{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:08:31Z","timestamp":1792696111400,"version":"4.5.0"},"reference-count":174,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Advanced glycation end products (AGEs) represent a class of toxic and irreversible compounds formed through non-enzymatic reactions between proteins or lipids and carbonyl compounds. AGEs can arise endogenously under normal metabolic conditions and in pathological states such as diabetes, kidney disease, and inflammatory disorders. Additionally, they can be obtained exogenously through dietary intake, particularly from foods high in fat or sugar, as well as grilled and processed items. AGEs accumulate in various organs and have been increasingly recognized as significant contributors to the progression of numerous diseases, particularly kidney disease. As the kidney plays a crucial role in AGE metabolism and excretion, it is highly susceptible to AGE-induced damage. In this review, we provide a comprehensive discussion on the role of AGEs in the onset and progression of various kidney diseases, including diabetic nephropathy, chronic kidney disease, and acute kidney injury. We explore the potential biological mechanisms involved, such as AGE accumulation, the AGEs-RAGE axis, oxidative stress, inflammation, gut microbiota dysbiosis, and AGE-induced DNA damage. Furthermore, we discuss recent findings on the metabolic characteristics of AGEs in vivo and their pathogenic impact on renal function. Additionally, we examine the clinical significance of AGEs in the early diagnosis, treatment, and prognosis of kidney diseases, highlighting their potential as biomarkers and therapeutic targets. By integrating recent advancements in AGE research, this review aims to provide new insights and strategies for mitigating AGE-related renal damage and improving kidney disease management.<\/jats:p>","DOI":"10.3390\/nu17050758","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:53:06Z","timestamp":1740124386000},"page":"758","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Potential Role of Advanced Glycation End Products in the Development of Kidney Disease"],"prefix":"10.3390","volume":"17","author":[{"given":"Yibin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-7080","authenticated-orcid":false,"given":"Lei","family":"King","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-1224","authenticated-orcid":false,"given":"Liegang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"},{"name":"Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135735","DOI":"10.1016\/j.foodchem.2023.135735","article-title":"Dietary advanced glycation end products (dAGEs): An insight between modern diet and health","volume":"415","author":"Tian","year":"2023","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dozio, E., Caldiroli, L., Molinari, P., Castellano, G., Delfrate, N.W., Romanelli, M.M.C., and Vettoretti, S. (2023). Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12030584"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.advms.2024.01.003","article-title":"Effect of advanced glycation end-products in a wide range of medical problems including COVID-19","volume":"69","author":"Kuzan","year":"2024","journal-title":"Adv. Med. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.ejheart.2007.09.009","article-title":"Advanced glycation end-products (AGEs) and heart failure: Pathophysiology and clinical implications","volume":"9","author":"Hartog","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.kint.2017.11.034","article-title":"Advanced glycation end products in the pathogenesis of chronic kidney disease","volume":"93","author":"Rabbani","year":"2018","journal-title":"Kidney Int."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Steenbeke, M., Speeckaert, R., Desmedt, S., Glorieux, G., Delanghe, J.R., and Speeckaert, M.M. (2022). The Role of Advanced Glycation End Products and Its Soluble Receptor in Kidney Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073439"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.drudis.2020.07.003","article-title":"Advanced glycation end products in diabetes, cancer and phytochemical therapy","volume":"25","author":"Dariya","year":"2020","journal-title":"Drug Discov. Today"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/dme.13651","article-title":"Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus","volume":"35","author":"Yozgatli","year":"2018","journal-title":"Diabet. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/dme.13201","article-title":"Methylglyoxal is associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus","volume":"33","author":"Jensen","year":"2016","journal-title":"Diabet. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.2337\/db16-0310","article-title":"Advanced Glycation End Products Predict Loss of Renal Function and Correlate with Lesions of Diabetic Kidney Disease in American Indians with Type 2 Diabetes","volume":"65","author":"Saulnier","year":"2016","journal-title":"Diabetes"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12986-018-0306-7","article-title":"Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies","volume":"15","author":"Chen","year":"2018","journal-title":"Nutr. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1111\/1541-4337.12593","article-title":"Dietary advanced glycation end-products: Perspectives linking food processing with health implications","volume":"19","author":"Zhang","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_13","unstructured":"Muhammad, E.H.C., Susu, M.Z., Anwarul, H., and Rashad, A. (2024). Diabetic Foot Ulcer Wound Healing and Tissue Regeneration: Signaling Pathways and Mechanisms. Diabetic Foot Ulcers, IntechOpen."