{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:56:36Z","timestamp":1760057796842,"version":"build-2065373602"},"reference-count":85,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Stilbenes are a class of natural polyphenols with multiple positive pharmacologic assets such as antioxidant, anti-inflammatory and anticancer effects. While monomeric stilbenes, represented mostly by resveratrol and pterostilbene, have been studied intensely in the last two decades, oligomeric compounds, which may have better prospects of becoming potent nutraceuticals, are much less studied. The goal of this review is to compile all available literature to date on the beneficial pharmacologic effects of Gnetin C, a resveratrol dimer, in cancer and other diseases. While studies have shown the beneficial effects of Gnetin C, as a single compound or a component of melinjo seed extract, through cellular models, in vivo preclinical studies are still lacking. This is except for prostate cancer, where various animal models, including xenografts and transgenic mice, have been used to evaluate Gnetin C\u2019s more potent anti-inflammatory and anticancer effects compared to resveratrol and its monomeric analogs. Since Gnetin C\u2019s safety has already been demonstrated in healthy volunteers, it is now logical to evaluate its efficacy for prostate cancer chemoprevention, interception and therapy in clinical trials.<\/jats:p>","DOI":"10.3390\/nu17050863","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:46:46Z","timestamp":1740739606000},"page":"863","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gnetin C in Cancer and Other Diseases: What Do We Know So Far?"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-0066","authenticated-orcid":false,"given":"Gisella","family":"Campanelli","sequence":"first","affiliation":[{"name":"Department of Veterinary Biomedical Sciences, Lewyt College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-2575","authenticated-orcid":false,"given":"Anait S.","family":"Levenson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biomedical Sciences, Lewyt College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112356","DOI":"10.1016\/j.ejmech.2020.112356","article-title":"Resveratrol\u2014A comprehensive review of recent advances in anticancer drug design and development","volume":"200","author":"Ahmadi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/biof.1400","article-title":"Effect of resveratrol and pterostilbene on aging and longevity","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/biof.1396","article-title":"Resveratrol, pterostilbene, and dementia","volume":"44","author":"Lange","year":"2018","journal-title":"Biofactors"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12836","DOI":"10.1021\/acs.jafc.0c00070","article-title":"Chemistry of Pterostilbene and Its Metabolic Effects","volume":"68","author":"Kim","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/10408363.2011.631268","article-title":"Natural polyphenols in cancer therapy","volume":"48","author":"Asensi","year":"2011","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1055\/s-0029-1185533","article-title":"Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells","volume":"75","author":"Miksits","year":"2009","journal-title":"Planta Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1021\/jm100274c","article-title":"Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites","volume":"53","author":"Hoshino","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00280-010-1525-4","article-title":"Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats","volume":"68","author":"Kapetanovic","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11418-020-01412-x","article-title":"Resveratrol oligomer structure in Dipterocarpaceaeous plants","volume":"74","author":"Ito","year":"2020","journal-title":"J. Nat. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Shen, J., Zhou, Q., Li, P., Wang, Z., Liu, S., He, C., Zhang, C., and Xiao, P. (2017). Update on Phytochemistry and Pharmacology of Naturally Occurring Resveratrol Oligomers. Molecules, 22.","DOI":"10.3390\/molecules22122050"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kang, J.E., Yoo, N., Jeon, B.J., Kim, B.S., and Chung, E.H. (2022). Resveratrol Oligomers, Plant-Produced Natural Products With Anti-virulence and Plant Immune-Priming Roles. Front. Plant Sci., 13.","DOI":"10.3389\/fpls.2022.885625"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112983","DOI":"10.1016\/j.jep.2020.112983","article-title":"Resveratrol oligomers from Paeonia suffruticosa protect mice against cognitive dysfunction by regulating cholinergic, antioxidant and anti-inflammatory pathways","volume":"260","author":"Liu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8632","DOI":"10.1021\/jf201561e","article-title":"Resveratrol oligomers isolated from Carex species inhibit growth of human colon tumorigenic cells mediated by cell cycle arrest","volume":"59","author":"Gromek","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"765832","DOI":"10.1155\/2014\/765832","article-title":"Resveratrol oligomers for the prevention and treatment of cancers","volume":"2014","author":"Xue","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1021\/jf803077p","article-title":"Stilbenoids isolated from the seeds of Melinjo (Gnetum gnemon L.) and their biological