{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:50:19Z","timestamp":1790801419204,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council for Scientific and Technological Development (CNPq)","award":["302298\/2017-7"],"award-info":[{"award-number":["302298\/2017-7"]}]},{"name":"National Council for Scientific and Technological Development (CNPq)","award":["TED 132\/2018"],"award-info":[{"award-number":["TED 132\/2018"]}]},{"name":"Ministry of Health (Brazil)","award":["302298\/2017-7"],"award-info":[{"award-number":["302298\/2017-7"]}]},{"name":"Ministry of Health (Brazil)","award":["TED 132\/2018"],"award-info":[{"award-number":["TED 132\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: This study is a systematic review of guidelines that aims to synthesize evidence-based recommendations to support appropriate nutritional management for patients with amyotrophic lateral sclerosis (ALS). Methods: PubMed\/MEDLINE, Embase, Scopus, SciELO, Web of Science, LILACS, ScienceDirect, and Google Scholar were searched for records published up to July 2024. Clinical practice guidelines addressing any aspect of nutritional intervention in ALS were included. No language or country of publication restrictions were applied. Data extraction was performed by two independent reviewers. The methodological quality of the reports was assessed using the AGREE II instrument. Discrepancies were resolved by consensus. Results: The findings and main recommendations were summarized narratively. A total of 837 records were identified, and 11 were included in this review. The overall AGREE II scores for the included studies ranged from 3 to 7. The summary of nutritional recommendations was organized into topics: (1) dysphagia, (2) nutritional assessment, (3) energy, (4) protein, (5) supplementation, and (6) percutaneous endoscopic gastrostomy (PEG). This review summarizes relevant and updated nutritional recommendations to maintain or restore the nutritional status of patients with ALS, contributing to their quality of life and survival time. Conclusions: These nutritional recommendations will help health professionals and caregivers to implement and standardize nutritional care according to evidence-based practice in ALS. PROSPERO registration number CRD42021233088.<\/jats:p>","DOI":"10.3390\/nu17050782","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T10:55:48Z","timestamp":1740480948000},"page":"782","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evidence-Based Nutritional Recommendations for Maintaining or Restoring Nutritional Status in Patients with Amyotrophic Lateral Sclerosis: A Systematic Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9988-877X","authenticated-orcid":false,"given":"Mariana Dantas","family":"de Carvalho Vilar","sequence":"first","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Systematic Review and Meta-Analysis Laboratory-Lab-SYS\/CNPq, Natal 59078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-455X","authenticated-orcid":false,"given":"Karla Monica Dantas","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-1678","authenticated-orcid":false,"given":"Sancha Helena","family":"de Lima Vale","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Systematic Review and Meta-Analysis Laboratory-Lab-SYS\/CNPq, Natal 59078-970, Brazil"},{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Emilio Teixeira","family":"Dourado Junior","sequence":"additional","affiliation":[{"name":"Department of Integrated Medicine, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gidyenne Christine Bandeira Silva","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Systematic Review and Meta-Analysis Laboratory-Lab-SYS\/CNPq, Natal 59078-970, Brazil"},{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-7251","authenticated-orcid":false,"given":"Grasiela","family":"Piuvezam","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Systematic Review and Meta-Analysis Laboratory-Lab-SYS\/CNPq, Natal 59078-970, Brazil"},{"name":"Department of Public Health, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Brandao-Neto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-7048","authenticated-orcid":false,"given":"Lucia","family":"Leite-Lais","sequence":"additional","affiliation":[{"name":"Laboratory of Technological Innovation in Health (LAIS), Federal University of Rio Grande do Norte, Natal 59012-300, Brazil"},{"name":"Systematic Review and Meta-Analysis Laboratory-Lab-SYS\/CNPq, Natal 59078-970, Brazil"},{"name":"Department of Nutrition, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N. 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