{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:46:36Z","timestamp":1791891996394,"version":"4.3.4"},"reference-count":208,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Groupe Lipides et Nutrition (GLN)"},{"name":"MobiDoc 941 managed by the ANPR under the EU SWAFY project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are known to help resolve inflammation through generation of anti-inflammatory eicosanoids and specialized pro-resolving mediators, including resolvins, protectins, and maresins. Through binding to the GPR120\/FFAR4 receptor, their beneficial effects result from phospholipid membrane remodeling, impairment of inflammatory signaling molecules clustering, subsequent inhibition of NF-\u03baB and inflammasome activation, and a reduction in oxidative stress. Obesity, a chronic inflammatory disease that contributes to metabolic disorders, is alleviated by n-3 PUFAs. In the adipose tissue (AT) of individuals with obesity, n-3 PUFAs counteract hypoxia, inhibit immune cell infiltration and AT inflammation, improve insulin sensitivity, and reduce fat mass. Beyond AT, n-3 PUFAs also alleviate other metabolic disorders such as metabolic-associated steatotic liver disease (MASLD), gut dysbiosis, and\/or renal dysfunction. In cardiovascular disease (CVD), they are mainly recommended as a secondary prevention for patients with coronary heart disease risks. This review provides an in-depth analysis of the benefits of n-3 PUFAs in obesity and related metabolic diseases, examining both the mechanistic and clinical aspects. Additionally, it also explores the effects of n-3 PUFAs in obesity-related chronic inflammatory conditions, including inflammatory bowel disease, psoriasis, rheumatoid arthritis, osteoarthritis, and multiple sclerosis, by targeting specific pathophysiological mechanisms. Clinical applications and limitations of n-3 PUFAs are discussed based on findings from human clinical trials.<\/jats:p>","DOI":"10.3390\/nu17071253","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:36:45Z","timestamp":1743737805000},"page":"1253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Beneficial Effects of Omega-3 Fatty Acids on Obesity and Related Metabolic and Chronic Inflammatory Diseases"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-120X","authenticated-orcid":false,"given":"Donia","family":"Jerab","sequence":"first","affiliation":[{"name":"CarMeN Laboratory, Institut National de Recherche pour l\u2019 Agriculture, l\u2019 Alimentation et l\u2019Environnement, UMR1397, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U 1060, Universit\u00e9 Claude Bernard Lyon I, 69310 Pierre-B\u00e9nite, France"},{"name":"Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Blangero","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Institut National de Recherche pour l\u2019 Agriculture, l\u2019 Alimentation et l\u2019Environnement, UMR1397, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U 1060, Universit\u00e9 Claude Bernard Lyon I, 69310 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-2399","authenticated-orcid":false,"given":"Paulo C\u00e9sar Trindade","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Health Sciences Center, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-3809","authenticated-orcid":false,"given":"Jos\u00e9 Luiz","family":"de Brito Alves","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Health Sciences Center, Federal University of Para\u00edba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Kefi","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henda","family":"Jamoussi","sequence":"additional","affiliation":[{"name":"Research Unit \u201cObesity: Etiopathology and Treatment, UR18ES01\u201d, Faculty of Medicine, Tunis El Manar University, Tunis 2092, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2418-1438","authenticated-orcid":false,"given":"Beatrice","family":"Morio","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Institut National de Recherche pour l\u2019 Agriculture, l\u2019 Alimentation et l\u2019Environnement, UMR1397, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U 1060, Universit\u00e9 Claude Bernard Lyon I, 69310 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-540X","authenticated-orcid":false,"given":"Assia","family":"Eljaafari","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, Institut National de Recherche pour l\u2019 Agriculture, l\u2019 Alimentation et l\u2019Environnement, UMR1397, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U 1060, Universit\u00e9 Claude Bernard Lyon I, 69310 Pierre-B\u00e9nite, France"},{"name":"Department of Clinical Research, Hospices Civils de Lyon, 69002 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-pathol-012615-044359","article-title":"Obesity, Inflammation, and Cancer","volume":"11","author":"Deng","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"ref_2","unstructured":"NCD Risk Factor Collaboration (NCD-RisC) (2024). Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet, 403, 1027\u20131050."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","article-title":"Adipose-tissue plasticity in health and disease","volume":"185","author":"Sakers","year":"2022","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pestel, J., Blangero, F., and Eljaafari, A. (2023). Pathogenic Role of Adipose Tissue-Derived Mesenchymal Stem Cells in Obesity and Obesity-Related Inflammatory Diseases. Cells, 12.","DOI":"10.3390\/cells12030348"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chehimi, M., Vidal, H., and Eljaafari, A. (2017). Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases. J. Clin. Med., 6.","DOI":"10.3390\/jcm6070068"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101882","DOI":"10.1016\/j.eclinm.2023.101882","article-title":"Pharmacotherapy of obesity: An update on the available medications and drugs under investigation","volume":"58","author":"Chakhtoura","year":"2023","journal-title":"eClinicalMedicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"924","DOI":"10.2337\/dc16-0350","article-title":"Bariatric\/Metabolic Surgery to Treat Type 2 Diabetes in Patients with a BMI < 35 kg\/m2","volume":"39","author":"Cummings","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Negi, A., Asokkumar, R., Ravi, R., Lopez-Nava, G., and Bautista-Casta\u00f1o, I. (2022). Nutritional Management and Role of Multidisciplinary Follow-Up after Endoscopic Bariatric Treatment for Obesity. Nutrients, 14.","DOI":"10.3390\/nu14163450"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100002","DOI":"10.1016\/j.fufo.2020.100002","article-title":"Managing obesity through natural polyphenols: A review","volume":"1\u20132","author":"Singh","year":"2020","journal-title":"Future Foods"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Dong, L., Qin, C., Li, Y., Wu, Z., and Liu, L. (2022). Oat phenolic compounds regulate metabolic syndrome in high fat diet-fed mice via gut microbiota. Food Biosci., 50.","DOI":"10.1016\/j.fbio.2022.101946"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.1039\/D2FO01746F","article-title":"Whole grain benefit: Synergistic effect of oat phenolic compounds and \u03b2-glucan on hyperlipidemia via gut microbiota in high-fat-diet mice","volume":"13","author":"Li","year":"2022","journal-title":"Food Funct."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Araujo, P., Belghit, I., Aars\u00e6ther, N., Espe, M., Lucena, E., and Holen, E. (2019). The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells. Nutrients, 11.","DOI":"10.3390\/nu11050966"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Liddle, D.M., Hutchinson, A.L., Wellings, H.R., Power, K.A., Robinson, L.E., and Monk, J.M. (2017). Integrated Immunomodulatory Mechanisms through which Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate Obese Adipose Tissue Dysfunction. Nutrients, 9.","DOI":"10.3390\/nu9121289"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1017\/S0029665120007077","article-title":"n-3 PUFA and inflammation: From membrane to nucleus and from bench to bedside","volume":"79","author":"Calder","year":"2020","journal-title":"Proc. Nutr. Soc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12746","DOI":"10.1073\/pnas.1404372111","article-title":"Phospholipase A2 regulates eicosanoid class switching during inflammasome activation","volume":"111","author":"Norris","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2013.10.006","article-title":"Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases","volume":"19","author":"Spite","year":"2014","journal-title":"Cell Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20081880","article-title":"Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions","volume":"206","author":"Serhan","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/fsn3.121","article-title":"Long-chain polyunsaturated fatty acid sources and evaluation of their nutritional and functional properties","volume":"2","author":"Abedi","year":"2014","journal-title":"Food Sci. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.plipres.2016.07.002","article-title":"Metabolism and functional effects of plant-derived omega-3 fatty acids in humans","volume":"64","author":"Baker","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1051\/ocl.2010.0325","article-title":"The omega-6\/omega-3 fatty acid ratio: Health implications","volume":"17","author":"Simopoulos","year":"2010","journal-title":"Ol\u00e9agineux Corps Gras Lipides"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Simopoulos, A.P. (2016). An Increase in the Omega-6\/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients, 8.","DOI":"10.3390\/nu8030128"},{"key":"ref_22","first-page":"53","article-title":"Cross sectional study about nutritional risk factors of metabolically unhealthy obesity","volume":"61","author":"Berriche","year":"2023","journal-title":"Rom. J. Intern. Med."