Timidum Gen. Nov., Comb. Nov","volume":"50","author":"Nakazawa","year":"2000","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fshw.2018.12.001","article-title":"Oral Microbiota: A New View of Body Health","volume":"8","author":"Lu","year":"2019","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8727","DOI":"10.1038\/ncomms9727","article-title":"Gut Mucosal Microbiome across Stages of Colorectal Carcinogenesis","volume":"6","author":"Nakatsu","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Han, H.S., Lee, S.Y., Oh, S.Y., Moon, H.W., Cho, H., and Kim, J.H. (2019). Correlations of the Gastric and Duodenal Microbiota with Histological, Endoscopic, and Symptomatic Gastritis. J. Clin. Med., 8.","DOI":"10.3390\/jcm8030312"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3748\/wjg.v28.i3.365","article-title":"Microbiome Changes in the Gastric Mucosa and Gastric Juice in Different Histological Stages of Helicobacter Pylori-Negative Gastric Cancers","volume":"28","author":"Sun","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, L., Xin, Y., Zhou, J., Tian, Z., Liu, C., Yu, X., Meng, X., Jiang, W., Zhao, S., and Dong, Q. (2020). Gastric Mucosa-Associated Microbial Signatures of Early Gastric Cancer. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.01548"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1136\/gutjnl-2016-312766","article-title":"Quantitation of Faecal Fusobacterium Improves Faecal Immunochemical Test in Detecting Advanced Colorectal Neoplasia","volume":"66","author":"Wong","year":"2017","journal-title":"Gut"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s12029-024-01021-x","article-title":"Role of the Microbiome in the Diagnosis and Management of Gastroesophageal Cancers","volume":"55","author":"Mascaretti","year":"2024","journal-title":"J. Gastrointest. Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhang, R., Wu, Y., Ju, W., Wang, S., Liu, Y., and Zhu, H. (2024). Gut Microbiome Alterations during Gastric Cancer: Evidence Assessment of Case\u2013Control Studies. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1406526"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1099\/jmm.0.007302-0","article-title":"Molecular Characterization of the Stomach Microbiota in Patients with Gastric Cancer and in Controls","volume":"58","author":"Dicksved","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Li, X.-X., Wong, G.L.-H., To, K.-F., Wong, V.W.-S., Lai, L.H., Chow, D.K.-L., Lau, J.Y.-W., Sung, J.J.-Y., and Ding, C. (2009). Bacterial Microbiota Profiling in Gastritis without Helicobacter Pylori Infection or Non-Steroidal Anti-Inflammatory Drug Use. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007985"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rau, S., Gregg, A., Yaceczko, S., and Limketkai, B. (2024). Prebiotics and Probiotics for Gastrointestinal Disorders. Nutrients, 16.","DOI":"10.3390\/nu16060778"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Raoul, P., Maccauro, V., Cintoni, M., Scarpellini, E., Ianiro, G., Gasbarrini, A., Mele, M.C., and Rinninella, E. (2024). Microbiota\u2013Gastric Cancer Interactions and the Potential Influence of Nutritional Therapies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031679"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/1\/142\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:57:45Z","timestamp":1760115465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/1\/142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,31]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["nu17010142"],"URL":"https:\/\/doi.org\/10.3390\/nu17010142","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,31]]}}}