{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:42:00Z","timestamp":1760146920495,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CHRU of Montpellier","award":["AOI UF 8751","UF 8854"],"award-info":[{"award-number":["AOI UF 8751","UF 8854"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objective: Developing a scoring assessment tools for the determination of low bone mass for age at lumbar spine and hip in patients with anorexia nervosa (AN). Methods: The areal bone mineral density (aBMD) was determined with dual-energy X-ray absorptiometry (DXA). In 331 women with AN and 121 controls, aged from 14.5 to 34.9 years, univariate and multivariate logistic regression analyses were performed to address the association of Z-score aBMD evaluated at lumbar spine and hip with several parameters. Results: For the lumbar spine and hip, the three risk factors significantly and independently associated with Z-score aBMD were age of patients (variable in class \u226520 year vs. &lt;20 year), minimal disease-related BMI (continuous variable), and duration of amenorrhea without contraceptive use (variable in class \u226518 months vs. &lt;18 months), with close values for the odds ratio for the two bone sites. A simple risk score equation was developed and tested combining only these three parameters. The AUC\u2019s measuring the score\u2019s performance were, respectively, 0.85 [95% CI: 0.79\u20130.90] with a sensitivity of 83% and specificity of 71%, and 0.82 [95% CI: 0.76\u20130.86] with a sensitivity of 92% and specificity of 55% to detect low aBMD in lumbar spine and hip. The cut-off values for low bone mass for age were 0.9 and 1.33 for the two bone sites. The prediction model revealed that a minimum of 83% of the patients presenting low bone mass for age were correctly identified. Conclusions: the study presents for the first time a risk score for diagnosing low bone mass for age in young patients with AN. Considering its excellent sensitivity, and its ease of use, requiring only three parameters that are well identified in this disease, this new score may be useful in clinical settings when DXA scans are not feasible.<\/jats:p>","DOI":"10.3390\/nu17010161","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T12:37:19Z","timestamp":1735648639000},"page":"161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Risk Score to Identify Low Bone Mineral Density for Age in Young Patients with Anorexia Nervosa"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1727-1048","authenticated-orcid":false,"given":"Laurent","family":"Maimoun","sequence":"first","affiliation":[{"name":"Physiology and Experimental Medicine of the Heart and Muscles (PhyMedExp), CNRS, INSERM, University of Montpellier, 34295 Montpellier, France"},{"name":"Department of Nuclear Medicine, CHU Montpellier, 34295 Montpellier, France"},{"name":"Service de M\u00e9decine Nucl\u00e9aire, H\u00f4pital Lapeyronie, 371, Avenue du Doyen Gaston Giraud, CHU de Montpellier, CEDEX 5, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Huguet","sequence":"additional","affiliation":[{"name":"Unit of Clinical Research and Epidemiology, CHU Montpellier, University of Montpellier, 34000 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-7263","authenticated-orcid":false,"given":"Eric","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, Nutrition, CHU Montpellier, 34295 Montpellier, France"},{"name":"Central Information Commission (CIC), INSERM 1411, 34295 Montpellier, France"},{"name":"Institute of Functional Genomics, CNRS, INSERM, University of Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes, Nutrition, CHU Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maude","family":"Seneque","sequence":"additional","affiliation":[{"name":"Department of Emergency and Post-Emergency Psychiatry, CHU Montpellier, INSERM, University of Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gaspari","sequence":"additional","affiliation":[{"name":"Unit of Paediatric Endocrinology and Gynaecology, CHU Montpellier, University of Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Boudousq","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, CHU N\u00eemes, 30029 N\u00eemes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Maimoun Nande","sequence":"additional","affiliation":[{"name":"Departement of Biophysique, Faculty of Medicine, University of Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[{"name":"Department of Emergency and Post-Emergency Psychiatry, CHU Montpellier, INSERM, University of Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Sultan","sequence":"additional","affiliation":[{"name":"Unit of Paediatric Endocrinology and Gynaecology, CHU Montpellier, University of Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-2961","authenticated-orcid":false,"given":"Denis","family":"Mariano-Goulart","sequence":"additional","affiliation":[{"name":"Physiology and Experimental Medicine of the Heart and Muscles (PhyMedExp), CNRS, INSERM, University of Montpellier, 34295 Montpellier, France"},{"name":"Department of Nuclear Medicine, CHU Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-7299","authenticated-orcid":false,"given":"Marie-Christine","family":"Picot","sequence":"additional","affiliation":[{"name":"Unit of Clinical Research and Epidemiology, CHU Montpellier, University of Montpellier, 34000 Montpellier, France"},{"name":"Central Information Commission (CIC), INSERM 1411, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-9982","authenticated-orcid":false,"given":"Sebastien","family":"Guillaume","sequence":"additional","affiliation":[{"name":"Department of Emergency and Post-Emergency Psychiatry, CHU Montpellier, INSERM, University of Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1210\/jc.2007-1434","article-title":"Weight gain and restoration of menses as predictors of bone mineral density change in adolescent girls with anorexia nervosa-1","volume":"93","author":"Misra","year":"2008","journal-title":"J. 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