{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:49:17Z","timestamp":1788572957884,"version":"build-2803163510"},"reference-count":43,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Nutrients"],"abstract":"<jats:p>Dental caries remains a prevalent chronic disease driven by dysbiosis in the oral biofilm, with Streptococcus mutans playing a central role in its pathogenesis. Objective: This study aimed to assess the effect of D-tagatose on cariogenic risk by analyzing randomized clinical trials (RCTs). Methods: A systematic literature review was conducted targeting RCTs published up to 2024 in eight databases and two gray literature sources. The search strategy utilized Medical Subject Headings (MeSHs) and relevant keywords combined via Boolean operators using the query \u201cTagatose OR D-tagatose AND Dental Caries\u201d. Eligible studies must evaluate the impact of D-tagatose on cariogenic risk, as indicated by reductions in colony-forming units (CFUs) and\/or improvements in salivary pH levels in treatment groups. Results: From 1139 retrieved records, three studies met the inclusion criteria. Two of these studies consistently demonstrated significant reductions in CFU counts in vitro and changes in oral bacteria in groups treated with D-tagatose alone or in mixtures with other agents compared to controls using other non-caloric sweeteners or placebos (p &lt; 0.01). However, the quality of the evidence was heterogeneous, with certain methodological concerns. Conclusions: Although the findings suggest potential benefits of D-tagatose in reducing cariogenic risk, limitations such as small sample sizes and variability in study methodologies warrant caution. Further robust investigations are needed to substantiate these promising results and support the integration of D-tagatose into oral care formulations aimed at reducing cariogenic risk.<\/jats:p>","DOI":"10.3390\/nu17020293","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T04:42:08Z","timestamp":1736916128000},"page":"293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of D-Tagatose on Cariogenic Risk: A Systematic Review of Randomized Clinical Trials"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-5112","authenticated-orcid":false,"given":"Liss\u00e9","family":"Angarita-Davila","sequence":"first","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Medicina, Universidad Andres Bello, Concepci\u00f3n 3349001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-0848","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Fuentes-Barr\u00eda","sequence":"additional","affiliation":[{"name":"Vicerrector\u00eda de Investigaci\u00f3n e Innovaci\u00f3n, Universidad Arturo Prat, Iquique 1100000, Chile"},{"name":"Escuela de Ondontolog\u00eda, Facultad de Odontolog\u00eda, Universidad Andres Bello, Concepci\u00f3n 3349001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6956-6315","authenticated-orcid":false,"given":"Diana","family":"Rojas-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Medicina, Universidad Andres Bello, Santiago 7550000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Aguilera-Egu\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Salud P\u00fablica, Facultad de Medicina, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n 3349001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-5567","authenticated-orcid":false,"given":"Miguel","family":"Alarc\u00f3n-Rivera","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias del Deporte y Actividad F\u00edsica, Facultad de Salud, Universidad Santo Tom\u00e1s, Talca 3460000, Chile"},{"name":"Facultad de Medicina, Universidad Cat\u00f3lica del Maule, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-9004","authenticated-orcid":false,"given":"Eduardo","family":"Guzm\u00e1n-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Escuela de Kinesiolog\u00eda, Facultad de Salud, Universidad Santo Tom\u00e1s, Talca 3460000, Chile"},{"name":"Escuela de Kinesiolog\u00eda, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ealla, K.K.R., Kumari, N., Chintalapani, S., Uppu, S., Sahu, V., Veeraraghavan, V.P., Ramani, P., and Govindool, S.R. 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