{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:50:51Z","timestamp":1792014651988,"version":"4.4.0"},"reference-count":63,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID (Agencia Nacional de Investigaci\u00f3n y Desarrollo)","award":["#1221098"],"award-info":[{"award-number":["#1221098"]}]},{"name":"ANID (Agencia Nacional de Investigaci\u00f3n y Desarrollo)","award":["#21220864"],"award-info":[{"award-number":["#21220864"]}]},{"name":"BECA ANID DOCTORADO NACIONAL","award":["#1221098"],"award-info":[{"award-number":["#1221098"]}]},{"name":"BECA ANID DOCTORADO NACIONAL","award":["#21220864"],"award-info":[{"award-number":["#21220864"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: This study investigates the effects of a high-fat diet (HFD) during pregnancy and lactation on maternal and offspring health, focusing on behavioral, metabolic, and fatty acid composition outcomes in a rat model. Methods: Twelve female Sprague\u2013Dawley rats were fed either a control diet, CD (n = 6), or HFD (n = 6) for 12 weeks, encompassing mating, gestation, and lactation periods (18 weeks). Anxiety-like behavior, maternal behavior, depression-like behavior, and social play were studied. Post mortem, the liver function, hepatic steatosis, and fatty acid composition (erythrocytes, liver, adipose tissue) were evaluated. In regard to desaturase enzymes (\u0394-6D and \u0394-5D), liver activity, protein mass, and gene expression (RT-PCR) were analyzed. Additionally, gene expression of PPAR-\u03b1, ACOX, CPT1-\u03b1, SREBP-1c, ACC, and FAS was assessed. Statistical analysis was performed using Student\u2019s t-test, mean \u00b1 SD (p &lt; 0.05). Results: The HFD significantly increased maternal weight and anxiety-like behavior while reducing social interactions exclusively in male offspring (p &lt; 0.05). It also led to a significant decrease in the synthesis and content of n-3 PUFAs in the analyzed tissues, induced hepatic steatosis, and upregulated the expression of pro-lipogenic genes in the maternal liver. Conclusions: These findings suggest that long-term HFD consumption alters tissue fatty acid composition, disrupts metabolic homeostasis, and contributes to behavioral changes, increasing anxiety-like behaviors in pregnant dams and reducing social interactions in male offspring. Overall, this study provides further insight into the detrimental effects of HFD consumption during the perinatal period.<\/jats:p>","DOI":"10.3390\/nu17071180","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:06:35Z","timestamp":1743141995000},"page":"1180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High-Fat Diet in Perinatal Period Promotes Liver Steatosis and Low Desaturation Capacity of Polyunsaturated Fatty Acids in Dams: A Link with Anxiety-Like Behavior in Rats"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9813-8815","authenticated-orcid":false,"given":"Lorena","family":"Mercado-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"},{"name":"Direccion de Postgrado, Facultad Medicina, Universidad Andres Bello, Santiago 8370035, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-7543","authenticated-orcid":false,"given":"Yasna","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"},{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-9709","authenticated-orcid":false,"given":"Camila","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3075-5383","authenticated-orcid":false,"given":"Mar\u00eda Paz","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"},{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6844-956X","authenticated-orcid":false,"given":"Robinson","family":"Carrasco-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Laboratory of Stress Neurobiology, Interdisciplinary Centre for Health Studies (CIESAL), Institute of Physiology, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie Vanessa","family":"Caicedo-Paz","sequence":"additional","affiliation":[{"name":"Escuela de Agronom\u00eda, Facultad de Ciencias Agron\u00f3micas y de los Alimentos, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Quillota 2260000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9909-9826","authenticated-orcid":false,"given":"Alexies","family":"Dagnino-Subiabre","sequence":"additional","affiliation":[{"name":"Laboratory of Stress Neurobiology, Interdisciplinary Centre for Health Studies (CIESAL), Institute of Physiology, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-5341","authenticated-orcid":false,"given":"Alejandra","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Campus San Felipe, Universidad de Valpara\u00edso, San Felipe 2170000, Chile"},{"name":"Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-6142","authenticated-orcid":false,"given":"Rodrigo","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"940937","DOI":"10.3389\/fcimb.2022.940937","article-title":"Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring","volume":"12","author":"Denizli","year":"2022","journal-title":"Front. 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