{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:11:19Z","timestamp":1791562279493,"version":"4.3.4"},"reference-count":93,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: This systematic review focused on collecting the most significant findings on the impact of the administration of Bifidobacterium infantis (or Bifidobacterium longum subps. infantis) and Bifidobacterium breve, alone, in conjunction, or in combination with other strains, in the treatment of neurodegenerative diseases including Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD). These diseases are characterized by the progressive degeneration of neurons, resulting in a broad spectrum of clinical manifestations. AD is typified by a progressive decline in cognitive abilities, while PD is marked by motor symptoms associated with the loss of dopamine (DA). Methods: Five different databases, ScienceDirect, Scopus, Wiley, PubMed, and Web of Science (WoS), were reviewed and the studies were screened for inclusion by the following criteria: (i) studies that specifically evaluated the use of Bifidobacterium infantis, Bifidobacterium longum subsp. infantis, or Bifidobacterium breve as a therapeutic intervention, either in human or animal models, in the context of neurodegenerative diseases; (ii) the studies were required to address one or more of the pathologies examined in this article, and the pathologies included, but were not limited to, neurodegeneration, Alzheimer\u2019s disease, Parkinson\u2019s disease, and oxidative stress; (iii) the full text was accessible online; and (iv) the article was written in English. Results: The data suggest that these probiotics have neuroprotective effects that may delay disease progression. Conclusions: This study provides updated insights into the use of these Bifidobacterium strains in neurodegenerative diseases like AD and PD, with the main limitation being the limited number of clinical trials available.<\/jats:p>","DOI":"10.3390\/nu17030391","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T05:50:53Z","timestamp":1737525053000},"page":"391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-0065","authenticated-orcid":false,"given":"Manuel","family":"Reiriz","sequence":"first","affiliation":[{"name":"NBC Group, School of Life and Nature Sciences, Nebrija University, 28248 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9893-0227","authenticated-orcid":false,"given":"Ana Isabel","family":"Beltr\u00e1n-Velasco","sequence":"additional","affiliation":[{"name":"NBC Group, School of Life and Nature Sciences, Nebrija University, 28248 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-3513","authenticated-orcid":false,"given":"V\u00edctor","family":"Echeverry-Alzate","sequence":"additional","affiliation":[{"name":"NBC Group, School of Life and Nature Sciences, Nebrija University, 28248 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-5860","authenticated-orcid":false,"given":"Esther","family":"Mart\u00ednez-Miguel","sequence":"additional","affiliation":[{"name":"NBC Group, School of Life and Nature Sciences, Nebrija University, 28248 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"G\u00f3mez-Senent","sequence":"additional","affiliation":[{"name":"NBC Group, School of Life and Nature Sciences, Nebrija University, 28248 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-5186","authenticated-orcid":false,"given":"Sara","family":"Uceda","sequence":"additional","affiliation":[{"name":"NBC Group, School of Life and Nature Sciences, Nebrija University, 28248 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2397-2801","authenticated-orcid":false,"given":"Vicente Javier","family":"Clemente-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s\/n, 28670 Madrid, Spain"},{"name":"Grupo de Investigaci\u00f3n en Cultura, Educaci\u00f3n y Sociedad, Universidad de la Costa, Barranquilla 080002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dugger, B.N., and Dickson, D.W. (2017). Pathology of neurodegenerative diseases. Cold Spring Harb. Perspect. Biol., 9.","DOI":"10.1101\/cshperspect.a028035"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chi, H., Chang, H.Y., and Sang, T.K. (2018). Neuronal cell death mechanisms in major neurodegenerative diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103082"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.clinthera.2021.05.006","article-title":"Modifiable risk factors in Alzheimer disease and related dementias: A review","volume":"43","author":"Litke","year":"2021","journal-title":"Clin. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Agnello, L., and Ciaccio, M. (2022). Neurodegenerative diseases: From molecular basis to therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112854"},{"key":"ref_5","unstructured":"GBD 2019 Dementia Forecasting Collaborators (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 7, e105\u2013e125."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0002-9343(00)00412-5","article-title":"The evolution of free radicals and oxidative stress","volume":"108","author":"McCord","year":"2000","journal-title":"Am. