{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:17:13Z","timestamp":1788884233485,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["J94I19000930006"],"award-info":[{"award-number":["J94I19000930006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: The TAS1R2 SNP rs35874116 has previously been associated with sweet taste, diet, and health status, although never comprehensively in a single study. Also, associations between TAS1R2 and sweet taste might be body mass index (BMI)-dependent. Therefore, this study aimed to conduct a comprehensive investigation of rs35874116 and sweet taste intensity and liking, food liking, and diet and health status whilst considering BMI. Methods: Five-hundred and fifty-four participants were recruited. Linear regression models were used to explore rs35874116 associations with sweet taste intensity and liking, food liking, and diet and health status. A secondary analysis stratified participants by BMI &lt;25\/\u226525 kg\/m2. Results: The rs35874116 wildtype was associated with increased sweet taste intensity (p = 0.0345, B 1.29, SE 0.61) and liking (p = 0.021, B 0.25, SE 0.11). However, these associations only remained in BMI \u226525 individuals (intensity: p = 0.037, B 1.29, SE 0.61, liking: p = 0.008, B 0.46, SE 0.17). It was also associated with decreased diet quality (p = 0.03, B \u22120.27, SE 0.13) and reduced free sugar consumption but increased saturated fat consumption in BMI \u226525 individuals (free sugars: p = 0.0416, B \u22120.8, SE 0.38, saturated fat: p = 0.031, B 1.38, SE 0.62). There was no association with the mean liking score for sweet foods, although there were some associations with individual foods, which require further investigation. There were no associations with health status. Conclusions: This study revealed an association between the rs35874116 wildtype and an increased intensity and liking of the sweet taste and a corresponding worse overall dietary quality. This study adds to previous evidence regarding how associations between TAS1R2 and sweet taste are BMI-dependent.<\/jats:p>","DOI":"10.3390\/nu17020329","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T11:24:56Z","timestamp":1737113096000},"page":"329","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["TAS1R2 rs35874116 Associations with Taste, Diet, and Health in an Italian Population"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-8707","authenticated-orcid":false,"given":"Harry","family":"Stevens","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, University of Trieste, 34100 Trieste, Italy"},{"name":"Lake Lucerne Institute, 6354 Vitznau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-1151","authenticated-orcid":false,"given":"Catherine Anna-Marie","family":"Graham","sequence":"additional","affiliation":[{"name":"Lake Lucerne Institute, 6354 Vitznau, Switzerland"},{"name":"Cereneo Foundation\u2014Center for Interdisciplinary Research, 6354 Vitznau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-2537","authenticated-orcid":false,"given":"Maria Pina","family":"Concas","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2102-6735","authenticated-orcid":false,"given":"Francesco","family":"Piluso","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Trieste, 34100 Trieste, Italy"},{"name":"Lake Lucerne Institute, 6354 Vitznau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Mavrommatis","sequence":"additional","affiliation":[{"name":"Lake Lucerne Institute, 6354 Vitznau, Switzerland"},{"name":"Faculty of Sport, Technology and Health Sciences, St Mary\u2019s University Twickenham, London TW1 4SX, UK"},{"name":"MyHealthChecked PLC, Cardiff, CF24 5EA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-5402","authenticated-orcid":false,"given":"Alexandra","family":"King","sequence":"additional","affiliation":[{"name":"Faculty of Sport, Technology and Health Sciences, St Mary\u2019s University Twickenham, London TW1 4SX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leta","family":"Pilic","sequence":"additional","affiliation":[{"name":"Faculty of Sport, Technology and Health Sciences, St Mary\u2019s University Twickenham, London TW1 4SX, UK"},{"name":"Optimyse Nutrition Ltd., Radlett, WD7 9DJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Trieste, 34100 Trieste, Italy"},{"name":"Lake Lucerne Institute, 6354 Vitznau, Switzerland"},{"name":"Institute for Maternal and Child Health, IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/S0140-6736(19)30041-8","article-title":"Health effects of dietary risks in 195 countries, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"393","author":"Afshin","year":"2019","journal-title":"Lancet"},{"key":"ref_2","unstructured":"(2024, August 08). 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