{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:19:08Z","timestamp":1776129548352,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine University of Osijek","award":["IP2-MEFOS-2020"],"award-info":[{"award-number":["IP2-MEFOS-2020"]}]},{"name":"Faculty of Medicine University of Osijek","award":["P16-MEFOS-2023"],"award-info":[{"award-number":["P16-MEFOS-2023"]}]},{"name":"Faculty of Medicine University of Osijek","award":["UIP-2019-04-3494"],"award-info":[{"award-number":["UIP-2019-04-3494"]}]},{"name":"Croatian Science Foundation grant","award":["IP2-MEFOS-2020"],"award-info":[{"award-number":["IP2-MEFOS-2020"]}]},{"name":"Croatian Science Foundation grant","award":["P16-MEFOS-2023"],"award-info":[{"award-number":["P16-MEFOS-2023"]}]},{"name":"Croatian Science Foundation grant","award":["UIP-2019-04-3494"],"award-info":[{"award-number":["UIP-2019-04-3494"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Patients with psoriasis exhibit endothelial dysfunction (EDy), which increases their cardiovascular risk. Excessive salt intake impairs endothelium-dependent vascular reactivity. However, research on EDy in psoriasis has focused primarily on larger vessels, leaving skin microcirculation unexplored. This study aimed to investigate the effects of a low-salt diet (LS diet, ~3.75 g\/day) on microvascular reactivity in patients with chronic plaque psoriasis. Methods: Laser Doppler flowmetry was used to assess skin microcirculation blood flow in response to vascular occlusion (postocclusive reactive hyperemia, PORH), acetylcholine (acetylcholine-induced dilation, AChID), sodium nitroprusside (SNP-induced dilation, SNPID), and local heating (local thermal hyperemia, LTH). Blood and 24 h urine samples were collected for biochemical and inflammatory parameters and dietary adherence monitoring. Results: The results showed significant reductions in systolic (p = 0.021) and mean arterial blood pressure (p = 0.007) after the LS diet. AChID increased by 16% (p = 0.029) regardless of blood pressure changes, especially in normolipemic, normotensive patients without excess visceral fat. Importantly, significant sex differences were observed, with significant improvement in endothelial function observed only in women (p = 0.031 vs. p = 0.477). PORH did not change significantly; however, a Fourier transformation analysis revealed that the endothelial component of the PORH was significantly improved following the LS diet protocol. The duration of psoriasis negatively correlated with changes in AChID (R = \u22120.46, p = 0.036) and LTH (R = \u22120.45, p = 0.041) after the LS diet, indicating that prolonged low-grade inflammation reduced endothelial function reversibility. Additionally, lower triglyceride, uric acid, and BMI levels were significant predictors of better endothelial function improvement following the LS diet. Conclusions: This study supports the beneficial effect of the early introduction of an LS diet in the treatment protocols for patients with psoriasis.<\/jats:p>","DOI":"10.3390\/nu17040693","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T11:31:17Z","timestamp":1739791877000},"page":"693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Two-Week Low-Salt Diet Improves Acetylcholine-Induced Microvascular Dilation in Biologically Na\u00efve Psoriasis Patients"],"prefix":"10.3390","volume":"17","author":[{"given":"Ivana","family":"Krajina","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"},{"name":"Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-6137","authenticated-orcid":false,"given":"Mario","family":"\u0160tefani\u0107","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Oncology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-7721","authenticated-orcid":false,"given":"Ines","family":"Drenjan\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakov","family":"Mili\u0107","sequence":"additional","affiliation":[{"name":"Catholic Faculty of Theology, University of Zagreb, Vlaska 38, HR-10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-8317","authenticated-orcid":false,"given":"Nikolina","family":"Kolobari\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5784-5663","authenticated-orcid":false,"given":"Vera","family":"Plu\u017eari\u0107","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"},{"name":"Department of Laboratory Medicine and Pharmacy, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-7720","authenticated-orcid":false,"given":"Stana","family":"Toki\u0107","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pharmacy, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-1391","authenticated-orcid":false,"given":"Tatjana","family":"Matijevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"},{"name":"Department of Infectiology and Dermatovenereology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Tolu\u0161i\u0107 Levak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"},{"name":"Department of Histology and Embryology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Ko\u017eul","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"},{"name":"Department of Infectiology and Dermatovenereology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"\u0160ola","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-0021","authenticated-orcid":false,"given":"Ana","family":"Stupin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-5849","authenticated-orcid":false,"given":"Martina","family":"Mihalj","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Osijek, J. 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