{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:28:46Z","timestamp":1790555326777,"version":"4.1.0"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Vitamin B12 and folic acid (FA) are crucial for children\u2019s hematopoiesis after hematopoietic stem cell transplantation (HSCT). This study evaluates the B12 and FA level changes before and after HSCT. Methods: We retrospectively collected data from 125 patients who underwent HSCT between March 2019 and February 2024. B12 and FA levels were measured at three time points: before transplantation, one month after, and six months after. Sixty-two patients had complete data. B12 deficiency was defined as levels &lt; 200 pg\/mL and insufficiency as 200\u2013300 pg\/mL. Folate deficiency was classified as insufficiency \u2264 3 ng\/mL, indeterminate for 4.0\u20135.8 ng\/mL and typical for 5.9\u201326.8 ng\/mL. Patients with B12 &lt; 300 pg\/mL and folic acid &lt; 5 ng\/mL were treated at all stages. Results: Among the 62 patients, 24 (38.7%) were girls, with a median age of 4 years (1.75\u20138.25). Median B12 levels were 398 pg\/mL (pre-transplant), 892 pg\/mL (1 month post), and 430 pg\/mL (6 months post). The second time point had significantly higher B12 levels (p &lt; 0.001). Median folate levels were 9.7 ng\/mL, 6.95 ng\/mL, and 11.3 ng\/mL at the respective time points (p &lt; 0.05), with the second time point significantly lower. Conclusions: Pediatric HSCT patients experience increased demands for B12 and FA despite accurate treatment, leading to potential deficiencies. Close monitoring, early supplementation, and supplementing high levels of these micronutrients are essential.<\/jats:p>","DOI":"10.3390\/nu17030377","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T08:46:26Z","timestamp":1737449186000},"page":"377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Folate and Vitamin B12 Status in Pediatric Hematopoietic Stem Cell Transplantation Patients"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-9849","authenticated-orcid":false,"given":"Gizem","family":"Zengin Ersoy","sequence":"first","affiliation":[{"name":"Pediatric Hematology & Oncology and Stem Cell Transplantation Department, Umraniye Training and Research Hospital, Health Sciences University, 34668 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-3147","authenticated-orcid":false,"given":"Beg\u00fcm","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Pediatric Hematology & Oncology and Stem Cell Transplantation Department, Umraniye Training and Research Hospital, Health Sciences University, 34668 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-2054","authenticated-orcid":false,"given":"Suar","family":"\u00c7ak\u0131 K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Pediatric Hematology & Oncology and Stem Cell Transplantation Department, Umraniye Training and Research Hospital, Health Sciences University, 34668 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/bmt.2015.6","article-title":"Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: Current practice in Europe, 2015","volume":"50","author":"Sureda","year":"2015","journal-title":"Bone Marrow Transpl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbmt.2015.07.003","article-title":"Systematic Nutritional Support in Allogeneic Hematopoietic Stem Cell Transplant Recipients","volume":"21","author":"Fuji","year":"2015","journal-title":"Biol. 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