{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:22:25Z","timestamp":1792671745123,"version":"4.5.0"},"reference-count":185,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Minerals are essential nutrients that play critical roles in human health by regulating various physiological functions. Examples include bone development, enzyme function, nerve signaling, and the immune response. Both the deficiencies and toxicities of minerals can have significant health implications. Deficiencies in macrominerals such as calcium, magnesium, and phosphate can lead to osteoporosis (associated with falls and fractures), cardiovascular events, and neuromuscular dysfunction. Trace mineral deficiencies, such as iron and zinc. Selenium deficiency impairs oxygen transport, immune function, and antioxidant defenses, contributing to anemia, delaying wound healing, and increasing susceptibility to infectious diseases. Conversely, excessive intake of minerals can have severe health consequences. Hypercalcemia can cause kidney stones and cardiac arrhythmias as well as soft-tissue calcification, whereas excessive iron deposition can lead to oxidative stress and organ\/tissue damage. Maintaining adequate mineral levels through a balanced diet, guided supplementation, and monitoring at-risk populations is essential for good health and preventing disorders related to deficiencies and toxicities. Public health interventions and education about dietary sources of minerals are critical for minimizing health risks and ensuring optimal well-being across populations. While a comprehensive analysis of all macro and micronutrients is beyond the scope of this article, we have chosen to focus on calcium, magnesium, and phosphate. We summarize the consequences of deficiency and the adverse events associated with the overconsumption of other minerals.<\/jats:p>","DOI":"10.3390\/nu17030454","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:42:23Z","timestamp":1737970943000},"page":"454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":195,"title":["Minerals and Human Health: From Deficiency to Toxicity"],"prefix":"10.3390","volume":"17","author":[{"given":"Mohammed S.","family":"Razzaque","sequence":"first","affiliation":[{"name":"Department of Medical Education, University of Texas, Rio Grande Valley, Edinburg, TX 78520, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-8595","authenticated-orcid":false,"given":"Sunil J.","family":"Wimalawansa","sequence":"additional","affiliation":[{"name":"Cardiometabolic Institute, Brunswick, NJ 08902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Weyh, C., Kr\u00fcger, K., Peeling, P., and Castell, L. (2022). The Role of Minerals in the Optimal Functioning of the Immune System. Nutrients, 14.","DOI":"10.3390\/nu14030644"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1093\/jas\/sky195","article-title":"Effects of supplementing organic microminerals and methionine during the rearing phase of replacement gilts on lameness, growth, and body composition","volume":"96","author":"Faba","year":"2018","journal-title":"J. Anim. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Islam, M.R., Islam, M.R., Shalahuddin Qusar, M.M.A., Islam, M.S., Kabir, M.H., Mustafizur Rahman, G.K.M., Islam, M.S., and Hasnat, A. (2018). Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: A case-control study. BMC Psychiatry, 18.","DOI":"10.1186\/s12888-018-1685-z"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13045-021-01202-2","article-title":"Burden of anemia and its underlying causes in 204 countries and territories, 1990-2019: Results from the Global Burden of Disease Study 2019","volume":"14","author":"Safiri","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mogire, R.M., Muriuki, J.M., Morovat, A., Mentzer, A.J., Webb, E.L., Kimita, W., Ndungu, F.M., Macharia, A.W., Cutland, C.L., and Sirima, S.B. (2022). Vitamin D Deficiency and Its Association with Iron Deficiency in African Children. Nutrients, 14.","DOI":"10.3390\/nu14071372"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Uwitonze, A.M., Ojeh, N., Murererehe, J., Atfi, A., and Razzaque, M.S. (2020). Zinc Adequacy Is Essential for the Maintenance of Optimal Oral Health. Nutrients, 12.","DOI":"10.3390\/nu12040949"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chao, H.C. (2023). Zinc Deficiency and Therapeutic Value of Zinc Supplementation in Pediatric Gastrointestinal Diseases. Nutrients, 15.","DOI":"10.3390\/nu15194093"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zoidis, E., Seremelis, I., Kontopoulos, N., and Danezis, G.P. (2018). Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins. Antioxidants, 7.","DOI":"10.3390\/antiox7050066"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/thy.2023.0556","article-title":"Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","volume":"34","author":"Huwiler","year":"2024","journal-title":"Thyroid"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sadler, R.A., Mallard, B.A., Shandilya, U.K., Hachemi, M.A., and Karrow, N.A. (2024). The Immunomodulatory Effects of Selenium: A Journey from the Environment to the Human Immune System. Nutrients, 16.","DOI":"10.3390\/nu16193324"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gombart, A.F., Pierre, A., and Maggini, S. (2020). A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients, 12.","DOI":"10.3390\/nu12010236"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Erem, S., Atfi, A., and Razzaque, M.S. (2019). Anabolic effects of vitamin D and magnesium in aging bone. J. Steroid Biochem. Mol. Biol., 193.","DOI":"10.1016\/j.jsbmb.2019.105400"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Razzaque, M.S. (2018). Magnesium: Are We Consuming Enough?. Nutrients, 10.","DOI":"10.3390\/nu10121863"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/cen.14350","article-title":"Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial","volume":"94","author":"Schutten","year":"2021","journal-title":"Clin. Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1210\/me.2004-0532","article-title":"Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: More complicated than we thought","volume":"19","author":"Stocco","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.7556\/jaoa.2018.037","article-title":"Role of magnesium in vitamin D activation and function","volume":"118","author":"Uwitonze","year":"2018","journal-title":"J. Am. Osteopath. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.crphys.2022.04.001","article-title":"Zinc and its role in vitamin D function","volume":"5","author":"Amos","year":"2022","journal-title":"Curr. Res. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-030-91623-7_3","article-title":"Extracellular Phosphate, Inflammation and Cytotoxicity","volume":"1362","author":"Michigami","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1096\/fj.05-5432fje","article-title":"Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process","volume":"20","author":"Razzaque","year":"2006","journal-title":"FASEB J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molmed.2006.05.002","article-title":"Hypervitaminosis D and premature aging: Lessons learned from Fgf23 and Klotho mutant mice","volume":"12","author":"Razzaque","year":"2006","journal-title":"Trends Mol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Vervloet, M. (2019). Modifying Phosphate Toxicity in Chronic Kidney Disease. Toxins, 11.","DOI":"10.3390\/toxins11090522"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/MNH.0b013e3281c55eca","article-title":"Mineral metabolism and aging: The fibroblast growth factor 23 enigma","volume":"16","author":"Lanske","year":"2007","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7762\/cnr.2015.4.1.1","article-title":"The role of calcium in human aging","volume":"4","author":"Beto","year":"2015","journal-title":"Clin. Nutr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: Dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling: Function and dysfunction","volume":"71","author":"Brini","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"LeBrasseur, N. (2003). Calcium for strong clotting. J. Cell Biol., 160.","DOI":"10.1083\/jcb1607iti2"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12020-020-02324-2","article-title":"Diagnosis and management of hypocalcemia","volume":"69","author":"Pepe","year":"2020","journal-title":"Endocrine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4103\/2230-8210.95665","article-title":"Calcium and bone disorders in pregnancy","volume":"16","author":"Mahadevan","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.2022.18331","article-title":"Hypercalcemia: A Review","volume":"328","author":"Walker","year":"2022","journal-title":"Jama"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1007\/s12325-024-02843-8","article-title":"Palopegteriparatide treatment Improves renal function in adults with chronic hypoparathyroidism: 1-year results from the phase 3 PaTHway trial","volume":"41","author":"Rejnmark","year":"2024","journal-title":"Adv. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/1097-0142(19940415)73:8<2223::AID-CNCR2820730831>3.0.CO;2-C","article-title":"Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate","volume":"73","author":"Wimalawansa","year":"1994","journal-title":"Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e70247","DOI":"10.1002\/hsr2.70247","article-title":"Treatment utcomes of hypercalcemia of malignancy among advanced cancer patients attending palliative care Unit of a tertiary care hospital in Bangladesh: An observational study","volume":"7","author":"Rouf","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_33","first-page":"1779","article-title":"Hypercalcemia of malignancy and new treatment options","volume":"11","author":"Sternlicht","year":"2015","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_34","first-page":"39","article-title":"Cancer-associated hypercalcemia and parathyroid hormone-related peptide: A new peptide with diverse roles","volume":"7","author":"Cooper","year":"1997","journal-title":"Reg. Pept. Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1210\/clinem\/dgac621","article-title":"Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline","volume":"108","author":"Clines","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_36","first-page":"e71392","article-title":"Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases","volume":"16","author":"Fatima","year":"2024","journal-title":"Cureus"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1007\/s12011-020-02513-0","article-title":"The role of magnesium in pregnancy and in fetal programming of adult diseases","volume":"199","author":"Fanni","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/0004563213517628","article-title":"Contemporary view of the clinical relevance of magnesium homeostasis","volume":"51","author":"Ayuk","year":"2014","journal-title":"Ann. Clin. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1210\/endrev\/bnac028","article-title":"Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes","volume":"44","author":"Oost","year":"2023","journal-title":"Endocr. Rev."},{"key":"ref_40","first-page":"6250312","article-title":"Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia","volume":"2017","author":"Mawri","year":"2017","journal-title":"Case Rep. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40560-018-0291-y","article-title":"Hypomagnesemia in critically ill patients","volume":"6","author":"Hansen","year":"2018","journal-title":"J. Intensive Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s10930-020-09935-8","article-title":"Role of oxidative stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) infection: A review","volume":"39","author":"Suhail","year":"2020","journal-title":"Protein J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.immuni.2020.05.002","article-title":"Immunology of COVID-19: Current state of the science","volume":"52","author":"Vabret","year":"2020","journal-title":"Immunity"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100742","DOI":"10.1016\/j.cpcardiol.2020.100742","article-title":"Thrombosis and Coagulopathy in COVID-19","volume":"46","author":"Montes","year":"2021","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tcm.2020.12.004","article-title":"COVID-19 and thrombosis: From bench to bedside","volume":"31","author":"Ali","year":"2021","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"117723","DOI":"10.1016\/j.lfs.2020.117723","article-title":"Myocardial injury and COVID-19: Possible mechanisms","volume":"253","author":"Gill","year":"2020","journal-title":"Life Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.atherosclerosis.2020.10.014","article-title":"Endothelial dysfunction in COVID-19: Current findings and therapeutic implications","volume":"314","author":"Nagele","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s40620-020-00864-4","article-title":"Prevention of hypomagnesemia in critically ill patients with acute kidney injury on continuous kidney replacement therapy: The role of early supplementation and close monitoring","volume":"34","author":"Regolisti","year":"2021","journal-title":"J. Nephrol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Dominguez, L.J., Veronese, N., Guerrero-Romero, F., and Barbagallo, M. (2021). Magnesium in infectious diseases in older people. Nutrients, 13.","DOI":"10.3390\/nu13010180"},{"key":"ref_50","first-page":"93","article-title":"Relationship of magnesemia with myocardial damage and mortality in patients with COVID-19","volume":"34","author":"Gunay","year":"2021","journal-title":"Magnes. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Aal-Hamad, A.H., Al-Alawi, A.M., Kashoub, M.S., and Falhammar, H. (2023). Hypermagnesemia in clinical practice. Medicina, 59.","DOI":"10.3390\/medicina59071190"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ams2.334","article-title":"The characteristics of patients with hypermagnesemia who underwent emergency hemodialysis","volume":"5","author":"Nishikawa","year":"2018","journal-title":"Acute Med. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Tosto, F., Magro, G., Laterza, V., and Romozzi, M. (2024). Neurological manifestations of hypermagnesemia: A narrative review. Acta Neurol. Belg.","DOI":"10.1007\/s13760-024-02653-3"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e00127-20","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS coronavirus","volume":"94","author":"Wan","year":"2020","journal-title":"J. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Dakal, T.C. (2021). SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19. Immunobiology, 226.","DOI":"10.1016\/j.imbio.2020.152021"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/iid3.528","article-title":"The effect of low serum calcium level on the severity and mortality of COVID patients: A systematic review and meta-analysis","volume":"9","author":"Alemzadeh","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"144","DOI":"10.30699\/ijp.2020.130491.2442","article-title":"Hypocalcemia in COVID-19: A prognostic marker for severe disease","volume":"16","author":"Raesi","year":"2021","journal-title":"Iran. J. Pathol."},{"key":"ref_58","first-page":"S207","article-title":"Vascular biology of magnesium and its transporters in hypertension","volume":"23","author":"Yogi","year":"2010","journal-title":"Magnes. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"11287","DOI":"10.18632\/aging.103526","article-title":"Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019","volume":"12","author":"Sun","year":"2020","journal-title":"Aging"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Souza, A.C.R., Vasconcelos, A.R., Dias, D.D., Komoni, G., and Name, J.J. (2023). The integral role of magnesium in muscle integrity and aging: A comprehensive review. Nutrients, 15.","DOI":"10.3390\/nu15245127"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wu, Z., Yang, X., Ruan, Z., Li, L., Wu, J., and Wang, B. (2023). Nonlinear relationship between dietary calcium and magnesium intake and peripheral neuropathy in the general population of the United States. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1217465"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/advances\/nmaa160","article-title":"Perspective: Characterization of dietary supplements containing calcium and magnesium and their respective ratio-Is a rising ratio a cause for concern?","volume":"12","author":"Costello","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e002111","DOI":"10.1136\/bmjopen-2012-002111","article-title":"Modifying effect of calcium\/magnesium intake ratio and mortality: A population-based cohort study","volume":"3","author":"Dai","year":"2013","journal-title":"BMJ Open"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1681\/ASN.2010060617","article-title":"Magnesium modulates ROMK channel-mediated potassium secretion","volume":"21","author":"Yang","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pathophys.2007.09.005","article-title":"Magnesium transport in hypertension","volume":"14","author":"Sontia","year":"2007","journal-title":"Pathophysiology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00467-012-2350-2","article-title":"Disorders of calcium and magnesium balance: A physiology-based approach","volume":"28","author":"Hoorn","year":"2013","journal-title":"Pediatr. Nephrol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Suzuki, Y., B\u00fcrzle, M., and Hediger, M.A. (2010). 