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Twarda-Clapa, A., Olczak, A., Bia\u0142kowska, A.M., and Kozio\u0142kiewicz, M. (2022). Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells, 11.","DOI":"10.3390\/cells11081312"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2151302","DOI":"10.1155\/2019\/2151302","article-title":"RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease","volume":"2019","author":"Asadipooya","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zawada, A., Machowiak, A., Rychter, A.M., Ratajczak, A.E., Szymczak-Tomczak, A., Dobrowolska, A., and Krela-Ka\u017amierczak, I. (2022). Accumulation of Advanced Glycation End-Products in the Body and Dietary Habits. Nutrients, 14.","DOI":"10.3390\/nu14193982"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00726-008-0071-4","article-title":"Determination of Nepsilon-(carboxymethyl)lysine in food systems by ultra performance liquid chromatography-mass spectrometry","volume":"36","author":"Assar","year":"2009","journal-title":"Amino Acids"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.foodchem.2015.06.049","article-title":"Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: Presentation of a dietary AGE database","volume":"190","author":"Scheijen","year":"2016","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jada.2010.03.018","article-title":"Advanced glycation end products in foods and a practical guide to their reduction in the diet","volume":"110","author":"Uribarri","year":"2010","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10995","DOI":"10.1021\/acs.jafc.5b05750","article-title":"Effects of Long-Term Exposure to Free N\u03b5-(Carboxymethyl)lysine on Rats Fed a High-Fat Diet","volume":"63","author":"Li","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1021\/acs.jafc.9b01324","article-title":"Effects of Protein-Derived Amino Acid Modification Products Present in Infant Formula on Metabolic Function, Oxidative Stress, and Intestinal Permeability in Cell Models","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.arr.2018.06.005","article-title":"Dietary advanced glycation end products and their relevance for human health","volume":"47","author":"Nowotny","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Feng, N., Feng, Y., Tan, J., Zhou, C., Xu, J., Chen, Y., Xiao, J., He, Y., Wang, C., and Zhou, M. (2023). Inhibition of advance glycation end products formation, gastrointestinal digestion, absorption and toxicity: A comprehensive review. Int. J. Biol. Macromol., 249.","DOI":"10.1016\/j.ijbiomac.2023.125814"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1080\/10408398.2020.1863904","article-title":"Advanced glycation end products in food and their effects on intestinal tract","volume":"62","author":"Nie","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cmet.2018.08.014","article-title":"The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality","volume":"28","author":"Chaudhuri","year":"2018","journal-title":"Cell Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1080\/10408398.2019.1693958","article-title":"The fate of dietary advanced glycation end products in the body: From oral intake to excretion","volume":"60","author":"Liang","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1196\/annals.1333.072","article-title":"Significance of proximal tubular metabolism of advanced glycation end products in kidney diseases","volume":"1043","author":"Saito","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Fotheringham, A.K., Gallo, L.A., Borg, D.J., and Forbes, J.M. (2022). Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney?. Nutrients, 14.","DOI":"10.3390\/nu14132675"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2174\/092986707780830989","article-title":"The road to advanced glycation end products: A mechanistic perspective","volume":"14","author":"Cho","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Maurelli, M., Gisondi, P., and Girolomoni, G. (2023). Advanced Glycation End Products and Psoriasis. Vaccines, 11.","DOI":"10.3390\/vaccines11030617"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Staniszewska, M., Bronowicka-Szyde\u0142ko, A., Gostomska-Pampuch, K., Szkudlarek, J., Barty\u015b, A., Bieg, T., Gamian, E., Kochman, A., Picur, B., and Pietkiewicz, J. (2021). The melibiose-derived glycation product mimics a unique epitope present in human and animal tissues. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-82585-7"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ediga, H.H., Hester, P., Yepuri, A., Reddy, G.B., and Madala, S.K. (2023). N\u03b5-Carboxymethyl-Lysine Modification of Extracellular Matrix Proteins Augments Fibroblast Activation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115811"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1039\/C5FO00918A","article-title":"Carboxymethyl-lysine: Thirty years of investigation in the field of AGE formation","volume":"7","year":"2016","journal-title":"Food Funct."