{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:11:35Z","timestamp":1789873895489,"version":"4.0.1"},"reference-count":213,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Minority Health and Health Disparities","award":["U54 MD007582"],"award-info":[{"award-number":["U54 MD007582"]}]},{"name":"National Institute of Minority Health and Health Disparities","award":["P20 MD006738"],"award-info":[{"award-number":["P20 MD006738"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Biological aging is a substantial change that leads to different diseases, including osteoporosis (OP), a condition involved in loss of bone density, deterioration of bone structure, and increased fracture risk. In old people, there is a natural decline in bone mineral density (BMD), exacerbated by hormonal changes, particularly during menopause, and it continues in the early postmenopausal years. During this transition time, hormonal alterations are linked to elevated oxidative stress (OS) and decreased antioxidant defenses, leading to a significant increase in OP. Aging is significantly associated with an abnormal ratio of oxidant\/antioxidant and modified nuclear factor erythroid-derived two related factor2 (Nrf2)\/Kelch-like ECH-associated protein 1 (Keap1) pathway. OS adversely affects bone health by promoting osteoclastic (bone resorbing) activity and impairing osteoblastic (bone-forming cells). Nrf2 is critical in controlling OS and various cellular processes. The expression of Nrf2 is linked to multiple age-related diseases, including OP, and Nrf2 deficiency leads to unbalanced bone formation\/resorption and a consequent decline in bone mass. Various drugs are available for treating OP; however, long-term uses of these medicines are implicated in diverse illnesses such as cancer, cardiovascular, and stroke. At the same time, multiple categories of natural products, in particular flavonoids, were proposed as safe alternatives with antioxidant activity and substantial anti-osteoporotic effects.<\/jats:p>","DOI":"10.3390\/nu17020267","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T05:40:40Z","timestamp":1736746840000},"page":"267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nrf2 Activation as a Therapeutic Target for Flavonoids in Aging-Related Osteoporosis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8322-8067","authenticated-orcid":false,"given":"Samia S.","family":"Messeha","sequence":"first","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"},{"name":"College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidara F.","family":"Fidudusola","sequence":"additional","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Gendy","sequence":"additional","affiliation":[{"name":"School of Allied Health Sciences, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekan M.","family":"Latinwo","sequence":"additional","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline O.","family":"Odewumi","sequence":"additional","affiliation":[{"name":"College of Science and Technology, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-1085","authenticated-orcid":false,"given":"Karam F. A.","family":"Soliman","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm.1979","article-title":"TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation","volume":"15","author":"Tang","year":"2009","journal-title":"Nat. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/j.injury.2007.02.014","article-title":"Fracture healing in osteoporotic fractures: Is it really different? A basic science perspective","volume":"38","author":"Giannoudis","year":"2007","journal-title":"Injury"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/156720512799015064","article-title":"Metabolic dysfunction in Alzheimer\u2019s disease and related neurodegenerative disorders","volume":"9","author":"Cai","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/1933719113518992","article-title":"Hormonal changes during menopause and the impact on fluid regulation","volume":"21","author":"Stachenfeld","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/cen.14049","article-title":"Identifying and addressing osteoporosis knowledge gaps in women with premature ovarian insufficiency and early menopause: A mixed-methods study","volume":"91","author":"Goh","year":"2019","journal-title":"Clin. Endocrinol."},{"key":"ref_6","unstructured":"Volodymyr, S., Marina, S., Olexandr, D., Anna, S., and Oleksandr, K. (March, January 27). Management of Menopausal Osteoporosis. Proceedings of the 8th International Scientific and Practical Conference \u201cPriority Areas of Research in the Scientific Activity of Teachers\u201d, Zagreb, Croatia. 298p."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Caplan, R.M. (2024). Menopause and Osteoporosis. Long Life Strategy: A Guide for Living a Longer, Healthier, and More Fulfilling Life, Springer.","DOI":"10.1007\/978-3-031-44518-7"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1474-9726.2010.00616.x","article-title":"Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration","volume":"9","author":"Jilka","year":"2010","journal-title":"Aging Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bone.2005.12.082","article-title":"Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females","volume":"39","author":"Abdallah","year":"2006","journal-title":"Bone"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/jbmr.2892","article-title":"Identification of Senescent Cells in the Bone Microenvironment","volume":"31","author":"Farr","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1474-9726.2011.00669.x","article-title":"Senescence-associated intrinsic mechanisms of osteoblast dysfunctions","volume":"10","author":"Kassem","year":"2011","journal-title":"Aging Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bone.2016.01.014","article-title":"Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage","volume":"85","author":"Singh","year":"2016","journal-title":"Bone"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chandra, A., and Rajawat, J. (2021). Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073553"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ayub, N., Faraj, M., Ghatan, S., Reijers, J.A.A., Napoli, N., and Oei, L. (2021). The Treatment Gap in Osteoporosis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10133002"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1359\/jbmr.2003.18.11.1947","article-title":"BMD at multiple sites and risk of fracture of multiple types: Long-term results from the Study of Osteoporotic Fractures","volume":"18","author":"Stone","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bone.2019.02.013","article-title":"Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis","volume":"122","author":"Bellavia","year":"2019","journal-title":"Bone"},{"key":"ref_17","first-page":"589","article-title":"Epigenetic mechanisms in bone","volume":"52","author":"Marc","year":"2014","journal-title":"Clin. Chem. Lab Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Marini, F., Cianferotti, L., and Brandi, M.L. (2016). Epigenetic Mechanisms in Bone Biology and Osteoporosis: Can They Drive Therapeutic Choices?. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17081329"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ygeno.2018.05.001","article-title":"New insights into the epigenetics of osteoporosis","volume":"111","author":"Letarouilly","year":"2019","journal-title":"Genomics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.molmed.2016.06.002","article-title":"Osteoporosis: The Result of an \u2019Aged\u2019 Bone Microenvironment","volume":"22","author":"Yu","year":"2016","journal-title":"Trends Mol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wang, N., Xin, H., Xu, P., Yu, Z., and Shou, D. (2019). Erxian Decoction Attenuates TNF-\u03b1 Induced Osteoblast Apoptosis by Modulating the Akt\/Nrf2\/HO-1 Signaling Pathway. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00988"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1080\/15592294.2017.1345832","article-title":"Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women","volume":"12","author":"Reppe","year":"2017","journal-title":"Epigenetics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"14852","DOI":"10.1002\/jcp.28304","article-title":"Role of physical exercise in the regulation of epigenetic mechanisms in inflammation, cancer, neurodegenerative diseases, and aging process","volume":"234","author":"Ferioli","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cmet.2012.01.001","article-title":"Acute exercise remodels promoter methylation in human skeletal muscle","volume":"15","author":"Yan","year":"2012","journal-title":"Cell Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pharmthera.2018.02.006","article-title":"Nucleosidic DNA demethylating epigenetic drugs\u2014A comprehensive review from discovery to clinic","volume":"188","author":"Agrawal","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cellsig.2015.02.006","article-title":"Decitabine represses osteoclastogenesis through inhibition of RANK and NF-\u03baB","volume":"27","author":"Guan","year":"2015","journal-title":"Cell Signal"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1136\/bjsm.2008.052704","article-title":"A meta-analysis of impact exercise on postmenopausal bone loss: The case for mixed loading exercise programmes","volume":"43","author":"Carroll","year":"2009","journal-title":"Br. J. Sports Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"bvaa200","DOI":"10.1210\/jendso\/bvaa200","article-title":"Gene Testing in Everyday Clinical Use: Lessons from the Bone Clinic","volume":"5","author":"Duncan","year":"2021","journal-title":"J. Endocr. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/jbmr.344","article-title":"Trabecular bone microstructure and local gene expression in iliac crest biopsies of men with idiopathic osteoporosis","volume":"26","author":"Patsch","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"27285","DOI":"10.1074\/jbc.M702810200","article-title":"Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids","volume":"282","author":"Almeida","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1210\/jc.2009-2677","article-title":"Update in new anabolic therapies for osteoporosis","volume":"95","author":"Canalis","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","first-page":"371","article-title":"Bone biology. I: Structure, blood supply, cells, matrix, and mineralization","volume":"45","author":"Buckwalter","year":"1996","journal-title":"Instr. Course Lect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/aja.1001830102","article-title":"Bone cell biology: The regulation of development, structure, and function in the skeleton","volume":"183","author":"Marks","year":"1988","journal-title":"Am. J. Anat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.289.5484.1501","article-title":"The osteoblast: A sophisticated fibroblast under central surveillance","volume":"289","author":"Ducy","year":"2000","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.abb.2014.05.003","article-title":"Osteoblast and osteocyte: Games without frontiers","volume":"561","author":"Capulli","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discov."},{"key":"ref_37","first-page":"953","article-title":"Bone lining cells: Structure and function","volume":"3","author":"Miller","year":"1989","journal-title":"Scanning Microsc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2353\/ajpath.2009.080627","article-title":"A physical mechanism for coupling bone resorption and formation in adult human bone","volume":"174","author":"Andersen","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_39","first-page":"189","article-title":"Osteoporosis and bone functional adaptation: Mechanobiological regulation of bone architecture in growing and adult bone, a review","volume":"37","author":"Mosley","year":"2000","journal-title":"J. Rehabil. Res. Dev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/dvdy.20603","article-title":"Buried alive: How osteoblasts become osteocytes","volume":"235","author":"Hall","year":"2006","journal-title":"Dev. Dyn."