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. (2019). Oxidative stress: A key modulator in neurodegenerative diseases. Molecules, 24.","DOI":"10.3390\/molecules24081583"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2022.03.001","article-title":"Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment","volume":"345","author":"Esmaeili","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Teleanu, D.M., Niculescu, A.G., Lungu, I.I., Radu, C.I., Vlad\u00e2cenco, O., Roza, E., Cost\u0103chescu, B., Grumezescu, A.M., and Teleanu, R.I. (2022). An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115938"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/15622975.2019.1696473","article-title":"Management of mild cognitive impairment (MCI): The need for national and international guidelines","volume":"21","author":"Kasper","year":"2020","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/mds.27902","article-title":"Prevalence and clinical aspects of mild cognitive impairment in Parkinson\u2019s disease: A meta-analysis","volume":"35","author":"Baiano","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/1533317518791401","article-title":"Mild cognitive impairment in clinical practice: A review article","volume":"33","author":"Jongsiriyanyong","year":"2018","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e13229","DOI":"10.1111\/jsr.13229","article-title":"Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer\u2019s disease: A systematic review","volume":"30","author":"Blackman","year":"2021","journal-title":"J. Sleep Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"757","DOI":"10.24976\/Discov.Med.202335178.71","article-title":"Etiology of Alzheimer\u2019s Disease","volume":"35","author":"Zhang","year":"2023","journal-title":"Discov. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Breijyeh, Z., and Karaman, R. (2020). Comprehensive review on Alzheimer\u2019s disease: Causes and treatment. Molecules, 25.","DOI":"10.3390\/molecules25245789"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00401-013-1111-z","article-title":"Clathrin adaptor CALM\/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer\u2019s brains","volume":"125","author":"Ando","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-cellbio-100913-013053","article-title":"Astrocyte regulation of synaptic behavior","volume":"30","author":"Allen","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer\u2019s disease","volume":"164","author":"Karran","year":"2016","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hulshof, L.A., van Nuijs, D., Hol, E.M., and Middeldorp, J. (2022). The role of astrocytes in synapse loss in Alzheimer\u2019s disease: A systematic review. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.899251"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Subramanian, J., Savage, J.C., and Tremblay, M.\u00c8 (2020). Synaptic loss in Alzheimer\u2019s disease: Mechanistic insights provided by two-photon in vivo imaging of transgenic mouse models. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.592607"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.semcdb.2022.05.028","article-title":"Synapse pathology in Alzheimer\u2019s disease","volume":"139","author":"Griffiths","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1874609814666210302085232","article-title":"Alzheimer\u2019s Disease: Pathogenesis and Therapeutic Interventions","volume":"15","author":"Ogbodo","year":"2022","journal-title":"Curr. Aging Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1016\/j.cell.2023.08.021","article-title":"Alzheimer\u2019s disease: From immunotherapy to immunoprevention","volume":"186","author":"Jucker","year":"2023","journal-title":"Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/bs.pbr.2020.01.001","article-title":"New players in basal ganglia dysfunction in Parkinson\u2019s disease","volume":"252","author":"Meoni","year":"2020","journal-title":"Prog. Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1016\/j.celrep.2019.08.058","article-title":"hESC-derived dopaminergic transplants integrate into basal ganglia circuitry in a preclinical model of Parkinson\u2019s disease","volume":"28","author":"Adler","year":"2019","journal-title":"Cell Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12264-022-00934-6","article-title":"Parkinson\u2019s disease: A multisystem disorder","volume":"39","author":"Costa","year":"2023","journal-title":"Neurosci. Bull."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cacabelos, R. (2017). Parkinson\u2019s disease: From pathogenesis to pharmacogenomics. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030551"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1474-4422(23)00404-0","article-title":"A biological classification of Parkinson\u2019s disease: The SynNeurGe research diagnostic criteria","volume":"23","author":"Adler","year":"2024","journal-title":"Lancet Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11910-017-0802-6","article-title":"Microbiota-brain-gut axis and neurodegenerative diseases","volume":"17","author":"Quigley","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-161141","article-title":"The gut microbiota and Alzheimer\u2019s disease","volume":"58","author":"Jiang","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.18632\/aging.102930","article-title":"Gut microbiota and pro\/prebiotics in Alzheimer\u2019s disease","volume":"12","author":"Pluta","year":"2020","journal-title":"Aging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/JAD-215411","article-title":"Investigating