{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:21Z","timestamp":1792800021209,"version":"4.5.0"},"reference-count":152,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The pathophysiology of fibromyalgia, a condition that causes chronic pain throughout the body, involves abnormal pain signaling, genetic predispositions, and abnormal neuroendocrine function, significantly impairing quality of life. Fibromyalgia is commonly characterized by musculoskeletal pain, chronic fatigue, and severe sleep alterations. Changes in the central processing of sensory input and defects in endogenous pain inhibition could be the basis of enhanced and persistent pain sensitivity in individuals with fibromyalgia. The term central sensitivity syndrome was chosen as an umbrella term for fibromyalgia and related illnesses, including myalgic encephalomyelitis\/chronic fatigue syndrome, migraine, and irritable bowel syndrome. Given the substantial impact of fibromyalgia on health, there is a need for new prevention and treatment strategies, particularly those involving bioavailable nutraceuticals and\/or phytochemicals. This approach is particularly important considering the adverse effects of current fibromyalgia pharmaceutical treatments, such as antidepressants and anticonvulsants, which can lead to physical dependence and tolerance. Natural products have recently been considered for the design of innovative analgesics and antinociceptive agents to manage fibromyalgia pain. Polyphenols show promise in the management of neuropathic pain and fibromyalgia, especially considering how anti-inflammatory treatments, including corticosteroids and nonsteroidal medical drugs, are effective only when inflammatory processes coexist and are not recommended as the primary treatment for fibromyalgia.<\/jats:p>","DOI":"10.3390\/nu17030530","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:08:26Z","timestamp":1738300106000},"page":"530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Management of Fibromyalgia: Novel Nutraceutical Therapies Beyond Traditional Pharmaceuticals"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-4616","authenticated-orcid":false,"given":"Antonella","family":"Antonelli","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino, C\u00e0 Le Suore 2\/4, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino, C\u00e0 Le Suore 2\/4, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-900X","authenticated-orcid":false,"given":"Elizabeth","family":"Fear","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, Institute for Advanced Biomedical Technologies, University \u201cG. D\u2019Annunzio\u201d of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Pure and Applied Sciences, University of Urbino, C\u00e0 Le Suore 2\/4, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, University of Urbino, C\u00e0 Le Suore 2\/4, 61029 Urbino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.math.2008.09.001","article-title":"The Mechanisms of Manual Therapy in the Treatment of Musculoskeletal Pain: A Comprehensive Model","volume":"14","author":"Bialosky","year":"2009","journal-title":"Man. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.4088\/JCP.8139tx1cc","article-title":"Recognizing and diagnosing fibromyalgia","volume":"71","author":"Culpepper","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.4088\/JCP.8139tx2cc","article-title":"Evaluating the patient with fibromyalgia","volume":"71","author":"Culpepper","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Siracusa, R., Di Paola, R., Cuzzocrea, S., and Impellizzeri, D. (2021). Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083891"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.36076\/ppj.2020\/23\/461","article-title":"Efficacy of Manual Therapy on Pain, Impact of Disease, and Quality of Life in the Treatment of Fibromyalgia: A Systematic Review","volume":"23","author":"Schulze","year":"2020","journal-title":"Pain Physician"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Gyorfi, M., Rupp, A., and Abd-Elsayed, A. (2022). Fibromyalgia Pathophysiology. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123070"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Staud, R., Godfrey, M.M., and Stroman, P.W. (2023). Fibromyalgia is associated with hypersensitivity but not with abnormal pain modulation: Evidence from QST trials and spinal fMRI. Front. Pain Res., 4.","DOI":"10.3389\/fpain.2023.1284103"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/pm\/pnac076","article-title":"The Impact of Micro RNA-320a Serum Level on Severity of Symptoms and Cerebral Processing of Pain in Patients with Fibromyalgia","volume":"23","author":"Hussein","year":"2022","journal-title":"Pain Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1002\/art.24849","article-title":"Elevated insular glutamate in fibromyalgia is associated with experimental pain","volume":"60","author":"Harris","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/art.33339","article-title":"Reduced insular \u03b3-aminobutyric acid in fibromyalgia","volume":"64","author":"Foerster","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa1204471","article-title":"An