{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T07:17:49Z","timestamp":1786864669982,"version":"build-2736575974"},"reference-count":76,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2023 Jiangsu Provincial Education Science Planning Subjects Establishment","award":["C\/2023\/01\/129"],"award-info":[{"award-number":["C\/2023\/01\/129"]}]},{"name":"2023 Jiangsu Provincial Education Science Planning Subjects Establishment","award":["L202206"],"award-info":[{"award-number":["L202206"]}]},{"name":"2023 Jiangsu Provincial Education Science Planning Subjects Establishment","award":["YFF24000662"],"award-info":[{"award-number":["YFF24000662"]}]},{"name":"2023 Jiangsu Provincial Education Science Planning Subjects Establishment","award":["BSU20240500"],"award-info":[{"award-number":["BSU20240500"]}]},{"name":"Peking University Medical\u2013Qingyan Boshi Joint Laboratory for skin nutrition and anti-aging","award":["C\/2023\/01\/129"],"award-info":[{"award-number":["C\/2023\/01\/129"]}]},{"name":"Peking University Medical\u2013Qingyan Boshi Joint Laboratory for skin nutrition and anti-aging","award":["L202206"],"award-info":[{"award-number":["L202206"]}]},{"name":"Peking University Medical\u2013Qingyan Boshi Joint Laboratory for skin nutrition and anti-aging","award":["YFF24000662"],"award-info":[{"award-number":["YFF24000662"]}]},{"name":"Peking University Medical\u2013Qingyan Boshi Joint Laboratory for skin nutrition and anti-aging","award":["BSU20240500"],"award-info":[{"award-number":["BSU20240500"]}]},{"name":"Peking University Health Science Center for the study on the effects of anti-aging nutritional interventions on athletes\u2019 skin health","award":["C\/2023\/01\/129"],"award-info":[{"award-number":["C\/2023\/01\/129"]}]},{"name":"Peking University Health Science Center for the study on the effects of anti-aging nutritional interventions on athletes\u2019 skin health","award":["L202206"],"award-info":[{"award-number":["L202206"]}]},{"name":"Peking University Health Science Center for the study on the effects of anti-aging nutritional interventions on athletes\u2019 skin health","award":["YFF24000662"],"award-info":[{"award-number":["YFF24000662"]}]},{"name":"Peking University Health Science Center for the study on the effects of anti-aging nutritional interventions on athletes\u2019 skin health","award":["BSU20240500"],"award-info":[{"award-number":["BSU20240500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Higenamine, a bioactive alkaloid derived from plants such as Aconitum and Annona squamosa, has been traditionally used in Chinese medicine for treating heart diseases like bradycardia, arrhythmia, and heart failure. It exhibits multiple pharmacological effects, including anti-oxidative stress, improved cellular energy metabolism, anti-apoptosis, and enhanced erectile dysfunction. Aim and Methods: To investigate the reasons for these functions of higenamine and its application in the clinic, the literature of the database was searched and read in this study. Results: As a non-selective \u03b2-agonist, higenamine activates both \u03b21- and \u03b22-adrenergic receptors, leading to cardiovascular benefits such as increased heart rate and myocardial contractility, as well as bronchodilation. It has also been studied for its potential in weight loss, anti-inflammatory properties, and antioxidant properties, with applications in treating asthma, cardiovascular diseases, and ischemia-reperfusion injuries. However, its clinical use is limited by the need for further research on its long-term safety, pharmacokinetics, and interactions with other drugs. Despite its promising therapeutic potential, higenamine\u2019s inclusion in the World Anti-Doping Agency\u2019s banned list highlights concerns over its stimulant effects and safety in athletic contexts. Conclusions: Future studies should focus on optimizing its clinical applications while ensuring safety and efficacy. In terms of clinical applications, future research will also be able to explore more possibilities to use higenamine more in the treatment of diseases.<\/jats:p>","DOI":"10.3390\/nu17061030","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T13:07:51Z","timestamp":1741957671000},"page":"1030","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Narrative Review on Higenamine: Pharmacological Properties and Clinical Applications"],"prefix":"10.3390","volume":"17","author":[{"given":"Hanghao","family":"Shi","sequence":"first","affiliation":[{"name":"College of Physical Education, Shanghai University of Sport, Shanghai 200438, China"},{"name":"Department of Physical Education, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cheng","sequence":"additional","affiliation":[{"name":"Russian Sports University, Moscow 105122, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6768-4884","authenticated-orcid":false,"given":"Huixin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Sport University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqi","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Sport University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"You","sequence":"additional","affiliation":[{"name":"Beijing Sport University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Sport University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Sport University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7867-6807","authenticated-orcid":false,"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Sport University, Beijing 100084, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfang","family":"Shu","sequence":"additional","affiliation":[{"name":"College of Physical Education, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wen, J., Li, M., Zhang, W., Wang, H., Bai, Y., Hao, J., Liu, C., Deng, K., and Zhao, Y. 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