},{"key":"ref_23","first-page":"A501","article-title":"Apports spontan\u00e9s en acides gras om\u00e9ga 3 chez des diab\u00e9tiques de type 2 tunisiens","volume":"21","author":"Jamoussi","year":"2014","journal-title":"Ol\u00e9agineux Corps Gras Lipides"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/NT.0000000000000512","article-title":"Dietary Guidelines for Americans, 2020\u20132025: Understanding the Scientific Process, Guidelines, and Key Recommendations","volume":"56","author":"Snetselaar","year":"2021","journal-title":"Nutr. Today"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.bbalip.2014.06.002","article-title":"Role of free fatty acid receptors in the regulation of energy metabolism","volume":"1841","author":"Hara","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Han, L., Song, S., Niu, Y., Meng, M., and Wang, C. (2017). Eicosapentaenoic Acid (EPA) Induced Macrophages Activation through GPR120-Mediated Raf-ERK1\/2-IKK\u03b2-NF-\u03baB p65 Signaling Pathways. Nutrients, 9.","DOI":"10.3390\/nu9090937"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.immuni.2013.05.015","article-title":"Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation","volume":"38","author":"Yan","year":"2013","journal-title":"Immunity"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1194\/jlr.R400010-JLR200","article-title":"PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis","volume":"45","author":"Li","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","article-title":"PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation","volume":"1812","author":"Varga","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1523-1755.2005.00151.x","article-title":"EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-gamma-dependent mechanism","volume":"67","author":"Li","year":"2005","journal-title":"Kidney Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1189\/jlb.1007688","article-title":"Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: Comparison with other polyunsaturated fatty acids","volume":"84","author":"Rueda","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.prostaglandins.2015.07.003","article-title":"Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome","volume":"121","author":"Laiglesia","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejphar.2015.03.091","article-title":"Omega-3 fatty acids, lipid rafts, and T cell signaling","volume":"785","author":"Hou","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejphar.2016.04.024","article-title":"Mechanisms for the activation of Toll-like receptor 2\/4 by saturated fatty acids and inhibition by docosahexaenoic acid","volume":"785","author":"Hwang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2337\/db17-1488","article-title":"The Transplantation of \u03c93 PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders","volume":"67","author":"Bidu","year":"2018","journal-title":"Diabetes"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s00125-005-0053-y","article-title":"Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet","volume":"49","author":"Flachs","year":"2006","journal-title":"Diabetologia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1161\/ATVBAHA.106.136853","article-title":"Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects","volume":"27","author":"Itoh","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"da Cunha de S\u00e1, R.D.C., Sim\u00e3o, J.d.J., Silva, V.S.d., Farias, T.M.d., Cruz, M.M., Antraco, V.J., Armelin-Correa, L., and Alonso-Vale, M.I. (2021). Fish Oil Enriched in EPA, but Not in DHA, Reverses the Metabolic Syndrome and Adipocyte Dysfunction Induced by a High-Fat Diet. Nutrients, 13.","DOI":"10.3390\/nu13030754"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/oby.2010.194","article-title":"Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: Improvement of the inflammatory status","volume":"19","author":"Figueras","year":"2011","journal-title":"Obesity"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1743-7075-8-31","article-title":"The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters","volume":"8","author":"Fan","year":"2011","journal-title":"Nutr. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yang, X., Li, X., Hu, M., Huang, J., Yu, S., Zeng, H., and Mao, L. (2024). EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation-targeting GPR120\/PPAR\u03b3 pathway. J. Nutr. Biochem., 130.","DOI":"10.1016\/j.jnutbio.2024.109648"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mce.2015.02.012","article-title":"Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPAR\u03b3 mediated pathways in 3T3-L1 adipocytes","volume":"406","author":"Hasan","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1194\/jlr.M065458","article-title":"EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet","volume":"57","author":"Pinel","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s11745-004-1345-9","article-title":"Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue","volume":"39","author":"Ruzickova","year":"2004","journal-title":"Lipids"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1158\/0008-5472.CAN-19-3184","article-title":"Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor Macrophages","volume":"80","author":"Liu","year":"2020","journal-title":"Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s00394-021-02502-6","article-title":"Transgenerational supplementation with eicosapentaenoic acid reduced the metabolic consequences on the whole body and skeletal muscle in mice receiving an obesogenic diet","volume":"60","author":"Pinel","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Pinel, A., Rigaudi\u00e8re, J.