{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:17:38Z","timestamp":1788322658511,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comercial Quimica Mass\u00f3"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: The global prevalence of mental health disorders, particularly anxiety and depression, has increased significantly, with rates further elevated by the COVID-19 pandemic. Conventional pharmacological treatments, while effective, often lead to side effects that can impact patient adherence and quality of life. This has driven interest in safer, natural adjunctive therapies. Crocus sativus L. (Iridaceae) (saffron) and Scutellaria baicalensis\u00a0Georgi (Lamiaceae) (scutellaria) have individually shown potential, in humans and animals, respectively, as mood regulators, with bioactive compounds that modulate neurotransmitter systems and possess anti-inflammatory and anxiolytic effects. This study aimed (1) to explore the efficacy and safety of scutellaria extracts in humans and (2) to test a possible synergistic effect when combining scutellaria and saffron on mood regulation in individuals experiencing mild-to-moderate depressive symptoms. Methods: In a randomized, double-blind, placebo-controlled trial, 180 participants with mild-to-moderate depressive symptoms were assigned to receive either scutellaria extract alone (SCUTELL\u2019UP\u00ae), saffron extract alone (SAFFR\u2019ACTIV\u00ae), a combination of scutellaria and saffron extracts (SAFFR\u2019UP\u00ae), or a placebo for six weeks. The primary outcome was assessed using a standardized depression scale (Beck Depression Inventory). The secondary outcomes, including anxiety, emotional state, well-being level, and sleep quality, were all assessed using validated questionnaires. Safety and tolerability were evaluated throughout the study period. Results: The results confirmed the beneficial effects of saffron extract on depressive and anxious symptoms, as well as its role in improving sleep quality. For the first time in humans, scutellaria extract demonstrated a positive effect on mood regulation. Furthermore, a synergistic effect of the combination of these two extracts was identified, leading to enhanced improvements in depressive and anxious symptoms and emotional well-being among individuals with mild-to-moderate depression, compared to the placebo group. Minimal adverse effects were reported across all treatment groups. Conclusions: This natural adjunctive nutritional strategy offers a promising alternative for individuals seeking safer options for mental health support. Further research is warranted to exclude potential long-term side effects and to explore potential mechanisms of this combined supplementation.<\/jats:p>","DOI":"10.3390\/nu17050809","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T08:28:31Z","timestamp":1740558511000},"page":"809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants with Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-3924","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Dormal","sequence":"first","affiliation":[{"name":"Center of Investigation in Clinical Nutrition, Universit\u00e9 Catholique de Louvain, Rue du Marathon, 3, B-1348 Louvain-la-Neuve, Belgium"},{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-6221","authenticated-orcid":false,"given":"Marl\u00e8ne","family":"Suchareau","sequence":"additional","affiliation":[{"name":"Comercial Quimica Masso, Viladomat, 321, 08029 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-727X","authenticated-orcid":false,"given":"Sylvie","family":"Copine","sequence":"additional","affiliation":[{"name":"Center of Investigation in Clinical Nutrition, Universit\u00e9 Catholique de Louvain, Rue du Marathon, 3, B-1348 Louvain-la-Neuve, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Simar","sequence":"additional","affiliation":[{"name":"Center of Investigation in Clinical Nutrition, Universit\u00e9 Catholique de Louvain, Rue du Marathon, 3, B-1348 Louvain-la-Neuve, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-5278","authenticated-orcid":false,"given":"Louise","family":"Deldicque","sequence":"additional","affiliation":[{"name":"Center of Investigation in Clinical Nutrition, Universit\u00e9 Catholique de Louvain, Rue du Marathon, 3, B-1348 Louvain-la-Neuve, Belgium"},{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic","volume":"398","author":"Santomauro","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.15585\/mmwr.mm7013e2","article-title":"Symptoms of Anxiety or Depressive Disorder and Use of Mental Health Care Among Adults During the COVID-19 Pandemic\u2014United States, August 2020\u2013February 2021","volume":"70","author":"Vahratian","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_3","unstructured":"(2025, February 06). Europe Brain Health Supplements Market Size. Report, 2030 [WWW Document]. n.d. Available online: https:\/\/www.grandviewresearch.com\/industry-analysis\/europe-brain-health-supplements-market-report."