{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:41:36Z","timestamp":1790361696403,"version":"4.1.0"},"reference-count":230,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Subvenci\u00f3n para la Instalaci\u00f3n en la Academia","award":["SA77210098"],"award-info":[{"award-number":["SA77210098"]}]},{"name":"Subvenci\u00f3n para la Instalaci\u00f3n en la Academia","award":["USS-FIN-25-APCS-05"],"award-info":[{"award-number":["USS-FIN-25-APCS-05"]}]},{"name":"Vicerrector\u00eda de Investigaci\u00f3n y Doctorados de la Universidad San Sebasti\u00e1n\u2014Fondo","award":["SA77210098"],"award-info":[{"award-number":["SA77210098"]}]},{"name":"Vicerrector\u00eda de Investigaci\u00f3n y Doctorados de la Universidad San Sebasti\u00e1n\u2014Fondo","award":["USS-FIN-25-APCS-05"],"award-info":[{"award-number":["USS-FIN-25-APCS-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Breastfeeding is the best way to provide newborns with crucial nutrients and produce a unique bond between mother and child. Breast milk is rich in nutritious and non-nutritive bioactive components, such as immune cells, cytokines, chemokines, immunoglobulins, hormones, fatty acids, and other constituents. Maternal effects during gestation and lactation can alter these components, influencing offspring outcomes. Chronic inflammatory maternal conditions, such as obesity, diabetes, and hypertension, impact breast milk composition. Breast milk from obese mothers exhibits changes in fat content, cytokine levels, and hormonal concentrations, potentially affecting infant growth and health. Similarly, diabetes alters the composition of breast milk, impacting immune factors and metabolic markers. Other pro-inflammatory conditions, such as dyslipidemia and metabolic syndrome, have been barely studied. Thus, maternal obesity, diabetes, and altered tension parameters have been described as modifying the composition of breast milk in its macronutrients and other important biomolecules, likely affecting the offspring\u2019s weight. This review emphasizes the impact of chronic inflammatory conditions on breast milk composition and its potential implications for offspring development through the revision of full-access original articles.<\/jats:p>","DOI":"10.3390\/nu17030387","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T03:40:17Z","timestamp":1737517217000},"page":"387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Impact of Maternal Chronic Inflammatory Conditions on Breast Milk Composition: Possible Influence on Offspring Metabolic Programming"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8289-6120","authenticated-orcid":false,"given":"Gabriela","family":"Arenas","sequence":"first","affiliation":[{"name":"Facultad de Medicina y Ciencia, Universidad San Sebasti\u00e1n, Santiago 7510602, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6061-216X","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Barrera","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda y Ciencias de la Rehabilitaci\u00f3n, Universidad San Sebasti\u00e1n, Santiago 7510157, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4198-7011","authenticated-orcid":false,"given":"Susana","family":"Contreras-Duarte","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebasti\u00e1n, Santiago 8420524, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"ref_1","unstructured":"Kalarikkal, S., and Pfleghaar, J. 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