{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:22:10Z","timestamp":1781767330086,"version":"3.54.5"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Small intestinal bacterial overgrowth (SIBO) is a dysbiosis marked by an excessive proliferation of bacteria in the small intestine, resulting in abdominal symptoms that significantly affect patients\u2019 quality of life. Objectives: This study aims to evaluate the impact of a comprehensive therapeutic approach in improving the quality of life of patients with SIBO. Methods: For this purpose, standardized questionnaires were used at baseline, 30 days and 90 days, including the IBS-QOL (Irritable Bowel Syndrome Quality of Life Questionnaire), the GSRS (Gastrointestinal Symptom Rating Scale), the EuroQOL-5D, and the Bristol Scale. Results: The results show that a comprehensive approach, combining pharmacological treatment, appropriate dietary intervention, and strategies aimed at improving gut microbiota and intestinal permeability, produces a sustained improvement in the quality of life of a significant proportion of patients who participated in the study. Furthermore, the results suggest that, although gas normalization is a relevant indicator, clinical improvement and quality of life depend considerably on patients\u2019 subjective perception of their health. Conclusions: This finding underscores the importance of recognizing SIBO as a prevalent condition that requires accurate diagnoses and individualized treatments to improve patients\u2019 well-being.<\/jats:p>","DOI":"10.3390\/nu17071251","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T05:51:26Z","timestamp":1743659486000},"page":"1251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Should We Treat SIBO Patients? Impact on Quality of Life and Response to Comprehensive Treatment: A Real-World Clinical Practice Study"],"prefix":"10.3390","volume":"17","author":[{"given":"Ana Reyes","family":"Li\u00e9bana-Castillo","sequence":"first","affiliation":[{"name":"Valencian Digestive Institute (IVADI), 46021 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-247X","authenticated-orcid":false,"given":"Luc\u00eda","family":"Redondo-Cuevas","sequence":"additional","affiliation":[{"name":"Valencian Digestive Institute (IVADI), 46021 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Valencian Digestive Institute (IVADI), 46021 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7746-3906","authenticated-orcid":false,"given":"Vanessa","family":"Mart\u00edn-Carbonell","sequence":"additional","affiliation":[{"name":"Valencian Digestive Institute (IVADI), 46021 Valencia, Spain"},{"name":"Digestive Section, Hospital de Sagunto Internal Medicine Service, 46520 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-6429","authenticated-orcid":false,"given":"Laura","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Valencian Digestive Institute (IVADI), 46021 Valencia, Spain"},{"name":"Digestive Section, Hospital de Sagunto Internal Medicine Service, 46520 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aroa","family":"Olivares","sequence":"additional","affiliation":[{"name":"Valencian Digestive Institute (IVADI), 46021 Valencia, 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Mol. Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jgh.16013","article-title":"Altered gut microbiota in patients with small intestinal bacterial overgrowth","volume":"38","author":"Bamba","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Oana, K., Shimizu, K., Takada, T., Makino, H., Yamazaki, M., Katto, M., Ando, M., Kurakawa, T., and Oishi, K. (2023). Manipulating the growth environment through co-culture to enhance stress tolerance and viability of probiotic strains in the gastrointestinal tract. Appl. Environ. Microbiol., 89.","DOI":"10.1128\/aem.01502-23"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Li, J., Zhang, R., Ma, J., Tang, S., Li, Y., Li, Y., and Wan, J. (2021). Mucosa-Associated Microbial Profile Is Altered in Small Intestinal Bacterial Overgrowth. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.710940"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5056\/jnm19113","article-title":"Breath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review with Meta-analysis","volume":"26","author":"Losurdo","year":"2020","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1053\/j.gastro.2022.04.002","article-title":"Small Intestinal Bacterial Overgrowth-Pathophysiology and Its Implications for Definition and Management","volume":"163","author":"Bushyhead","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.14309\/ajg.0000000000000501","article-title":"ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth","volume":"115","author":"Pimentel","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.7453\/gahmj.2014.019","article-title":"Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth","volume":"3","author":"Chedid","year":"2014","journal-title":"Glob. Adv. Health Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Guo, H., Lu, S., Zhang, J., Chen, C., Du, Y., Wang, K., and Duan, L. (2023). Berberine and rifaximin effects on small intestinal bacterial overgrowth: Study protocol for an investigator-initiated, double-arm, open-label, randomized clinical trial (BRIEF-SIBO study). Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1121435"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/MCG.0000000000000814","article-title":"Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence","volume":"51","author":"Zhong","year":"2017","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Perna, S., Alalwan, T.A., Alaali, Z., Alnashaba, T., Gasparri, C., Infantino, V., Hammad, L., Riva, A., Petrangolini, G., and Allegrini, P. (2019). The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205232"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.3390\/nu11092170","article-title":"Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial","volume":"11","author":"Yasukawa","year":"2019","journal-title":"Nutrients."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1111\/j.1572-0241.2008.02030.x","article-title":"Small intestinal bacterial overgrowth recurrence after antibiotic therapy","volume":"103","author":"Lauritano","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_14","first-page":"56","article-title":"Evaluaci\u00f3n de la calidad de vida en las enfermedades digestivas","volume":"27","author":"Vivancos","year":"2004","journal-title":"Gastroenterol. Epatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.1365-2036.1997.00160.x","article-title":"Patient-perceived severity of irritable bowel syndrome in relation to symptoms, health resource utilization and quality of life","volume":"11","author":"Hahn","year":"1997","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_16","first-page":"637","article-title":"Adaptaci\u00f3n en espa\u00f1ol del cuestionario IBSQOL para la medicina de la calidad de vida en pacientes con s\u00edndrome del intestino irritable","volume":"92","author":"Badia","year":"2000","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"EuroQol Group (1990). EuroQol\u2014A new facility for the measurement of health-related quality of life. Health Policy, 16, 199\u2013208.","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"ref_18","first-page":"79","article-title":"La versi\u00f3n espa\u00f1ola del EuroQol: Descripci\u00f3n y aplicaciones","volume":"112","author":"Badia","year":"1999","journal-title":"Med. Clin."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1080\/00365520310004209","article-title":"An irritable bowel syndrome-specific symptom questionnaire: Development and validation","volume":"38","author":"Wiklund","year":"2003","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/2050640619900577","article-title":"Discriminant and convergent validity of the GSRS-IBS symptom severity measure for irritable bowel syndrome: A population study","volume":"8","author":"Jones","year":"2020","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_21","first-page":"312","article-title":"Adaptation and validation of the Bristol scale stool form translated into the Spanish language among health professionals and patients","volume":"101","author":"Comas","year":"2009","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Redondo-Cuevas, L., Belloch, L., Mart\u00edn-Carbonell, V., Nicol\u00e1s, A., Alexandra, I., Sanchis, L., Ynfante, M., Colmenares, M., Mora, M., and Liebana, A.R. (2024). Do herbal supplements and probiotics complement antibiotics and diet in the management of SIBO? A randomized clinical trial. Nutrients, 16.","DOI":"10.3390\/nu16071083"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2020.06.090","article-title":"AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review","volume":"159","author":"Quigley","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/1751-2980.13189","article-title":"Impact of Small Intestinal Bacterial Overgrowth on Symptoms and Quality of Life in Irritable Bowel Syndrome","volume":"24","author":"Chuah","year":"2023","journal-title":"J. Dig. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1097\/MCG.0b013e31821fbf44","article-title":"Quality of Life in Patients with Irritable Bowel Syndrome","volume":"45","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e14817","DOI":"10.1111\/nmo.14817","article-title":"Critical Appraisal of the SIBO Hypothesis and Breath Testing: A Clinical Practice Update Endorsed by the European Society of Neurogastroenterology and Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS)","volume":"36","author":"Kashyap","year":"2024","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Abuelazm, M., Muhammad, S., Gamal, M., Labieb, F., Amin, M.A., Abdelazeem, B., and Bra\u0161i\u0107, J.R. (2022). The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 14.","DOI":"10.3390\/nu14132618"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2311986","DOI":"10.1080\/21642850.2024.2311986","article-title":"Examining Interactions of Illness Perceptions, Avoidance Behavior and Patient Status in Predicting Quality of Life Among People with Irritable Bowel Syndrome","volume":"12","author":"Ekholm","year":"2024","journal-title":"Health Psychol. Behav. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12986-022-00700-5","article-title":"Antimicrobial Treatment Improves Tryptophan Metabolism and Mood of Patients with Small Intestinal Bacterial Overgrowth","volume":"19","author":"Chojnacki","year":"2022","journal-title":"Nutr. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1097\/SGA.0000000000000530","article-title":"Health-Related Quality of Life in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis","volume":"43","author":"Cassar","year":"2020","journal-title":"Gastroenterol. Nurs."