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.exger.2010.11.007","article-title":"Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes","volume":"46","author":"Yamagishi","year":"2011","journal-title":"Exp. Gerontol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1007\/s13197-015-1851-y","article-title":"Advanced glycation End-products (AGEs): An emerging concern for processed food industries","volume":"52","author":"Sharma","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Monnier, V.M., and Sell, D.R. (2005). The Advanced Maillard Reaction in Aging and Age-related Diseases Probed with Pentosidine. Maillard Reactions in Chemistry, Food, and Health, Woodhead Publishing.","DOI":"10.1533\/9781845698393.4.235"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s12276-021-00561-7","article-title":"Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury","volume":"53","author":"Rungratanawanich","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/j.jrn.2023.09.005","article-title":"Circulating Concentrations of advanced Glycation end Products, Carboxymethyl Lysine and Methylglyoxal are Associated With Renal Function in Individuals With Diabetes","volume":"34","author":"Ding","year":"2024","journal-title":"J. Ren. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.ijbiomac.2020.10.030","article-title":"Variants in the RARRES2 gene are associated with serum chemerin and increase the risk of diabetic kidney disease in type 2 diabetes","volume":"165","author":"Zhao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41581-018-0001-y","article-title":"CKD in diabetes: Diabetic kidney disease versus nondiabetic kidney disease","volume":"14","author":"Anders","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jare.2017.04.004","article-title":"Diabetic nephropathy: Time to withhold development and progression\u2014A review","volume":"8","author":"Salem","year":"2017","journal-title":"J. Adv. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.numecd.2013.04.004","article-title":"AGEs, rather than hyperglycemia, are responsible for microvascular complications in diabetes: A \u201cglycoxidation-centric\u201d point of view","volume":"23","author":"Chilelli","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.bbrc.2012.06.049","article-title":"Aristolochic acid-induced accumulation of methylglyoxal and N\u03b5-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy","volume":"423","author":"Li","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S2213-8587(17)30104-3","article-title":"Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: A meta-analysis of individual participant data from randomised controlled trials","volume":"5","author":"Zoungas","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1152\/physrev.00001.2019","article-title":"Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases","volume":"100","author":"Schalkwijk","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1681\/ASN.2014101047","article-title":"Uremic Toxicity of Advanced Glycation End Products in CKD","volume":"27","author":"Stinghen","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.2337\/dc12-2689","article-title":"Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products","volume":"36","author":"Beisswenger","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"9845175","DOI":"10.1155\/2017\/9845175","article-title":"Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation","volume":"2017","author":"Dozio","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.numecd.2021.10.007","article-title":"Skin autofluorescence is associated with progression of kidney disease in type 2 diabetes: A prospective cohort study from the Hong Kong diabetes biobank","volume":"32","author":"Jin","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.2337\/dc17-0421","article-title":"The Relationship of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE) and Carboxymethyl Lysine (CML) to the Incidence of Diabetic Nephropathy in Persons With Type 1 Diabetes","volume":"40","author":"Klein","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"684","DOI":"10.2337\/dc21-2196","article-title":"Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes","volume":"45","author":"Koska","year":"2022","journal-title":"Diabetes Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e002667","DOI":"10.1136\/bmjdrc-2021-002667","article-title":"Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT\/EDIC","volume":"10","author":"Monnier","year":"2022","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Steenbeke, M., De Decker, I., Marchand, S., Glorieux, G., Van Biesen, W., Lapauw, B., Delanghe, J.R., and Speeckaert, M.M. (2022). Dietary Advanced Glycation End Products in an Elderly Population with Diabetic Nephropathy: An Exploratory Investigation. Nutrients, 14.","DOI":"10.3390\/nu14091818"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.2337\/dc15-0925","article-title":"Relationship between levels of advanced glycation end products and their soluble receptor and adverse outcomes in adults with type 2 diabetes","volume":"38","author":"Thomas","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e4421","DOI":"10.7717\/peerj.4421","article-title":"Glycaemic control in type 2 diabetic patients with chronic kidney disease: The impacts on enzymatic antioxidants and soluble RAGE","volume":"6","author":"Wong","year":"2018","journal-title":"PeerJ"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tifs.2018.09.020","article-title":"Advanced glycation end-products (AGEs) in foods and their detecting techniques and methods: A review","volume":"82","author":"Wei","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejphar.2018.06.001","article-title":"AGE-RAGE axis blockade in diabetic nephropathy: Current status and future directions","volume":"833","author":"Sanajou","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1172\/JCI116552","article-title":"Increased collagen-linked