{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:29:00Z","timestamp":1780374540159,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pukyong National University","award":["2023"],"award-info":[{"award-number":["2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: This research investigated the effects of myricitrin on hypercholesterolemia and non-alcoholic fatty liver disease (NAFLD) in mice given a high-cholesterol diet (HCD). Methods: C57BL\/6J mice were maintained for 20 weeks on an HCD with or without myricitrin. Results: Myricitrin had no impact on the food consumption, body weight, or plasma triglyceride concentrations. However, myricitrin-supplemented mice had lower plasma total cholesterol (TC) concentrations and LDL + VLDL-cholesterol\/TC proportion, and higher HDL-cholesterol\/TC proportion than control mice, which resulted in a markedly decreased atherogenic index. Moreover, the levels of plasma C-reactive protein, oxidized LDL, lipoprotein(a), and plasminogen activator inhibitor-1, which are indicators for cardiovascular disease (CVD), were reduced, while levels of plasma paraoxonase, a cardioprotective enzyme, were greater in myricitrin-supplemented mice than in control mice. Myricitrin also meaningfully reduced liver weight and hepatic cholesterol content, and slightly alleviated fatty liver and fibrosis caused by an HCD. The plasma and hepatic cholesterol-lowering effects of myricitrin were partly associated with decreased activities of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase and acyl-CoA:cholesterol acyltransferase, which are involved in cholesterol synthesis and esterification, respectively, as well as mRNA expression. Myricitrin also altered other hepatic genes implicated in cholesterol homeostasis, including the downregulation of SREBP2 and ABCA1 mRNA expression and the upregulation of LDLR mRNA expression. Moreover, myricitrin decreased TBARS levels in the liver and erythrocytes by activating antioxidant enzymes (SOD and catalase). Conclusions: These results indicate that dietary myricitrin may offer therapeutic benefits for HCD-caused hypercholesterolemia and NAFLD, and may help reduce CVD risk.<\/jats:p>","DOI":"10.3390\/nu17030415","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T12:24:09Z","timestamp":1737635049000},"page":"415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Myricitrin Alleviates Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease in High Cholesterol Diet-Fed Mice"],"prefix":"10.3390","volume":"17","author":[{"given":"Young-Je","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sojeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HwiCheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0299-1613","authenticated-orcid":false,"given":"Sang Ryong","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-460X","authenticated-orcid":false,"given":"Un Ju","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1388-1981(00)00156-6","article-title":"Dietary Cholesterol and Atherosclerosis","volume":"1529","author":"McNamara","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fernandez, M.L., and Murillo, A.G. (2022). Is There a Correlation Between Dietary and Blood Cholesterol? Evidence from Epidemiological Data and Clinical Interventions. Nutrients, 14.","DOI":"10.3390\/nu14102168"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5551\/jat.49098","article-title":"Hypercholesterolemia and Lifetime Risk of Coronary Heart Disease in the General Japanese Population: Results from the Suita Cohort Study","volume":"27","author":"Sugiyama","year":"2020","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Eng, J.M., and Estall, J.L. (2021). Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol. Cells, 10.","DOI":"10.3390\/cells10071805"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/hep.30223","article-title":"Relationship among Fatty Liver, Specific and Multiple-Site Atherosclerosis, and 10-year Framingham Score","volume":"69","author":"Pais","year":"2019","journal-title":"Hepatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"20406223221122478","DOI":"10.1177\/20406223221122478","article-title":"Association of NAFLD with Cardiovascular Disease and All-Cause Mortality: A Large-Scale Prospective Cohort Study Based on UK Biobank","volume":"13","author":"Ma","year":"2022","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13568-019-0924-0","article-title":"Myricitrin Exhibits Anti-Atherosclerotic and Anti-Hyperlipidemic Effects in Diet-Induced Hypercholesterolemic Rats","volume":"9","author":"Gao","year":"2019","journal-title":"AMB Express"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhang, B., Shen, Q., Chen, Y., Pan, R., Kuang, S., Liu, G., Sun, G., and Sun, X. (2017). Myricitrin Alleviates Oxidative Stress-Induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy. Sci. Rep., 7.","DOI":"10.1038\/srep44239"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kim, D.Y., Kim, S.R., and Jung, U.J. (2020). Myricitrin Ameliorates Hyperglycemia, Glucose Intolerance, Hepatic Steatosis, and Inflammation in High-Fat Diet\/Streptozotocin-Induced Diabetic Mice. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051870"},{"key":"ref_10","first-page":"7381","article-title":"Myricitrin Ameliorates Ethanol-Induced Steatosis in mouse AML12 Liver Cells by Activating AMPK and Reducing Oxidative Stress and Expression of Inflammatory Cytokines","volume":"17","author":"Gao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0021-9150(85)90138-8","article-title":"Variation in Susceptibility to Atherosclerosis Among Inbred Strains of Mice","volume":"57","author":"Paigen","year":"1985","journal-title":"Atherosclerosis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"42774","DOI":"10.1074\/jbc.M306022200","article-title":"Cholesterol and Cholate Components of an Atherogenic Diet Induce Distinct Stages of Hepatic Inflammatory Gene Expression","volume":"278","author":"Vergnes","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/hep.21874","article-title":"Lipid-Induced Oxidative Stress Causes Steatohepatitis in Mice Fed an Atherogenic Diet","volume":"46","author":"Matsuzawa","year":"2007","journal-title":"Hepatology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/hep.25789","article-title":"Synergistic Interaction of Dietary Cholesterol and Dietary Fat in Inducing Experimental Steatohepatitis","volume":"57","author":"Savard","year":"2013","journal-title":"Hepatology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejphar.2008.01.045","article-title":"Ezetimibe Improves High Fat and Cholesterol Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice","volume":"584","author":"Zheng","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jhep.2008.08.012","article-title":"Dietary Resveratrol Alters Lipid Metabolism-Related Gene Expression of Mice on an Atherogenic Diet","volume":"49","author":"Ahn","year":"2008","journal-title":"J. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jnutbio.2011.02.001","article-title":"Naringin, the Major Grapefruit Flavonoid, Specifically Affects Atherosclerosis Development in Diet-Induced Hypercholesterolemia in Mice","volume":"23","author":"Chanet","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.clnu.2008.06.002","article-title":"Effect of Bamboo Culm Extract on Oxidative Stress and Genetic Expression: Bamboo Culm Extract Ameliorates Cell Adhesion Molecule Expression and NF\u03baB Activity through the Suppression of the Oxidative Stress","volume":"27","author":"Lee","year":"2008","journal-title":"Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0014-5793(91)80962-3","article-title":"Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein","volume":"286","author":"Mackness","year":"1991","journal-title":"FEBS Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0005-2744(74)90098-9","article-title":"Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts","volume":"370","author":"Shapiro","year":"1974","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0022-2275(20)34791-X","article-title":"Rat liver acyl-coenzyme A: Cholesterol acyltransferase: Its regulation in vivo and some of its properties in vitro","volume":"21","author":"Erickson","year":"1980","journal-title":"J. Lipid Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"ref_25","unstructured":"Bergmeyer, H.U. (1974). Catalase. Methods of Enzymatic Analysis, Academic Press."},{"key":"ref_26","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/physrev.00047.2003","article-title":"Role of Oxidative Modifications in Atherosclerosis","volume":"84","author":"Stocker","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-Density Lipoproteins Cause Atherosclerotic Cardiovascular Disease. 1. Evidence from Genetic Epidemiologic, and Clinical Studies. A Consensus Statement from the European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.ATV.0000033829.14012.18","article-title":"Oxidized LDL in Carotid Plaques and Plasma Associates with Plaque Instability","volume":"22","author":"Nishi","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/CIRCULATIONAHA.104.529297","article-title":"Plasma Oxidized Low-Density Lipoprotein, a Strong Predictor for Acute Coronary Heart Disease Events in Apparently Healthy, Middle-Aged Men from the General Population","volume":"112","author":"Meisinger","year":"2005","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1161\/ATVBAHA.124.319483","article-title":"Lipoprotein(a) in the Year 2024: A Look Back and a Look Ahead","volume":"44","author":"Tsimikas","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jacc.2020.06.040","article-title":"Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk","volume":"76","author":"Mehta","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Amezcua-Castillo, E., Gonz\u00e1lez-Pacheco, H., S\u00e1enz-San Mart\u00edn, A., M\u00e9ndez-Ocampo, P., Gutierrez-Moctezuma, I., Mass\u00f3, F., Sierra-Lara, D., Springall, R., Rodr\u00edguez, E., and Arias-Mendoza, A. (2023). C-Reactive Protein: The Quintessential Marker of Systemic Inflammation in Coronary Artery Disease-Advancing Toward Precision Medicine. Biomedicines, 11.","DOI":"10.3390\/biomedicines11092444"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/jth.15701","article-title":"Elevated Plasma Levels of Plasminogen Activator Inhibitor-1 Are Associated with Risk of Future Incident Venous Thromboembolism","volume":"20","author":"Frischmuth","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/01.ATV.21.3.415","article-title":"Paraoxonase1-192 Polymorphism Modulates the Nonfatal Myocardial Infarction Risk Associated with Decreased HDLs","volume":"21","author":"Marrugat","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.atherosclerosis.2015.06.004","article-title":"Paraoxonase-1 and Oxidized Lipoprotein Lipids: The Cardiovascular