369Physiology and pathology of calcium and magnesium transport. The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease, Olgaard, K., Salusky, I.B., Silver, J., Eds., Oxford University Press.","DOI":"10.1093\/med\/9780199559176.003.022"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1053\/j.ajkd.2023.10.017","article-title":"Magnesium Disorders: Core Curriculum 2024","volume":"83","author":"Adomako","year":"2024","journal-title":"Am. J. Kidney Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.clnesp.2024.05.011","article-title":"Vitamins, minerals and their maternal levels\u2019 role in brain development: An updated literature-review","volume":"63","author":"Hosseini","year":"2024","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Fiorentini, D., Cappadone, C., Farruggia, G., and Prata, C. (2021). Magnesium: Biochemistry, nutrition, detection, and social impact of diseases linked to Its deficiency. Nutrients, 13.","DOI":"10.3390\/nu13041136"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1089\/jwh.2013.4270","article-title":"Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: The Women\u2019s Health Initiative","volume":"22","author":"Cauley","year":"2013","journal-title":"J. Womens Health"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1753-4887.2011.00465.x","article-title":"Suboptimal magnesium status in the United States: Are the health consequences underestimated?","volume":"70","author":"Rosanoff","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/ajcn\/nqy274","article-title":"Magnesium status and supplementation influence vitamin D status and metabolism: Results from a randomized trial","volume":"108","author":"Dai","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/MNH.0000000000000998","article-title":"New insights into renal calcium-sensing receptor activation","volume":"33","author":"Dimke","year":"2024","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_75","first-page":"167","article-title":"Molecular regulation of calcium-sensing receptor (CaSR)-mediated signaling","volume":"10","author":"Tian","year":"2024","journal-title":"Chronic Dis. Transl. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1016\/j.tjnut.2023.05.009","article-title":"Association between a Calcium-to-Magnesium Ratio and Osteoporosis among Puerto Rican Adults","volume":"153","author":"Fouhy","year":"2023","journal-title":"J. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3945\/an.115.008631","article-title":"Essential nutrient Interactions: Does low or suboptimal magnesium status interact with vitamin D and\/or calcium status?","volume":"7","author":"Rosanoff","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/tjb-2023-0022","article-title":"Evaluation of calcium\/magnesium ratio in patients with type 2 diabetes mellitus","volume":"48","year":"2023","journal-title":"Turk J. Biochem."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Guerrero-Romero, F., Mercado, M., Rodriguez-Moran, M., Ramirez-Renteria, C., Martinez-Aguilar, G., Marrero-Rodriguez, D., Ferreira-Hermosillo, A., Simental-Mendia, L.E., Remba-Shapiro, I., and Gamboa-Gomez, C.I. (2022). Magnesium-to-calcium ratio and mortality from COVID-19. Nutrients, 14.","DOI":"10.3390\/nu14091686"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.diabet.2019.12.003","article-title":"Associations of serum magnesium levels and calcium-magnesium ratios with mortality in patients with coronary artery disease","volume":"46","author":"Li","year":"2020","journal-title":"Diabetes Metab."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Escobedo-Monge, M.F., Barrado, E., Parodi-Roman, J., Escobedo-Monge, M.A., Torres-Hinojal, M.C., and Marugan-Miguelsanz, J.M. (2022). Magnesium status and Ca\/Mg ratios in a series of children and adolescents with chronic diseases. Nutrients, 14.","DOI":"10.3390\/nu14142941"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Azem, R., Daou, R., Bassil, E., Anvari, E.M., Taliercio, J.J., Arrigain, S., Schold, J.D., Vachharajani, T., Nally, J., and Na Khoul, G.N. (2020). Serum magnesium, mortality and disease progression in chronic kidney disease. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-1713-3"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"La Carrubba, A., Veronese, N., Di Bella, G., Cusumano, C., Di Prazza, A., Ciriminna, S., Ganci, A., Naro, L., Dominguez, L.J., and Barbagallo, M. (2023). Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study. Nutrients, 15.","DOI":"10.3390\/nu15040830"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"nzz034-P10","DOI":"10.1093\/cdn\/nzz034.P10-100-19","article-title":"Calcium to magnesium Ratio higher than optimal across age groups","volume":"3","author":"DeLuccia","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Ciosek, Z., Kot, K., Kosik-Bogacka, D., Lanocha-Arendarczyk, N., and Rotter, I. (2021). The effects of calcium, magnesium, phosphorus, fluoride, and lead on bone tissue. Biomolecules, 11.","DOI":"10.3390\/biom11040506"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/ajcn\/nqy037","article-title":"Calcium, magnesium, and whole-milk intakes and high-aggressive prostate cancer in the North Carolina-Louisiana Prostate Cancer Project (PCaP)","volume":"107","author":"Steck","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J., Weiss, S.T., and Hollis, B.W. (2024). Integrating Endocrine, Genomic, and Extra-Skeletal Benefits of Vitamin D into National and Regional Clinical Guidelines. Nutrients, 16.","DOI":"10.3390\/nu16223969"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2023). Controlling chronic diseases and acute Infections with vitamin D sufficiency. Nutrients, 15.","DOI":"10.3390\/nu15163623"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mce.2011.05.017","article-title":"Vitamin