pentosidine levels and advanced glycosylation end products in early diabetic nephropathy","volume":"92","author":"Beisswenger","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.2337\/diabetes.54.11.3103","article-title":"Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes","volume":"54","author":"Genuth","year":"2005","journal-title":"Diabetes"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1172\/JCI11771","article-title":"Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice","volume":"108","author":"Yamamoto","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wang, J., Xiang, H., Lu, Y., Wu, T., and Ji, G. (2021). New progress in drugs treatment of diabetic kidney disease. Biomed. Pharmacother., 141.","DOI":"10.1016\/j.biopha.2021.111918"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","author":"Stevens","year":"2024","journal-title":"Kidney Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabet.2009.06.005","article-title":"Advanced glycation end-products: Implications for diabetic and non-diabetic nephropathies","volume":"36","author":"Daroux","year":"2010","journal-title":"Diabetes Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000381315","article-title":"The low AGE diet: A neglected aspect of clinical nephrology practice?","volume":"130","author":"Uribarri","year":"2015","journal-title":"Nephron"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Molinari, P., Caldiroli, L., Dozio, E., Rigolini, R., Giubbilini, P., Romanelli, M.M.C., Messa, P., and Vettoretti, S. (2021). AGEs and sRAGE Variations at Different Timepoints in Patients with Chronic Kidney Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10121994"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Dozio, E., Vettoretti, S., Caldiroli, L., Nerini-Molteni, S., Tacchini, L., Ambrogi, F., Messa, P., and Corsi Romanelli, M.M. (2020). Advanced Glycation End Products (AGE) and Soluble Forms of AGE Receptor: Emerging Role as Mortality Risk Factors in CKD. Biomedicines, 8.","DOI":"10.3390\/biomedicines8120638"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1373\/clinchem.2016.264135","article-title":"Cross-sectional Analysis of AGE-CML, sRAGE, and esRAGE with Diabetes and Cardiometabolic Risk Factors in a Community-Based Cohort","volume":"63","author":"Loomis","year":"2017","journal-title":"Clin. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11010-016-2829-4","article-title":"AGEs\/sRAGE, a novel risk factor in the pathogenesis of end-stage renal disease","volume":"423","author":"Prasad","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000512385","article-title":"Serum and Tissue Levels of Advanced Glycation End Products and Risk of Mortality in Patients on Maintenance Hemodialysis","volume":"52","author":"Jiang","year":"2021","journal-title":"Am. J. Nephrol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2215\/CJN.00540119","article-title":"Circulating Advanced Glycation Endproducts and Long-Term Risk of Cardiovascular Mortality in Kidney Transplant Recipients","volume":"14","author":"Sotomayor","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Baye, E., de Courten, M.P., Walker, K., Ranasinha, S., Earnest, A., Forbes, J.M., and de Courten, B. (2017). Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: A randomised crossover trial. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-04214-6"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1053\/j.jrn.2016.05.003","article-title":"Dietary Advanced Glycation End Products and Risk of Chronic Kidney Disease","volume":"26","author":"Ejtahed","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.ajkd.2008.06.018","article-title":"Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women","volume":"53","author":"Semba","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.jrn.2009.08.001","article-title":"Serum carboxymethyl-lysine, a dominant advanced glycation end product, is associated with chronic kidney disease: The Baltimore longitudinal study of aging","volume":"20","author":"Semba","year":"2010","journal-title":"J. Ren. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/jgs.14062","article-title":"Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial","volume":"64","author":"Camargo","year":"2016","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1053\/j.jrn.2006.04.012","article-title":"Advanced glycation end products in renal failure","volume":"16","author":"Thornalley","year":"2006","journal-title":"J. Ren. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/sj.ki.5002513","article-title":"Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function","volume":"72","author":"Rabbani","year":"2007","journal-title":"Kidney Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1681\/ASN.2004080635","article-title":"Profound mishandling of protein glycation degradation products in uremia and dialysis","volume":"16","author":"Agalou","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_79","first-page":"276","article-title":"Low-molecular but not high-molecular advanced glycation end products (AGEs) are removed by high-flux dialysis","volume":"54","author":"Gerdemann","year":"2000","journal-title":"Clin. Nephrol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.ajkd.2003.11.022","article-title":"Glycoxidation and inflammation in renal failure patients","volume":"43","author":"Peppa","year":"2004","journal-title":"Am. J. Kidney Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1042\/bst0311394","article-title":"Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis","volume":"31","author":"Agalou","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ki.1996.186","article-title":"Advanced