casual associations among gut microbiota, metabolites, and neurodegenerative diseases: A mendelian randomization study","volume":"87","author":"Ning","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"104675","DOI":"10.1016\/j.micpath.2020.104675","article-title":"Human gut microbiota and its association with pathogenesis and treatments of neurodegenerative diseases","volume":"150","author":"Chen","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1093\/brain\/awab156","article-title":"The role of gut dysbiosis in Parkinson\u2019s disease: Mechanistic insights and therapeutic options","volume":"144","author":"Wang","year":"2021","journal-title":"Brain"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1007\/s12035-020-02073-3","article-title":"Gut microbiota and dysbiosis in Alzheimer\u2019s disease: Implications for pathogenesis and treatment","volume":"57","author":"Liu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"105840","DOI":"10.1016\/j.phrs.2021.105840","article-title":"The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders","volume":"172","author":"Doboszewska","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., Koga, N., Hattori, K., Ota, M., and Kunugi, H. (2019). Bifidobacterium and Lactobacillus counts in the gut microbiota of patients with bipolar disorder and healthy controls. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00730"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/07315724.2018.1487346","article-title":"The effects of probiotic formulation pretreatment (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) on a lipopolysaccharide rat model","volume":"38","author":"Mohammadi","year":"2019","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10123-018-00051-3","article-title":"Probiotic mixture of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 attenuates hippocampal apoptosis induced by lipopolysaccharide in rats","volume":"22","author":"Mohammadi","year":"2019","journal-title":"Int. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1039\/C9FO02961C","article-title":"The potential of proteins, hydrolysates and peptides as growth factors for Lactobacillus and Bifidobacterium: Current research and future perspectives","volume":"11","author":"Zhang","year":"2020","journal-title":"Food Funct."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"121699","DOI":"10.1016\/j.lfs.2023.121699","article-title":"Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota","volume":"324","author":"Ni","year":"2023","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s41390-023-02716-w","article-title":"Bifidobacterium infantis as a probiotic in preterm infants: A systematic review and meta-analysis","volume":"94","author":"Batta","year":"2023","journal-title":"Pediatr. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2174\/13816128113199990422","article-title":"Probiotics in the mechanism of protection against gut inflammation and therapy of gastrointestinal disorders","volume":"20","author":"Dylag","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/pr.2014.156","article-title":"Bifidobacterium longum subspecies infantis: Champion colonizer of the infant gut","volume":"77","author":"Underwood","year":"2015","journal-title":"Pediatr. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jclinepi.2021.02.003","article-title":"Updating guidance for reporting systematic reviews: Development of the PRISMA 2020 statement","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Hooijmans, C.R., Rovers, M.M., de Vries, R.B., Leenaars, M., Ritskes-Hoitinga, M., and Langendam, M.W. (2014). SYRCLE\u2019s risk of bias tool for animal studies. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-43"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3920\/BM2018.0170","article-title":"Effects of Bifidobacterium breve A1 on the cognitive function of older adults with memory complaints: A randomised, double-blind, placebo-controlled trial","volume":"10","author":"Kobayashi","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.clnu.2014.09.023","article-title":"Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota\u2014The \u201cRISTOMED project\u201d: Randomized controlled trial in healthy older people","volume":"34","author":"Valentini","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Hsu, Y.C., Huang, Y.Y., Tsai, S.Y., Kuo, Y.W., Lin, J.H., Ho, H.H., Chen, J.F., Hsia, K.C., and Sun, Y. (2023). Efficacy of probiotic supplements on brain-derived neurotrophic factor, inflammatory biomarkers, oxidative stress and cognitive function in patients with Alzheimer\u2019s dementia: A 12-week randomized, double-blind active-controlled study. Nutrients, 16.","DOI":"10.3390\/nu16010016"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-220148","article-title":"Effect of probiotic Bifidobacterium breve in improving cognitive function and preventing brain atrophy in older patients with suspected mild cognitive impairment: Results of a 24-week randomized, double-blind, placebo-controlled trial","volume":"88","author":"Asaoka","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kobayashi, Y., Sugahara, H., Shimada, K., Mitsuyama, E., Kuhara, T., Yasuoka, A., Kondo, T., Abe, K., and Xiao, J.Z. (2017). Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer\u2019s disease. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-13368-2"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"220","DOI":"10.29252\/ibj.24.4.220","article-title":"Assessment of probiotics mixture on memory function, inflammation markers, and oxidative stress in an Alzheimer\u2019s disease model of rats","volume":"24","author":"Mehrabadi","year":"2020","journal-title":"Iran. Biomed. J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zhu, G., Zhao, J., Zhang, H., Chen, W., and Wang, G. (2021). Administration of Bifidobacterium breve improves the brain function of A\u03b21-42-treated mice via the modulation of the gut microbiome. Nutrients, 13.","DOI":"10.3390\/nu13051602"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Abdelhamid, M., Zhou, C., Jung, C.G., and Michikawa, M. (2022). Probiotic Bifidobacterium breve MCC1274 mitigates Alzheimer\u2019s disease-related pathologies in wild-type mice. Nutrients, 14.","DOI":"10.3390\/nu14122543"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3233\/JAD-215025","article-title":"Probiotic Bifidobacterium breve prevents memory impairment through the reduction of both amyloid-\u03b2 production and microglia activation in APP knock-in mouse","volume":"85","author":"Abdelhamid","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/iub.2589","article-title":"The beneficial effect of synbiotics consumption on Alzheimer\u2019s disease mouse model via reducing local and systemic inflammation","volume":"74","author":"Deng","year":"2022","journal-title":"IUBMB Life"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhu, G., Guo, M., Zhao, J., Zhang, H., Wang, G., and Chen, W. (2022). Bifidobacterium breve intervention combined with environmental enrichment alleviates cognitive impairment by regulating the gut microbiota and microbial metabolites in Alzheimer\u2019s disease mice. Front. Immunol., 20.","DOI":"10.3389\/fimmu.2022.1013664"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zhu, G., Guo, M., Zhao, J., Zhang, H., Wang, G., and Chen, W. (2022). Integrative metabolomic characterization reveals the mediating effect of Bifidobacterium breve on amino acid metabolism in a mouse model of Alzheimer\u2019s disease. Nutrients, 14.","DOI":"10.3390\/nu14040735"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/acs.jafc.3c00652","article-title":"Bifidobacterium breve HNXY26M4 attenuates cognitive deficits and neuroinflammation by regulating the gut\u2013brain axis in APP\/PS1 mice","volume":"71","author":"Zhu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"982","DOI":"10.26599\/FSHW.2022.9250084","article-title":"Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer\u2019s disease by modulating glutamine metabolism of the gut microbiome","volume":"13","author":"Zhu","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ishii, T., Furuoka, H., Kaya, M., and Kuhara, T. (2021). Oral administration of probiotic Bifidobacterium breve improves facilitation of hippocampal memory extinction via restoration of aberrant higher induction of neuropsin in an MPTP-induced mouse model of Parkinson\u2019s disease. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020167"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Li, T., Chu, C., Yu, L., Zhai, Q., Wang, S., Zhao, J., Zhang, H., Chen, W., and Tian, F. (2022). Neuroprotective effects of Bifidobacterium breve CCFM1067 in MPTP-induced mouse models of Parkinson\u2019s disease. Nutrients, 14.","DOI":"10.3390\/nu14214678"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Higgins, J.P.T., and Green, S. (2008). Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions, Wiley.","DOI":"10.1002\/9780470712184"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.gerinurse.2023.03.006","article-title":"Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment","volume":"51","author":"Fei","year":"2023","journal-title":"Geriatr. Nurs."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3920\/BM2019.0200","article-title":"Lactobacillus plantarum DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways","volume":"11","author":"Zaydi","year":"2020","journal-title":"Benef. Microbes"},{"key":"ref_70","first-page":"715","article-title":"Lactiplantibacillus plantarum as a promising adjuvant for neurological disorders therapy through the brain-gut axis and related action pathways","volume":"65","author":"Manassi","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ghuge, S., Rahman, Z., Bhale, N.A., Dikundwar, A.G., and Dandekar, M.P. (2023). Multistrain probiotic rescinds quinpirole-induced obsessive-compulsive disorder phenotypes by reshaping of microbiota gut-brain axis in rats. Pharmacol. Biochem. Behav., 232.","DOI":"10.1016\/j.pbb.2023.173652"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Beltr\u00e1n-Velasco, A.I., Reiriz, M., Uceda, S., and Echeverry-Alzate, V. (2024). Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25053010"},{"key":"ref_73","first-page":"KC01","article-title":"Anti-Alzheimer properties of probiotic, Lactobacillus plantarum MTCC 1325 in Alzheimer\u2019s disease induced albino rats","volume":"11","author":"Nimgampalle","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12264-013-1423-y","article-title":"Oxidative stress in Alzheimer\u2019s disease","volume":"30","author":"Chen","year":"2014","journal-title":"Neurosci. Bull."