{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:15:08Z","timestamp":1787879708912,"version":"build-2784847793"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Silesia","award":["KNW-1-204\/N\/8\/0"],"award-info":[{"award-number":["KNW-1-204\/N\/8\/0"]}]},{"name":"Association for the Development of Old Age Neurology","award":["KNW-1-204\/N\/8\/0"],"award-info":[{"award-number":["KNW-1-204\/N\/8\/0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Calcitriol, beyond its well-established role in calcium and phosphate homeostasis, contributes to immunological processes. No known vitamin D dosage regimen effectively corrects the deficiency while accounting for immunoregulatory effects. Therefore, the purpose of this assessment was to determine whether regular administration of low doses of vitamin D might correct deficiency and have immunoregulatory effects. Methods: A total of 35 healthy volunteers were asked to supplement with vitamin D daily at a dosage of 500 or 1000 IU, depending on the degree of deficiency, for 12 months. At the beginning of the study and after the end of the supplementation period, concentrations of 25(OH)D; PTH; total calcium; inorganic phosphorus; and the inflammatory cytokines IL-17, IL-10, TGF-\u03b2, and IFN-\u03b3 were determined in all participants. Results: Correction of vitamin D deficiency was achieved with accompanying decreases in PTH and pro-inflammatory cytokine concentrations, while the concentration of anti-inflammatory cytokines remained stable. Conclusions: Therefore, regular vitamin D supplementation, even in small doses, effectively corrected the deficiency and had immunomodulatory effects.<\/jats:p>","DOI":"10.3390\/nu17020352","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T09:11:13Z","timestamp":1737364273000},"page":"352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does Systematic Use of Small Doses of Vitamin D Have Anti-Inflammatory Effects and Effectively Correct Deficiency Among Healthy Adults?"],"prefix":"10.3390","volume":"17","author":[{"given":"Anna","family":"Walawska-Hrycek","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeniusz","family":"Hrycek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medical Sciences, Andrzej Frycz Modrzewski Krak\u00f3w University, 30-705 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-7013","authenticated-orcid":false,"given":"Weronika","family":"Galus","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina","family":"J\u0119drzejowska-Szypu\u0142ka","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-3088","authenticated-orcid":false,"given":"Ewa","family":"Krzystanek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences in Katowice, Medical University of Silesia, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.3390\/nu7043011","article-title":"Vitamin D and 1,25(OH)2D regulation of T cells","volume":"7","author":"Cantorna","year":"2015","journal-title":"Nutrients"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.4049\/jimmunol.168.3.1181","article-title":"1,25-Dihydroxyvitamin D3 Inhibits IFN-Gamma and IL-4 Levels During in vitro Polarization of Primary Murine CD4+ T Cells","volume":"168","author":"Freedman","year":"2002","journal-title":"J. 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