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These factors lead to airflow obstruction and chronic respiratory symptoms. Additionally, the increased risk of infections exacerbates airway inflammation in COPD patients. As a consequence of the complex pathomechanisms and difficulty in treatment, COPD is among the leading causes of mortality both in the western countries and in the developing world. Results: The management of COPD is still a challenge for the clinicians; however, alternative interventions such as smoking cessation and lifestyle changes from a sedentary life to moderate physical activity with special attention to the diet may ameliorate patients\u2019 health. Here, we reviewed the effects of different dietary components and supplements on the conditions of COPD. Conclusions: COPD patients are continuously exposed to heavy metals, which are commonly present in cigarette smoke and polluted air. Meanwhile, they often experience significant nutrient deficiencies, which affect the detoxification of these toxic metals. This in turn can further disrupt nutritional balance by interfering with the absorption, metabolism, and utilization of essential micronutrients. Therefore, awareness and deliberate efforts should be made to check levels of micronutrients, with special attention to ensuring adequate levels of antioxidants, vitamin D, vitamin K2, magnesium, and iron, as these may be particularly important in reducing the risk of COPD development and limiting disease severity.<\/jats:p>","DOI":"10.3390\/nu17071149","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T09:13:26Z","timestamp":1742980406000},"page":"1149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nutritional Support of Chronic Obstructive Pulmonary Disease"],"prefix":"10.3390","volume":"17","author":[{"given":"P\u00e9ter","family":"Simon","sequence":"first","affiliation":[{"name":"National Kor\u00e1nyi Institute of Pulmonology, 1121 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Gastroenterology Center Buda, 1117 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Szalontai","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Szent-Gy\u00f6rgyi Albert Medical Center, University of Szeged, 6772 Deszk, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta","family":"Kari","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics, Core Facility, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Neuperger","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics, Core Facility, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Zavala","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics, Core Facility, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-7097","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Kanizsai","sequence":"additional","affiliation":[{"name":"Avidin Ltd., 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3 G.","family":"Pusk\u00e1s","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics, Core Facility, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Anthelos Ltd., 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"National Kor\u00e1nyi Institute of Pulmonology, 1121 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-5632","authenticated-orcid":false,"given":"Gabor J.","family":"Szebeni","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genomics, Core Facility, HUN-REN Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Department of Internal Medicine, Hematology Centre, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.clnu.2023.04.005","article-title":"Global prevalence of malnutrition in patients with chronic obstructive pulmonary disease: Systemic review and meta-analysis","volume":"42","author":"Deng","year":"2023","journal-title":"Clin. 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