Risk in Young Finns Study","volume":"241","author":"Kresanov","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.jacc.2006.01.074","article-title":"Association of Paraoxonase-1 Activity and Concentration with Angiographic Severity and Extent of Coronary Artery Disease","volume":"47","author":"James","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_39","first-page":"2429","article-title":"Protective Effect of High Density Lipoprotein Associated Paraoxonase: Inhibition of the Biological Activity of Minimally Oxidized Low Density Lipoprotein","volume":"47","author":"Watson","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1172\/JCI1649","article-title":"Paraoxonase Inhibits High-Density Lipoprotein Oxidation and Preserves Its Functions: A Possible Peroxidative Role for Paraoxonase","volume":"101","author":"Aviram","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Melo, D., Coimbra, S., Rocha, S., and Santos-Silva, A. (2023). Inhibition of Erythrocyte\u2019s Catalase, Glutathione Peroxidase or Peroxiredoxin 2\u2014Impact on Cytosol and Membrane. Arch. Biochem. Biophys., 739.","DOI":"10.1016\/j.abb.2023.109569"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1161\/hq0701.092092","article-title":"Changes in Expression of Antioxidant Enzymes Affect Cell-Mediated LDL Oxidation and Oxidized LDL-Induced Apoptosis in Mouse Aortic Cells","volume":"21","author":"Guo","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1046\/j.1523-1755.1999.00351.x","article-title":"Lp(a) and LDL Induce Apoptosis in Human Endothelial Cells and in Rabbit Aorta: Role of Oxidative Stress","volume":"55","author":"Galle","year":"1999","journal-title":"Kidney Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1089\/ars.2010.3502","article-title":"Critical Role of the Nitric Oxide\/Reactive Oxygen Species Balance in Endothelial Progenitor Dysfunction","volume":"15","author":"Fleissner","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D\u2019Arcangelo, D., Norelli, S., Valle, G., Nisini, R., and Beninati, S. (2019). Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/8748253"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Kim, E.J., Kim, B.H., Seo, H.S., Lee, Y.J., Kim, H.H., Son, H.H., and Choi, M.H. (2014). Cholesterol-Induced Non-Alcoholic Fatty Liver Disease and Atherosclerosis Aggravated by Systemic Inflammation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097841"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.bbadis.2015.05.015","article-title":"Recent Insights on the Role of Cholesterol in Non-Alcoholic Fatty Liver Disease","volume":"1852","author":"Arguello","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cmet.2012.04.004","article-title":"Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease","volume":"15","author":"Min","year":"2012","journal-title":"Cell Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1172\/JCI2961","article-title":"Activation of Cholesterol Synthesis in Preference to Fatty Acid Synthesis in Liver and Adipose Tissue of Transgenic Mice Overproducing Sterol Regulatory Element-Binding Protein-2","volume":"101","author":"Horton","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1073\/pnas.80.11.3499","article-title":"Rates of Receptor-Dependent and -Independent Low Density Lipoprotein Uptake in the Hamster","volume":"80","author":"Spady","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/ATVBAHA.108.179564","article-title":"The LDL Receptor","volume":"29","author":"Goldstein","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1194\/jlr.M200414-JLR200","article-title":"Role of the Hepatic ABCA1 Transporter in Modulating Intrahepatic Cholesterol and Plasma HDL Cholesterol Concentrations","volume":"44","author":"Basso","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1161\/ATVBAHA.112.301110","article-title":"Liver ABCA1 Deletion in LDLrKO Mice Does Not Impair Macrophage Reverse Cholesterol Transport or Exacerbate Atherogenesis","volume":"33","author":"Bi","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Vinu\u00e9, \u00c1., Herrero-Cervera, A., and Gonz\u00e1lez-Navarro, H. (2018). Understanding the Impact of Dietary Cholesterol on Chronic Metabolic Diseases through Studies in Rodent Models. Nutrients, 10.","DOI":"10.3390\/nu10070939"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of Oxidative Stress in the Pathogenesis of Nonalcoholic Fatty Liver Disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.freeradbiomed.2012.08.570","article-title":"Knockout of SOD1 Alters Murine Hepatic Glycolysis, Gluconeogenesis, and Lipogenesis","volume":"53","author":"Wang","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3109\/10715762.2016.1164856","article-title":"Cu, Zn-SOD Deficiency Induces the Accumulation of Hepatic Collagen","volume":"50","author":"Sakiyama","year":"2016","journal-title":"Free Radic. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4196\/kjpp.2017.21.3.317","article-title":"Endogenous Catalase Delays High-Fat Diet-Induced Liver Injury in Mice","volume":"21","author":"Piao","year":"2017","journal-title":"Korean J. Physiol. Pharmacol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/415\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:34:53Z","timestamp":1759919693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["nu17030415"],"URL":"https:\/\/doi.org\/10.3390\/nu17030415","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]}}}