{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:21:30Z","timestamp":1778152890415,"version":"3.51.4"},"reference-count":70,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["CIBEROBN CB12\/03\/30038"],"award-info":[{"award-number":["CIBEROBN CB12\/03\/30038"]}]},{"name":"Instituto de Salud Carlos III","award":["201630.10"],"award-info":[{"award-number":["201630.10"]}]},{"name":"Instituto de Salud Carlos III","award":["RED2022-134800-T"],"award-info":[{"award-number":["RED2022-134800-T"]}]},{"name":"Fundaci\u00f3 La Marat\u00f3 TV3","award":["CIBEROBN CB12\/03\/30038"],"award-info":[{"award-number":["CIBEROBN CB12\/03\/30038"]}]},{"name":"Fundaci\u00f3 La Marat\u00f3 TV3","award":["201630.10"],"award-info":[{"award-number":["201630.10"]}]},{"name":"Fundaci\u00f3 La Marat\u00f3 TV3","award":["RED2022-134800-T"],"award-info":[{"award-number":["RED2022-134800-T"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n (Ministerio de Ciencias e Innovaci\u00f3n, Spain","award":["CIBEROBN CB12\/03\/30038"],"award-info":[{"award-number":["CIBEROBN CB12\/03\/30038"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n (Ministerio de Ciencias e Innovaci\u00f3n, Spain","award":["201630.10"],"award-info":[{"award-number":["201630.10"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n (Ministerio de Ciencias e Innovaci\u00f3n, Spain","award":["RED2022-134800-T"],"award-info":[{"award-number":["RED2022-134800-T"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: The rising prevalence of metabolic-dysfunction-associated steatotic liver disease (MASLD) is a significant health challenge, and the consumption of ultra-processed foods (UPFs) could play a key role. Aim: The aim is assess the impact of UPF consumption changes on the development and progression of MASLD in adults. Design: This is a longitudinal study to assess how changes in UPF consumption affect liver fat and MASLD parameters over 6 months in 70 participants. Methods: Dietary intake was assessed using a validated food frequency questionnaire, and foods were classified according to the NOVA system. Participants were divided into three groups based on UPF consumption changes: maximum (T1), medium (T2), and minimum reduction (T3). Fatty liver parameters were assessed with magnetic resonance imaging and ultrasonography. Mediterranean diet (Med-diet) adherence and sociodemographic parameters were also recorded. The General Linear Model was used to determine relationships between UPF consumption, fatty liver disease parameters, and diet. Results: Participants in T1 experienced a 7.7% reduction in intrahepatic fat content (IFC) compared to 2.6% in T3. T1 showed increased Med-diet adherence and decreased meat and sweets consumption. The energy intake decreased by 605.3 kcal\/day in T1, while T3 showed an increase of 209.5 kcal\/day. Conclusions: Reducing UPF consumption leads to a decrease in IFC, associated with high Med-diet adherence and low calorie intake. Adopting these dietary patterns aligns with global sustainability goals and could further benefit MASLD patients by addressing environmental challenges alongside improving liver health.<\/jats:p>","DOI":"10.3390\/nu17030472","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T07:54:08Z","timestamp":1738050848000},"page":"472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ultra-Processed Food Consumption and Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD): A Longitudinal and Sustainable Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-1588","authenticated-orcid":false,"given":"Silvia","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition CB12\/03\/30038), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-135X","authenticated-orcid":false,"given":"Margalida","family":"Monserrat-Mesquida","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition CB12\/03\/30038), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Ugarriza","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition CB12\/03\/30038), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Primary Health Care Center Camp Red\u00f3, IBSalut, 07010 Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Casares","sequence":"additional","affiliation":[{"name":"Radiodiagnosis Service, Red Asistencial Juaneda, 07011 Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-4730","authenticated-orcid":false,"given":"Cristina","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain"},{"name":"Clinical Analysis Service, University Hospital Son Espases, 07120 Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mateos","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition CB12\/03\/30038), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Hospital of Manacor, 07500 Manacor, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Escarlata","family":"Angullo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition CB12\/03\/30038), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Primary Health Care Center Escola Graduada, IBSalut, 07001 Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-0761","authenticated-orcid":false,"given":"Josep A.","family":"Tur","sequence":"additional","affiliation":[{"name":"Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain"},{"name":"CIBEROBN (Physiopathology of Obesity and Nutrition CB12\/03\/30038), Institute of Health Carlos III, 28029 Madrid, 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