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.pmn.2021.12.004","article-title":"Psychosocial and Sensory Factors Contribute to Self-Reported Pain and Quality of Life in Young Adults with Irritable Bowel Syndrome","volume":"23","author":"Chen","year":"2022","journal-title":"Pain Manag. Nurs."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/ueg2.12277","article-title":"Irritable Bowel Syndrome: Factors of Importance for Disease-Specific Quality of Life","volume":"10","author":"Melchior","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.cgh.2023.09.022","article-title":"Quality of Life and Bidirectional Gut-Brain Interactions in Irritable Bowel Syndrome from Adolescence to Adulthood","volume":"22","author":"Kull","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000502815","article-title":"Relationship between stool form and quality of life in patients with chronic constipation: An internet questionnaire survey","volume":"102","author":"Ohkubo","year":"2021","journal-title":"Digestion"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/apt.17356","article-title":"Factors Associated with Lower Disease-Specific and Generic Health-Related Quality of Life in Rome IV Irritable Bowel Syndrome","volume":"57","author":"Goodoory","year":"2023","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Paduano, D., Cingolani, A., Tanda, E., and Usai, P. (2019). Effect of Three Diets (Low-FODMAP, Gluten-Free and Balanced) on Irritable Bowel Syndrome Symptoms and Health-Related Quality of Life. Nutrients, 11.","DOI":"10.3390\/nu11071566"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/jhn.13194","article-title":"Evaluation of the Effects of the FODMAP Diet and Probiotics on Irritable Bowel Syndrome (IBS) Symptoms, Quality of Life and Depression in Women with IBS","volume":"37","author":"Tek","year":"2024","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.cgh.2021.07.004","article-title":"Food Avoidance and Restriction in Irritable Bowel Syndrome: Relevance for Symptoms, Quality of Life and Nutrient Intake","volume":"20","author":"Melchior","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4161\/gmic.29796","article-title":"Effect of Commensals and Probiotics on Visceral Sensitivity and Pain in Irritable Bowel Syndrome","volume":"5","author":"Theodorou","year":"2014","journal-title":"Gut Microbes"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rastgoo, S., Ebrahimi-Daryani, N., Agah, S., Karimi, S., Taher, M., Rashidkhani, B., Hejazi, E., Mohseni, F., Ahmadzadeh, M., and Sadeghi, A. (2021). Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.746703"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Dudzi\u0144ska, E., Grabrucker, A.M., Kwiatkowski, P., Sitarz, R., and Sienkiewicz, M. (2023). The Importance of Visceral Hypersensitivity in Irritable Bowel Syndrome\u2014Plant Metabolites in IBS Treatment. Pharmaceuticals, 16.","DOI":"10.3390\/ph16101405"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.2174\/0113892010261502231102040149","article-title":"Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders","volume":"25","author":"Lashgari","year":"2024","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Min, M., Nadora, D., Chakkalakal, M., Afzal, N., Subramanyam, C., Gahoonia, N., Pan, A., Thacker, S., Nong, Y., and Chambers, C.J. (2024). An oral botanical supplement improves small intestinal bacterial overgrowth (SIBO) and facial redness: Results of an open-label clinical study. Nutrients, 16.","DOI":"10.3390\/nu16183149"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MOG.0000000000000040","article-title":"Small intestinal bacterial overgrowth: What it is and what it is not","volume":"30","author":"Quigley","year":"2014","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11894-019-0671-z","article-title":"The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO)","volume":"21","author":"Quigley","year":"2019","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_46","first-page":"502190","article-title":"Small Intestinal Bacterial Overgrowth (SIBO), a clinically overdiagnosed entity?","volume":"47","year":"2024","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1089\/acm.2020.0275","article-title":"Alternative treatment approaches to small intestinal bacterial overgrowth: A systematic review","volume":"27","author":"Nickles","year":"2021","journal-title":"J. Altern. Complement. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ueg2.12116","article-title":"The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth","volume":"9","author":"Richard","year":"2021","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s12664-022-01292-x","article-title":"Asian-Pacific consensus on small intestinal bacterial overgrowth in gastrointestinal disorders: An initiative of the Indian Neurogastroenterology and Motility Association","volume":"41","author":"Ghoshal","year":"2022","journal-title":"Indian J. Gastroenterol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/7\/1251\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:09:16Z","timestamp":1760029756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/7\/1251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["nu17071251"],"URL":"https:\/\/doi.org\/10.3390\/nu17071251","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]}}}