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1196\/annals.1402.018","article-title":"Osteocytes as dynamic multifunctional cells","volume":"1116","author":"Bonewald","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S8756-3282(96)00365-1","article-title":"Identification of apoptotic changes in osteocytes in normal and pathological human bone","volume":"20","author":"Noble","year":"1997","journal-title":"Bone"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.060107","article-title":"Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss","volume":"21","author":"Aguirre","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11914-014-0194-3","article-title":"Apoptotic osteocytes and the control of targeted bone resorption","volume":"12","author":"Plotkin","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1158\/0008-5472.CAN-18-0056","article-title":"Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells","volume":"78","author":"Liu","year":"2018","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tem.2020.11.007","article-title":"Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment","volume":"32","author":"Bellavia","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Florencio-Silva, R., Sasso, G.R., Sasso-Cerri, E., Sim\u00f5es, M.J., and Cerri, P.S. (2015). Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. Biomed. Res. Int., 2015.","DOI":"10.1155\/2015\/421746"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/ar.1092260403","article-title":"Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff\u2019s law: The remodeling problem","volume":"226","author":"Frost","year":"1990","journal-title":"Anat. Rec."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ar.1092260402","article-title":"Skeletal structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff\u2019s law: The bone modeling problem","volume":"226","author":"Frost","year":"1990","journal-title":"Anat. Rec."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sun, Y.X., Xu, A.H., Yang, Y., and Li, J. (2015). Role of Nrf2 in bone metabolism. J. Biomed. Sci., 22.","DOI":"10.1186\/s12929-015-0212-5"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1242\/jcs.063032","article-title":"Bone remodelling at a glance","volume":"124","author":"Crockett","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11914-012-0099-y","article-title":"The interaction of biological factors with mechanical signals in bone adaptation: Recent developments","volume":"10","author":"Robling","year":"2012","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.exger.2017.01.011","article-title":"Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause","volume":"90","author":"Pereira","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1359\/jbmr.2000.15.8.1526","article-title":"Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study","volume":"15","author":"Garnero","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00223-010-9393-9","article-title":"Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures","volume":"87","author":"Baek","year":"2010","journal-title":"Calcif. Tissue Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"21237","DOI":"10.1074\/jbc.M701341200","article-title":"Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts","volume":"282","author":"Huang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ilankoon, I., Samarasinghe, K., and Elg\u00e1n, C. (2021). Menopause is a natural stage of aging: A qualitative study. BMC Women\u2019s Health, 21.","DOI":"10.1186\/s12905-020-01164-6"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP.17.S6.1","article-title":"American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of menopause","volume":"17","author":"Goodman","year":"2011","journal-title":"Endocr. Pract."},{"key":"ref_62","first-page":"18","article-title":"Menopause uncertainty: The impact of two educational interventions among women during menopausal transition and beyond","volume":"19","author":"Afshari","year":"2020","journal-title":"Prz. Menopauzalny"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.maturitas.2009.08.003","article-title":"Premature menopause or early menopause: Long-term health consequences","volume":"65","author":"Shuster","year":"2010","journal-title":"Maturitas"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1210\/jc.2008-0567","article-title":"Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition","volume":"93","author":"Sowers","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tem.2012.03.008","article-title":"Estrogen and the skeleton","volume":"23","author":"Khosla","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bone.2009.11.006","article-title":"Osteocyte apoptosis and control of bone resorption following ovariectomy in mice","volume":"46","author":"Emerton","year":"2010","journal-title":"Bone"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1469-7580.2011.01449.x","article-title":"Structural and functional changes in the alveolar bone osteoclasts of estrogen-treated rats","volume":"220","author":"Faloni","year":"2012","journal-title":"J. Anat."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-0765.2006.00932.x","article-title":"Decrease in the number and apoptosis of alveolar bone osteoclasts in estrogen-treated rats","volume":"42","author":"Faloni","year":"2007","journal-title":"J. Periodontal Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha","volume":"106","author":"Cenci","year":"2000","journal-title":"J. Clin. Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.yexcr.2009.01.014","article-title":"Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL-regulated interaction of estrogen receptor-alpha with BCAR1 and Traf6","volume":"315","author":"Robinson","year":"2009","journal-title":"Exp. Cell Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1073\/pnas.2005859117","article-title":"Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site","volume":"117","author":"Li","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI200318859","article-title":"A crucial role for thiol antioxidants in estrogen-deficiency bone loss","volume":"112","author":"Lean","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cccn.2005.04.014","article-title":"Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats","volume":"360","author":"Muthusami","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11914-003-0009-4","article-title":"Role of cytokines in postmenopausal bone loss","volume":"1","author":"Pfeilschifter","year":"2003","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Moskot, M., Jak\u00f3bkiewicz-Banecka, J., Kloska, A., Smoli\u0144ska, E., Mozolewski, P., Malinowska, M., Rych\u0142owski, M., Banecki, B., W\u0119grzyn, G., and Gabig-Cimi\u0144ska, M. (2015). Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids. Sci. Rep., 5.","DOI":"10.1038\/srep09378"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/r\/10-13","article-title":"Oxidative stress: An evolving definition","volume":"10","author":"Ji","year":"2021","journal-title":"Fac. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sies, H. (2020). Oxidative Stress: Concept and Some Practical Aspects. Antioxidants, 9.","DOI":"10.3390\/antiox9090852"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12032-022-01749-1","article-title":"Molecular perspective on targeted therapy in breast cancer: A review of current status","volume":"39","year":"2022","journal-title":"Med. Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Lin, L., Wu, Q., Lu, F., Lei, J., Zhou, Y., Liu, Y., Zhu, N., Yu, Y., Ning, Z., and She, T. (2023). Nrf2 signaling pathway: Current status and potential therapeutic targetable role in human cancers. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1184079"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.lfs.2015.05.015","article-title":"Potential drugs which activate nuclear factor E2-related factor 2 signaling to prevent diabetic cardiovascular complications: A focus on fumaric acid esters","volume":"134","author":"Zhou","year":"2015","journal-title":"Life Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12263-012-0324-4","article-title":"Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway","volume":"8","author":"Cimino","year":"2013","journal-title":"Genes Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: Pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim Biophys Acta Mol. Basis Dis."},{"key":"ref_83","first-page":"490","article-title":"Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies","volume":"2","author":"Paramasivan","year":"2019","journal-title":"Cancer Drug Resist."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"637","DOI":"10.14336\/AD.2018.0513","article-title":"The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1\/Nrf2\/ARE Signaling Pathway in Chronic Diseases","volume":"10","author":"Tu","year":"2019","journal-title":"Aging Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.freeradbiomed.2015.06.013","article-title":"Epigenetic regulation of Keap1-Nrf2 signaling","volume":"88","author":"Guo","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3172480","DOI":"10.1155\/2018\/3172480","article-title":"Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke","volume":"2018","author":"Ehnert","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1007\/s00432-023-04734-x","article-title":"The role of the Nrf2\/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours","volume":"149","author":"Zisterer","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Yi, M., Cruz Cisneros, L., Cho, E.J., Alexander, M., Kimelman, F.A., Swentek, L., Ferrey, A., Tantisattamo, E., and Ichii, H. (2024). Nrf2 pathway and oxidative stress as a common target for treatment of diabetes and its comorbidities. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25020821"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4826724","DOI":"10.1155\/2017\/4826724","article-title":"The Nrf2\/Keap1\/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus","volume":"2017","author":"David","year":"2017","journal-title":"J. Diabetes Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Gao, X., Wang, B., Huang, Y., Wu, M., Li, Y., Li, Y., Zhu, X., and Wu, M. (2023). Role of the Nrf2 Signaling Pathway in Ovarian Aging: Potential Mechanism and Protective Strategies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713327"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.freeradbiomed.2013.08.005","article-title":"Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation","volume":"65","author":"Hyeon","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s12035-022-03093-x","article-title":"Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2\/HO-1 Pathway","volume":"60","author":"Samy","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2015.06.006","article-title":"Molecular basis of the Keap1-Nrf2 system","volume":"88","author":"Suzuki","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Baeza-P\u00e9rez, L.G., Calzada-Mendoza, C.C., Hern\u00e1ndez-Campos, M.E., L\u00f3pez-S\u00e1nchez, P., and Anguiano-Robledo, L. (2025, January 08). Hormonal Replacement Therapy Modulates the Expression of Nrf2 and the Activity of Antioxidant Enzymes in Vascular Organs in a Model of Ovariectomy. Available online: https:\/\/www.jstage.jst.go.jp\/article\/jpssuppl\/WCP2018\/0\/WCP2018_PO4-2-46\/_article.","DOI":"10.1254\/jpssuppl.WCP2018.0_PO4-2-46"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2014.12.066","article-title":"Deletion of Nrf2 reduces skeletal mechanical properties and decreases load-driven bone formation","volume":"74","author":"Sun","year":"2015","journal-title":"Bone"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"40007","DOI":"10.1074\/jbc.M403715200","article-title":"Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts","volume":"279","author":"Salim","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jcp.10321","article-title":"Hypoxia is a major stimulator of osteoclast formation and bone resorption","volume":"196","author":"Arnett","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00774-015-0656-4","article-title":"Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases","volume":"33","author":"Callaway","year":"2015","journal-title":"J. Bone Miner. Metab."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1172\/JCI28550","article-title":"Estrogen deficiency and bone loss: An inflammatory tale","volume":"116","author":"Weitzmann","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Pellegrini, G.G., Cregor, M., McAndrews, K., Morales, C.C., McCabe, L.D., McCabe, G.P., Peacock, M., Burr, D., Weaver, C., and Bellido, T. (2017). Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171161"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bone.2014.01.025","article-title":"Nrf2 is a novel regulator of bone acquisition","volume":"63","author":"Park","year":"2014","journal-title":"Bone"},{"key":"ref_103","first-page":"726590","article-title":"Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis","volume":"2014","author":"Brines","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.freeradbiomed.2012.10.536","article-title":"Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL","volume":"53","author":"Rana","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1182\/blood-2018-11-852459","article-title":"Myeloma bone disease: From biology findings to treatment approaches","volume":"133","author":"Terpos","year":"2019","journal-title":"Blood"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"12929","DOI":"10.1096\/fj.201900887RR","article-title":"Octyl itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling","volume":"33","author":"Sun","year":"2019","journal-title":"FASEB J."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Sun, X., Xie, Z., Hu, B., Zhang, B., Ma, Y., Pan, X., Huang, H., Wang, J., Zhao, X., and Jie, Z. (2020). The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-\u03bab signaling. Redox Biol., 28.","DOI":"10.1016\/j.redox.2019.101309"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-020-00128-8","article-title":"Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis","volume":"9","author":"Chen","year":"2021","journal-title":"Bone Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00223-019-00576-3","article-title":"Role of Nrf2 in Fracture Healing: Clinical Aspects of Oxidative Stress","volume":"105","author":"Kubo","year":"2019","journal-title":"Calcif. Tissue Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.12659\/MSM.908699","article-title":"Lutein Suppresses Oxidative Stress and Inflammation by Nrf2 Activation in an Osteoporosis Rat Model","volume":"24","author":"Li","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0163-7258(02)00297-8","article-title":"Mechanisms involved in the side effects of glucocorticoids","volume":"96","author":"Asadullah","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.04.014","article-title":"Chlorogenic acid promotes the Nrf2\/HO-1 anti-oxidative pathway by activating p21(Waf1\/Cip1) to resist dexamethasone-induced apoptosis in osteoblastic cells","volume":"137","author":"Han","year":"2019","journal-title":"Free Radic. Biol.Med."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Xu, W.N., Zheng, H.L., Yang, R.Z., Jiang, L.S., and Jiang, S.D. (2019). HIF-1\u03b1 Regulates Glucocorticoid-Induced Osteoporosis Through PDK1\/AKT\/mTOR Signaling Pathway. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00922"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Li, H., Qian, W., Weng, X., Wu, Z., Li, H., Zhuang, Q., Feng, B., and Bian, Y. (2012). Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037030"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/jcp.24589","article-title":"P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts","volume":"229","author":"Zhen","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"9102012","DOI":"10.1155\/2020\/9102012","article-title":"Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1039\/C3NP70065H","article-title":"Natural product-derived pharmacological modulators of Nrf2\/ARE pathway for chronic diseases","volume":"31","author":"Kumar","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4161\/auto.19012","article-title":"Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress","volume":"8","author":"Bhogal","year":"2012","journal-title":"Autophagy"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.1074\/jbc.M114.563114","article-title":"Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation","volume":"289","author":"Zhao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/jor.21452","article-title":"Effects of \u03b1-tocopherol on the early phase of osteoporotic fracture healing","volume":"29","author":"Shuid","year":"2011","journal-title":"J. Orthop. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00223-014-9900-5","article-title":"Nrf2 deficiency impairs fracture healing in mice","volume":"95","author":"Lippross","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0891-5849(01)00610-4","article-title":"Oxidative stress modulates osteoblastic differentiation of vascular and bone cells","volume":"31","author":"Mody","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1084\/jem.20062525","article-title":"Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification","volume":"204","author":"Morita","year":"2007","journal-title":"J. Exp. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","article-title":"What old means to bone","volume":"21","author":"Manolagas","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.injury.2005.07.027","article-title":"Overview of the fracture healing cascade","volume":"36","author":"Phillips","year":"2005","journal-title":"Injury"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.molmed.2009.08.004","article-title":"Oxidative stress in bone remodelling and disease","volume":"15","author":"Wauquier","year":"2009","journal-title":"Trends Mol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Chen, L.R., Ko, N.Y., and Chen, K.H. (2019). Medical Treatment for Osteoporosis: From Molecular to Clinical Opinions. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092213"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/14712598.2018.1401607","article-title":"Monoclonal antibodies for treating osteoporosis","volume":"18","author":"Faienza","year":"2018","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/jwh.2013.4611","article-title":"Osteoporosis prevention, screening, and treatment: A review","volume":"23","author":"Kling","year":"2014","journal-title":"J. Womens Health"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Wong, S.K., Chin, K.Y., and Ima-Nirwana, S. (2020). Quercetin as an Agent for Protecting the Bone: A Review of the Current Evidence. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176448"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.foodchem.2018.04.039","article-title":"Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L.) peel: A review","volume":"261","author":"Singh","year":"2018","journal-title":"Food Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1100\/2011\/471426","article-title":"Quercetin protects primary human osteoblasts exposed to cigarette smoke through activation of the antioxidative enzymes HO-1 and SOD-1","volume":"11","author":"Braun","year":"2011","journal-title":"Sci. World J."