{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:27:27Z","timestamp":1787808447135,"version":"build-2784847793"},"reference-count":88,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>As the prevalence of chronic diseases persists at epidemic proportions, health practitioners face ongoing challenges in providing effective lifestyle treatments for their patients. Even for those patients on GLP-1 agonists, nutrition counseling remains a crucial strategy for managing these conditions over the long term. This paper aims to address the concerns of patients and practitioners who are interested in a low-carbohydrate or ketogenic diet, but who have concerns about its efficacy, safety, and long-term viability. The authors of this paper are practitioners who have used this approach and researchers engaged in its study. The paper reflects our opinion and is not meant to review low-carbohydrate diets systematically. In addressing common concerns, we hope to show that this approach has been well researched and can no longer be seen as a \u201cfad diet\u201d with adverse health effects such as impaired renal function or increased risk of heart disease. We also address persistent questions about patient adherence, affordability, and environmental sustainability. This paper reflects our perspective as clinicians and researchers engaged in the study and application of low-carbohydrate dietary interventions. While the paper is not a systematic review, all factual claims are substantiated with citations from the peer-reviewed literature and the most rigorous and recent science. To our knowledge, this paper is the first to address potential misconceptions about low-carbohydrate and ketogenic diets comprehensively.<\/jats:p>","DOI":"10.3390\/nu17061047","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T04:29:28Z","timestamp":1742185768000},"page":"1047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Myths and Facts Regarding Low-Carbohydrate Diets"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4367-4861","authenticated-orcid":false,"given":"Nina","family":"Teicholz","sequence":"first","affiliation":[{"name":"Independent Researcher, New York, NY 10024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Croft","sequence":"additional","affiliation":[{"name":"Independent Researcher, Houston, TX 77074, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Saner","sequence":"additional","affiliation":[{"name":"Department of Family & Community Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shebani","family":"Sethi","sequence":"additional","affiliation":[{"name":"Metabolic Psychiatry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-0351","authenticated-orcid":false,"given":"Jeff S.","family":"Volek","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micalla","family":"Williden","sequence":"additional","affiliation":[{"name":"Independent Researcher, 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Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"m4743","DOI":"10.1136\/bmj.m4743","article-title":"Efficacy and Safety of Low and Very Low Carbohydrate Diets for Type 2 Diabetes Remission: Systematic Review and Meta-analysis of Published and Unpublished Randomized Trial Data","volume":"372","author":"Goldenberg","year":"2021","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41430-024-01431-x","article-title":"Effects of Low-carbohydrate Diets, With and Without Caloric Restriction, on Inflammatory Markers in Adults: A Systematic Review and Meta-analysis of Randomized Clinical Trials","volume":"78","author":"Kazeminasab","year":"2024","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Volek, J.S., Phinney, S.D., Krauss, R.M., Johnson, R.J., Saslow, L.R., Gower, B., Yancy, W.S., King, J.C., Hecht, F.M., and Teicholz, N. (2021). Alternative Dietary Patterns for Americans: Low-Carbohydrate Diets. Nutrients, 13.","DOI":"10.3390\/nu13103299"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.2337\/dci18-0033","article-title":"Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"41","author":"Davies","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"(2020). Diabetes Canada Position Statement on Low-Carbohydrate Diets for Adults With Diabetes: A Rapid Review. Can. J. Diabetes, 44, 295\u2013299.","DOI":"10.1016\/j.jcjd.2020.04.001"},{"key":"ref_7","unstructured":"Stranks, S.N., and Lawlor-Smith, N. (2025, March 09). Managing Type 2 Diabetes with Therapeutic Carbohydrate Reduction (TCR) [Internet], Available online: https:\/\/www.diabetessociety.com.au\/wp-content\/uploads\/2023\/11\/Managing-Type-2-Diabetes-with-Therapeutic-Carbohydrate-reduction-TCR-November-2023_Final.pdf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2337\/dci19-0014","article-title":"Nutrition Therapy for Adults with Diabetes or Prediabetes: A Consensus Report","volume":"42","author":"Evert","year":"2019","journal-title":"Diabetes Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100005","DOI":"10.1016\/j.obpill.2021.100005","article-title":"Nutrition