{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:51:23Z","timestamp":1788648683382,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: In recent years, progress in the field of care has made prematurity an increasingly frequent phenomenon. The premature newborn, due to incompetence, is often subjected to parenteral nutrition (PN) for prolonged periods, and there may be several complications associated with it, first and foremost metabolic complications. Methods: In particular, the aim of this study was to evaluate how specific risk factors and\/or auxological parameters influenced plasma variations in calcium, phosphorus, and magnesium levels. This is because, although little analyzed in the past, these electrolytes are essential for limiting the onset of unfavorable outcomes in neonatal age. This retrospective observational study was conducted by accessing the site intranet of the University Hospital \u201cP. Giaccone\u201d of Palermo, recruiting all newborns with PN necessities (106 in a total of 191), admitted to NICU in the period between 1 January 2020 and 1 January 2023. Infants undergoing PN through a central venous catheter (CVC), who remained in situ for a period \u2265 72 h, admitted to the NICU for the first time, were included. Infants with congenital malformations and\/or deceased and\/or transferred and\/or without CVC or with CVC who remained in situ for a period &lt; 72 h were excluded. We thus obtained 35 newborns in 2020, 33 newborns in 2021, and 38 newborns in 2022. Results: Hypophosphatemia was associated with a lower weight percentile (average 34.8 \u00b0C vs. 50.8 \u00b0C; p = 0.02) and a longer duration of PN (average 34.6 days vs. 17.3 days; p = 0.002). Newborns with hypercalcemia had, on average, lower gestational age (average 31.6 weeks vs. 35.7 weeks; p = 0.049) and weight at birth (average 1586 g vs. 2520 g; p = 0.038). Newborns with hypermagnesemia had, on average, higher weight and length (average weight percentile 62.1 \u00b0C vs. 42.7 \u00b0C; p = 0.038; average length percentile 66.7 \u00b0C vs. 44.4 \u00b0C; p = 0.003). Among the risk factors, cesarean section and undergoing surgery most influence the serum trend of the analyzed electrolytes. Conclusions: Although our results are partial and preliminary and have not always reached statistical significance, it is clear that dyselectrolytemias, in the context of metabolic complications PN-related, must be re-evaluated and carefully examined by the clinician. Prospective and controlled trials are needed to confirm our data, i.e., that the \u201ccalcium-phosphorus-magnesium axis\u201d no longer plays only the niche role that was previously believed.<\/jats:p>","DOI":"10.3390\/nu17050775","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T07:45:08Z","timestamp":1740469508000},"page":"775","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u201cCalcium-Phosphorus-Magnesium Axis\u201d and the Metabolic Issue of Newborns Undergoing Parenteral Nutrition: Is It Time to Change Our Perspectives?"],"prefix":"10.3390","volume":"17","author":[{"given":"Veronica","family":"Notarbartolo","sequence":"first","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit, University Hospital \u201cPaolo Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Carta","sequence":"additional","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit, University Hospital \u201cPaolo Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bintu Ayla","family":"Badiane","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Puccio","sequence":"additional","affiliation":[{"name":"Neonatology and Neonatal Intensive Care Unit, University Hospital \u201cPaolo Giaccone\u201d, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Corsello","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-1635","authenticated-orcid":false,"given":"Mario","family":"Giuffr\u00e8","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"ref_1","unstructured":"(2024, December 12). Available online: www.sin-neonatologia.it."},{"key":"ref_2","unstructured":"(2024, December 11). Available online: www.iss.it."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clp.2014.02.006","article-title":"Complications associated with parenteral nutrition in the neonate","volume":"41","author":"Calkins","year":"2014","journal-title":"Clin. Perinatol."},{"key":"ref_4","unstructured":"Hamdan, M., and Puckett, Y. (2022). Total Parenteral Nutrition, StatPearl."},{"key":"ref_5","unstructured":"NICE (2020). Neonatal Parenteral Nutrition. NICE Guideline, NICE."},{"key":"ref_6","unstructured":"Bolisetty, S. (2024, December 12). Newborn Parenteral Nutrition. NSW Guideline, Available online: https:\/\/www.seslhd.health.nsw.gov.au\/."},{"key":"ref_7","first-page":"779","article-title":"Complications of Parenteral Nutrition in Neonates","volume":"7","author":"Waffa","year":"2014","journal-title":"Res. J. Pharm. Tech."},{"key":"ref_8","first-page":"S27","article-title":"Nutritional requirements and parenteral nutrition in preterm infants","volume":"24","author":"Velaphi","year":"2011","journal-title":"S Afr. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000358466","article-title":"Practice of Parenteral Nutrition in VLBW and ELBW Infants","volume":"110","author":"Embleton","year":"2014","journal-title":"Nutr. Care Preterm Infants"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1055\/s-0041-1722941","article-title":"Central Line Utilization and Complications in Infants with Congenital Diaphragmatic Hernia","volume":"29","author":"Grover","year":"2022","journal-title":"Am. J. Perinatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.siny.2016.08.002","article-title":"Total parenteral nutrition for the very low birth weight infant","volume":"22","author":"Patel","year":"2016","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13052-018-0505-x","article-title":"Indications and complications of inpatient parenteral nutrition prescribed to children in a large tertiary referral hospital","volume":"44","author":"Mantegazza","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bonsante, F., Iacobelli, S., Latorre, G., Rigo, J., De Felice, C., Robillard, P.Y., and Gouyon, J.B. (2013). Initial Amino Acid Intake Influences Phosphorus and Calcium Homeostasis in Preterm Infants\u2014It Is Time to Change the Composition of the Early Parenteral Nutrition. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072880"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ncp.10474","article-title":"ASPEN Consensus Recommendations for Refeeding Syndrome","volume":"35","author":"Seres","year":"2020","journal-title":"Nutr. Clin. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.earlhumdev.2015.08.007","article-title":"Calcium, phosphorus, and bone metabolism in the fetus and newborn","volume":"91","author":"Kovacs","year":"2015","journal-title":"Early Hum. Dev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4318075","DOI":"10.1155\/2019\/4318075","article-title":"Clinical Approach to Hypocalcemia in Newborn Period and Infancy: Who Should Be Treated?","volume":"2019","author":"Vuralli","year":"2019","journal-title":"Int. J. Pediatr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1016\/j.clnu.2018.06.950","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: Calcium, phosphorus and magnesium","volume":"37","author":"Mihatsch","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/MPG.0000000000000251","article-title":"Early Postnatal Calcium and Phosphorus Metabolism in Preterm Infants","volume":"58","author":"Christmann","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1891\/0730-0832.33.3.155","article-title":"Review of Micronutrients in Parenteral Nutrition for the NICU Population","volume":"33","author":"Johnson","year":"2014","journal-title":"Neonatal Netw."},{"key":"ref_20","unstructured":"Moscatelli, A., Buratti, S., and Buffoni, I. (2024, December 10). Raccomandazioni per la Nutrizione Parenterale in Terapia Intensiva Neonatale e Pediatrica. Available online: https:\/\/www.gaslini.org\/reparti\/terapia-intensiva-neonatale-e-pediatrica."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/archdischild-2012-301633","article-title":"How to use\u2026 alkaline phosphatase in neonatology","volume":"97","author":"Tinnion","year":"2012","journal-title":"Arch. Dis. Child. Educ. Pract."},{"key":"ref_22","first-page":"e371","article-title":"Hypercalcemia and hypophosphatemia among preterm infants receiving aggressive parenteral nutrition","volume":"116","author":"Galletti","year":"2018","journal-title":"Arch. Argent. Pediatr."},{"key":"ref_23","unstructured":"Griffin, I.J. (2022). Parenteral Nutrition in Premature Infants, UpToDate."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1442-200X.2012.03590.x","article-title":"Refeeding syndrome in a small-for-dates micro-preemie receiving early parenteral nutrition","volume":"54","author":"Mizumoto","year":"2021","journal-title":"Pediatr. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.clnu.2012.09.004","article-title":"Enhanced feeding in very-low-birthweight infants may cause electrolyte disturbances and septicemia\u2014A randomized, controlled trial","volume":"32","author":"Moltu","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_26","unstructured":"(2024, November 25). Available online: www.medscape.org."},{"key":"ref_27","unstructured":"Abrams, S.A. (2022). Neonatal Hypocalcemia, UpToDate."},{"key":"ref_28","unstructured":"Fanaroff, A.A., and Fanaroff, J.M. (2020). Cure del Neonato ad Alto Rischio, Edizione Italiana."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Rigo, J., Pieltain, C., Christmann, V., Bonsante, F., Moltu, S.J., Iacobelli, S., and Marret, S. (2017). Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis. Nutrients, 9.","DOI":"10.3390\/nu9101125"},{"key":"ref_30","unstructured":"(2024, December 20). Available online: www.inescharts.com."},{"key":"ref_31","unstructured":"Gruppo di Nutrizione Parenterale Neonatale (2017). Manuale di Nutrizione Parenterale Neonatale, Societ\u00e0 Italiana di Neonatologia (SIN)."},{"key":"ref_32","unstructured":"(2025, January 19). Available online: www.R-project.org\/."