{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:27:31Z","timestamp":1768292851454,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: What if porcine placental extract (PPE) could combat post-menopausal weight gain and lipid imbalances without the side effects of traditional hormone treatments? The menopause marks a critical shift in women\u2019s health, with declining estrogen levels driving increased risks of obesity, metabolic dysfunction, and cardiovascular disease. While hormone replacement therapy remains a common intervention, concerns over its long-term safety have intensified the search for safer alternatives. Objectives: This study aims to explore the metabolic effects of porcine placental extract (PPE) by using an ovariectomized (OVX) rat model to mimic the hormonal landscape of the menopause. Methods: Twenty OVX Wistar rats were assigned to either a control group receiving phosphate-buffered saline or a PPE-treated group given intraperitoneal PPE injections for two weeks. Results: Remarkably, the PPE-treated rats showed significantly lower body weights than the controls. Biochemical analysis revealed that the PPE-treated rats had improved lipid profiles, involving lower total cholesterol and triglyceride levels. Histological examinations of the PPE-treated rats showed no adverse changes in the uterus or mammary glands. Conclusions: These results highlight PPE\u2019s potential as a non-hormonal, tissue-safe intervention for combating weight gain and lipid imbalances in post-menopausal conditions. By promoting lipolysis without impacting reproductive health or muscle mass, PPE opens the door to new possibilities for managing post-menopausal metabolic health. However, further research is needed to determine its long-term efficacy.<\/jats:p>","DOI":"10.3390\/nu17060984","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:39:03Z","timestamp":1741711143000},"page":"984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Porcine Placental Extract Improves the Lipid Profile and Body Weight in a Post-Menopausal Rat Model Without Affecting Reproductive Tissues"],"prefix":"10.3390","volume":"17","author":[{"given":"Tugsjargal","family":"Purevdorj","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moeka","family":"Arata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Nii","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-7762","authenticated-orcid":false,"given":"Shota","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"},{"name":"Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo 060-0808, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5350-8331","authenticated-orcid":false,"given":"Hiroki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7840-1432","authenticated-orcid":false,"given":"Hiroaki","family":"Inui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyo","family":"Kinouchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5745-3623","authenticated-orcid":false,"given":"Kanako","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-5687","authenticated-orcid":false,"given":"Takeshi","family":"Iwasa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Opoku, A.A., Abushama, M., and Konje, J.C. 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