-P., Morio, B., and Capel, F. (2021). Adipose Tissue Dysfunctions in Response to an Obesogenic Diet Are Reduced in Mice after Transgenerational Supplementation with Omega 3 Fatty Acids. Metabolites, 11.","DOI":"10.3390\/metabo11120838"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.clnesp.2021.04.023","article-title":"Effects of omega-3 supplementation on body weight and body fat mass: A systematic review","volume":"44","author":"Delpino","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1017\/S0007114512001559","article-title":"Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: A systematic review of randomised clinical trials","volume":"107","author":"Aguilera","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"nzz041.P21-001-19","DOI":"10.1093\/cdn\/nzz041.P21-001-19","article-title":"Omega-3 Red Blood Cell Content Is Associated with Fat Mass Index and Leptin in Subjects with Obesity and Heart Failure with Preserved Ejection Fraction (P21-001-19)","volume":"3","author":"Billingsley","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.3390\/nu7085291","article-title":"Red Blood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following n-3 Fatty Acid Supplementation","volume":"7","author":"Flock","year":"2015","journal-title":"Nutrients"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.atherosclerosis.2015.03.043","article-title":"Red blood cell fatty acids and biomarkers of inflammation: A cross-sectional study in a community-based cohort","volume":"240","author":"Fontes","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.clnesp.2024.06.053","article-title":"Role of Omega-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic (DHA) as modulatory and anti-inflammatory agents in noncommunicable diet-related diseases\u2014Reports from the last 10 years","volume":"63","author":"Banaszak","year":"2024","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e13349","DOI":"10.1111\/obr.13349","article-title":"The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases","volume":"23","author":"Hariharan","year":"2022","journal-title":"Obes. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/HYPERTENSIONAHA.114.05112","article-title":"Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat","volume":"65","author":"Wei","year":"2015","journal-title":"Hypertension"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"135196","DOI":"10.1016\/j.neulet.2020.135196","article-title":"Direct evidence of bradycardic effect of omega-3 fatty acids acting on nucleus ambiguus","volume":"735","author":"Barr","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_59","first-page":"CD003177","article-title":"Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease","volume":"3","author":"Abdelhamid","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Djuricic, I., and Calder, P.C. (2021). Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients, 13.","DOI":"10.3390\/nu13072421"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa1811403","article-title":"Marine n\u22123 Fatty Acids and Prevention of Cardiovascular Disease and Cancer","volume":"380","author":"Manson","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e867","DOI":"10.1161\/CIR.0000000000000482","article-title":"Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease","volume":"135","author":"Siscovick","year":"2017","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1812792","article-title":"Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia","volume":"380","author":"Bhatt","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/cvr\/cvaa184","article-title":"Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: A prospective, placebo-controlled randomized trial (EVAPORATE): Interim results","volume":"117","author":"Budoff","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1001\/jama.2020.22258","article-title":"Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial","volume":"324","author":"Nicholls","year":"2020","journal-title":"JAMA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/CIRCULATIONAHA.121.055654","article-title":"Effect of Long-Term Marine \u0277-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis","volume":"144","author":"Gencer","year":"2021","journal-title":"Circulation"},{"key":"ref_67","first-page":"19","article-title":"Omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases","volume":"84","author":"Tutor","year":"2024","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_68","first-page":"323","article-title":"Drug interactions with HMG-CoA reductase inhibitors (statins): The importance of CYP enzymes, transporters and pharmacogenetics","volume":"11","author":"Neuvonen","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"de Lorgeril, M., Salen, P., Defaye, P., and Rabaeus, M. (2013). Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: Do statins inhibit omega-3?. BMC Med., 11.","DOI":"10.1186\/1741-7015-11-5"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S1734-1140(10)70311-X","article-title":"Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids","volume":"62","author":"Arnold","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Bird, J.K., Calder, P.C., and Eggersdorfer, M. (2018). The Role of n-3 Long Chain Polyunsaturated Fatty Acids in Cardiovascular Disease Prevention, and Interactions with Statins. Nutrients, 10.","DOI":"10.3390\/nu10060775"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12933-018-0740-x","article-title":"Omega-3 polyunsaturated fatty acids favourably modulate cardiometabolic biomarkers in type 2 diabetes: A meta-analysis and meta-regression of randomized controlled trials","volume":"17","author":"Matu","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Acosta-Monta\u00f1o, P., and Garc\u00eda-Gonz\u00e1lez, V. (2018). Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis. Nutrients, 10.","DOI":"10.3390\/nu10040393"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Lepretti, M., Martucciello, S., Burgos Aceves, M.A., Putti, R., and Lionetti, L. (2018). Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress. Nutrients, 10.","DOI":"10.3390\/nu10030350"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"108120","DOI":"10.1016\/j.diabres.2020.108120","article-title":"Improvement of NRF2 gene expression and antioxidant status in patients with type 2 diabetes mellitus after supplementation with omega-3 polyunsaturated fatty acids: A double-blind randomised placebo-controlled clinical trial","volume":"162","author":"Golpour","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1194\/jlr.M500300-JLR200","article-title":"Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells","volume":"47","author":"Aas","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jnutbio.2015.02.001","article-title":"Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids","volume":"26","author":"Bhaswant","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1080\/10408398.2021.1875977","article-title":"Omega-3 supplementation and diabetes: A systematic review and meta-analysis","volume":"62","author":"Delpino","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"He, X.-X., Wu, X.-L., Chen, R.-P., Chen, C., Liu, X.-G., Wu, B.-J., and Huang, Z.-M. (2016). Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162368"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-nutr-071812-161139","article-title":"Fatty acid-regulated transcription factors in the liver","volume":"33","author":"Jump","year":"2013","journal-title":"Annu. Rev. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Herrera Vielma, F., Valenzuela, R., Videla, L.A., and Z\u00fa\u00f1iga-Hern\u00e1ndez, J. (2021). N-3 Polyunsaturated Fatty Acids and Their Lipid Mediators as A Potential Immune-Nutritional Intervention: A Molecular and Clinical View in Hepatic Disease and Other Non-Communicable Illnesses. Nutrients, 13.","DOI":"10.3390\/nu13103384"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Lytle, K.A., Wong, C.P., and Jump, D.B. (2017). Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-\/- mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173376"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Yang, W., Tao, K., Zhang, P., Chen, X., Sun, X., and Li, R. (2022). Maresin 1 protects against lipopolysaccharide\/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response. Biochem. Pharmacol., 195.","DOI":"10.1016\/j.bcp.2021.114863"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Chen, J., Wang, D., Zong, Y., and Yang, X. (2021). DHA Protects Hepatocytes from Oxidative Injury through GPR120\/ERK-Mediated Mitophagy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115675"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Depner, C.M., Traber, M.G., Bobe, G., Kensicki, E., Bohren, K.M., Milne, G., and Jump, D.B. (2013). A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-\/- mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083756"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3945\/jn.112.171322","article-title":"Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-\/-) mouse model of western diet-induced nonalcoholic