},{"key":"ref_33","unstructured":"Triola, M.M., Triola, M.F., and Giraudo, M.T. (2022). Fondamenti di Statistica Biomedica. Per le Discipline Biomediche, Pearson. [2nd ed.]."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Cormack, B.E., Harding, J.E., Miller, S.P., and Bloomfield, F.H. (2019). The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review. Nutrients, 11.","DOI":"10.3390\/nu11092029"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1055\/s-0039-1677713","article-title":"Hypophosphatemia is Prevalent among Preterm Infants Less than 1,500 Grams","volume":"36","author":"Lyon","year":"2019","journal-title":"Am. J. Perinatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9748031","DOI":"10.1155\/2017\/9748031","article-title":"Risk Factors for the Development of Refeeding Syndrome-Like Hypophosphatemia in Very Low Birth Weight Infants","volume":"2017","author":"Igarashi","year":"2017","journal-title":"Dis. Markers"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zhang, H., Jia, Q., Piao, M., Chang, Y., Zhang, J., Tong, X., and Han, T. (2021). Screening of Serum Alkaline Phosphatase and Phosphate Helps Early Detection of Metabolic Bone Disease in Extremely Low Birth Weight Infants. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.642158"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e2662","DOI":"10.5812\/ijp.2662","article-title":"Factors Associated With Changes in Magnesium Levels in Asymptomatic Neonates: A Longitudinal Analysis","volume":"26","author":"Mehta","year":"2016","journal-title":"Iran. J. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pereira-da-Silva, L., Macedo, I., Rosa, M.L., and Bridges, K.M. (2014). Calcium and Phosphorus Intake by Parenteral Nutrition in Preterm Infants. Diet and Nutrition in Critical Care, Springer.","DOI":"10.1007\/978-1-4614-8503-2_68-1"},{"key":"ref_40","first-page":"182","article-title":"Correlation between calcium and phosphorus in cord blood and birth size in term infants","volume":"68","author":"Colak","year":"2016","journal-title":"Minerva Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1017\/S0007114511001747","article-title":"Association between calcium in cord blood and newborn size in Bangladesh","volume":"106","author":"Doi","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13052-021-01104-6","article-title":"Severe hypercalcemia associated with hypophosphatemia in very premature infants: A case report","volume":"47","author":"Improda","year":"2021","journal-title":"Ital. J. Pediatr."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kovacs, C.S., and Ward, L.M. (2020). Physiology of Calcium, Phosphorus, and Bone Metabolism During Fetal and Neonatal Development. Maternal-Fetal and Neonatal Endocrinology, Academic Press. Chapter 33.","DOI":"10.1016\/B978-0-12-814823-5.00033-7"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"841","DOI":"10.17219\/acem\/70081","article-title":"Early hypophosphatemia in very low birth weight preterm infants","volume":"27","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Guthrie, G., and Burrin, D. (2021). Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates. Nutrients, 13.","DOI":"10.3390\/nu13020508"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.11138\/ccmbm\/2017.14.1.167","article-title":"Clinical-laboratory findings of bone metabolism in healthy premature and full-term neonates: Preliminary results","volume":"14","author":"Dokos","year":"2017","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jceh.2021.08.024","article-title":"Serum Level of Alanine and Aspartate Aminotransferase Levels in Newborns in India","volume":"12","author":"Chhavi","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Gatti, S., Quattrini, S., Palpacelli, A., Catassi, G.N., Lionetti, M.E., and Catassi, C. (2022). Metabolic Bone Disease in Children with Intestinal Failure and Long-Term Parenteral Nutrition: A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14050995"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1186\/cc11483","article-title":"Alkaline phosphatase activity after cardiothoracic surgery in infants and correlation with post-operative support and inflammation: A prospective cohort study","volume":"16","author":"Davidson","year":"2012","journal-title":"Crit. Care"},{"key":"ref_50","first-page":"771","article-title":"Refeeding Syndrome in the Neonatal Intensive Care Unit","volume":"26","author":"Bradford","year":"2021","journal-title":"J. Pediatr. Pharmacol. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mihatsch, W., Thome, U., and de Pipaon, M.S. (2021). Update on Calcium and Phosphorus Requirements of Preterm Infants and Recommendations for Enteral Mineral Intake. Nutrients, 13.","DOI":"10.3390\/nu13051470"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/5\/775\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:40:41Z","timestamp":1760028041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/5\/775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,23]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["nu17050775"],"URL":"https:\/\/doi.org\/10.3390\/nu17050775","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,23]]}}}