and physical activity: An Obesity Medicine Association (OMA) Clinical Practice Statement 2022","volume":"1","author":"Alexander","year":"2022","journal-title":"Obes. Pillars"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e722","DOI":"10.1161\/CIR.0000000000001040","article-title":"Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association","volume":"145","author":"Joseph","year":"2022","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/ajcn\/nqab270","article-title":"The carbohydrate-insulin model: A physiological perspective on the obesity pandemic","volume":"114","author":"Ludwig","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1161\/CIR.0000000000001146","article-title":"Popular Dietary Patterns: Alignment with American Heart Association 2021 Dietary Guidance: A Scientific Statement from the American Heart Association","volume":"147","author":"Gardner","year":"2023","journal-title":"Circulation"},{"key":"ref_13","unstructured":"Volek, J.S., and Phinney, S.D. (2011). The Art and Science of Low Carbohydrate Living, Beyond Obesity Publishing."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e4488","DOI":"10.7717\/peerj.4488","article-title":"The use of nutritional supplements to induce ketosis and reduce symptoms associated with keto-induction: A narrative review","volume":"6","author":"Harvey","year":"2018","journal-title":"PeerJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nut.2014.06.011","article-title":"Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base","volume":"31","author":"Feinman","year":"2015","journal-title":"Nutrition"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/S0140-6736(17)32252-3","article-title":"Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study","volume":"390","author":"Dehghan","year":"2017","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Volek, J.S., Yancy, W.S., Gower, B.A., Phinney, S.D., Slavin, J., Koutnik, A.P., Hurn, M., Spinner, J., Cucuzzella, M., and Hecht, F.M. (2024). Expert consensus on nutrition and lower-carbohydrate diets: An evidence- and equity-based approach to dietary guidance. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1376098"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S2213-8587(20)30042-5","article-title":"Risk factors and prevention strategies for diabetic ketoacidosis in people with established type 1 diabetes","volume":"8","author":"Ehrmann","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bja.2019.03.028","article-title":"Perioperative diabetic ketoacidosis associated with sodium-glucose co-transporter-2 inhibitors: A systematic review","volume":"123","author":"Thiruvenkatarajan","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"ref_20","unstructured":"Devlin, T. (2010). Textbook of Biochemistry with Clinical Correlations, John Wiley & Sons, Inc.. [7th ed.]."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"k2340","DOI":"10.1136\/bmj.k2340","article-title":"Dietary carbohydrates: Role of quality and quantity in chronic disease","volume":"361","author":"Ludwig","year":"2018","journal-title":"BMJ"},{"key":"ref_22","unstructured":"Chourpiliadis, C., and Mohiuddin, S.S. (2024, September 28). Biochemistry, Gluconeogenesis, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544346\/."},{"key":"ref_23","unstructured":"Food and Nutrition Board, Institute of Medicine, and National Academies of Sciences (2005). Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids, National Academy Press."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11745-010-3467-3","article-title":"Limited effect of dietary saturated fat on plasma saturated fat in the context of a low carbohydrate diet","volume":"45","author":"Forsythe","year":"2010","journal-title":"Lipids"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jacc.2020.05.077","article-title":"Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review","volume":"76","author":"Astrup","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Astrup, A., Teicholz, N., Magkos, F., Bier, D.M., Brenna, J.T., King, J.C., Mente, A., Ordovas, J.M., Volek, J.S., and Yusuf, S. (2021). Dietary Saturated Fats and Health: Are the U.S. Guidelines Evidence-Based?. Nutrients, 13.","DOI":"10.3390\/nu13103305"},{"key":"ref_27","unstructured":"Virta Health (2024, September 24). How to Eat Low Carb as a Vegan or Vegetarian [Internet]. Virta Health. February 2018. Available online: https:\/\/www.virtahealth.com\/blog\/vegan-vegetarian-low-carb-keto."