{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:48:00Z","timestamp":1782956880380,"version":"3.54.5"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Fundaci\u00f3n Gonzalo R\u00edo Arronte","award":["S.0634"],"award-info":[{"award-number":["S.0634"]}]},{"name":"the Fundaci\u00f3n Gonzalo R\u00edo Arronte","award":["FIS\/IMSS\/PROT\/ESP\/1851"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/ESP\/1851"]}]},{"name":"the Fundaci\u00f3n Gonzalo R\u00edo Arronte","award":["FIS-2023-3-117"],"award-info":[{"award-number":["FIS-2023-3-117"]}]},{"name":"Institution of Private Assistance","award":["S.0634"],"award-info":[{"award-number":["S.0634"]}]},{"name":"Institution of Private Assistance","award":["FIS\/IMSS\/PROT\/ESP\/1851"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/ESP\/1851"]}]},{"name":"Institution of Private Assistance","award":["FIS-2023-3-117"],"award-info":[{"award-number":["FIS-2023-3-117"]}]},{"name":"the Coordinaci\u00f3n de Investigaci\u00f3n en Salud","award":["S.0634"],"award-info":[{"award-number":["S.0634"]}]},{"name":"the Coordinaci\u00f3n de Investigaci\u00f3n en Salud","award":["FIS\/IMSS\/PROT\/ESP\/1851"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/ESP\/1851"]}]},{"name":"the Coordinaci\u00f3n de Investigaci\u00f3n en Salud","award":["FIS-2023-3-117"],"award-info":[{"award-number":["FIS-2023-3-117"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objective: This study is aimed to assess the link between oxidative stress markers and incident hyperglycemia in women with gestational diabetes mellitus (GDM) during an educational intervention. Methods: The study used a prospective cohort. Pregnant women with GDM who were 18\u201340 years old (n = 201) participated in an 18-month postpartum educational intervention emphasizing healthy practices (nutrition, breastfeeding, physical activity, and psychosocial support). GDM women were tested with an oral glucose tolerance test (OGTT) after the third month postpartum, and were classified as follows: (1) incident hyperglycemia (IHypergly) (n = 86) if they had a fasting plasma glucose (FPG) of 100\u2013125 mg\/dL, and impaired glucose tolerance of 2 h (140\u2013199 mg\/dL), or type 2 diabetes (T2D) with an FPG \u2265 126 or \u2265200 mg\/dL (2 h); and (2) without incident hyperglycemia (n = 115) if they had an FPG &lt; 100 mg\/dL and &lt;140 mg\/dL 2 h post-OGTT. Participants were evaluated at the end of pregnancy and post-intervention. Clinical, biochemical, anthropometric, dietary, and oxidative stress markers data (malondialdehyde, reduced glutathione, antioxidant capacity, carbonylated proteins, and adiponectin) were recorded. Multivariate logistic regression analysis identified an association between oxidative stress markers and incident hyperglycemia in women with GDM. Results: A total of 6% progressed to T2D, and 36.8% to prediabetes. At baseline, Ihypergly women exhibited elevated oxidative stress markers and adiponectin, and lower antioxidant capacity. Post-intervention, they showed higher antioxidant capacity, GSH, and adiponectin, and lower MDA. Basal malondialdehyde, pregestational BMI, HbA1c, and sugary food consumption positively correlated with Ihypergly. A high intake of antioxidants inversely correlated with incident hyperglycemia. Conclusions: Higher concentrations of plasma markers of oxidative stress are associated with postpartum incident hyperglycemia in women with gestational diabetes.<\/jats:p>","DOI":"10.3390\/nu17040680","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T04:48:51Z","timestamp":1739508531000},"page":"680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of Oxidative Stress Markers with Incident Hyperglycemia in Gestational Diabetes Mellitus in an Educational Intervention"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-8228","authenticated-orcid":false,"given":"M\u00f3nica L.","family":"Ruiz-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-4931","authenticated-orcid":false,"given":"Rita A.","family":"G\u00f3mez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Leticia","family":"Valdez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"\u00c1ngeles Mej\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-3540","authenticated-orcid":false,"given":"Rafael","family":"Mondrag\u00f3n Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"D\u00edaz Flores","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-7743","authenticated-orcid":false,"given":"Ricardo C\u00e9sar","family":"Salda\u00f1a Espinoza","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Ang\u00e9lica","family":"Ram\u00edrez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Endocrinolog\u00eda, Unidad M\u00e9dica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 4 \u201cLuis Castelazo Ayala\u201d, Instituto Mexicano del Seguro Social (IMSS), Rio de la Magdalena 289, Mexico City 01090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Flor","family":"D\u00edaz Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Unidad M\u00e9dica de Alta Especialidad, Hospital de Gineco-Obstetricia No. 3, Centro M\u00e9dico Nacional \u201cLa Raza\u201d, Dr. V\u00edctor Manuel Espinosa de los Reyes S\u00e1nchez, Instituto Mexicano del Seguro Social (IMSS), Eje vial 1 Poniente, Mexico City 02990, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-6704","authenticated-orcid":false,"given":"Niels H.","family":"Wacher","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica UMAE HE CMN SXXI, Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtemoc 330, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2025). Chapter 2: Diagnosis and Classification of diabetes: Standards of Care in Diabetes-2025. Diabetes Care, 48, S27\u2013S49.","DOI":"10.2337\/dc25-S002"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"109050","DOI":"10.1016\/j.diabres.2021.109050","article-title":"IDF Diabetes Atlas: Estimation of global and regional gestational diabetes mellitus prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group`s Criteria","volume":"183","author":"Wang","year":"2022","journal-title":"Diabetes Res. Clin. 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