oxidation protein products as a novel marker of oxidative stress in uremia","volume":"49","author":"Friedlander","year":"1996","journal-title":"Kidney Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.2215\/CJN.02420311","article-title":"Skin autofluorescence and the association with renal and cardiovascular risk factors in chronic kidney disease stage 3","volume":"6","author":"McIntyre","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/ndt\/gfq369","article-title":"Skin autofluorescence is associated with renal function and cardiovascular diseases in pre-dialysis chronic kidney disease patients","volume":"26","author":"Tanaka","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/MNH.0b013e32833e9259","article-title":"Skin autofluorescence as a measure of advanced glycation endproduct deposition: A novel risk marker in chronic kidney disease","volume":"19","author":"Smit","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.diabet.2013.03.003","article-title":"Skin autofluorescence is associated with past glycaemic control and complications in type 1 diabetes mellitus","volume":"39","author":"Genevieve","year":"2013","journal-title":"Diabetes Metab."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.2337\/dc12-1077","article-title":"Skin autofluorescence reflects integration of past long-term glycemic control in patients with type 1 diabetes","volume":"36","author":"Sugisawa","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1681\/ASN.2005020144","article-title":"Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients","volume":"16","author":"Meerwaldt","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/dmrr.283","article-title":"Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products","volume":"18","author":"Zheng","year":"2002","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1196\/annals.1333.055","article-title":"Renal effects of oral maillard reaction product load in the form of bread crusts in healthy and subtotally nephrectomized rats","volume":"1043","author":"Hofmann","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.ki.5002162","article-title":"Restricted intake of dietary advanced glycation end products retards renal progression in the remnant kidney model","volume":"71","author":"Feng","year":"2007","journal-title":"Kidney Int."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1210\/jc.2009-0089","article-title":"Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: Role of the antiinflammatory AGE receptor-1","volume":"94","author":"Vlassara","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3164\/jcbn.12-40","article-title":"Dietary advanced glycation end products restriction diminishes inflammation markers and oxidative stress in patients with type 2 diabetes mellitus","volume":"52","author":"Wrobel","year":"2013","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.ASN.0000051593.41395.B9","article-title":"Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients","volume":"14","author":"Uribarri","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ki.2011.57","article-title":"Targeted reduction of advanced glycation improves renal function in obesity","volume":"80","author":"Harcourt","year":"2011","journal-title":"Kidney Int."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Miyagawa, T., Iwata, Y., Oshima, M., Ogura, H., Sato, K., Nakagawa, S., Yamamura, Y., Kamikawa, Y., Miyake, T., and Kitajima, S. (2022). Soluble receptor for advanced glycation end products protects from ischemia- and reperfusion-induced acute kidney injury. Biol. Open, 11.","DOI":"10.1242\/bio.058852"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Zakiyanov, O., Kriha, V., Vachek, J., Zima, T., Tesar, V., and Kalousova, M. (2013). Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: A cross sectional study. BMC Nephrol., 14.","DOI":"10.1186\/1471-2369-14-245"},{"key":"ref_99","first-page":"319","article-title":"Acute respiratory distress syndrome, acute kidney injury, and mortality after trauma are associated with increased circulation of syndecan-1, soluble thrombomodulin, and receptor for advanced glycation end products","volume":"96","author":"Dixon","year":"2024","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jss.2007.07.014","article-title":"sRAGE is elevated in septic patients and associated with patients outcome","volume":"147","author":"Bopp","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/SHK.0000000000000278","article-title":"Soluble RAGE and the RAGE ligands HMGB1 and S100A12 in critical illness: Impact of glycemic control with insulin and relation with clinical outcome","volume":"43","author":"Ingels","year":"2015","journal-title":"Shock"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11010-011-1001-4","article-title":"The association of receptor of advanced glycated end products and inflammatory mediators contributes to endothelial dysfunction in a prospective study of acute kidney injury patients with sepsis","volume":"359","author":"Sadik","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1172\/JCI119853","article-title":"Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy","volume":"100","author":"Horie","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1681\/ASN.V1191656","article-title":"Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease","volume":"11","author":"Tanji","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/00365510510013794","article-title":"Advanced