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1080\/14786419.2018.1460834","article-title":"A new flavonol glycoside and other flavonoids from the aerial parts of Taverniera aegyptiaca","volume":"33","author":"Hassan","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3748\/wjg.v19.i7.1011","article-title":"Dietary flavonoid intake and risk of stomach and colorectal cancer","volume":"19","author":"Woo","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11914-014-0212-5","article-title":"The effects of flavonoids on bone","volume":"12","author":"Welch","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"162750","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: An overview","volume":"2013","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.taap.2018.12.019","article-title":"Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination","volume":"365","author":"Chen","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0976-9668.92322","article-title":"Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: An overview","volume":"2","author":"Qureshi","year":"2011","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00198-017-4255-1","article-title":"The effect of icariin on bone metabolism and its potential clinical application","volume":"29","author":"Wang","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-0035-1558294","article-title":"Beneficial Effects of a Flavonoid Fraction of Herba Epimedii on Bone Metabolism in Ovariectomized Rats","volume":"82","author":"Zhao","year":"2016","journal-title":"Planta Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.intimp.2018.07.017","article-title":"Isomeric flavonoid aglycones derived from Epimedii Folium exerted different intensities in anti-osteoporosis through OPG\/RANKL protein targets","volume":"62","author":"Jiang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/21551197.2012.698220","article-title":"Flavonoid intake and bone health","volume":"31","author":"Weaver","year":"2012","journal-title":"J. Nutr. Gerontol. Geriatr."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.2147\/DDDT.S315249","article-title":"Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis","volume":"15","author":"Wei","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopha.2017.01.067","article-title":"Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation","volume":"88","author":"Qi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.redox.2013.07.005","article-title":"Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-\u03baB pathways in diabetic neuropathy","volume":"1","author":"Negi","year":"2013","journal-title":"Redox Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.msec.2017.09.005","article-title":"Mixed-ligand copper(II) complex of quercetin regulate osteogenesis and angiogenesis","volume":"83","author":"Vimalraj","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-9422(02)00116-4","article-title":"Genistein","volume":"60","author":"Dixon","year":"2002","journal-title":"Phytochemistry"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/13697130500345257","article-title":"Effect of pure genistein on bone markers and hot flushes","volume":"8","author":"Albertazzi","year":"2005","journal-title":"Climacteric"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11657-024-01467-3","article-title":"Effects of isoflavone interventions on bone turnover markers and factors regulating bone metabolism in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials","volume":"20","author":"Inpan","year":"2024","journal-title":"Arch. Osteoporos."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"839","DOI":"10.7326\/0003-4819-146-12-200706190-00005","article-title":"Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: A randomized trial","volume":"146","author":"Marini","year":"2007","journal-title":"Ann. Intern Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s001980050065","article-title":"The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats","volume":"8","author":"Fanti","year":"1998","journal-title":"Osteoporos. Int."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s12272-010-0418-8","article-title":"Formononetin prevents ovariectomy-induced bone loss in rats","volume":"33","author":"Ha","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.2147\/DDDT.S227738","article-title":"The Osteoprotective Effects of Kaempferol: The Evidence from In Vivo and In Vitro Studies","volume":"13","author":"Wong","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mce.2008.02.027","article-title":"Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats","volume":"289","author":"Trivedi","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.intimp.2016.12.020","article-title":"Kaempferol slows intervertebral disc degeneration by modifying LPS-induced osteogenesis\/adipogenesis imbalance and inflammation response in BMSCs","volume":"43","author":"Zhu","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/bem.22012","article-title":"Effects of combined treatment with ibandronate and pulsed electromagnetic field on ovariectomy-induced osteoporosis in rats","volume":"38","author":"Zhou","year":"2017","journal-title":"Bioelectromagnetics"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exphem.2016.10.005","article-title":"Tumor necrosis factor \u03b1 in the onset and progression of leukemia","volume":"45","author":"Zhou","year":"2017","journal-title":"Exp. Hematol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.bcp.2005.12.023","article-title":"Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells","volume":"71","author":"Pang","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.lfs.2010.12.009","article-title":"8-Prenylkaempferol accelerates osteoblast maturation through bone morphogenetic protein-2\/p38 pathway to activate Runx2 transcription","volume":"88","author":"Chiou","year":"2011","journal-title":"Life Sci."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Sharma, A.R., and Nam, J.S. (2019). Kaempferol stimulates WNT\/\u03b2-catenin signaling pathway to induce differentiation of osteoblasts. J. Nutr. Biochem., 74.","DOI":"10.1016\/j.jnutbio.2019.108228"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Huang, J., Wu, C., Tian, B., Zhou, X., Ma, N., and Qian, Y. (2016). Myricetin Prevents Alveolar Bone Loss in an Experimental Ovariectomized Mouse Model of Periodontitis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030422"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1055\/a-1224-3625","article-title":"Current Pharmacological Trends on Myricetin","volume":"70","author":"Gupta","year":"2020","journal-title":"Drug Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/00071668.2018.1564239","article-title":"EDACO, a derivative of myricetin, inhibits the differentiation of Gaoyou duck embryonic osteoclasts in vitro","volume":"60","author":"Fu","year":"2019","journal-title":"Br. Poult. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bcp.2014.10.019","article-title":"Myricetin prevents titanium particle-induced osteolysis in vivo and inhibits RANKL-induced osteoclastogenesis in vitro","volume":"93","author":"Wu","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"105742","DOI":"10.1016\/j.intimp.2019.105742","article-title":"Activation of Nrf2\/HO-1 signal with Myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis","volume":"75","author":"Pan","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jot.2015.07.001","article-title":"Comparative study of two types of herbal capsules with different Epimedium species for the prevention of ovariectomised-induced osteoporosis in rats","volume":"4","author":"Chen","year":"2016","journal-title":"J. Orthop. Translat."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/jcp.24158","article-title":"Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling","volume":"228","author":"Ming","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bbrc.2018.11.201","article-title":"Icariin inhibits RANKL-induced osteoclastogenesis via modulation of the NF-\u03baB and MAPK signaling pathways","volume":"508","author":"Xu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.phymed.2009.08.007","article-title":"Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression","volume":"17","author":"Hsieh","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1039\/c8pp00174j","article-title":"Icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2\/ARE and reducing AP-1 and NF-\u03baB signaling pathways: A comparative study on UVB-irradiated human keratinocytes","volume":"17","author":"Hwang","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.biopha.2016.08.016","article-title":"Icariin attenuated oxidative stress induced-cardiac apoptosis by mitochondria protection and ERK activation","volume":"83","author":"Song","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Ramesh, P., Jagadeesan, R., Sekaran, S., Dhanasekaran, A., and Vimalraj, S. (2021). Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.779638"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jnutbio.2009.11.002","article-title":"The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss","volume":"22","author":"Kim","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.cellbi.2007.01.038","article-title":"Modulatory effects of luteolin on osteoblastic function and inflammatory mediators in osteoblastic MC3T3-E1 cells","volume":"31","author":"Choi","year":"2007","journal-title":"Cell Biol. Int."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"155516","DOI":"10.1016\/j.phymed.2024.155516","article-title":"Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling","volume":"128","author":"Chai","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/mnfr.201400592","article-title":"Rooibos flavonoids, orientin and luteolin, stimulate mineralization in human osteoblasts through the Wnt pathway","volume":"59","author":"Nash","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.lfs.2007.09.028","article-title":"Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages","volume":"81","author":"Chen","year":"2007","journal-title":"Life Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1021\/jf902680n","article-title":"Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation","volume":"58","author":"Trzeciakiewicz","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jnutbio.2009.01.017","article-title":"Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway","volume":"21","author":"Trzeciakiewicz","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Lee, J.Y., Park, Y.D., Kang, K.L., Lee, J.C., and Heo, J.S. (2013). Hesperetin alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of periodontal ligament stem cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0067504"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1152\/japplphysiol.00441.2007","article-title":"Hesperidin inhibits ovariectomized-induced osteopenia and shows differential effects on bone mass and strength in young and adult intact rats","volume":"104","author":"Horcajada","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Song, X., Chen, X., Jiang, R., Peng, K., Tang, X., and Liu, Z. (2021). Antiosteoporotic effect of hesperidin against ovariectomy-induced osteoporosis in rats via reduction of oxidative stress and inflammation. J. Biochem. Mol. Toxicol., 35.","DOI":"10.1002\/jbt.22832"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Zhang, M., Chen, D., Zeng, N., Liu, Z., Chen, X., Xiao, H., Xiao, L., Liu, Z., Dong, Y., and Zheng, J. (2022). Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53. Front Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.820922"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Hu, H.Y., Zhang, Z.Z., Jiang, X.Y., Duan, T.H., Feng, W., and Wang, X.G. (2023). Hesperidin Anti-Osteoporosis by Regulating Estrogen Signaling Pathways. Molecules, 28.","DOI":"10.3390\/molecules28196987"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10616-014-9694-3","article-title":"Apigenin inhibits osteoblastogenesis and osteoclastogenesis and prevents bone loss in ovariectomized mice","volume":"67","author":"Goto","year":"2015","journal-title":"Cytotechnology"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.2174\/0113816128298755240613100018","article-title":"Total Flavonoids Isolated from the Leaves of Eucommia ulmoides Augment Peak Bone Mass in Female Rats and Show no Side Effects in Other Organs","volume":"30","author":"Zhang","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Lin, S., Yincang, W., Jiazhe, D., Xilin, X., and Zhang, X. (2024). Pharmacology and mechanisms of apigenin in preventing osteoporosis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1486646"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e14053","DOI":"10.1111\/acel.14053","article-title":"HuR-positive stress granules: Potential targets for age-related osteoporosis","volume":"23","author":"Huai","year":"2024","journal-title":"Aging Cell"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Ali, D., Okla, M., Abuelreich, S., Vishnubalaji, R., Ditzel, N., Hamam, R., Kowal, J.M., Sayed, A., Aldahmash, A., and Alajez, N.M. (2024). Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1360054"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11010-015-2452-9","article-title":"Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways","volume":"407","author":"Zhang","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"ref_192","first-page":"216","article-title":"Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-alpha-induced production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells","volume":"62","author":"Choi","year":"2007","journal-title":"Pharmazie"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1359\/jbmr.040120","article-title":"The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis","volume":"19","author":"Dang","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Harahap, I.A., Schmidt, M., Pruszy\u0144ska-Oszma\u0142ek, E., Sassek, M., and Suliburska, J. (2024). Impact of Lactobacillus acidophilus and Its Combination with Isoflavone Products on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in a Post-Menopausal Osteoporotic Rat Model. Nutrients, 16.","DOI":"10.3390\/nu16152524"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Harahap, I.A., Olejnik, A., Kowalska, K., and Suliburska, J. (2024). Effects of Daidzein, Tempeh, and a Probiotic Digested in an Artificial Gastrointestinal Tract on Calcium Deposition in Human Osteoblast-like Saos-2 Cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25021008"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Harahap, I.A., Kuligowski, M., Cieslak, A., Ko\u0142odziejski, P.A., and Suliburska, J. (2024). Effect of Tempeh and Daidzein on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in Ovariectomized Rats. Nutrients, 16.","DOI":"10.3390\/nu16050651"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0006-2952(02)01585-X","article-title":"Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production","volume":"65","author":"Jia","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_198","first-page":"35","article-title":"Daidzein promotes proliferation and differentiation in osteoblastic OCT1 cells via activation of the BMP-2\/Smads pathway","volume":"72","author":"Yu","year":"2017","journal-title":"Pharmazie"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jcp.20008","article-title":"A low dose of daidzein acts as an ERbeta-selective agonist in trabecular osteoblasts of young female piglets","volume":"200","author":"Lieberherr","year":"2004","journal-title":"J. Cell. Physiol."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Tyagi, A.M., Srivastava, K., Sharan, K., Yadav, D., Maurya, R., and Singh, D. (2011). Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: A key mechanism for anti-osteoclastogenic effect. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021216"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jcb.22935","article-title":"Phytoestrogens directly inhibit TNF-\u03b1-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression","volume":"112","author":"Karieb","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"102372","DOI":"10.1016\/j.arr.2024.102372","article-title":"Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases","volume":"99","author":"Chen","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1254\/jphs.12243FP","article-title":"Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes","volume":"121","author":"Sakai","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"ref_204","first-page":"2922","article-title":"[Absorption mechanism of neobavaisoflavone in Caco-2 cell monolayer mode]","volume":"41","author":"Xu","year":"2016","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"9067","DOI":"10.1111\/jcmm.15543","article-title":"Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-\u03baB, MAPK and Akt pathways","volume":"24","author":"Chen","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/ddr.21811","article-title":"Neobavaisoflavone protects osteoblasts from dexamethasone-induced oxidative stress by upregulating the CRNDE-mediated Nrf2\/HO-1 signaling pathway","volume":"82","author":"Zhu","year":"2021","journal-title":"Drug Dev. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"256","DOI":"10.14573\/altex.2013.2.256","article-title":"Towards evidence-based translational research: The pros and cons of conducting systematic reviews of animal studies","volume":"30","author":"Leenaars","year":"2013","journal-title":"Altex"},{"key":"ref_209","first-page":"33","article-title":"Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: Meta-analysis of randomized controlled trials","volume":"19","author":"Taku","year":"2010","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clnu.2007.10.012","article-title":"Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials","volume":"27","author":"Ma","year":"2008","journal-title":"Clin. Nutr."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.bone.2008.12.020","article-title":"Effect of long-term intervention of soy isoflavones on bone mineral density in women: A meta-analysis of randomized controlled trials","volume":"44","author":"Liu","year":"2009","journal-title":"Bone"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1359\/jbmr.080201","article-title":"OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration","volume":"23","author":"Marini","year":"2008","journal-title":"J. Bone Miner. Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1089\/jmf.2016.3705","article-title":"Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"19","author":"Daily","year":"2016","journal-title":"J. Med. Food"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/2\/267\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:27:34Z","timestamp":1759919254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/2\/267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":213,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["nu17020267"],"URL":"https:\/\/doi.org\/10.3390\/nu17020267","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]}}}