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ajcnut.2024.01.009","article-title":"Increased low-density lipoprotein cholesterol on a low-carbohydrate diet in adults with normal but not high body weight: A meta-analysis","volume":"119","author":"Norwitz","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jacadv.2024.101109","article-title":"Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial","volume":"3","author":"Budoff","year":"2024","journal-title":"JACC Adv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12933-018-0698-8","article-title":"Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1 year: An open label, non-randomized, controlled study","volume":"17","author":"Bhanpuri","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Norwitz, N.G., Soto-Mota, A., and Kalayjian, T. (2022). A Company Is Only as Healthy as Its Workers: A 6-Month Metabolic Health Management Pilot Program Improves Employee Health and Contributes to Cost Savings. Metabolites, 12.","DOI":"10.3390\/metabo12090848"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"703","DOI":"10.7326\/M19-0655","article-title":"Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Cohort Studies","volume":"171","author":"Zeraatkar","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.7326\/M19-0699","article-title":"Reduction of Red and Processed Meat Intake and Cancer Mortality and Incidence: A Systematic Review and Meta-analysis of Cohort Studies","volume":"171","author":"Han","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"732","DOI":"10.7326\/M19-1583","article-title":"Patterns of Red and Processed Meat Consumption and Risk for Cardiometabolic and Cancer Outcomes: A Systematic Review and Meta-analysis of Cohort Studies","volume":"171","author":"Vernooij","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7326\/M19-0622","article-title":"Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials","volume":"171","author":"Zeraatkar","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.2337\/dci21-0034","article-title":"Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes","volume":"44","author":"Riddle","year":"2021","journal-title":"Diabetes Care"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.2196\/diabetes.6981","article-title":"A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes","volume":"2","author":"McKenzie","year":"2017","journal-title":"JMIR Diabetes"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Athinarayanan, S.J., Adams, R.N., Hallberg, S.J., McKenzie, A.L., Bhanpuri, N.H., Campbell, W.W., Volek, J.S., Phinney, S.D., and McCarter, J.P. (2019). Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00348"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/bmjnph-2022-000544","article-title":"What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss","volume":"6","author":"Unwin","year":"2023","journal-title":"BMJ Nutr. Prev. Health"},{"key":"ref_40","first-page":"6","article-title":"Low-Carbohydrate and Ketogenic Dietary Patterns for Type 2 Diabetes Management","volume":"41","author":"Oh","year":"2024","journal-title":"Fed. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kelly, T., Unwin, D., and Finucane, F. (2020). Low-Carbohydrate Diets in the Management of Obesity and Type 2 Diabetes: A Review from Clinicians Using the Approach in Practice. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17072557"},{"key":"ref_42","unstructured":"Society of Metabolic Health Practitioners (2024, September 24). Clinical Guidelines for Therapeutic Carbohydrate Restriction [Internet]. February 2022. Available online: https:\/\/thesmhp.org\/wp-content\/uploads\/2023\/02\/Clinical-Guidelines-General-Intervention-v1.3.9-updated-web-link-1.pdf."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12325-018-0824-8","article-title":"Body Weight Considerations in the Management of Type 2 Diabetes","volume":"36","author":"Apovian","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Aldhaleei, W.A., Abegaz, T.M., and Bhagavathula, A.S. (2024). Glucagon-like Peptide-1 Receptor Agonists Associated Gastrointestinal Adverse Events: A Cross-Sectional Analysis of the National Institutes of Health All of Us Cohort. Pharmaceuticals, 17.","DOI":"10.3390\/ph17020199"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"661","DOI":"10.37765\/ajmc.2023.89466","article-title":"Treatment modification after initiating second-line medication for type 2 diabetes","volume":"29","author":"Liss","year":"2023","journal-title":"Am. J. Manag. Care"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s10620-005-9027-7","article-title":"A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms","volume":"51","author":"Austin","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"ref_47","unstructured":"Yancy, W.S., Provenzale, D., and Westman, E.C. (2001). Improvement of gastroesophageal reflux disease after initiation of a low-carbohydrate diet: Five brief case reports. Altern. Ther. Health Med., 7."