steatohepatitis","volume":"143","author":"Depner","year":"2013","journal-title":"J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1172\/JCI124219","article-title":"A maresin 1\/ROR\u03b1\/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis","volume":"129","author":"Han","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1194\/jlr.M500365-JLR200","article-title":"Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways","volume":"47","author":"Botolin","year":"2006","journal-title":"J. Lipid Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"25892","DOI":"10.1074\/jbc.274.36.25892","article-title":"Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2337\/db09-1554","article-title":"Antiobesity effect of eicosapentaenoic acid in high-fat\/high-sucrose diet-induced obesity: Importance of hepatic lipogenesis","volume":"59","author":"Sato","year":"2010","journal-title":"Diabetes"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/hep.27289","article-title":"WELCOME Study Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study","volume":"60","author":"Scorletti","year":"2014","journal-title":"Hepatology"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Vell, M.S., Creasy, K.T., Scorletti, E., Seeling, K.S., Hehl, L., Rendel, M.D., Schneider, K.M., and Schneider, C.V. (2023). Omega-3 intake is associated with liver disease protection. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1192099"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/1440-1681.13750","article-title":"Omega-3 polyunsaturated fatty acids in the treatment of non-alcoholic fatty liver disease: An umbrella systematic review and meta-analysis","volume":"50","author":"Musazadeh","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_94","first-page":"e68002","article-title":"Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis","volume":"16","author":"Aziz","year":"2024","journal-title":"Cureus"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/nutrit\/nuy022","article-title":"Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease","volume":"76","author":"Venditti","year":"2018","journal-title":"Nutr. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clnu.2015.04.004","article-title":"A randomized controlled trial of the effects of n-3 fatty acids on resolvins in chronic kidney disease","volume":"35","author":"Mas","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1097\/HJH.0000000000000621","article-title":"n-3 fatty acids reduce plasma 20-hydroxyeicosatetraenoic acid and blood pressure in patients with chronic kidney disease","volume":"33","author":"Barden","year":"2015","journal-title":"J. Hypertens."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/sj.ki.5000291","article-title":"N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity","volume":"69","author":"Battistini","year":"2006","journal-title":"Kidney Int."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.3945\/ajcn.2008.26867","article-title":"The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: Meta-analysis of clinical trials","volume":"89","author":"Miller","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.jrn.2014.01.014","article-title":"Effects of oral supplementation with omega-3 fatty acids on nutritional state and inflammatory markers in maintenance hemodialysis patients","volume":"24","author":"Gharekhani","year":"2014","journal-title":"J. Ren. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2215\/CJN.00630206","article-title":"N-3 fatty acids as secondary prevention against cardiovascular events in patients who undergo chronic hemodialysis: A randomized, placebo-controlled intervention trial","volume":"1","author":"Svensson","year":"2006","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1476-511X-13-127","article-title":"Effects of fish oil on serum lipid profile in dialysis patients: A systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Zhu","year":"2014","journal-title":"Lipids Health Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/db06-0911","article-title":"Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation","volume":"56","author":"Hosogai","year":"2007","journal-title":"Diabetes"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"E877","DOI":"10.1152\/ajpendo.00626.2010","article-title":"Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: Adipogenesis, insulin, and hypoxia","volume":"300","author":"He","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"113963","DOI":"10.1016\/j.celrep.2024.113963","article-title":"Adipose stem cells control obesity-induced T cell infiltration into adipose tissue","volume":"43","author":"Liao","year":"2024","journal-title":"Cell Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.tem.2024.06.013","article-title":"Adipose stem cells drive T cell infiltration in obesity","volume":"35","author":"Balcerczyk","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance","volume":"95","author":"Hotamisligil","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1126\/science.1160794","article-title":"A