D metabolism and function in the skin","volume":"347","author":"Bikle","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/fsn3.3213","article-title":"The biological responses of vitamin K2: A comprehensive review","volume":"11","author":"Yan","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e001715","DOI":"10.1136\/openhrt-2021-001715","article-title":"Vitamin K(2)-a neglected player in cardiovascular health: A narrative review","volume":"8","author":"Hariri","year":"2021","journal-title":"Open Heart"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1530\/EC-21-0445","article-title":"Directly measured free and total 25-hydroxyvitamin D levels in relation to metabolic health in multi-ethnic postmenopausal females in Saudi Arabia","volume":"10","author":"Alharazy","year":"2021","journal-title":"Endocr. Connect."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2024). Physiology of Vitamin D-Focusing on Disease Prevention. Nutrients, 16.","DOI":"10.3390\/nu16111666"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jsbmb.2016.09.016","article-title":"Non-musculoskeletal benefits of vitamin D","volume":"175","author":"Wimalawansa","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_95","unstructured":"Wimalawansa, S. (2025). Enhancing the design of nutrient clinical trials for disease prevention: A focus on vitamin D: A systematic review. Nutrition Reviews, Oxford University Press."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00394-015-0859-4","article-title":"A dose-response study of vitamin D3 supplementation in healthy Chinese: A 5-arm randomized, placebo-controlled trial","volume":"55","author":"Yao","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Grant, W., Wimalawansa, S.J., Pludowski, P., and Cheng, R. (2025). Vitamin D: Evidence-based health benefits and recommendations for population guidelines. Nutrients, 17.","DOI":"10.3390\/nu17020277"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Sun, M., Wu, X., Yu, Y., Wang, L., Xie, D., Zhang, Z., Chen, L., Lu, A., Zhang, G., and Li, F. (2020). Disorders of calcium and phosphorus metabolism and the proteomics\/metabolomics-based research. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.576110"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.neuron.2023.05.018","article-title":"A central regulation of PTH secretion and function","volume":"111","author":"Ducy","year":"2023","journal-title":"Neuron"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"E724","DOI":"10.1152\/ajpendo.00557.2012","article-title":"CaSR-mediated interactions between calcium and magnesium homeostasis in mice","volume":"304","author":"Quinn","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2023). Physiological Basis for Using Vitamin D to Improve health. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061542"},{"key":"ref_102","first-page":"1","article-title":"Biology of vitamin D","volume":"10","author":"Wimalawansa","year":"2019","journal-title":"J. Steroids Horm. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10661-006-9365-8","article-title":"Evaluating controlling factors to Al(i)\/(Ca + Mg) molar ratio in acidic soil water, southern and southwestern China: Multivariate approach","volume":"129","author":"Guo","year":"2007","journal-title":"Environ. Monit. Assess."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1749-6632.2011.06374.x","article-title":"Vitamin D: An essential component for skeletal health","volume":"1240","author":"Wimalawansa","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_105","first-page":"33","article-title":"Chronic kidney disease of multifunctional origin (CKDmfo) prevailing in Sri Lanka: Re-evaluated","volume":"6","author":"Dunuweera","year":"2017","journal-title":"World J. Pharma. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15436\/2378-6841.16.029","article-title":"Effect of Water Hardness on Non-Communicable Diseases, Including Chronic Kidney Disease of Multifactorial Origin (CKDmfo\/CKDuo)","volume":"2","author":"Wimalawansa","year":"2016","journal-title":"J. Environ. Health Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s40001-023-01162-y","article-title":"Nanocrystal-induced chronic tubular-nephropathy in tropical countries: Diagnosis, mitigation, and eradication","volume":"28","author":"Wimalawansa","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J., and Dissanayake, C.B. (2019). Factors Affecting the Environmentally Induced, Chronic Kidney Disease of Unknown Aetiology in Dry Zonal Regions in Tropical Countries\u2014Novel Findings. Environments, 7.","DOI":"10.3390\/environments7010002"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11157-019-09521-0","article-title":"Molecular and cellular toxicity of fluoride in mystery, tubulointerstitial chronic kidney disease: A systematic review","volume":"19","author":"Wimalawansa","year":"2019","journal-title":"Rev. Environ. Sci. Bio\/Technol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e02309","DOI":"10.1016\/j.heliyon.2019.e02309","article-title":"Public health interventions for chronic diseases: Cost-benefit modelizations for eradicating chronic kidney disease of multifactorial origin (CKDmfo\/CKDu) from tropical countries","volume":"5","author":"Wimalawansa","year":"2019","journal-title":"Heliyon"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e220239","DOI":"10.1530\/EC-22-0239","article-title":"Interactions between FGF23 and vitamin D","volume":"11","author":"Razzaque","year":"2022","journal-title":"Endocr. Connect."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2131\/jts.40.55","article-title":"Biological effects of inorganic phosphate: Potential signal of toxicity","volume":"40","author":"Hong","year":"2015","journal-title":"J. Toxicol. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-91623-7_1","article-title":"Phosphate metabolism: From physiology to toxicity","volume":"1362","author":"Razzaque","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.clnu.2017.07.025","article-title":"High dietary phosphorus intake is associated with an increased risk of type 2 diabetes in the large prospective E3N cohort study","volume":"37","author":"Mancini","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-030-91623-7_10","article-title":"Common dietary sources of natural and artificial phosphate in food","volume":"1362","author":"Miyamoto","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Itkonen, S.T., and Lamberg-Allardt, C. (2023). Phosphorus\u2014A scoping review for Nordic Nutrition Recommendations 2023. Food Nutr. Res., 67.","DOI":"10.29219\/fnr.v67.10318"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1253\/circj.CJ-14-0735","article-title":"Vascular toxicity of phosphate in chronic kidney disease: Beyond vascular calcification","volume":"78","author":"Gross","year":"2014","journal-title":"Circ. J."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Mironov, N., Haque, M., Atfi, A., and Razzaque, M.S. (2022). Phosphate dysregulation and metabolic syndrome. Nutrients, 14.","DOI":"10.3390\/nu14214477"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Sakaguchi, Y., Hamano, T., and Isaka, Y. (2017). Effects of magnesium on the phosphate Toxicity in chronic kidney disease: Time for intervention studies. Nutrients, 9.","DOI":"10.3390\/nu9020112"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ki.2008.130","article-title":"Hyperphosphatemia of chronic kidney disease","volume":"74","author":"Hruska","year":"2008","journal-title":"Kidney Int."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1186\/cc9215","article-title":"Treatment of hypophosphatemia in the intensive care unit: A review","volume":"14","author":"Geerse","year":"2010","journal-title":"Crit. Care"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/pds.2183","article-title":"The association of vitamin D use with hypercalcemia and hyperphosphatemia in hemodialysis patients: A case-crossover study","volume":"20","author":"Kilpatrick","year":"2011","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s40620-019-00617-y","article-title":"Management of hyperkalemia in patients with kidney disease: A position paper endorsed by the Italian Society of Nephrology","volume":"32","author":"Bianchi","year":"2019","journal-title":"J. Nephrol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ncpneph0124","article-title":"Hypophosphatemia: An evidence-based approach to its clinical consequences and management","volume":"2","author":"Amanzadeh","year":"2006","journal-title":"Nat. Clin. Pr. Nephrol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"100076","DOI":"10.1016\/j.jtemin.2023.100076","article-title":"Overview of the vital roles of macro minerals in the human body","volume":"4","author":"Ali","year":"2023","journal-title":"J. Trace Elem. Miner."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/japplphysiol.00237.2017","article-title":"The interplay between iron and oxygen homeostasis with a particular focus on the heart","volume":"123","author":"Robbins","year":"2017","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.freeradbiomed.2018.07.018","article-title":"An intimate crosstalk between iron homeostasis and oxygen metabolism regulated by the hypoxia-inducible factors (HIFs)","volume":"133","author":"Hirota","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Lin, P.H., Sermersheim, M., Li, H., Lee, P.H.U., Steinberg, S.M., and Ma, J. (2017). Zinc in wound healing modulation. Nutrients, 10.","DOI":"10.3390\/nu10010016"},{"key":"ref_129","unstructured":"Soliman, A.T., Alaaraj, N., Noor, H., Alyafei, F., Ahmed, S., Shaat, M., Itani, M., Elalaily, R., and Soliman, N. (2022). Nutritional interventions during adolescence and their possible effects. Acta Biomed., 93."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e20161319","DOI":"10.1542\/peds.2016-1319","article-title":"Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function","volume":"138","author":"Mireku","year":"2016","journal-title":"Pediatrics"},{"key":"ref_131","first-page":"2087","article-title":"Iron deficiency and cognitive functions","volume":"10","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11154-022-09760-7","article-title":"Iodine status and supplementation in pregnancy: An overview of the evidence provided by meta-analyses","volume":"24","author":"Croce","year":"2023","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Kabthymer, R.H., Shaka, M.F., Ayele, G.M., and Malako, B.G. (2021). Systematic review and meta-analysis of iodine deficiency and its associated factors among pregnant women in Ethiopia. BMC Pregnancy Childbirth, 21.","DOI":"10.1186\/s12884-021-03584-0"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1473S","DOI":"10.1093\/jn\/133.5.1473S","article-title":"The evidence linking zinc deficiency with children\u2019s cognitive and motor functioning","volume":"133","author":"Black","year":"2003","journal-title":"J. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/physrev.00035.2014","article-title":"The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism","volume":"95","author":"Kambe","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/cid\/ciac807","article-title":"Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial","volume":"76","author":"Mhalla","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1620\/tjem.251.175","article-title":"COVID-19 Pandemic: Can Maintaining Optimal Zinc Balance Enhance Host Resistance?","volume":"251","author":"Razzaque","year":"2020","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.csbj.2021.02.015","article-title":"COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?","volume":"19","author":"Razzaque","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.12669\/pjms.38.5.5175","article-title":"Correlation between helicobacter pylori infection and iron deficiency in children","volume":"38","author":"Zhang","year":"2022","journal-title":"Pak. J. Med. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Yiannikourides, A., and Latunde-Dada, G.O. (2019). A Short Review of Iron Metabolism and Pathophysiology of Iron Disorders. Medicines, 6.","DOI":"10.3390\/medicines6030085"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Akimbekov, N.S., Coban, S.O., Atfi, A., and Razzaque, M.S. (2024). The role of magnesium in pancreatic beta-cell function and homeostasis. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1458700"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/(SICI)1096-9136(199604)13:4<389::AID-DIA65>3.0.CO;2-J","article-title":"Chromium deficiency might contribute to insulin resistance, type 2 diabetes mellitus, dyslipidaemia, and atherosclerosis","volume":"13","author":"Mahdi","year":"1996","journal-title":"Diabet. Med."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Bai, J., Xun, P., Morris, S., Jacobs, D.R., Liu, K., and He, K. (2015). Chromium exposure and incidence of metabolic syndrome among American young adults over a 23-year follow-up: The CARDIA Trace Element Study. Sci. Rep., 5.","DOI":"10.1038\/srep15606"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Son, J., Morris, J.S., and Park, K. (2018). Toenail Chromium Concentration and Metabolic Syndrome among Korean Adults. Int. J. Environ. Res. Public. Health, 15.","DOI":"10.3390\/ijerph15040682"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Ahmad, R., Shaju, R., Atfi, A., and Razzaque, M.S. (2024). Zinc and Diabetes: A Connection between Micronutrient and Metabolism. Cells, 13.","DOI":"10.3390\/cells13161359"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Wang, H., Hu, Y.F., Hao, J.H., Chen, Y.H., Su, P.Y., Wang, Y., Yu, Z., Fu, L., Xu, Y.Y., and Zhang, C. (2015). Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: A population-based birth cohort study. Sci. Rep., 5.","DOI":"10.1038\/srep11262"},{"key":"ref_147","first-page":"133","article-title":"Heavy metal toxicity and the environment","volume":"101","author":"Tchounwou","year":"2012","journal-title":"Exp. Suppl."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"236","DOI":"10.5114\/ceji.2015.52837","article-title":"Selected aspects of the action of cobalt ions in the human body","volume":"40","author":"Czarnek","year":"2015","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10653-024-02345-0","article-title":"Uptake and in-vitro bioaccessibility of toxic metals in cocoa beans: Human health risks","volume":"47","author":"Frimpong","year":"2024","journal-title":"Environ. Geochem. Health"},{"key":"ref_150","first-page":"Qe01","article-title":"Minerals in Pregnancy and Lactation: A Review Article","volume":"11","author":"Khayat","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Grossklaus, R., Liesenk\u00f6tter, K.P., Doubek, K., V\u00f6lzke, H., and Gaertner, R. (2023). Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review. Nutrients, 15.","DOI":"10.3390\/nu15102249"},{"key":"ref_152","first-page":"CD000937","article-title":"Magnesium supplementation in pregnancy","volume":"2014","author":"Makrides","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Farias, P.M., Marcelino, G., Santana, L.F., de Almeida, E.B., Guimar\u00e3es, R.C.A., Pott, A., Hiane, P.A., and Freitas, K.C. (2020). Minerals in Pregnancy and Their Impact on Child Growth and Development. Molecules, 25.","DOI":"10.3390\/molecules25235630"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1590\/1806-9282.20220769","article-title":"Vitamin and mineral levels during pregnancy","volume":"68","author":"Hansu","year":"2022","journal-title":"Rev. Assoc. Med. Bras. (1992)"},{"key":"ref_155","first-page":"2424","article-title":"Novel gene mutations in patients with 1alpha-hydroxylase deficiency that confer partial enzyme activity in vitro","volume":"87","author":"Wang","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4274\/jcrpe.2800","article-title":"Identification and Functional Characterization of a Calcium-Sensing Receptor Mutation in an Infant with Familial Hypocalciuric Hypercalcemia","volume":"8","author":"Papadopoulou","year":"2016","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1681\/ASN.2007121360","article-title":"A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis","volume":"19","author":"Iwaki","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cytogfr.2005.01.002","article-title":"FGF23 and disorders of phosphate homeostasis","volume":"16","author":"Yu","year":"2005","journal-title":"Cytokine Growth Factor. Rev."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrendo.2009.196","article-title":"The FGF23-Klotho axis: Endocrine regulation of phosphate homeostasis","volume":"5","author":"Razzaque","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.4158\/EP12186.CR","article-title":"A novel GATA3 nonsense mutation in a newly diagnosed adult patient of hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome","volume":"19","author":"Nanba","year":"2013","journal-title":"Endocr. Pract."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Marini, F., Giusti, F., Cioppi, F., Maraghelli, D., Cavalli, T., Tonelli, F., and Brandi, M.L. (2021). Bone and Mineral Metabolism Phenotypes in MEN1-Related and Sporadic Primary Hyperparathyroidism, before and after Parathyroidectomy. Cells, 10.","DOI":"10.3390\/cells10081895"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MNH.0000000000000612","article-title":"Genetic variants of mineral metabolism in health and disease","volume":"29","year":"2020","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Sood, S., Chaudhary, D.R., Jhorar, P., and Rana, R.S. (2023). Biofortification: An approach to eradicate micronutrient deficiency. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1233070"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4172\/2157-7110.1000257","article-title":"Rational food fortification programs to alleviate micronutrient deficiencies","volume":"4","author":"Wimalawansa","year":"2013","journal-title":"J. Food Process. Technol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1177\/15648265130342S110","article-title":"A review of vitamin D fortification: Implications for nutrition programming in Southeast Asia","volume":"34","author":"Yang","year":"2013","journal-title":"Food Nutr. Bull."},{"key":"ref_166","first-page":"1","article-title":"Reconciling the irreconcilable: Micronutrients in clinical nutrition and public health","volume":"4","author":"Smith","year":"2015","journal-title":"Vitam. Miner."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Silva, P., Araujo, R., Lopes, F., and Ray, S. (2023). Nutrition and food literacy: Framing the challenges to health communication. Nutrients, 15.","DOI":"10.3390\/nu15224708"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0140-6736(18)30313-1","article-title":"Intervention strategies to improve nutrition and health behaviours before conception","volume":"391","author":"Barker","year":"2018","journal-title":"Lancet"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Wu, H., Bai, M., Li, X., Xing, Y., and Sun, S. (2022). Diagnosis and treatment of brain injury complicated by hypernatremia. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.1026540"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"R225","DOI":"10.1186\/cc11872","article-title":"Severe hyperkalemia requiring hospitalization: Predictors of mortality","volume":"16","author":"An","year":"2012","journal-title":"Crit. Care"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Costa, D., Patella, G., Provenzano, M., Ielapi, N., Faga, T., Zicarelli, M., Arturi, F., Coppolino, G., Bolignano, D., and De Sarro, G. (2023). Hyperkalemia in CKD: An overview of available therapeutic strategies. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1178140"},{"key":"ref_172","first-page":"1539","article-title":"Iron poisoning in young children: Association with the birth of a sibling","volume":"168","author":"Juurlink","year":"2003","journal-title":"CMAJ"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1399-0012.1995.tb00303.x","article-title":"Hepatic failure due to massive iron ingestion successfully treated with liver transplantation","volume":"9","author":"Kozaki","year":"1995","journal-title":"Clin. Transpl."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.4103\/jfmpc.jfmpc_805_23","article-title":"Accidental iron poisoning in children\u2014Experience from a teaching institution","volume":"12","author":"Chandran","year":"2023","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"bcr2012007670","DOI":"10.1136\/bcr-2012-007670","article-title":"Near fatal iron intoxication managed conservatively","volume":"2013","author":"Sankar","year":"2013","journal-title":"BMJ Case Rep."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/bpa.12333","article-title":"Understanding aspects of aluminum exposure in Alzheimer\u2019s disease development","volume":"26","author":"Kandimalla","year":"2016","journal-title":"Brain Pathol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Charkiewicz, A.E., Omeljaniuk, W.J., Nowak, K., Garley, M., and Niklinski, J. (2023). Cadmium toxicity and health effects-A brief summary. Molecules, 28.","DOI":"10.3390\/molecules28186620"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.toxlet.2010.04.016","article-title":"Chronic renal failure in Sri Lanka caused by elevated dietary cadmium: Trojan horse of the green revolution","volume":"198","author":"Bandara","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Umair, M., and Alfadhel, M. (2019). Genetic disorders associated with metal metabolism. Cells, 8.","DOI":"10.3390\/cells8121598"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00125817-200103000-00004","article-title":"Hemochromatosis-associated morbidity in the United States: An analysis of the National Hospital Discharge Survey, 1979\u20131997","volume":"3","author":"Brown","year":"2001","journal-title":"Genet. Med."},{"key":"ref_181","unstructured":"Porter, J.L., and Rawla, P. (2025). Hemochromatosis. StatPearls, StatPearls Publishing LLC."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1053\/j.gastro.2007.07.020","article-title":"Distinct Wilson\u2019s disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B","volume":"133","author":"Burstein","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/B978-0-444-63233-3.00018-X","article-title":"Wilson disease and related copper disorders","volume":"147","author":"Lorincz","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"8441","DOI":"10.3390\/cimb46080498","article-title":"Is Copper Still Safe for Us? What Do We Know and What Are the Latest Literature Statements?","volume":"46","author":"Charkiewicz","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2147\/JMDH.S93454","article-title":"Menkes disease: What a multidisciplinary approach can do","volume":"9","author":"Ojha","year":"2016","journal-title":"J. Multidiscip. Healthc."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/454\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:36:47Z","timestamp":1759919807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,26]]},"references-count":185,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["nu17030454"],"URL":"https:\/\/doi.org\/10.3390\/nu17030454","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,26]]}}}