{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:44:05Z","timestamp":1791895445620,"version":"4.3.4"},"reference-count":187,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Slovak Research and Development Agency","award":["APVV-21-0355"],"award-info":[{"award-number":["APVV-21-0355"]}]},{"name":"The Slovak Research and Development Agency","award":["VEGA 1\/0341\/23"],"award-info":[{"award-number":["VEGA 1\/0341\/23"]}]},{"name":"Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic","award":["APVV-21-0355"],"award-info":[{"award-number":["APVV-21-0355"]}]},{"name":"Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic","award":["VEGA 1\/0341\/23"],"award-info":[{"award-number":["VEGA 1\/0341\/23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The global pandemic of obesity poses a serious health, social, and economic burden. Patients living with obesity are at an increased risk of developing noncommunicable diseases or to die prematurely. Obesity is a state of chronic low-grade inflammation. Neutrophils are first to be recruited to sites of inflammation, where they contribute to host defense via phagocytosis, degranulation, and extrusion of neutrophil extracellular traps (NETs). NETs are web-like DNA structures of nuclear or mitochondrial DNA associated with cytosolic antimicrobial proteins. The primary function of NETosis is preventing the dissemination of pathogens. However, neutrophils may occasionally misidentify host molecules as danger-associated molecular patterns, triggering NET formation. This can lead to further recruitment of neutrophils, resulting in propagation and a vicious cycle of persistent systemic inflammation. This scenario may occur when neutrophils infiltrate expanded obese adipose tissue. Thus, NETosis is implicated in the pathophysiology of autoimmune and metabolic disorders, including obesity. This review explores the role of NETosis in obesity and two obesity-associated conditions\u2014hypertension and liver steatosis. With the rising prevalence of obesity driving research into its pathophysiology, particularly through diet-induced obesity models in rodents, we discuss insights gained from both human and animal studies. Additionally, we highlight the potential offered by rodent models and the opportunities presented by genetically modified mouse strains for advancing our understanding of obesity-related inflammation.<\/jats:p>","DOI":"10.3390\/nu17020241","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T06:25:54Z","timestamp":1736490354000},"page":"241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pathophysiological Role of Neutrophil Extracellular Traps in Diet-Induced Obesity and Metabolic Syndrome in Animal Models"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8349-6130","authenticated-orcid":false,"given":"Andrej","family":"Feje\u0161","sequence":"first","affiliation":[{"name":"Institute of Molecular Biomedicine, Medical Faculty, Comenius University, 83303 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-9265","authenticated-orcid":false,"given":"Katar\u00edna","family":"\u0160ebekov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biomedicine, Medical Faculty, Comenius University, 83303 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-9626","authenticated-orcid":false,"given":"Veronika","family":"Borb\u00e9lyov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biomedicine, Medical Faculty, Comenius University, 83303 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"ref_1","unstructured":"WOF (2024). 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