{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:49:44Z","timestamp":1775062184707,"version":"3.50.1"},"reference-count":153,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fresenius Kabi"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A wide range of factors contribute to the overlap of hyperglycemia\u2014acute or chronic\u2014and sarcopenia, as well as their associated adverse consequences, which can lead to impaired physical function, reduced quality of life, and increased mortality risk. These factors include malnutrition (both overnutrition and undernutrition) and low levels of physical activity. Hyperglycemia and sarcopenia are interconnected through a vicious cycle of events that mutually reinforce and worsen each other. To explore this association, our review compiles evidence on: (i) the impact of hyperglycemia on motor and muscle function, with a focus on the mechanisms underlying biochemical changes in the muscles of individuals with or at risk of diabetes and sarcopenia; (ii) the importance of the clinical assessment and control of sarcopenia under hyperglycemic conditions; and (iii) the potential benefits of medical nutrition therapy and increased physical activity as muscle-targeted treatments for this population. Based on the reviewed evidence, we conclude that a regular intake of key functional nutrients, together with structured and supervised resistance and\/or aerobic physical activity, can help maintain euglycemia and improve muscle status in all patients with hyperglycemia and sarcopenia.<\/jats:p>","DOI":"10.3390\/nu17030499","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T11:10:39Z","timestamp":1738149039000},"page":"499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-5906","authenticated-orcid":false,"given":"\u00c1ngel Luis","family":"Abad-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital General Universitario Dr. Balmis, 03010 Alicante, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante (ISABIAL), 03010 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-4451","authenticated-orcid":false,"given":"Silvia","family":"Veses","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Universitario Doctor Peset, 46017 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-8290","authenticated-orcid":false,"given":"Mar\u00eda","family":"Argente Pla","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital Universitari i Polit\u00e8cnic La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Civera","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, University Clinical Hospital, Valencia, INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7091-421X","authenticated-orcid":false,"given":"Katherine","family":"Garc\u00eda-Malpartida","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Universitario Doctor Peset, 46017 Valencia, Spain"},{"name":"School of Health Sciences, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Grecia 31, 12006 Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-0722","authenticated-orcid":false,"given":"Carlos","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Consorcio Hospital General Universitario de Valencia, Departamento de Medicina, University of Valencia, 46016 Valencia, 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Salom","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Universitario Doctor Peset, 46017 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yun Wu Xiong","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital Cl\u00ednico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-4853","authenticated-orcid":false,"given":"Clara","family":"Joaquim","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, 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