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Shi, S., Zhang, Q., Sang, Y., Ge, S., Wang, Q., Wang, R., and He, J. (2022). Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 15.","DOI":"10.3390\/nu15010051"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1038\/s41467-023-41283-w","article-title":"Bacteroides Fragilis in the gut microbiomes of Alzheimer\u2019s disease activates microglia and triggers pathogenesis in neuronal C\/EBP\u03b2 transgenic mice","volume":"14","author":"Xia","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1038\/s41467-024-47683-w","article-title":"Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer\u2019s disease mouse models","volume":"15","author":"Beauchamp","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3746\/pnf.2019.24.3.265","article-title":"The effects of probiotic Lactobacillus and Bifidobacterium strains on memory and learning behavior, long-term potentiation (LTP), and some biochemical parameters in \u03b2-amyloid-induced rat\u2019s model of Alzheimer\u2019s disease","volume":"24","author":"Rezaeiasl","year":"2019","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","article-title":"Brain dopamine and the syndromes of Parkinson and Huntington clinical, morphological and neurochemical correlations","volume":"20","author":"Bernheimer","year":"1973","journal-title":"J. Neurol. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/jnc.14898","article-title":"The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases","volume":"152","author":"Li","year":"2020","journal-title":"J. Neurochem."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Cheng, Q., Wang, J., Li, M., Fang, J., Ding, H., Meng, J., Zhang, J., Fang, X., Liu, H., and Ma, C. (2022). CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson\u2019s disease. Redox Biol., 56.","DOI":"10.1016\/j.redox.2022.102430"},{"key":"ref_82","first-page":"100087","article-title":"Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson\u2019s disease","volume":"3","author":"Ghyselinck","year":"2021","journal-title":"Int. J. Pharm. X"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Huang, H.J., Chen, J.L., Liao, J.F., Chen, Y.H., Chieu, M.W., Ke, Y.Y., Hsu, C.C., Tsai, Y.C., and Hsieh-Li, H.M. (2021). Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer\u2019s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis. BMC Complement. Med. Ther., 21.","DOI":"10.1186\/s12906-021-03426-8"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Lin, S.W., Tsai, Y.S., Chen, Y.L., Wang, M.F., Chen, C.C., Lin, W.H., and Fang, T.J. (2021). Lactobacillus plantarum GKM3 promotes longevity, memory retention, and reduces brain oxidation stress in SAMP8 mice. Nutrients, 13.","DOI":"10.3390\/nu13082860"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/JAD-200488","article-title":"Probiotic Bifidobacterium breve in improving cognitive functions of older adults with suspected mild cognitive impairment: A randomized, double-blind, placebo-controlled trial","volume":"77","author":"Xiao","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.apsb.2019.07.001","article-title":"Probiotics modulate the microbiota\u2013gut\u2013brain axis and improve memory deficits in aged SAMP8 mice","volume":"10","author":"Yang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/978-1-4939-7883-0_26","article-title":"Oxidative stress assessment in zebrafish larvae","volume":"1797","author":"Domingues","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s11356-012-0909-x","article-title":"Glutathione, glutathione s-transferase, and glutathione conjugates, complementary markers of oxidative stress in aquatic biota","volume":"19","author":"Hellou","year":"2012","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Lin, W.Y., Lin, J.H., Kuo, Y.W., Chiang, P.F.R., and Ho, H.H. (2022). Probiotics and their metabolites reduce oxidative stress in middle-aged mice. Curr. Microbiol., 79.","DOI":"10.1007\/s00284-022-02783-y"},{"key":"ref_90","first-page":"e2244912","article-title":"Therapeutic Effects of Butyrate on Pediatric Obesity: A Randomized Clinical Trial","volume":"5","author":"Coppola","year":"2022","journal-title":"JAMA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2638703","DOI":"10.1155\/2020\/2638703","article-title":"Oxidative stress and dementia in Alzheimer\u2019s patients: Effects of synbiotic supplementation","volume":"2020","author":"Ton","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Li, S.C., Hsu, W.F., Chang, J.S., and Shih, C.K. (2019). Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Shows a Stronger Anti-Inflammatory Effect than Individual Strains in HT-29 Cells. Nutrients, 11.","DOI":"10.3390\/nu11050969"},{"key":"ref_93","first-page":"763","article-title":"Akkermansia muciniphila and Bifidobacterium bifidum Prevent NAFLD by Regulating FXR Expression and Gut Microbiota","volume":"11","author":"Nian","year":"2023","journal-title":"J. Clin. Transl. Hepatol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/391\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:33:33Z","timestamp":1759919613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":93,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["nu17030391"],"URL":"https:\/\/doi.org\/10.3390\/nu17030391","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]}}}