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/apt.13784","article-title":"Dietary carbohydrate intake, insulin resistance and gastro-oesophageal reflux disease: A pilot study in European- and African-American obese women","volume":"44","author":"Pointer","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.3748\/wjg.v18.i33.4593","article-title":"Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms","volume":"18","author":"Ho","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S2468-1253(24)00045-1","article-title":"A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARIBS): A single-centre, single-blind, randomised controlled trial","volume":"9","author":"Nybacka","year":"2024","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1093\/jn\/nxy197","article-title":"Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis","volume":"148","author":"Devries","year":"2018","journal-title":"J. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e004101","DOI":"10.1136\/bmjdrc-2024-004101","article-title":"The case for a ketogenic diet in the management of kidney disease","volume":"12","author":"Athinarayanan","year":"2024","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Iacovides, S., Maloney, S.K., Bhana, S., Angamia, Z., and Meiring, R.M. (2022). Could the Ketogenic Diet Induce a Shift in Thyroid Function and Support a Metabolic Advantage in Healthy Participants? A Pilot Randomized-controlled-crossover trial. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0269440"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/sj.ijo.0800634","article-title":"Gallbladder motility and gallstone formation in obese patients following very low calorie diets. Use it (fat) to lose it (well)","volume":"22","author":"Festi","year":"1998","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cgh.2013.11.031","article-title":"Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight loss: A meta-analysis of randomized controlled trials","volume":"12","author":"Stokes","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/BF01536623","article-title":"Gallbladder kinetics in obese patients. Effect of a regular meal and low-calorie meal","volume":"33","author":"Marzio","year":"1988","journal-title":"Dig. Dis. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cmet.2017.08.005","article-title":"A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice","volume":"26","author":"Roberts","year":"2017","journal-title":"Cell Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1001\/jama.280.23.2001","article-title":"Intensive lifestyle changes for reversal of coronary heart disease","volume":"280","author":"Ornish","year":"1998","journal-title":"JAMA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1080\/10408398.2022.2122923","article-title":"Effects of a vegetarian diet combined with exercise on lipid profiles and blood pressure: A systematic review and meta-analysis","volume":"64","author":"Niu","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e13462","DOI":"10.1111\/obr.13462","article-title":"Effects of vegan diets on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials","volume":"23","author":"Termannsen","year":"2022","journal-title":"Obes. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.clnu.2018.05.021","article-title":"Effect of vegetarian diets on the presentation of metabolic syndrome or its components: A systematic review and meta-analysis","volume":"38","author":"Picasso","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1001\/jamainternmed.2013.6473","article-title":"Vegetarian dietary patterns and mortality in Adventist Health Study 2","volume":"173","author":"Orlich","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0091-7435(72)90076-X","article-title":"Coronary heart disease: Risk factors as guides to preventive action","volume":"1","author":"Stamler","year":"1972","journal-title":"Prev. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.295.1.39","article-title":"Low-fat dietary pattern and weight change over 7 years: The Women\u2019s Health Initiative Dietary Modification Trial","volume":"295","author":"Howard","year":"2006","journal-title":"JAMA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/jama.1997.03550180059038","article-title":"Long-term cholesterol-lowering effects of 4 fat-restricted diets in hypercholesterolemic and combined hyperlipidemic men. The Dietary Alternatives Study","volume":"278","author":"Knopp","year":"1997","journal-title":"JAMA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1017\/S0007114513000548","article-title":"Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: A meta-analysis of randomised controlled trials","volume":"110","author":"Bueno","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Lei, L., Huang, J., Zhang, L., Hong, Y., Hui, S., and Yang, J. (2022). Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors in overweight and obese adults: A meta-analysis of randomized controlled trials. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.935234"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.2147\/DMSO.S467719","article-title":"Low-Carbohydrate Diet is More Helpful for Weight Loss Than Low-Fat Diet in Adolescents with Overweight and Obesity: A Systematic Review and Meta-Analysis","volume":"17","author":"Zhang","year":"2024","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"pgac107","DOI":"10.1093\/pnasnexus\/pgac107","article-title":"An analysis of the recent US dietary guidelines process in light of its federal mandate and a National Academies report","volume":"1","author":"Achterberg","year":"2022","journal-title":"PNAS Nexus"},{"key":"ref_71","first-page":"1","article-title":"A low-carbohydrate survey: Evidence for Sustainable Metabolic Syndrome Reversal","volume":"2","author":"Cucuzzella","year":"2017","journal-title":"J. Insul. Resist."