activity","volume":"57","author":"Kato","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1021\/np300841v","article-title":"trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence","volume":"76","author":"Ota","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/cam4.520","article-title":"Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo","volume":"4","author":"Narayanan","year":"2015","journal-title":"Cancer Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2017.04.027","article-title":"The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia","volume":"400","author":"Espinoza","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/mnfr.201100098","article-title":"Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis","volume":"55","author":"Kunimasa","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fct.2014.02.030","article-title":"Safety assessment of melinjo (Gnetum gnemon L.) seed extract: Acute and subchronic toxicity studies","volume":"67","author":"Tatefuji","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"589169","DOI":"10.1155\/2013\/589169","article-title":"Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study","volume":"2013","author":"Konno","year":"2013","journal-title":"Evid. Based Complement. Alternat Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1021\/jf4048435","article-title":"Pharmacokinetics and safety of resveratrol derivatives in humans after oral administration of melinjo (Gnetum gnemon L.) seed extract powder","volume":"62","author":"Tani","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_23","first-page":"405","article-title":"Stilbene derivatives from melinjo extract have antioxidant and immune modulatory effects in healthy individuals","volume":"2","author":"Espinoza","year":"2015","journal-title":"Integr. Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Nakagami, Y., Suzuki, S., Espinoza, J.L., Vu Quang, L., Enomoto, M., Takasugi, S., Nakamura, A., Nakayama, T., Tani, H., and Hanamura, I. (2019). Immunomodulatory and Metabolic Changes after Gnetin-C Supplementation in Humans. Nutrients, 11.","DOI":"10.3390\/nu11061403"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Oniki, K., Kawakami, T., Nakashima, A., Miyata, K., Watanabe, T., Fujikawa, H., Nakashima, R., Nasu, A., Eto, Y., and Takahashi, N. (2020). Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-61148-2"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13450","article-title":"Gnetin-C and other resveratrol oligomers with cancer chemopreventive potential","volume":"1403","author":"Espinoza","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1248\/bpb.35.993","article-title":"Inhibitory effect of gnetin C, a resveratrol dimer from melinjo (Gnetum gnemon), on tyrosinase activity and melanin biosynthesis","volume":"35","author":"Yanagihara","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1055\/s-0030-1250742","article-title":"Stilbenoids from the melinjo (Gnetum gnemon L.) fruit modulate cytokine production in murine Peyer\u2019s patch cells ex vivo","volume":"77","author":"Kato","year":"2011","journal-title":"Planta Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1248\/bpb.29.1490","article-title":"Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells","volume":"29","author":"Iliya","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1593\/neo.04337","article-title":"Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma","volume":"7","author":"Ferrer","year":"2005","journal-title":"Neoplasia"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Oczkowski, M., Dziendzikowska, K., Pasternak-Winiarska, A., Wlodarek, D., and Gromadzka-Ostrowska, J. (2021). Dietary Factors and Prostate Cancer Development, Progression, and Reduction. Nutrients, 13.","DOI":"10.3390\/nu13020496"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6399","DOI":"10.1021\/jf301499e","article-title":"Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells","volume":"60","author":"Lin","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsbmb.2010.11.002","article-title":"Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol: Implication of DNA binding and acetylation of the receptor","volume":"123","author":"Harada","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_34","first-page":"5892","article-title":"Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells","volume":"59","author":"Mitchell","year":"1999","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3177\/jnsv.53.556","article-title":"Resveratrol down-regulates the androgen receptor at the post-translational level in prostate cancer cells","volume":"53","author":"Harada","year":"2007","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1093\/hmg\/ddq354","article-title":"Resveratrol regulates the PTEN\/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines","volume":"19","author":"Wang","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Streicher, W., Luedeke, M., Azoitei, A., Zengerling, F., Herweg, A., Genze, F., Schrader, M.G., Schrader, A.J., and Cronauer, M.V. (2014). Stilbene induced inhibition of androgen receptor dimerization: Implications for AR and ARDeltaLBD-signalling in human prostate cancer cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098566"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1039\/C6MB00186F","article-title":"Molecular insight into the differential anti-androgenic activity of resveratrol and its natural analogs: In silico approach to understand biological actions","volume":"12","author":"Chakraborty","year":"2016","journal-title":"Mol. Biosyst."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Nikhil, K., Sharan, S., Chakraborty, A., and Roy, P. (2014). Pterostilbene-isothiocyanate conjugate suppresses growth of prostate cancer cells irrespective of androgen receptor status. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093335"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jsbmb.2017.08.016","article-title":"Resveratrol, piceatannol and analogs inhibit activation of both wild-type and T877A mutant androgen receptor","volume":"174","author":"Lundqvist","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"18469","DOI":"10.18632\/oncotarget.7841","article-title":"Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer","volume":"7","author":"Dhar","year":"2016","journal-title":"Oncotarget"},{"key":"ref_42","first-page":"3323","article-title":"Combination of resveratrol and antiandrogen flutamide has synergistic effect on androgen receptor inhibition in prostate cancer cells","volume":"31","author":"Kai","year":"2011","journal-title":"Anticancer. Res."},{"key":"ref_43","first-page":"1","article-title":"Stilbenes inhibit androgen receptor expression in 22Rv1 castrate-resistant prostate cancer cells","volume":"3","author":"Kumar","year":"2014","journal-title":"J. Med. Act. Plants"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2300479","DOI":"10.1002\/mnfr.202300479","article-title":"Molecular Efficacy of Gnetin C as Dual-Targeted Therapy for Castrate-Resistant Prostate Cancer","volume":"67","author":"Campanelli","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2174\/1389203723666220705152713","article-title":"MTA1: A Vital Modulator in Prostate Cancer","volume":"23","author":"Ma","year":"2022","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10555-014-9515-3","article-title":"Role of MTA1 in cancer progression and metastasis","volume":"33","author":"Sen","year":"2014","journal-title":"Cancer Metastasis Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/ijc.24928","article-title":"Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1\/NuRD complex","volume":"126","author":"Kai","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Li, K., Dias, S.J., Rimando, A.M., Dhar, S., Mizuno, C.S., Penman, A.D., Lewin, J.R., and Levenson, A.S. (2013). Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057542"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1002\/cam4.1209","article-title":"Targeting MTA1\/HIF-1alpha signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression","volume":"6","author":"Butt","year":"2017","journal-title":"Cancer Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1158\/1940-6207.CAPR-21-0242","article-title":"Dietary Pterostilbene for MTA1-Targeted Interception in High-Risk Premalignant Prostate Cancer","volume":"15","author":"Hemani","year":"2022","journal-title":"Cancer Prev. Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kumar, A., Dholakia, K., Sikorska, G., Martinez, L.A., and Levenson, A.S. (2019). MTA1-Dependent Anticancer Activity of Gnetin C in Prostate Cancer. Nutrients, 11.","DOI":"10.3390\/nu11092096"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.3390\/nu12123631","article-title":"Therapeutic Potential of Gnetin C in Prostate Cancer: A Pre-Clinical Study","volume":"12","author":"Gadkari","year":"2020","journal-title":"Nutrients"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Campanelli, G., Francois, E., Parupathi, P., Devarakonda, L.S., Yang, C., Kumar, A., and Levenson, A.S. (2024). The Therapeutic Efficacy and Mechanism of Action of Gnetin C, a Natural Compound from the Melinjo Plant, in a Preclinical Mouse Model of Advanced Prostate Cancer. Cancers, 16.","DOI":"10.3390\/cancers16071344"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Parupathi, P., Campanelli, G., Deabel, R.A., Puaar, A., Devarakonda, L.S., Kumar, A., and Levenson, A.S. (2022). Gnetin C Intercepts MTA1-Associated Neoplastic Progression in Prostate Cancer. Cancers, 14.","DOI":"10.3390\/cancers14246038"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1055\/s-2006-941545","article-title":"Involvement of nuclear factor-kappaB in the inhibition of pro-inflammatory mediators by pinosylvin","volume":"72","author":"Lee","year":"2006","journal-title":"Planta Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/011542650802300149","article-title":"A review of complementary and alternative approaches to immunomodulation","volume":"23","author":"Clarke","year":"2008","journal-title":"Nutr. Clin. Pract."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Pradhan, R., Chatterjee, S., Hembram, K.C., Sethy, C., Mandal, M., and Kundu, C.N. (2021). Nano formulated Resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages. J. Nutr. Biochem., 92.","DOI":"10.1016\/j.jnutbio.2021.108624"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1093\/carcin\/bgp199","article-title":"Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells","volume":"31","author":"Vo","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sauter, E.R., and Mohammed, A. (2024). Natural Products for Cancer Prevention and Interception: Preclinical and Clinical Studies and Funding Opportunities. Pharmaceuticals, 17.","DOI":"10.3390\/ph17010136"},{"key":"ref_60","first-page":"116","article-title":"Prevention of N-methylnitrosourea-induced colon carcinogenesis in rats by oxygenated carotenoid capsanthin and capsanthin-rich paprika juice","volume":"224","author":"Narisawa","year":"2000","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_61","first-page":"6112","article-title":"Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries","volume":"61","author":"Kresty","year":"2001","journal-title":"Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4161\/oxim.3.4.12858","article-title":"Exogenous antioxidants--Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses","volume":"3","author":"Bouayed","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/ptr.4605","article-title":"Stilbenoids from Gnetum macrostachyum attenuate human platelet aggregation and adhesion","volume":"26","author":"Kloypan","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2220\/biomedres.39.105","article-title":"Gnetin C, a resveratrol dimer, reduces amyloid-beta 1-42 (Abeta42) production and ameliorates Abeta42-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells","volume":"39","author":"Seino","year":"2018","journal-title":"Biomed. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2220\/biomedres.39.231","article-title":"Gnetin C suppresses double-stranded RNA-induced C-C motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling pathway","volume":"39","author":"Yoshida","year":"2018","journal-title":"Biomed. Res."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Kabir, T., Yoshiba, H., Agista, A.Z., Sultana, H., Ohsaki, Y., Yeh, C.L., Hirakawa, R., Tani, H., Ikuta, T., and Nochi, T. (2023). Protective Effects of Gnetin C from Melinjo Seed Extract against High-Fat Diet-Induced Hepatic Steatosis and Liver Fibrosis in NAFLD Mice Model. Nutrients, 15.","DOI":"10.3390\/nu15183888"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ikeda, E., Tanaka, D., Glogauer, M., Tenenbaum, H.C., and Ikeda, Y. (2022). Healing effects of monomer and dimer resveratrol in a mouse periodontitis model. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02499-2"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/JPER.17-0352","article-title":"Resveratrol derivative-rich melinjo seed extract induces healing in a murine model of established periodontitis","volume":"89","author":"Ikeda","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-F","article-title":"Wine, alcohol, platelets, and the French paradox for coronary heart disease","volume":"339","author":"Renaud","year":"1992","journal-title":"Lancet"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-0030-1248725","article-title":"Moderate red wine consumption and cardiovascular disease risk: Beyond the \u201cFrench paradox\u201d","volume":"36","author":"Lippi","year":"2010","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Bonnefont-Rousselot, D. (2016). Resveratrol and Cardiovascular Diseases. Nutrients, 8.","DOI":"10.3390\/nu8050250"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Guo, S., Zhou, Y., and Xie, X. (2022). Resveratrol inhibiting TGF\/ERK signaling pathway can improve atherosclerosis: Backgrounds, mechanisms and effects. Biomed. Pharmacother., 155.","DOI":"10.1016\/j.biopha.2022.113775"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1016\/j.bmcl.2009.09.074","article-title":"New stilbene dimers against amyloid fibril formation","volume":"20","author":"Riviere","year":"2010","journal-title":"Bioorg Med. Chem. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1021\/np500427v","article-title":"Unambiguous Determination of the Absolute Configuration of Dimeric Stilbene Glucosides from the Rhizomes of Gnetum africanum","volume":"77","author":"Buffeteau","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Hamada, H., and Gerk, P.M. (2019). Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/8361858"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jchromb.2017.12.004","article-title":"Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants","volume":"1073","author":"Herraiz","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"843","DOI":"10.4103\/1673-5374.268970","article-title":"Natural stilbenes effects in animal models of Alzheimer\u2019s disease","volume":"15","author":"Freyssin","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Wicinski, M., Domanowska, A., Wodkiewicz, E., and Malinowski, B. (2020). Neuroprotective Properties of Resveratrol and Its Derivatives-Influence on Potential Mechanisms Leading to the Development of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082749"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2010.05865.x","article-title":"Neuroprotective properties of resveratrol and derivatives","volume":"1215","author":"Richard","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1080\/09168451.2015.1056510","article-title":"Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract improves obesity and survival of C57BL\/6 mice fed a high-fat diet","volume":"79","author":"Ikuta","year":"2015","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1093\/nar\/gkm744","article-title":"Two faces of p53: Aging and tumor suppression","volume":"35","author":"Rodier","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"391075","DOI":"10.1155\/2015\/391075","article-title":"Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice","volume":"2015","author":"Watanabe","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.2174\/13816128113199990407","article-title":"Resveratrol and clinical trials: The crossroad from in vitro studies to human evidence","volume":"19","author":"Larrosa","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.bbadis.2014.12.024","article-title":"Resveratrol and inflammation: Challenges in translating pre-clinical findings to improved patient outcomes","volume":"1852","author":"Poulsen","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phrs.2017.08.002","article-title":"Anti-inflammatory activity of natural stilbenoids: A review","volume":"124","author":"Dvorakova","year":"2017","journal-title":"Pharmacol. 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