{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:20:14Z","timestamp":1789662014299,"version":"4.0.1"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The prevalence of vitamin D deficiency among intensive care unit (ICU) patients is potentially associated with an increased risk of mechanical ventilation, sepsis, prolonged hospital stays, and mortality. Although ICU patient care has significantly improved in recent years, the role of vitamin D supplementation remains under investigation. A literature review was conducted using PubMed, Web of Science, Embase, and Cochrane databases, focusing on randomized controlled trials published in the past five years on vitamin D supplementation in adult ICU patients. Patients\u2019 baseline vitamin D levels, administration routes, doses, biomarker changes, mechanical ventilation duration, length of hospital stay, and mortality were analyzed. Although vitamin D supplementation appears safe and may reduce ICU stay duration and mechanical ventilation time and improve SOFA scores, its impact on overall mortality remains uncertain. Routine supplementation for all ICU patients is not currently recommended; clinical decisions should consider individual baseline vitamin D levels, patient characteristics, severity of illness, doses, and administration methods.<\/jats:p>","DOI":"10.3390\/nu17050816","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T08:04:44Z","timestamp":1740643484000},"page":"816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Vitamin D Supplementation in Critically Ill Patients\u2014A Narrative Review of Randomized Controlled Trials Published in the Last 5 Years"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2222-6356","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"first","affiliation":[{"name":"NYU Langone Hospital\u2014Long Island, Mineola, NY 11501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruodi","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5916-0311","authenticated-orcid":false,"given":"Kunkun","family":"Wang","sequence":"additional","affiliation":[{"name":"Fairbanks Memorial Hospital, 340 Cowles Street, Fairbanks, AK 99701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Leo","sequence":"additional","affiliation":[{"name":"Duke Raleigh Hospital, a Campus of Duke University Hospital, School of Medicine, Duke University, Durham, NC 27708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyan","family":"Li","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Chow","sequence":"additional","affiliation":[{"name":"College of Arts and Science, New York University, New York, NY 10012, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Yang","sequence":"additional","affiliation":[{"name":"Dartmouth College, Hanover, NH 03755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4769-9712","authenticated-orcid":false,"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA"},{"name":"Department of Pharmacy, Hennepin Healthcare System, Minneapolis, MN 55415, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101271","DOI":"10.1016\/j.eujim.2020.101271","article-title":"High Dose Vitamin D Improves Total Serum Antioxidant Capacity and ICU Outcome in Critically Ill Patients\u2014A Randomized, Double-Blind Clinical Trial","volume":"42","author":"Sistanizad","year":"2021","journal-title":"Eur. 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