fMRI-based neurologic signature of physical pain","volume":"368","author":"Wager","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fusco, R., Siracusa, R., D\u2019Amico, R., Peritore, A.F., Cordaro, M., Gugliandolo, E., Crupi, R., Impellizzeri, D., Cuzzocrea, S., and Di Paola, R. (2019). Melatonin plus folic acid treatment ameliorates reserpine-induced fibromyalgia: An evaluation of pain, oxidative stress, and inflammation. Antioxidants, 8.","DOI":"10.3390\/antiox8120628"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hendrix, J., Nijs, J., Ickmans, K., Godderis, L., Ghosh, M., and Polli, A. (2020). The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms. Antioxidants, 9.","DOI":"10.3390\/antiox9111166"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ovrom, E.A., Mostert, K.A., Khakhkhar, S., McKee, D.P., Yang, P., and Her, Y.F. (2023). A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041119"},{"key":"ref_15","first-page":"482","article-title":"The plasma microRNA levels and their relationship with the general health and functional status in female patients with fibromyalgia syndrome","volume":"36","author":"Akaslan","year":"2021","journal-title":"Arch. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/art.41171","article-title":"Heritability of the fibromyalgia phenotype varies by age","volume":"72","author":"Dutta","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1007\/s12035-016-0235-2","article-title":"Circulating microRNA Profiles as LiquidBiopsies for the Characterization and Diagnosis of Fibromyalgia Syndrome","volume":"54","author":"Masotti","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Berg, F., Moser, D.A., Hagena, V., Streit, F., Mosch, B., Kumsta, R., Herpertz, S., and Diers, M. (2023). MicroRNA-Related Polymorphism and Their Association with Fibromyalgia. Genes, 14.","DOI":"10.20944\/preprints202306.0026.v1"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Nepotchatykh, E., Caraus, I., Elremaly, W., Leveau, C., Elbakry, M., Godbout, C., Rostami-Afshari, B., Petre, D., Khatami, N., and Franco, A. (2023). Circulating microRNA expression signatures accurately discriminate myalgic encephalomyelitis from fibromyalgia and comorbid conditions. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-28955-9"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tsamou, M., Kremers, F.A.C., Samaritakis, K.A., and Roggen, E.L. (2024). Identifying microRNAs Possibly Implicated in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome and Fibromyalgia: A Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179551"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e1199","DOI":"10.1097\/PR9.0000000000001199","article-title":"miR-374 family is a key regulator of chronic primary pain onset","volume":"9","author":"Hernandez","year":"2024","journal-title":"Pain Rep."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Philippe, S., Delay, M., Macian, N., Morel, V., and Pickering, M.E. (2023). Common miRNAs of Osteoporosis and Fibromyalgia: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713513"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Erbacher, C., Vaknine, S., Moshitzky, G., Lobentanzer, S., Eisenberg, L., Evdokimov, D., Sommer, C., Greenberg, D.S., Soreq, H., and \u00dc\u00e7eyler, N. (2022). Distinct CholinomiR Blood Cell Signature as a Potential Modulator of the Cholinergic System in Women with Fibromyalgia Syndrome. Cells, 11.","DOI":"10.3390\/cells11081276"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.55563\/clinexprheumatol\/iitbcp","article-title":"Bioinformatics analysis of gene and microRNA targets for fibromyalgia","volume":"39","author":"Qiu","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Braun, A., Evdokimov, D., Frank, J., Sommer, C., and \u00dc\u00e7eyler, N. (2020). MiR103a-3p and miR107 are related to adaptive coping in a cluster of fibromyalgia patients. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0239286"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1097\/j.pain.0000000000000668","article-title":"Increased cutaneous miR-let-7d expression correlates with small nerve fiber pathology in patients with fibromyalgia syndrome","volume":"157","author":"Leinders","year":"2016","journal-title":"Pain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1007\/s12035-015-9106-5","article-title":"Serum MicroRNA Signatures in Migraineurs During Attacks and in Pain-Free Periods","volume":"53","author":"Andersen","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cerd\u00e1-Olmedo, G., Mena-Dur\u00e1n, A.V., Monsalve, V., and Oltra, E. (2015). Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0121903"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00296-014-3139-3","article-title":"Profile of circulating microRNAs in fibromyalgia and their relation to symptom severity: An exploratory study","volume":"35","author":"Bjersing","year":"2015","journal-title":"Rheumatol. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1744806918819944","DOI":"10.1177\/1744806918819944","article-title":"Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers","volume":"15","year":"2019","journal-title":"Mol. Pain"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bjersing, J.L., Lundborg, C., Bokarewa, M.I., and Mannerkorpi, K. (2013). Profile of cerebrospinal microRNAs in fibromyalgia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078762"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Cohen-Biton, L., Buskila, D., and Gannot, R.N. (2023). Fibromyalgia as a Transparent Diseases. Preprints.","DOI":"10.20944\/preprints202311.0689.v1"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Dolcino, M., Tinazzi, E., Puccetti, A., and Lunardi, C. (2020). Gene Expression Profiling in Fibromyalgia Indicates an Autoimmune Origin of the Disease and Opens New Avenues for Targeted Therapy. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061814"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ejp.1871","article-title":"Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia","volume":"26","author":"Hsu","year":"2022","journal-title":"Eur. J. Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/cts.12679","article-title":"Metabolomic Differentials in Women with and Without Fibromyalgia","volume":"13","author":"Starkweather","year":"2020","journal-title":"Clin. Transl. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13041-024-01102-9","article-title":"S100 proteins: A new frontier in fibromyalgia research","volume":"17","year":"2024","journal-title":"Mol. Brain"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/annrheumdis-2016-209724","article-title":"EULAR revised recommendations for the management of fibromyalgia","volume":"76","author":"Macfarlane","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_38","first-page":"485272","article-title":"Treatment of Fibromyalgia Syndrome: Recommendations of Recent Evidence-Based Interdisciplinary Guidelines with Special Emphasis on Complementary and Alternative Therapies","volume":"2013","author":"Ablin","year":"2013","journal-title":"Evid.-Based Complement. Altern. Med. Vol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Maffei, M.E. (2020). Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative remedies. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217877"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"H\u00e4user, W., Urr\u00fatia, G., Tort, S., \u00dc\u00e7eyler, N., and Walitt, B. (2013). Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD010292"},{"key":"ref_41","first-page":"E581","article-title":"Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats","volume":"23","year":"2020","journal-title":"Pain Physician"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3899\/jrheum.170098","article-title":"Adherence and Persistence with Drug Therapy among Fibromyalgia Patients: Data from a Large Health Maintenance Organization","volume":"44","author":"Weitzman","year":"2017","journal-title":"J. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.31128\/AJGP-09-22-6564","article-title":"Low-dose naltrexone in the treatment of fibromyalgia: A systematic review and narrative synthesis","volume":"52","author":"Aitcheson","year":"2023","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2212939","DOI":"10.1001\/jamanetworkopen.2022.12939","article-title":"Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis","volume":"5","author":"Farag","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Maddox, E.K., Massoni, S.C., Hoffart, C.M., and Takata, Y. (2023). Dietary Effects on Pain Symptoms in Patients with Fibromyalgia Syndrome: Systematic Review and Future Directions. Nutrients, 15.","DOI":"10.3390\/nu15030716"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/10547738221126003","article-title":"Do Routine Laboratory Parameters have Predictive Ability to Differentiate Subjects with Fibromyalgia from Healthy Subjects?","volume":"32","author":"Rus","year":"2023","journal-title":"Clin. Nurs. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Alfosea-Cuadrado, G.M., Zarzoso-Foj, J., Adell, A., Valverde-Navarro, A.A., Gonz\u00e1lez-Soler, E.M., Mangas-Sanju\u00e1n, V., and Blasco-Serra, A. (2024). Population Pharmacokinetic\u2013Pharmacodynamic Analysis of a Reserpine-Induced Myalgia Model in Rats. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16081101"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nourhan, S.E., Medhat, W.S., and Mohammed, H.S. (2021). Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model. Biochim. Biophys. Acta Mol. Basis Dis., 1867.","DOI":"10.1016\/j.bbadis.2021.166150"},{"key":"ref_49","first-page":"CD012332","article-title":"Oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults","volume":"3","author":"Derry","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_50","first-page":"116","article-title":"Effects of nonsteroidal anti-inflammatory drugs at the molecular level","volume":"50","year":"2018","journal-title":"Eurasian J. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/YIC.0000000000000147","article-title":"Pregabalin for generalized anxiety disorder: An updated systematic review and meta-analysis","volume":"32","author":"Generoso","year":"2017","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/JCP.0b013e318267b8ca","article-title":"Add-on Treatment of Quetiapine for Fibromyalgia A Pilot, Randomized, Double-Blind, Placebo-Controlled 12-Week Trial","volume":"32","author":"Potvin","year":"2012","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"106321","DOI":"10.1016\/j.cct.2021.106321","article-title":"Randomized Clinical Trial of Fibromyalgia Inte-grative Training (FIT Teens) for Adolescents with Juvenile Fibromyalgia\u2013Study Design and Protocol","volume":"103","author":"Briggs","year":"2021","journal-title":"Contemp. Clin. Trials."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Smith, H.D., Bracken, D., and Smith, J.M. (2011). Pharmacotherapy for fibromyalgia. Front. Pharmacol. Neuropharmacol., 2.","DOI":"10.3389\/fphar.2011.00017"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"D\u2019Amico, R., Impellizzeri, D., Cuzzocrea, S., and Di Paola, R. (2020). Aliamides update: Palmitoylethanolamide and its formulations on management of peripheral neuropathic pain. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155330"},{"key":"ref_56","first-page":"631","article-title":"A randomized clinical trial of fibromyalgia treatment with acupuncture compared with fluoxetine","volume":"14","author":"Hadianfard","year":"2012","journal-title":"Iran. Red Crescent Med. J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Cohen-Biton, L., Buskila, D., and Nissanholtz-Gannot, R. (2022). Review of Fibromyalgia (FM) Syndrome Treatments. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191912106"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Silva, J.L., Santos, E.A., and Alvarez-Leite, J.I. (2023). Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?. Nutrients, 15.","DOI":"10.20944\/preprints202309.1822.v1"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/13543784.2023.2230118","article-title":"What is the progress of experimental drug development for fibromyalgia?","volume":"32","author":"Lawson","year":"2023","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lang-Illievich, K., Klivinyi, C., Rumpold-Seitlinger, G., Dorn, C., and Bornemann-Cimenti, H. (2022). The Effect of Palmitoyleth-anolamide on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers\u2014A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. Nutrients, 14.","DOI":"10.3390\/nu14194084"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/FBP.0000000000000195","article-title":"Withania somnifera (L.) Dunal root extract alleviates formalin-induced nociception in mice: Involvement of the opioidergic system","volume":"27","author":"Casu","year":"2016","journal-title":"Behav. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Bashir, A., Nabi, M., Tabassum, N., Afzal, S., and Ayoub, M. (2023). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1049334"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1124\/dmd.121.000455","article-title":"Withaferin A in the treatment of liver diseases: Progress and pharmacokinetic insights","volume":"50","author":"Xia","year":"2022","journal-title":"Drug Metab. Dispos. Biol. Fate Chem."},{"key":"ref_64","first-page":"115","article-title":"Revisiting the Multifaceted Therapeutic Potential of Withaferin A (WA), a Novel Steroidal Lactone, W-ferinAmax Ashwagandha, from Withania somnifera (L) Dunal","volume":"43","author":"Kumar","year":"2024","journal-title":"J. Am. Nutr. Assoc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/ar2662","article-title":"Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1\u03b2-stimulated fibroblast-like synoviocytes and in rat arthritis models","volume":"11","author":"Bang","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_66","first-page":"1192","article-title":"Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"17","author":"Sahebkar","year":"2016","journal-title":"Pain Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00011-015-0885-y","article-title":"Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-kappaB activation","volume":"64","author":"Fattori","year":"2015","journal-title":"Inflamm. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bbi.2018.01.009","article-title":"Curcumin Treatment Leads to Better Cognitive and Mood Function in a Model of Gulf War Illness with Enhanced Neurogenesis, and Alleviation of Inflammation and Mitochondrial Dysfunction in the Hippocampus","volume":"69","author":"Kodali","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1021\/acsptsci.2c00012","article-title":"Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials","volume":"6","author":"Kunnumakkara","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2217\/nnm-2017-0339","article-title":"Ferucarbotran-loaded red blood cells as long circulating MRI contrast agents: First in vivo results in mice","volume":"13","author":"Antonelli","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/cmmi.1562","article-title":"USPIO-loaded red blood cells as a biomimetic MR contrast agent: A relaxometric study","volume":"9","author":"Boni","year":"2014","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000078042","article-title":"Drug delivery through phagocytosis of red blood cells","volume":"31","author":"Serafini","year":"2004","journal-title":"Transfus. Med. Hemotherapy"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e0406","DOI":"10.15275\/rusomj.2018.0406","article-title":"The terpene-indole alkaloids loaded erythrocytes as a drug carrier: Design and assessment","volume":"7","author":"Halahakoon","year":"2018","journal-title":"Russ. Open Med. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"121419","DOI":"10.1016\/j.ijpharm.2021.121419","article-title":"Inspiring biomimetic system based on red blood cell membrane vesicles for effective curcumin loading and release","volume":"613","author":"Safarpour","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jconrel.2023.07.049","article-title":"Red blood cell-mimicking liposomes loading curcumin promote diabetic wound healing","volume":"361","author":"Tang","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Giordani, C., Matacchione, G., Giuliani, A., Valli, D., Scarpa, E.S., Antonelli, A., Sabbatinelli, J., Giacchetti, G., Sabatelli, S., and Olivieri, F. (2023). Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108820"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Mantle, D., Hargreaves, I.P., Domingo, J.C., and Castro-Marrero, J. (2024). Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010574"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1089\/ars.2013.5346","article-title":"Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia","volume":"19","author":"Cordero","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1089\/ars.2012.4892","article-title":"Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?","volume":"18","author":"Cordero","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Cordero, M.D., Cano-Garc\u00eda, F.J., Alcocer-G\u00f3mez, E., De Miguel, M., and S\u00e1nchez-Alc\u00e1zar, J.A. (2012). Oxidative stress correlates with headache symptoms in fibromyalgia: Coenzyme Q10 effect on clinical improvement. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035677"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/JCP.0000000000000097","article-title":"Coenzyme Q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: Results of a small clinical trial","volume":"34","author":"Cordero","year":"2014","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"bcr2013009019","DOI":"10.1136\/bcr-2013-009019","article-title":"High-dose thiamine improves the symptoms of fibromyalgia","volume":"2013","author":"Costantini","year":"2013","journal-title":"BMJ Case Rep."},{"key":"ref_83","first-page":"E877","article-title":"Is Serum Hypovitaminosis D Associated with Chronic Widespread Pain Including Fibromyalgia? A Meta-analysis of Observational Studies","volume":"18","author":"Hsiao","year":"2015","journal-title":"Pain Physician"},{"key":"ref_84","first-page":"e7198","article-title":"Innovations in the Management of Musculoskeletal Pain With Alpha-Lipoic Acid (IMPALA Trial): Study protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Alpha-Lipoic Acid for the Treatment of Fibromyalgia Pain","volume":"6","author":"Gilron","year":"2017","journal-title":"JMIR Res. Protoc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/j.pain.0000000000002028","article-title":"Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: The IMPALA trial","volume":"162","author":"Gilron","year":"2021","journal-title":"PAIN"},{"key":"ref_86","first-page":"S82","article-title":"A randomized controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: Preliminary data","volume":"33","author":"Leombruni","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.3390\/nu15092154","article-title":"Nutrient Therapy for the Improvement of Fatigue Symptoms Michael Barnish","volume":"15","author":"Sheikh","year":"2023","journal-title":"Nutrients"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1179\/1351000213Y.0000000079","article-title":"Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia","volume":"19","author":"Bozkurt","year":"2014","journal-title":"Redox Rep."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Lowry, E., Marley, J., McVeigh, J.G., McSorley, E., Allsopp, P., and Kerr, D. (2020). Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis. Nutrients, 12.","DOI":"10.3390\/nu12092664"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.mayocpiqo.2022.06.003","article-title":"Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia","volume":"6","author":"Munipalli","year":"2022","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Gharibpoor, F., Parsa, B.G., Sattari, N., Bidari, A., Nejatifar, F., and Montazeri, A. (2022). Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol., 6.","DOI":"10.1186\/s41927-022-00282-y"},{"key":"ref_92","first-page":"197","article-title":"Carnitine levels in painful muscles of patients with fibromyalgia","volume":"8","author":"Bengtsson","year":"1990","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s10067-011-1697-2","article-title":"The relationship between serum antioxidant vitamins, magnesium levels, and clinical parameters in patients with primary fibromyalgia syndrome","volume":"30","author":"Sakarya","year":"2011","journal-title":"Clin. Rheumatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1024\/0300-9831\/a000253","article-title":"Polyphenol-Rich Foods Alleviate Pain and Ameliorate Quality of Life in Fibromyalgic Women","volume":"87","author":"Paiva","year":"2017","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1582432","DOI":"10.1155\/2022\/1582432","article-title":"Oxidative Stress in Fibromyalgia: From Pathology to Treatment","volume":"2022","author":"Assavarittirong","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Shen, C.L., Schuck, A., Tompkins, C., Dunn, D.M., and Neugebauer, V. (2022). Bioactive Compounds for Fibromyalgia-like Symptoms: A Narrative Review and Future Perspectives. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19074148"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3344\/kjp.2017.30.4.250","article-title":"Vitamin D and fibromyalgia: A meta-analysis","volume":"30","author":"Makrani","year":"2017","journal-title":"Korean J. Pain"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/17512433.2022.2081151","article-title":"The efficacy of vitamin D in treatment of fibromyalgia: A meta-analysis of randomized con-trolled studies and systematic review","volume":"15","author":"Qu","year":"2022","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"105260","DOI":"10.1016\/j.jff.2022.105260","article-title":"Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia","volume":"97","author":"Mishra","year":"2022","journal-title":"J. Funct. Foods"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3346\/jkms.2011.26.10.1253","article-title":"Women with fibromyalgia have lower levels of calcium, magnesium, iron and manganese in hair mineral analysis","volume":"26","author":"Kim","year":"2011","journal-title":"J. Korean Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"21501327211038433","DOI":"10.1177\/21501327211038433","article-title":"Magnesium and Fibromyalgia: A Literature Review","volume":"12","author":"Boulis","year":"2021","journal-title":"J Prim. Care Community Health"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Macian, N., Dual\u00e9, C., Voute, M., Leray, V., Courrent, M., Bod\u00e9, P., Giron, F., Sonneville, S., Bernard, L., and Joanny, F. (2022). Short-term magnesium therapy alleviates moderate stress in patients with fibromyalgia: A randomized dou-ble-blind clinical trial. Nutrients, 14.","DOI":"10.3390\/nu14102088"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s40122-024-00641-2","article-title":"Neuronutritional Approach to Fibromyalgia Management: A Narrative Review","volume":"13","author":"Badaeva","year":"2024","journal-title":"Pain Ther."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Yao, W.C., Chen, H.J., Leong, K.H., Chang, K.L., Wang, Y.T.T., Wu, L.C., Tung, P.Y., Kuo, C.F., Lin, C.C., and Tsai, S.Y. (2021). The risk of fibromyalgia in patients with iron deficiency anemia: A nationwide population? Based cohort study. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-89842-9"},{"key":"ref_105","first-page":"10375","article-title":"Ferric carboxymaltose therapy reduces pain and improves the quality of life in female patients with fibromyalgia","volume":"27","author":"Hamarat","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s40744-017-0088-9","article-title":"A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia","volume":"5","author":"Boomershine","year":"2018","journal-title":"Rheumatol. Ther."},{"key":"ref_107","first-page":"71","article-title":"Fibromyalgia interventions, obstacles and prospects: Narrative review","volume":"42","author":"Wasti","year":"2023","journal-title":"Acta Myol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s11101-022-09838-9","article-title":"Polyphenols as possible alternative agents in chronic fatigue: A review","volume":"22","author":"Ullah","year":"2023","journal-title":"Phytochem. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.biopha.2017.10.077","article-title":"Central and peripheral anti-hyperalgesic effects of diosmin in a neuropathic pain model in rats","volume":"97","author":"Pellicer","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/1389200214666131210143407","article-title":"Delivery and Application of Dietary Polyphenols to Target Organs, Tissues and Intracellular Organelles","volume":"15","author":"Ohara","year":"2014","journal-title":"Curr. Drug Metab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1590\/1516-3180.2020.0766.r1.22042021","article-title":"Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: Systematic review","volume":"139","author":"Meireles","year":"2021","journal-title":"Sao Paulo Med. J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e4766","DOI":"10.1002\/ejp.4766","article-title":"Fibromyalgia severity and symptoms are associated with the disorders of gut-brain interaction","volume":"29","author":"Erdrich","year":"2025","journal-title":"Eur. J. Pain"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Wilke, W.S. (2018). Chapter 4, Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms\u2014A Review. Discussions of Unusual Topics in Fibromyalgia, IntechOpen. [1st ed.].","DOI":"10.5772\/66578"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11926-000-0053-3","article-title":"Evidence for metabolic abnormalities in the muscles