{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:14:56Z","timestamp":1791317696884,"version":"4.3.1"},"reference-count":108,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Thailand Science Research and Innovation Fund Chulalongkorn University","award":["FOODF67300006"],"award-info":[{"award-number":["FOODF67300006"]}]},{"name":"Thailand Science Research and Innovation Fund Chulalongkorn University","award":["1\/2567"],"award-info":[{"award-number":["1\/2567"]}]},{"name":"Second Century Fund (C2F)","award":["FOODF67300006"],"award-info":[{"award-number":["FOODF67300006"]}]},{"name":"Second Century Fund (C2F)","award":["1\/2567"],"award-info":[{"award-number":["1\/2567"]}]},{"name":"Thai Traditional Medical Knowledge Fund","award":["FOODF67300006"],"award-info":[{"award-number":["FOODF67300006"]}]},{"name":"Thai Traditional Medical Knowledge Fund","award":["1\/2567"],"award-info":[{"award-number":["1\/2567"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objectives: This systematically scoping review aims to evaluate the therapeutic potential and clinical benefits of specific Lactiplantibacillus plantarum (L. plantarum) strains in human health, identifying their strain-specific effects across various medical conditions. Methods: Following the PRISMA for Scoping Reviews (PRISMA-ScR) guidelines and employing the PICO framework, a comprehensive literature search was conducted in the PubMed and Embase databases to identify relevant studies published up to December 2023. Inclusion criteria were rigorously applied to ensure the selection of high-quality studies focusing on the clinical application of distinct L. plantarum stains. Results: This review analyzed several unique strains of L. plantarum across 69 studies, identifying several therapeutic benefits. L. plantarum 299v effectively improved gastrointestinal symptoms, enhanced oral health, and reduced systemic inflammation. L. plantarum IS-10506 exhibited notable immunomodulatory effects, especially in managing atopic dermatitis. L. plantarum LB931 showed promise in decreasing pathogenic colonization, supporting women\u2019s vaginal health. Additionally, L. plantarum CCFM8724 demonstrated potential in reducing early childhood caries, highlighting its promise in pediatric oral care. Conclusions: The therapeutic potential of L. plantarum is extensive, with certain strains exhibiting promising clinical benefits for specific health concerns. The findings of this review advocate for the integration of L. plantarum strains into clinical practice, emphasizing the need for further research to elucidate their mechanisms of action, optimal dosages, and long-term safety profiles.<\/jats:p>","DOI":"10.3390\/nu17071165","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T12:41:02Z","timestamp":1743079262000},"page":"1165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6517-9362","authenticated-orcid":false,"given":"Oranut","family":"Chatsirisakul","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Chulalongkorn University, Rama IV Rd., Pathumwan, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2543-0544","authenticated-orcid":false,"given":"Natasha","family":"Leenabanchong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Public Health, HRH Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Lak Si, Bangkok 10210, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9852-4189","authenticated-orcid":false,"given":"Yada","family":"Siripaopradit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Chulalongkorn University, Rama IV Rd., Pathumwan, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Medicine, National Taiwan University, Taipei 106319, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patsakorn","family":"Buhngamongkol","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Chulalongkorn University, Rama IV Rd., Pathumwan, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-9761","authenticated-orcid":false,"given":"Krit","family":"Pongpirul","sequence":"additional","affiliation":[{"name":"Center of Excellence in Preventive and Integrative Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Rd., Pathumwan, Bangkok 10330, Thailand"},{"name":"Department of Infection Biology & Microbiomes, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7ZX, UK"},{"name":"Bumrungrad International Hospital, Bangkok 10110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. 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