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Paiva, R., Correia, M., Delerue-Matos, C., and Amaral, J.S. (2024). Adulteration of Brain Health (Cognitive, Mood, and Sleep Enhancement) Food Supplements by the Addition of Pharmaceutical Drugs: A Comprehensive Review of Analytical Approaches and Trends. Foods, 13.","DOI":"10.3390\/foods13060908"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3949\/ccjm.73.4.351","article-title":"Side effects of antidepressants: An overview","volume":"73","author":"Khawam","year":"2006","journal-title":"Clevel. Clin. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S2215-0366(23)00262-6","article-title":"Antidepressant and antipsychotic side-effects and personalised prescribing: A systematic review and digital tool development","volume":"10","author":"Pillinger","year":"2023","journal-title":"Lancet Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chauhan, S., Tiwari, A., Verma, A., Padhan, P.K., Verma, S., and Gupta, P.C. (2024). Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review. Yale J. Biol. Med., 97.","DOI":"10.59249\/XURF4540"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1211\/0022357011775910","article-title":"St John\u2019s wort (Hypericum perforatum L.): A review of its chemistry, pharmacology and clinical properties","volume":"53","author":"Barnes","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2165\/00002018-200427110-00003","article-title":"Drug interactions with St John\u2019s wort: Mechanisms and clinical implications","volume":"27","author":"Mannel","year":"2004","journal-title":"Drug Saf."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15562\/bmj.v6i3.623","article-title":"Effect of oral saffron capsules on sleep quality in patients with diabetes at Zabol-Iran","volume":"6","author":"Dehghanmehr","year":"2017","journal-title":"Bali Med. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S2095-4964(15)60176-5","article-title":"A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes","volume":"13","author":"Hausenblas","year":"2015","journal-title":"J. Integr. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1515\/jcim-2015-0043","article-title":"A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression","volume":"13","author":"Mazidi","year":"2016","journal-title":"J. Complement. Integr. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4236\/jbbs.2013.33031","article-title":"Aqueous Extract of Saffron (Crocus sativus) Increases Brain Dopamine and Glutamate Concentrations in Rats","volume":"3","author":"Ettehadi","year":"2013","journal-title":"J. Behav. Brain Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/a-0660-9565","article-title":"The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis","volume":"85","author":"Hegyi","year":"2019","journal-title":"Planta Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"112613","DOI":"10.1016\/j.psychres.2019.112613","article-title":"Crocus sativus L. (saffron) versus sertraline on symptoms of depression among older people with major depressive disorders\u2013a double-blind, randomized intervention study","volume":"282","author":"Ahmadpanah","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1002\/ptr.8110","article-title":"New horizons for the study of saffron (Crocus sativus L.) and its active ingredients in the management of neurological and psychiatric disorders: A systematic review of clinical evidence and mechanisms","volume":"38","author":"Han","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.sleep.2022.03.001","article-title":"Effects of saffron supplementation on improving sleep quality: A meta-analysis of randomized controlled trials","volume":"92","author":"Lian","year":"2022","journal-title":"Sleep Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Pachikian, B.D., Copine, S., Suchareau, M., and Deldicque, L. (2021). Effects of Saffron Extract on Sleep Quality: A Randomized Double-Blind Controlled Clinical Trial. Nutrients, 13.","DOI":"10.3390\/nu13051473"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ctim.2018.09.023","article-title":"The effects of alcoholic extract of saffron (Crocus satious L.) on mild to moderate comorbid depression-anxiety, sleep quality, and life satisfaction in type 2 diabetes mellitus: A double-blind, randomized and placebo-controlled clinical trial","volume":"41","author":"Milajerdi","year":"2018","journal-title":"Complement. Ther. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Blasco-Fontecilla, H., Moyano-Ram\u00edrez, E., M\u00e9ndez-Gonz\u00e1lez, O., Rodrigo-Yanguas, M., Martin-Moratinos, M., and Bella-Fern\u00e1ndez, M. (2022). Effectivity of Saffron Extract (Saffr\u2019Activ) on Treatment for Children and Adolescents with Attention Deficit\/Hyperactivity Disorder (ADHD): A Clinical Effectivity Study. Nutrients, 14.","DOI":"10.3390\/nu14194046"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Limanaqi, F., Biagioni, F., Busceti, C.L., Polzella, M., Fabrizi, C., and Fornai, F. (2020). Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants, 9.","DOI":"10.3390\/antiox9030234"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jphp.13129","article-title":"Scutellaria baicalensis Georgi. (Lamiaceae): A review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"71","author":"Zhao","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ma, Y., Zhou, X., Zhang, F., Huang, C., Yang, H., Chen, W., and Tao, X. (2024). The effect of scutellaria baicalensis and its active ingredients on major depressive disorder: A systematic review and meta-analysis of literature in pre-clinical research. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1313871"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1590\/1516-4446-2012-1048","article-title":"Psychometric properties of the Beck Depression Inventory-II: A comprehensive review","volume":"35","author":"Wang","year":"2013","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_25","first-page":"23","article-title":"Potential therapeutic effects of baicalin and baicalein","volume":"14","author":"Sabry","year":"2024","journal-title":"Avicenna J. Phytomed."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/cts.13063","article-title":"Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study","volume":"14","author":"Li","year":"2021","journal-title":"Clin. Transl. Sci."},{"key":"ref_27","unstructured":"(2010). International Standard, 2010, Spices\u2014Saffron (Crocus sativus L.)\u2014Part 2: Test methods (Standard No. ISO 3632-2:2010 2010-10)."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., and Erbauch, J. (1961). Beck Depression Inventory (BDI), APA PsycTests. [Database record].","DOI":"10.1037\/t00741-000"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_30","unstructured":"Spielberger, C.D., Gorsuch, R.L., Lushene, R., Vagg, P.R., and Jacobs, G.A. (1983). Manual for the State-Trait Anxiety Inventory, Consulting Psychologists Press."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","article-title":"Development and validation of brief measures of positive and negative affect: The PANAS scales","volume":"54","author":"Watson","year":"1988","journal-title":"J. Personal. Soc. Psychol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1348\/0144665031752934","article-title":"The positive and negative affect schedule (PANAS): Construct validity, measurement properties and normative data in a large non-clinical sample","volume":"43","author":"Crawford","year":"2004","journal-title":"Br. J. Clin. Psychol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1037\/h0079854","article-title":"L\u2019\u00e9chelle de satisfaction de vie: Validation canadienne-fran\u00e7aise du \u00abSatisfaction with Life Scale\u00bb","volume":"21","author":"Blais","year":"1989","journal-title":"Can. J. Behav. Sci.\/Rev. Can. Sci. Du Comport."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Fordyce, M.W. (1977). Happiness Measures, APA PsycTests. [Database record].","DOI":"10.1037\/t42345-000"},{"key":"ref_35","unstructured":"World Health Organization (WHO) (2025, February 23). Use of Well-Being Measures in Primary Health Care\u2014The DepCare Project. Health for All, Target 12. Available online: https:\/\/iris.who.int\/bitstream\/handle\/10665\/349766\/WHO-EURO-1998-4234-43993-62027-eng.pdf."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Horton, C.J., Walsh, L.C., Rodriguez, A., and Kaufman, V.A. (2024). The diversity of well-being indicators: A latent profile analysis. Front. Psychol., 15.","DOI":"10.3389\/fpsyg.2024.1304074"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000376585","article-title":"The WHO-5 Well-Being Index: A systematic review of the literature","volume":"84","author":"Topp","year":"2015","journal-title":"Psychother. Psychosom."},{"key":"ref_38","first-page":"15","article-title":"Placebo effects on pharmacotherapy outcomes in major depression","volume":"24","author":"Hunter","year":"2007","journal-title":"Psychiatr. Times"},{"key":"ref_39","first-page":"12","article-title":"Is high placebo response really a problem in depression trials? A critical re-analysis of depression studies","volume":"16","author":"Whitlock","year":"2019","journal-title":"Innov. Clin. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.phymed.2017.10.005","article-title":"A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depression","volume":"36","author":"Tabeshpour","year":"2017","journal-title":"Phytomedicine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/jcpt.13040","article-title":"A placebo controlled randomized clinical trial of Crocus sativus L. (saffron) on depression and food craving among overweight women with mild to moderate depression","volume":"45","author":"Akhondzadeh","year":"2020","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jep.2004.11.004","article-title":"Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial","volume":"97","author":"Noorbala","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1055\/s-0042-116159","article-title":"Crocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical Trial","volume":"50","author":"Ghajar","year":"2017","journal-title":"Pharmacopsychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ctim.2017.06.001","article-title":"affron\u00ae a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial","volume":"33","author":"Kell","year":"2017","journal-title":"Complement. Ther. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jad.2018.02.070","article-title":"affron\u00ae, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study","volume":"232","author":"Lopresti","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"130199","DOI":"10.1016\/j.foodchem.2021.130199","article-title":"Improved quantification method of crocins in saffron extract using HPLC-DAD after qualification by HPLC-DAD-MS","volume":"362","author":"Suchareau","year":"2021","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.fitote.2012.03.022","article-title":"Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats","volume":"83","author":"Amin","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuroscience.2011.02.037","article-title":"Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices","volume":"180","author":"Berger","year":"2011","journal-title":"Neuroscience"},{"key":"ref_49","first-page":"3269","article-title":"Effect of aqueous, ethanolic and acetonitrile Crocus sativus L. extracts on stress biomarkers in male rats","volume":"7","author":"Mobarakeh","year":"2013","journal-title":"J. Med. Plants Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1734-1140(12)70735-1","article-title":"Central effect of crocin on penicillin-induced epileptiform activity in rats","volume":"64","author":"Tamaddonfard","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2011.02.038","article-title":"Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice","volume":"221","author":"Duarte","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0006-2952(02)01347-3","article-title":"Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi","volume":"64","author":"Hui","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pnpbp.2012.09.007","article-title":"Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: Involving the inhibition of cyclooxygenase-2 in rat brain","volume":"40","author":"Li","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(03)01422-5","article-title":"Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice","volume":"464","author":"Liao","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Liu, L., Dong, Y., Shan, X., Li, L., Xia, B., and Wang, H. (2019). Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo. Molecules, 24.","DOI":"10.3390\/molecules24020326"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.neuropharm.2008.07.040","article-title":"GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin","volume":"55","author":"Wang","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.intimp.2018.09.001","article-title":"Baicalin exerts neuroprotective effects via inhibiting activation of GSK3\u03b2\/NF-\u03baB\/NLRP3 signal pathway in a rat model of depression","volume":"64","author":"Zhang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhao, F., Tao, W., Shang, Z., Zhang, W., Ruan, J., Zhang, C., Zhou, L., Aiello, H., Lai, H., and Qu, R. (2020). Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.556845"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11064-023-04026-3","article-title":"Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms","volume":"49","author":"Wang","year":"2024","journal-title":"Neurochem. Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jabbarpoor Bonyadi, M.H., Yazdani, S., and Saadat, S. (2014). The ocular hypotensive effect of saffron extract in primary open angle glaucoma: A pilot study. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-399"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Piccardi, M., Fadda, A., Martelli, F., Marangoni, D., Magli, A., Minnella, A.M., Bertelli, M., Di Marco, S., Bisti, S., and Falsini, B. (2019). Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy. Nutrients, 11.","DOI":"10.3390\/nu11102461"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/5\/809\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:43:09Z","timestamp":1760028189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/5\/809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["nu17050809"],"URL":"https:\/\/doi.org\/10.3390\/nu17050809","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]}}}