},{"key":"ref_72","unstructured":"Ministry of Health (2015). Eating and Activity Guidelines for New Zealand Adults, Updated 2020."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/1747-0080.12534","article-title":"Low-carbohydrate, healthy-fat eating: A cost comparison with national dietary guidelines","volume":"77","author":"Zinn","year":"2020","journal-title":"Nutr. Diet."},{"key":"ref_74","unstructured":"Teicholz, N. (2024, September 25). For Richer, For Poorer: Low-Carb Diets Work for All Incomes [Internet]. Medscape. July 2024. Available online: https:\/\/www.medscape.com\/viewarticle\/richer-poorer-low-carb-diets-work-all-incomes-2024a1000cw5?form=fpf."},{"key":"ref_75","unstructured":"Cucuzzella, M., and Sullivan, K. (2024, September 15). Low-Carb for Any Budget: A Low-Carb Shopping and Recipe Starter [Internet]. February 2020. Updated April 2023. Available online: https:\/\/www.guidelinecentral.com\/guideline\/41586\/patient-education\/560599\/#section-anchor-2652973."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e018846","DOI":"10.1136\/bmjopen-2017-018846","article-title":"Assessing the nutrient intake of a low-carbohydrate, high-fat (LCHF) diet: A hypothetical case study design","volume":"8","author":"Zinn","year":"2018","journal-title":"BMJ Open"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Banner, L., Rice Bradley, B.H., and Clinthorne, J. (2024). Nutrient analysis of three low-carbohydrate diets differing in carbohydrate content. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1449109"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zinn, C., Lenferna De La Motte, K.A., Rush, A., and Johnson, R. (2022). Assessing the Nutrient Status of Low Carbohydrate, High-Fat (LCHF) Meal Plans in Children: A Hypothetical Case Study Design. Nutrients, 14.","DOI":"10.3390\/nu14081598"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0309-1651(85)90017-7","article-title":"Glucose Inhibits Cellular Ascorbic Acid Uptake by Fibroblasts in Vitro","volume":"9","author":"Harish","year":"1985","journal-title":"Cell Biol. Int. Rep."},{"key":"ref_80","unstructured":"U.S. Department of Agriculture and U.S. Department of Health and Human Services (2020). Dietary Guidelines for Americans, 2020\u20132025."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e2217481120","DOI":"10.1073\/pnas.2217481120","article-title":"Restoring particulate and mineral-associated organic carbon through regenerative agriculture","volume":"120","author":"Prairie","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_82","unstructured":"US Environmental Protection Agency (2024, September 24). Greenhouse Gas Emissions. Sources of Greenhouse Gas Emissions. Total U.S. Greenhouse Gas Emissions by Economic Sector in 2022. [Internet]. July 2024, Available online: https:\/\/www.epa.gov\/ghgemissions\/sources-greenhouse-gas-emissions."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.metabol.2017.10.010","article-title":"Keto-adaptation enhances exercise performance and body composition responses to training in endurance athletes","volume":"81","author":"McSwiney","year":"2018","journal-title":"Metabolism"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kephart, W.C., Pledge, C.D., Roberson, P.A., Mumford, P.W., Romero, M.A., Mobley, C.B., Martin, J.S., Young, K.C., Lowery, R.P., and Wilson, J.M. (2018). The Three-Month Effects of a Ketogenic Diet on Body Composition, Blood Parameters, and Performance Metrics in CrossFit Trainees: A Pilot Study. Sports, 6.","DOI":"10.3390\/sports6010001"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1550-2783-9-34","article-title":"Ketogenic diet does not affect strength performance in elite artistic gymnasts","volume":"9","author":"Paoli","year":"2012","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1249\/01.mss.0000538607.63990.a9","article-title":"The Effects Of a Six-week Ketogenic Diet on the Performance of Short-duration, High-intensity Exercise: A Pilot Study","volume":"50","author":"Miele","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_87","first-page":"259","article-title":"Effects of a 4-Week Very Low-Carbohydrate Diet on High-Intensity Interval Training Responses","volume":"17","author":"Cipryan","year":"2018","journal-title":"J. Sports Sci. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/milmed\/usz184","article-title":"Extended Ketogenic Diet and Physical Training Intervention in Military Personnel","volume":"184","author":"Volek","year":"2019","journal-title":"Mil. 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