{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:07:22Z","timestamp":1784779642411,"version":"3.55.0"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Higher Level Pessoal Training Coordination\u2014Brazil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Higher Level Pessoal Training Coordination\u2014Brazil (CAPES)","award":["406867\/2021-6"],"award-info":[{"award-number":["406867\/2021-6"]}]},{"DOI":"10.13039\/501100003593","name":"Foundation for the Support of Science and Research from Pernambuco State\u2014Brazil","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Foundation for the Support of Science and Research from Pernambuco State\u2014Brazil","doi-asserted-by":"publisher","award":["406867\/2021-6"],"award-info":[{"award-number":["406867\/2021-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: The consumption of diets with high fat, salt, and sugar content has been associated with increasing the risk of developing a range of pathologies, including cardiovascular disease, obesity, and diabetes. Furthermore, there is growing evidence to suggest a relationship between variation in the nutritional environment and pancreatic dysregulation, which may be a consequence of oxidative stress. This study aimed to examine the effects of a high-fat, high-carbohydrate (obesogenic) maternal diet during pregnancy and lactation on the metabolic health and pancreatic structure of rat offspring. Methods: Pregnant rats were divided into two groups: one fed a standard diet and the other an obesogenic diet. After weaning, male pups from both groups were fed the same diet until they were 30 days old, which is when they were euthanized. Results: Metabolic and murinometric changes: Increased body weight and pancreas size, elevated blood glucose and cholesterol levels, and reduced glucose tolerance (which is indicative of the beginning of insulin resistance). Oxidative stress: Higher levels of oxidative damage markers and decreased antioxidants in the pancreas, suggesting a state of oxidative stress in this organ. Changes in pancreatic structure: Increased size and number of pancreatic islets and decreased size and number of pancreatic acini. Conclusions: A maternal obesogenic diet induces metabolic alterations, increases oxidative stress, and causes changes in the structure of the pancreas in rat offspring, suggesting a higher risk of developing metabolic diseases such as type 2 diabetes in adulthood.<\/jats:p>","DOI":"10.3390\/nu17030578","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T05:50:36Z","timestamp":1738734636000},"page":"578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Repercussions of the Maternal Obesogenic Diet on the Oxidative Balance and Pancreatic Metabolism in Male Juvenile Offspring"],"prefix":"10.3390","volume":"17","author":[{"given":"Wellington","family":"de Almeida Oliveira","sequence":"first","affiliation":[{"name":"Graduate Program of Biochemistry and Physiology, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"},{"name":"Graduate Program of Nutrition, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizele","family":"Santiago de Moura Silva","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"},{"name":"Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, Federal University of Pernambuco, Rua Alto do Reservat\u00f3rio, s\/n\u2014CEP, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Nascimento da Silva","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"},{"name":"Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, Federal University of Pernambuco, Rua Alto do Reservat\u00f3rio, s\/n\u2014CEP, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Winglinson","family":"Oliveira Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, Federal University of Pernambuco, Rua Alto do Reservat\u00f3rio, s\/n\u2014CEP, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Graduate Program Multicenter in Physiological Sciences, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"da Silva Pacheco","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"},{"name":"Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, Federal University of Pernambuco, Rua Alto do Reservat\u00f3rio, s\/n\u2014CEP, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deisiane","family":"de Ara\u00fajo Correia","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, Federal University of Pernambuco, Rua Alto do Reservat\u00f3rio, s\/n\u2014CEP, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Graduate Program of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Daniele","family":"Teixeira Beltr\u00e3o de Lemos","sequence":"additional","affiliation":[{"name":"Graduate Program of Biochemistry and Physiology, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Carlos","family":"Amanaj\u00e1s de Aguiar J\u00fanior","sequence":"additional","affiliation":[{"name":"Professional Master Program in Biology Teaching, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaynan Raquel","family":"dos Prazeres Oliveira","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-9476","authenticated-orcid":false,"given":"Claudia","family":"Jacques Lagranha","sequence":"additional","affiliation":[{"name":"Graduate Program of Biochemistry and Physiology, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"},{"name":"Graduate Program of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Graduate Program of Neuropsychiatry and Behavioral Sciences Graduate Program, Federal University of Pernambuco, Recife 50670-901, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Pinheiro Fernandes","sequence":"additional","affiliation":[{"name":"Graduate Program of Nutrition, Federal University of Pernambuco, Recife 55670-901, PE, Brazil"},{"name":"Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, Federal University of Pernambuco, Rua Alto do Reservat\u00f3rio, s\/n\u2014CEP, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Graduate Program Multicenter in Physiological Sciences, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"},{"name":"Graduate Program of Nutrition, Physical Activity and Phenotypic Plasticity, Federal University of Pernambuco, Vit\u00f3ria de Santo Ant\u00e3o 55608-680, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref_1","unstructured":"WHO (2024, December 02). 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