glycation end product is implicated in amyloid-related kidney complications","volume":"65","author":"Matsunaga","year":"2005","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbagen.2011.03.014","article-title":"Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes","volume":"1820","author":"Yamagishi","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2174\/1389450054021873","article-title":"The role of AGEs and AGE inhibitors in diabetic cardiovascular disease","volume":"6","author":"Thomas","year":"2005","journal-title":"Curr. Drug Targets"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1365-2362.2010.02317.x","article-title":"Advanced glycation end-products and the kidney","volume":"40","author":"Busch","year":"2010","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/rp.56.1.1","article-title":"Protein glycation, diabetes, and aging","volume":"56","author":"Ulrich","year":"2001","journal-title":"Recent. Prog. Horm. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1042\/CS20160823","article-title":"Kidney, heart and brain: Three organs targeted by ageing and glycation","volume":"131","author":"Frimat","year":"2017","journal-title":"Clin. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.arr.2014.03.009","article-title":"Glycation: The angiogenic paradox in aging and age-related disorders and diseases","volume":"15","author":"Roca","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/cpt.148","article-title":"Emerging Targets for Therapeutic Development in Diabetes and Its Complications: The RAGE Signaling Pathway","volume":"98","author":"Litwinoff","year":"2015","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"He, W., Zhang, J., Gan, T.Y., Xu, G.J., and Tang, B.P. (2015). Advanced glycation end products induce endothelial-to-mesenchymal transition via downregulating Sirt 1 and upregulating TGF-\u03b2 in human endothelial cells. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/684242"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bbrc.2015.01.063","article-title":"SiRNA-HMGA2 weakened AGEs-induced epithelial-to-mesenchymal transition in tubular epithelial cells","volume":"457","author":"Bai","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI11951","article-title":"Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)","volume":"108","author":"Oldfield","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1681\/ASN.2006050525","article-title":"Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: Implications for diabetic renal disease","volume":"17","author":"Burns","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(98)01346-4","article-title":"Pathogenesis, prevention, and treatment of diabetic nephropathy","volume":"352","author":"Cooper","year":"1998","journal-title":"Lancet"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000226586","article-title":"A new perspective on therapeutic inhibition of advanced glycation in diabetic microvascular complications: Common downstream endpoints achieved through disparate therapeutic approaches?","volume":"30","author":"Sourris","year":"2009","journal-title":"Am. J. Nephrol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00125-011-2107-7","article-title":"Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-\u03b2 and vascular endothelial growth factor (VEGF) by pericytes","volume":"54","author":"Shimizu","year":"2011","journal-title":"Diabetologia"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1096\/fj.02-1117fje","article-title":"Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: Implications for diabetic renal and vascular disease","volume":"18","author":"Li","year":"2004","journal-title":"FASEB J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1210\/endo.142.5.8141","article-title":"Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: A potential mechanism for expansion of extracellular matrix in diabetes mellitus","volume":"142","author":"Twigg","year":"2001","journal-title":"Endocrinology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.atherosclerosis.2007.10.035","article-title":"Glycated LDL increases monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated chemotaxis","volume":"198","author":"Isoda","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/diabetes.50.12.2792","article-title":"Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB","volume":"50","author":"Bierhaus","year":"2001","journal-title":"Diabetes"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI118175","article-title":"Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes","volume":"96","author":"Schmidt","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1681\/ASN.2008050514","article-title":"RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes","volume":"20","author":"Coughlan","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0002-9440(10)63909-0","article-title":"RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy","volume":"162","author":"Wendt","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s001250050725","article-title":"Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury","volume":"40","author":"Soulis","year":"1997","journal-title":"Diabetologia"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.2337\/db06-0221","article-title":"RAGE control of diabetic nephropathy in a mouse model: Effects of RAGE gene disruption and administration of low-molecular weight heparin","volume":"55","author":"Myint","year":"2006","journal-title":"Diabetes"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1007\/s00125-010-1837-2","article-title":"Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor","volume":"53","author":"Sourris","year":"2010","journal-title":"Diabetologia"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e12850","DOI":"10.1111\/acel.12850","article-title":"Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions","volume":"18","author":"Teissier","year":"2019","journal-title":"Aging Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1039\/D4FO01545B","article-title":"Unveiling the dynamic processes of dietary advanced glycation end-products (dAGEs) in absorption, accumulation, and gut microbiota metabolism","volume":"15","author":"Wu","year":"2024","journal-title":"Food Funct."