{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:58:35Z","timestamp":1789232315924,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Yacon syrup (Smallanthus sonchifolius) has gained attention due to its high concentration of fructooligosaccharides (FOSs) and associated health benefits. This systematic review aimed to evaluate the effects of yacon syrup on metabolic parameters and intestinal health in humans over the last decade. Methods: Following PRISMA guidelines, we conducted a systematic search in databases, including Medline (PubMed), Science Direct, Embase, Scopus, and SciELO, up to October 2024. Inclusion criteria focused on clinical trials examining the impact of yacon syrup on glycemic control, lipid profile, insulin sensitivity, appetite regulation, and gut microbiota in healthy, overweight, or obese individuals. Seven studies met the inclusion criteria, encompassing 161 participants from diverse populations. Results: Yacon syrup supplementation demonstrated significant reductions in fasting insulin, HOMA-IR, and LDL cholesterol, alongside improvements in satiety and intestinal transit time. Acute supplementation with yacon syrup had inconsistent results for postprandial glycemia and insulin levels, probably due to prior individual gut microbiota composition. Longer interventions with yacon syrup were associated with enhanced microbiota modulation and appetite regulation, particularly in women. Mild gastrointestinal discomfort was reported, but with the continued use of yacon syrup, the symptoms decreased. Yacon syrup presents promising health benefits, including improved insulin sensitivity, weight management, and gut health. However, further research is needed to establish optimal dosing and long-term safety. Conclusions: This review highlights the potential of yacon syrup as a functional supplement for metabolic and gastrointestinal health.<\/jats:p>","DOI":"10.3390\/nu17050888","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:41:51Z","timestamp":1741066911000},"page":"888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impacts of Yacon Syrup (Smallanthus sonchifolius) on Human Health: A Systematic Review of Scientific Evidence from the Last Decade"],"prefix":"10.3390","volume":"17","author":[{"given":"Marcos F.","family":"Pereira","sequence":"first","affiliation":[{"name":"Higher Institute of Biomedical Sciences, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9430-3446","authenticated-orcid":false,"given":"Igor de Codes","family":"Soares","sequence":"additional","affiliation":[{"name":"Higher Institute of Biomedical Sciences, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2076-3721","authenticated-orcid":false,"given":"Mar\u00edlia Magalh\u00e3es","family":"Cabral","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Nutrition and Health, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Nutrition and Health, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7526-6984","authenticated-orcid":false,"given":"Gabriel M. A.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Higher Institute of Biomedical Sciences, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Chaves","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Higher Institute of Biomedical Sciences, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Augusto Ferreira","family":"Carioca","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Postgraduate Studies in Public Health, University of Fortaleza, Fortaleza 60811-905, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rayane C.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Nutrition and Health, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-2882","authenticated-orcid":false,"given":"Francisco Ernani A.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Nutrition and Health, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9295-8157","authenticated-orcid":false,"given":"Ariclecio C.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Higher Institute of Biomedical Sciences, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"},{"name":"Postgraduate Program in Nutrition and Health, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-2347","authenticated-orcid":false,"given":"Renalison","family":"Farias-Pereira","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The Dorothy and George Hennings College of Science, Mathematics and Technology, Kean University, Union, NJ 07083, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-3826","authenticated-orcid":false,"given":"Keciany Alves","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Higher Institute of Biomedical Sciences, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"},{"name":"Postgraduate Program in Nutrition and Health, State University of Ceara-UECE, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1248\/cpb.56.199","article-title":"Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production","volume":"56","author":"Hong","year":"2008","journal-title":"Chem. 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