{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:26:43Z","timestamp":1790386003547,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007686","name":"National Institute of Perinatology","doi-asserted-by":"publisher","award":["3300-11402-01-575-17"],"award-info":[{"award-number":["3300-11402-01-575-17"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007686","name":"National Institute of Perinatology","doi-asserted-by":"publisher","award":["FOSISS-2015-3-261661"],"award-info":[{"award-number":["FOSISS-2015-3-261661"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Council of Science and Technology","award":["3300-11402-01-575-17"],"award-info":[{"award-number":["3300-11402-01-575-17"]}]},{"name":"National Council of Science and Technology","award":["FOSISS-2015-3-261661"],"award-info":[{"award-number":["FOSISS-2015-3-261661"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Folate and B12, among other B vitamins, are methyl donors and contribute to multiple DNA methylation processes. Maternal deficiency of these nutrients may be associated with impaired fetal growth, affecting the nutritional status and adiposity of the newborn. This study aimed to describe maternal folate and B12 status throughout pregnancy and evaluate its association with neonatal nutritional status. Methods: We studied 90 healthy pregnant women and their babies from the prospective OBESO cohort (Mexico City). Serum folate and B12 concentrations were measured (ELISA) in the first and third trimesters of pregnancy. Deficiency was considered if serum folate was &lt;4 ng\/mL, red blood cell folate (RBC) &lt; 151 ng\/mL, active B12 &lt; 40 pmol\/L, and total B12 &lt; 203 pg\/mL). Maternal supplementation of these nutrients was recorded. Newborn assessment (24\u201372 h) included weight (BW), length (L), waist circumference (WC), and fat mass percentage (%FM; air-displacement plethysmography). Newborn nutritional status indexes were computed and interpreted (BMI\/age and length\/age) (term-WHO, preterm-Intergrowth). Mean differences, correlations, and multiple linear and logistic regressions were performed (SPSS v. 29). Results: One-third of women had total vitamin B12 deficiency at the end of pregnancy; no folate deficiency was observed. High doses for both folic acid and B12 supplementation were identified in the third trimester (2057.04 \u00b1 2100.74 \u03bcg\/d and 7.35 \u00b1 4.56 \u03bcg\/d). Higher first- and third-trimester maternal active B12 concentrations predicted higher WC and reduced the risk of LBW. Higher first-trimester Thcy levels increased the risk of stunting. Higher third-trimester total B12 and folate concentrations predicted higher WC; the latter was associated with higher FM% at birth. Conclusions: Maternal folate, B12, and Thcy levels influence newborn nutritional status alterations, including adiposity markers. It is vital to guarantee an optimal and balanced maternal B-complex status throughout pregnancy.<\/jats:p>","DOI":"10.3390\/nu17030372","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T04:19:51Z","timestamp":1737433191000},"page":"372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Maternal Folate and Vitamin B 12 Concentrations During Pregnancy Influence Neonatal Nutritional Status and Adiposity: Results from the OBESO Cohort"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-0244","authenticated-orcid":false,"given":"Isabel","family":"Gonz\u00e1lez-Ludlow","sequence":"first","affiliation":[{"name":"Nutrition and Bioprogramming Coordination, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4477-0317","authenticated-orcid":false,"given":"Ameyalli M.","family":"Rodr\u00edguez-Cano","sequence":"additional","affiliation":[{"name":"Nutrition and Bioprogramming Coordination, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-4351","authenticated-orcid":false,"given":"Jonatan A.","family":"Mendoza-Ortega","sequence":"additional","affiliation":[{"name":"Department of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Rodr\u00edguez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Nutrition and Bioprogramming Coordination, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-0360","authenticated-orcid":false,"given":"Blanca V.","family":"Su\u00e1rez-Rico","sequence":"additional","affiliation":[{"name":"Community Interventions Research Branch, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-9021","authenticated-orcid":false,"given":"Guadalupe","family":"Estrada-Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricruz","family":"Tolentino-Dolores","sequence":"additional","affiliation":[{"name":"Nutrition and Bioprogramming Coordination, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra B.","family":"Parra-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"S\u00e1nchez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Acevedo-Gallegos","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-5293","authenticated-orcid":false,"given":"Otilia","family":"Perichart-Perera","sequence":"additional","affiliation":[{"name":"Nutrition and Bioprogramming Coordination, National Institute of Perinatology, Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1016\/S0020-7292(15)30023-0","article-title":"The International Federation of Gynecology and Obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: \u201cThink Nutrition First\u201d","volume":"131","author":"Hanson","year":"2015","journal-title":"Int. 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