of patients with fibromyalgia","volume":"2","author":"Park","year":"2000","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Wang, Y., Fang, X., Ye, L., Li, Y., Shi, H., and Cao, Y. (2017). A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/6875968"},{"key":"ref_116","first-page":"513","article-title":"Saffron (Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trial","volume":"8","author":"Shakiba","year":"2018","journal-title":"Avicenna J. Phytomedicine"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Maldonado, C. (2017). Analgesic Potential of Extracts and Derived Natural Products from Medicinal Plants. Pain Relief-From Analgesics to Alternative Therapies, IntechOpen. Chapter 17.","DOI":"10.5772\/intechopen.68903"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s40199-019-00319-7","article-title":"The analgesic potential of glycosides derived from medicinal plants","volume":"28","author":"Khan","year":"2020","journal-title":"Daru"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Ruga, S., Galla, R., Ferrari, S., Invernizzi, M., and Uberti, F. (2023). Novel Approach to the Treatment of Neuropathic Pain Using a Combination with Palmitoylethanolamide and Equisetum arvense L. in an In Vitro Study. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065503"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Bertelli, A., Biagi, M., Corsini, M., Baini, G., Cappellucci, G., and Miraldi, E. (2021). Polyphenols: From Theory to Practice. Foods, 10.","DOI":"10.3390\/foods10112595"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"7432797","DOI":"10.1155\/2016\/7432797","article-title":"Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?","volume":"2016","author":"Hussain","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"173266","DOI":"10.1016\/j.ejphar.2020.173266","article-title":"Quercetin attenuates diabetic neuropathic pain by inhibiting mTOR\/p70S6K pathway-mediated changes of synaptic morphology and synaptic protein levels in spinal dorsal horn of db\/db mice","volume":"882","author":"Wang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Quinto-Ortiz, Y.E., Gonzales-Trujano, M.E., Moreno-P\u00e9rez, G.F., Jacinto-Guti\u00e9rrez, S., Pellicer, F., Fern\u00e1ndez-Guasti, A., and Hernandez-Leon, A. (2022). Pharmacological Interaction of Quercetin Derivatives of Tilia americana and Clinical Drugs in Experimental Fibromyalgia. Metabolites, 12.","DOI":"10.3390\/metabo12100916"},{"key":"ref_124","first-page":"2684","article-title":"Baicalin relieves neuropathic pain by regulating \u03b12-adrenoceptor levels in rats following spinal nerve injury","volume":"20","author":"Huang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/cbdv.201600060","article-title":"Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review","volume":"13","author":"Xiao","year":"2016","journal-title":"Chem. Biodivers."},{"key":"ref_126","first-page":"1343","article-title":"Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol","volume":"19","author":"Yao","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Rojas-Gonz\u00e1lez, A., Yuritzi Figueroa-Hern\u00e1ndez, C., Gonz\u00e1lez-Rios, O., Su\u00e1rez-Quiroz, M.L., Gonz\u00e1lez-Amaro, R.M., Hern\u00e1ndez-Estrada, Z.J., and Rayas-Duarte, P. (2022). Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review. Molecules, 27.","DOI":"10.3390\/molecules27113400"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Hajialyani, M., Hosein Farzaei, M., Echeverr\u00eda, J., Nabavi, S.M., Uriarte, E., and Sobarzo-S\u00e1nchez, E. (2019). Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence. Molecules, 24.","DOI":"10.3390\/molecules24030648"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Carballo-Villalobos, A.I., Gonz\u00e1lez-Trujano, M.E., Pellicer, F., and L\u00f3pez-Mu\u00f1oz, F.J. (2016). Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain. BioMed Res. Int., 2016.","DOI":"10.1155\/2016\/8263463"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10787-017-0326-3","article-title":"Pro-inflammatory cytokines involvement in the hesperidin antihyperalgesic effects at peripheral and central levels in a neuropathic pain model","volume":"25","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Eom, S., Lee, B.-B., Lee, S., Park, Y., Yeom, H.D., Kim, T.-H., Nam, S.-H., and Lee, J.H. (2022). Antioxidative and Analgesic Effects of Naringin through Selective Inhibition of Transient Receptor Potential Vanilloid Member. Antioxidants, 11.","DOI":"10.3390\/antiox11010064"},{"key":"ref_132","first-page":"1443","article-title":"Further Antinociceptive Properties of Naringenin on Acute and Chronic Pain in Mice","volume":"12","author":"Dallazen","year":"2017","journal-title":"Nat. Prod. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4196\/kjpp.2019.23.1.1","article-title":"An integrated review on new targets in the treatment of neuropathic pain","volume":"23","author":"Khangura","year":"2019","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Scarpa, E.S., Antonelli, A., Giancarlo, G., Sabatelli, S., Maggi, F., Caprioli, G., Giacchetti, G., and Micucci, M. (2024). Antioxidant, Anti-Inflammatory, Anti-Diabetic, and Pro-Osteogenic Activities of Polyphenols for the Treatment of Two Different Chronic Diseases: Type 2 Diabetes Mellitus and Osteoporosis. Biomolecules, 14.","DOI":"10.3390\/biom14070836"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Fattori, V., Hohmann, M.S.N., Rossaneis, A.C., Pinho-Ribeiro, F.A., and Verri, W.A. (2016). Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules, 21.","DOI":"10.3390\/molecules21070844"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.24095\/hpcdp.35.1.01","article-title":"Mobilizing Evidence for Impact: From CDIC to Health Promotion and Chronic Disease Prevention","volume":"35","author":"Robinson","year":"2015","journal-title":"Health Promot. Chronic Dis. Prev. Can."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1124\/jpet.121.001051","article-title":"Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model","volume":"381","author":"Nagakura","year":"2022","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"S461","DOI":"10.1016\/S1995-7645(14)60275-3","article-title":"Analgesic and anti-inflammatory activities of Piper nigrum L","volume":"7","author":"Tasleem","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"486","DOI":"10.11124\/JBISRIR-2016-003266","article-title":"The effects of curcuminoids on musculoskeletal pain: A systematic review","volume":"15","author":"Gaffey","year":"2017","journal-title":"JBI Database Syst. Rev. Implement. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1756284820977402","DOI":"10.1177\/1756284820977402","article-title":"A Systematic Review of the As-sociation Between Fibromyalgia and Functional Gastrointestinal Disorders","volume":"13","author":"Erdrich","year":"2020","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Settembre, C., D\u2019antonio, E., Moscato, P., Loi, G., Santonicola, A., and Iovino, P. (2022). Association Among Disorders of Gut-Brain Interac-tion (DGBI) and Fibromyalgia: A Prospective Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030809"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bja.2019.07.026","article-title":"Pain regulation by gut microbiota: Molecular mechanisms and therapeutic potential","volume":"123","author":"Guo","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Chaudhry, T.S., Senapati, S.G., Gadam, S., Sri Sai Mannam, H.P., Voruganti, H.V., Abbasi, Z., Abhinav, T., Challa, A.B., Pallipamu, N., and Bheemisetty, N. (2023). The Impact of Microbiota on the Gut-Brain Axis: Examining the Complex Interplay and Implications. J. Clin. Med., 12.","DOI":"10.3390\/jcm12165231"},{"key":"ref_144","first-page":"e28064","article-title":"The Role of Gut-Microbiota in the Pathophysiology and Therapy of Irritable Bowel Syndrome: A Systematic Review","volume":"14","author":"Shrestha","year":"2022","journal-title":"Cureus"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1097\/j.pain.0000000000001640","article-title":"Altered Microbiome Composition in Individuals with Fibromyalgia","volume":"160","author":"Minerbi","year":"2019","journal-title":"Pain"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Ustianowska, K., Ustianowski, \u0141., Machaj, F., Gor\u0105cy, A., Rosik, J., Szostak, B., Szostak, J., and Pawlik, A. (2022). The Role of the Human Microbiome in the Pathogenesis of Pain. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113267"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhou, J., and Wang, L. (2021). Role and Mechanism of Gut Microbiota in Human Disease. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.625913"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e143768","DOI":"10.1172\/JCI143768","article-title":"The Gut, its Microbiome, and the Brain: Connections and Communications","volume":"131","author":"Gershon","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000435933","article-title":"Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression","volume":"30","author":"Benson","year":"2015","journal-title":"Mod. Trends Pharm."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ebiom.2019.07.031","article-title":"Gut Microbiome and Serum Metabolome Analyses Identify Molecular Biomarkers and Altered Glutamate Metabolism in Fibromyalgia","volume":"46","author":"Abecia","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s10482-020-01474-7","article-title":"Human Gut Microbiota\/Microbiome in Health and Diseases: A Review","volume":"113","author":"Gomaa","year":"2020","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Yuan, S., Wang, K.S., Meng, H., Hou, X.T., Xue, J.C., Liu, B.H., Cheng, W.W., Li, J., Zhang, H.M., and Nan, J.X. (2023). The gut microbes in inflammatory bowel disease: Future novel target option for pharmacotherapy. Biomed. Pharmacother., 165.","DOI":"10.1016\/j.biopha.2023.114893"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/530\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:24:47Z","timestamp":1760027087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/3\/530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":152,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["nu17030530"],"URL":"https:\/\/doi.org\/10.3390\/nu17030530","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]}}}