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Jazani, N.H., Savoj, J., Lustgarten, M., Lau, W.L., and Vaziri, N.D. (2019). Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease. Diseases, 7.","DOI":"10.3390\/diseases7010021"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Taguchi, K., Fukami, K., Elias, B.C., and Brooks, C.R. (2021). Dysbiosis-Related Advanced Glycation Endproducts and Trimethylamine N-Oxide in Chronic Kidney Disease. Toxins, 13.","DOI":"10.3390\/toxins13050361"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1073\/pnas.94.12.6474","article-title":"Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy","volume":"94","author":"Koschinsky","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e2200046","DOI":"10.1002\/mnfr.202200046","article-title":"Dietary Advanced Glycation End-Products Affects the Progression of Early Diabetes by Intervening in Carbohydrate and Lipid Metabolism","volume":"66","author":"Wu","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/mnfr.201300847","article-title":"Maillard reaction products modulate gut microbiota composition in adolescents","volume":"58","author":"Seiquer","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1681\/ASN.2015111285","article-title":"Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation","volume":"28","author":"Andersen","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrneph.2016.73","article-title":"Chronic kidney disease: Microbiota trigger inflammation","volume":"12","author":"Carney","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/mnfr.201700118","article-title":"Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats","volume":"61","author":"Qu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1681\/ASN.2015030261","article-title":"Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps","volume":"27","author":"Rabb","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.kint.2017.02.011","article-title":"Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach","volume":"92","author":"Mishima","year":"2017","journal-title":"Kidney Int."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/j.ekir.2019.05.341","article-title":"SAT-301 Resistant Starch Ameliorates Advanced Glycation Endproduct-Induced Gut Dysbiosis and Albuminuria in a Mouse Model of Type 2 Diabetes","volume":"4","author":"Snelson","year":"2019","journal-title":"Kidney Int. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s10020-024-00905-9","article-title":"Advanced glycation end products and reactive oxygen species: Uncovering the potential role of ferroptosis in diabetic complications","volume":"30","author":"Chen","year":"2024","journal-title":"Mol. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/acs.chemrestox.6b00265","article-title":"Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage","volume":"29","author":"Yu","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000099029","article-title":"Genomic damage and malignancy in end-stage renal failure: Do advanced glycation end products contribute?","volume":"30","author":"Wagner","year":"2007","journal-title":"Kidney Blood Press. Res."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Hasegawa, S., Jao, T.M., and Inagi, R. (2017). Dietary Metabolites and Chronic Kidney Disease. Nutrients, 9.","DOI":"10.3390\/nu9040358"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000501356","article-title":"DNA Damage Repair and DNA Methylation in the Kidney","volume":"50","author":"Hayashi","year":"2019","journal-title":"Am. J. Nephrol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41581-022-00671-z","article-title":"Pathological consequences of DNA damage in the kidney","volume":"19","author":"Garaycoechea","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","article-title":"Cellular senescence of renal tubular epithelial cells in acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Ding, S., Guo, J., Chen, H., and Petretto, E. (2024). Multi-scalar data integration decoding risk genes for chronic kidney disease. BMC Nephrol., 25.","DOI":"10.1186\/s12882-024-03798-2"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s42764-024-00138-4","article-title":"Targeted DNA damage repair: Old mechanisms and new opportunities in clear cell renal cell carcinoma","volume":"5","author":"Lv","year":"2024","journal-title":"Genome Instab. Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1084\/jem.170.4.1387","article-title":"Endothelial receptor-mediated binding of glucose-modified albumin is associated with increased monolayer permeability and modulation of cell surface coagulant properties","volume":"170","author":"Esposito","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1097\/01.ASN.0000077413.41276.17","article-title":"Role of advanced glycation end products in diabetic nephropathy","volume":"14","author":"Forbes","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.freeradbiomed.2021.05.025","article-title":"AGE\/RAGE in diabetic kidney disease and ageing kidney","volume":"171","author":"Wu","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pharmthera.2017.02.030","article-title":"Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases","volume":"177","author":"Byun","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jdiacomp.2015.06.006","article-title":"Fluorophores advanced glycation end products (AGEs)-to-NADH ratio is predictor for diabetic chronic kidney and cardiovascular disease","volume":"29","author":"Ciobanu","year":"2015","journal-title":"J. Diabetes Complicat."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1262-3636(07)70106-4","article-title":"Urinary excretion of advanced glycation endproducts in patients with type 2 diabetes and various stages of proteinuria","volume":"30","author":"Turk","year":"2004","journal-title":"Diabetes Metab."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0026-0495(98)90303-1","article-title":"Specific fluorescence assay for advanced glycation end products in blood and urine of diabetic patients","volume":"47","author":"Yanagisawa","year":"1998","journal-title":"Metabolism"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ymeth.2021.12.008","article-title":"Methods to investigate advanced glycation end-product and their application in clinical practice","volume":"203","author":"Corica","year":"2022","journal-title":"Methods"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.abb.2003.08.013","article-title":"Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts","volume":"419","author":"Thornalley","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Wang, B., Jiang, T., Qi, Y., Luo, S., Xia, Y., Lang, B., Zhang, B., and Zheng, S. (2024). AGE-RAGE Axis and Cardiovascular Diseases: Pathophysiologic Mechanisms and Prospects for Clinical Applications. Cardiovasc. Drugs Ther.","DOI":"10.1007\/s10557-024-07639-0"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.phrs.2010.02.008","article-title":"The multifaceted therapeutic potential of benfotiamine","volume":"61","author":"Balakumar","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Ramis, R., Ortega-Castro, J., Caballero, C., Casasnovas, R., Cerrillo, A., Vilanova, B., Adrover, M., and Frau, J. (2019). How Does Pyridoxamine Inhibit the Formation of Advanced Glycation End Products? The Role of Its Primary Antioxidant Activity. Antioxidants, 8.","DOI":"10.3390\/antiox8090344"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2174\/092986709787581888","article-title":"Soluble forms of RAGE in human diseases: Clinical and therapeutical implications","volume":"16","author":"Santilli","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.2337\/db16-1281","article-title":"RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy","volume":"66","author":"Matsui","year":"2017","journal-title":"Diabetes"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1677\/joe.1.06524","article-title":"Renal effects of a neutralising RAGE-antibody in long-term streptozotocin-diabetic mice","volume":"188","author":"Jensen","year":"2006","journal-title":"J. Endocrinol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/jbmr.3925","article-title":"Effect of Advanced Glycation End-Products (AGE) Lowering Drug ALT-711 on Biochemical, Vascular, and Bone Parameters in a Rat Model of CKD-MBD","volume":"35","author":"Chen","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.2337\/diabetes.53.11.2921","article-title":"Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway","volume":"53","author":"Lindschau","year":"2004","journal-title":"Diabetes"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2180373","DOI":"10.1155\/2018\/2180373","article-title":"Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome","volume":"2018","author":"Mihai","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/cvr\/cvad083","article-title":"Cardiovascular complications in chronic kidney disease: A review from the European Renal and Cardiovascular Medicine Working Group of the European Renal Association","volume":"119","author":"Zoccali","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGF-\u03b2\/Smads in renal fibrosis and inflammation","volume":"7","author":"Lan","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"afae245","DOI":"10.1093\/ageing\/afae245","article-title":"Clinical biomarker-based biological ageing and the risk of adverse outcomes in patients with chronic kidney disease","volume":"53","author":"Xiang","year":"2024","journal-title":"Age Ageing"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4239\/wjd.v14.i8.1146","article-title":"Advanced glycation end products: Key mediator and therapeutic target of cardiovascular complications in diabetes","volume":"14","author":"Bansal","year":"2023","journal-title":"World J. Diabetes"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1021\/acs.jafc.7b05943","article-title":"Perspective of Advanced Glycation End Products on Human Health","volume":"66","author":"Lin","year":"2018","journal-title":"J. Agric. Food Chem."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/5\/758\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:39:36Z","timestamp":1760027976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/5\/758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":174,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["nu17050758"],"URL":"https:\/\/doi.org\/10.3390\/nu17050758","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]}}}