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Medicine","award":["23dk0110048h0002"],"award-info":[{"award-number":["23dk0110048h0002"]}]},{"name":"Japanese Society for Musculoskeletal Medicine","award":["24dk0110048h0003"],"award-info":[{"award-number":["24dk0110048h0003"]}]},{"name":"Japanese Society for Musculoskeletal Medicine","award":["2006-1"],"award-info":[{"award-number":["2006-1"]}]},{"name":"Japanese Society for Musculoskeletal Medicine","award":["2010-2"],"award-info":[{"award-number":["2010-2"]}]},{"name":"Japanese Society for Musculoskeletal Medicine","award":["2014-1"],"award-info":[{"award-number":["2014-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: As a result of aging societies, the increasing number of older adults requiring nursing care has become a serious issue and the extension of healthy life expectancy has become an urgent priority. Ergothioneine (EGT) is a sulfur-containing amino acid found in foods such as mushrooms. Low EGT blood concentrations have been reported to be associated with the risk of onset and progression of various diseases. However, the distribution of EGT blood concentrations and their association with dietary habits in the Japanese general population remains unclear. Methods: This cross-sectional study was conducted using data from the third survey of the Research on Osteoarthritis\/osteoporosis Against Disability (ROAD) study, which analyzed 1457 participants (474 men and 983 women) aged \u2265 40 years. Serum EGT concentrations and their association with dietary habits were analyzed. Results: Serum EGT concentrations (1) peaked in the 70s in men and the 60s in women, (2) were higher in women than in men, and (3) showed a significant positive correlation with fish intake and nutrients commonly found in fish. Conclusions: In the present study, we report for the first time an age- and sex-specific serum EGT distribution in a Japanese population and its association with dietary habits, particularly fish intake. These findings help define normal and abnormal EGT levels and suggest new potential sources of EGT.<\/jats:p>","DOI":"10.3390\/nu17030517","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:08:23Z","timestamp":1738235303000},"page":"517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Association Between Serum Ergothioneine Concentration and Japanese Dietary Habits: The Third Survey of the ROAD Study"],"prefix":"10.3390","volume":"17","author":[{"given":"Kosuke","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo 113-8655, Japan"},{"name":"Institute for Science of Life, Suntory Wellness Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Institute for Science of Life, Suntory Wellness Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Izumo","sequence":"additional","affiliation":[{"name":"Institute for Science of Life, Suntory Wellness Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Nakao","sequence":"additional","affiliation":[{"name":"Institute for Science of Life, Suntory Wellness Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4662-4248","authenticated-orcid":false,"given":"Toshiko","family":"Iidaka","sequence":"additional","affiliation":[{"name":"Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Muraki","sequence":"additional","affiliation":[{"name":"Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Oka","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal AI System Development, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Nadogaya Hospital, Chiba 277-0084, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Akune","sequence":"additional","affiliation":[{"name":"National Rehabilitation Center for Persons with Disabilities, Saitama 359-0042, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-0284","authenticated-orcid":false,"given":"Hiroshi","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Wakayama Medical University School of Medicine, Kimiidera 811-1, Wakayama 641-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-883X","authenticated-orcid":false,"given":"Hiroshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Wakayama Medical University School of Medicine, Kimiidera 811-1, Wakayama 641-8509, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Towa Hospital, Tokyo 120-0003, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Prevention Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref_1","unstructured":"National Institute of Population and Social Security Research in Japan (2024, November 26). 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