stress signaling pathway in adipose tissue regulates hepatic insulin resistance","volume":"322","author":"Sabio","year":"2008","journal-title":"Science"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.2337\/db15-0162","article-title":"Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1\/Th17 Balance and Monocyte Activation","volume":"64","author":"Eljaafari","year":"2015","journal-title":"Diabetes"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/21623945.2015.1134402","article-title":"Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects","volume":"5","author":"Chehimi","year":"2016","journal-title":"Adipocyte"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm.2001","article-title":"Normalization of obesity-associated insulin resistance through immunotherapy","volume":"15","author":"Winer","year":"2009","journal-title":"Nat. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1053\/j.gastro.2013.04.010","article-title":"Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals","volume":"145","author":"Fabbrini","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.2337\/db13-1511","article-title":"T cell-derived IL-22 amplifies IL-1\u03b2-driven inflammation in human adipose tissue: Relevance to obesity and type 2 diabetes","volume":"63","author":"Dalmas","year":"2014","journal-title":"Diabetes"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.biochi.2023.04.008","article-title":"Adipokines in obesity and metabolic-related-diseases","volume":"212","author":"Pestel","year":"2023","journal-title":"Biochimie"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5114\/ceji.2020.103418","article-title":"Obesity and chronic inflammation crosslinking","volume":"45","author":"Kucharska","year":"2020","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1126\/science.ade0113","article-title":"The link between obesity and autoimmunity","volume":"379","author":"Matarese","year":"2023","journal-title":"Science"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Gremese, E., Tolusso, B., Gigante, M.R., and Ferraccioli, G. (2014). Obesity as a Risk and Severity Factor in Rheumatic Diseases (Autoimmune Chronic Inflammatory Diseases). Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00576"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Grzechnik, K., and Targo\u0144ska-St\u0119pniak, B. (2023). Metabolic Syndrome and Rheumatoid Arthritis Activity: An Analysis of Clinical, Laboratory, and Ultrasound Parameters. Nutrients, 15.","DOI":"10.3390\/nu15224756"},{"key":"ref_122","first-page":"322","article-title":"Obesity, metabolic syndrome and other comorbidities in rheumatoid arthritis and psoriatic arthritis: Influence on disease activity and quality of life","volume":"44","author":"Azevedo","year":"2019","journal-title":"Acta Reumatol. Port."},{"key":"ref_123","first-page":"291546","article-title":"Obesity as a major risk factor for cancer","volume":"2013","author":"Silvestris","year":"2013","journal-title":"J. Obes."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Blangero, F., Robert, M., Andraud, T., Dumontet, C., Vidal, H., and Eljaafari, A. (2023). Contribution of Mesenchymal Stem Cells from Obese Adipose Tissue to PD-L1 Over-Expression and Breast Cancer Progression through Pathogenic Th17 Cell Activation. Cancers, 15.","DOI":"10.3390\/cancers15112963"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.it.2021.09.005","article-title":"ROR\u03b3t protein modifications and IL-17-mediated inflammation","volume":"42","author":"Kumar","year":"2021","journal-title":"Trends Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nri.2017.50","article-title":"The dichotomous nature of T helper 17 cells","volume":"17","author":"Stockinger","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni.2416","article-title":"Induction and molecular signature of pathogenic TH17 cells","volume":"13","author":"Lee","year":"2012","journal-title":"Nat. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.celrep.2016.05.088","article-title":"RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression","volume":"16","author":"Wu","year":"2016","journal-title":"Cell Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1600-065X.2008.00705.x","article-title":"The interleukin-23 axis in intestinal inflammation","volume":"226","author":"Ahern","year":"2008","journal-title":"Immunol. Rev."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Zhang, S., Gang, X., Yang, S., Cui, M., Sun, L., Li, Z., and Wang, G. (2021). The Alterations in and the Role of the Th17\/Treg Balance in Metabolic Diseases. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.678355"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e1801148","DOI":"10.1002\/mnfr.201801148","article-title":"Omega-3 Polyunsaturated Fatty Acids Inhibit IL-17A Secretion through Decreased ICAM-1 Expression in T Cells Co-Cultured with Adipose-Derived Stem Cells Harvested from Adipose Tissues of Obese Subjects","volume":"63","author":"Chehimi","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.3945\/jn.114.194407","article-title":"n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4+ T cells","volume":"144","author":"Allen","year":"2014","journal-title":"J. Nutr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12328-019-01037-y","article-title":"Relationship(s) between obesity and inflammatory bowel diseases: Possible intertwined pathogenic mechanisms","volume":"13","author":"Szilagyi","year":"2020","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"7868","DOI":"10.3748\/wjg.v22.i35.7868","article-title":"Interaction of obesity and inflammatory bowel disease","volume":"22","author":"Harper","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Bilski, J., Mazur-Bialy, A., Wojcik, D., Surmiak, M., Magierowski, M., Sliwowski, Z., Pajdo, R., Kwiecien, S., Danielak, A., and Ptak-Belowska, A. (2019). Role of Obesity, Mesenteric Adipose Tissue, and Adipokines in Inflammatory Bowel Diseases. Biomolecules, 9.","DOI":"10.3390\/biom9120780"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Scaioli, E., Liverani, E., and Belluzzi, A. (2017). The Imbalance between n-6\/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122619"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Monk, J.M., Hou, T.Y., Turk, H.F., Weeks, B., Wu, C., McMurray, D.N., and Chapkin, R.S. (2012). Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049739"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3945\/jn.111.147058","article-title":"Th17 Cell Accumulation Is Decreased during Chronic Experimental Colitis by (n-3) PUFA in Fat-1 Mice1\u201323","volume":"142","author":"Monk","year":"2012","journal-title":"J. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00394-008-0712-0","article-title":"Polyunsaturated fatty acids support epithelial barrier integrity and reduce IL-4 mediated permeability in vitro","volume":"47","author":"Willemsen","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1039\/c3fo60036j","article-title":"Effect of polyunsaturated fatty acids on tight junctions in a model of the human intestinal epithelium under normal and inflammatory conditions","volume":"4","author":"Beguin","year":"2013","journal-title":"Food Funct."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1054\/clnu.2001.0430","article-title":"Effect of eicosapentaenoic acid (EPA) on tight junction permeability in intestinal monolayer cells","volume":"20","author":"Usami","year":"2001","journal-title":"Clin. Nutr."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.molmed.2018.12.004","article-title":"Saving Problematic Mucosae: SPMs in Intestinal Mucosal Inflammation and Repair","volume":"25","author":"Quiros","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mam.2017.02.002","article-title":"Special pro-resolving mediator (SPM) actions in regulating gastro-intestinal inflammation and gut mucosal immune responses","volume":"58","author":"Wang","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/ibd.21374","article-title":"Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): A systematic review and meta-analyses","volume":"17","author":"Turner","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Radziszewska, M., Smarkusz-Zarzecka, J., Ostrowska, L., and Pogodzi\u0144ski, D. (2022). Nutrition and Supplementation in Ulcerative Colitis. Nutrients, 14.","DOI":"10.3390\/nu14122469"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1136\/gut.33.7.922","article-title":"Treatment of ulcerative colitis with fish oil supplementation: A prospective 12 month randomised controlled trial","volume":"33","author":"Hawthorne","year":"1992","journal-title":"Gut"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/BF02093614","article-title":"n-3 fatty acids only delay early relapse of ulcerative colitis in remission","volume":"41","author":"Loeschke","year":"1996","journal-title":"Dig. Dis. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.3748\/wjg.v11.i45.7118","article-title":"of P.I.B. Usefulness of \u03c9-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn\u2019s disease: A double-blind, randomized, placebo-controlled study","volume":"11","author":"Romano","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ibd\/izaa097","article-title":"Multidimensional Impact of Mediterranean Diet on IBD Patients","volume":"27","author":"Chicco","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/1203475415586332","article-title":"The Relationship of Obesity With the Severity of Psoriasis: A Systematic Review","volume":"19","author":"Fleming","year":"2015","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/BOR.0b013e3283031c99","article-title":"Psoriasis and metabolic disease: Epidemiology and pathophysiology","volume":"20","author":"Azfar","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_152","first-page":"125","article-title":"Links and risks associated with psoriasis and metabolic syndrome","volume":"5","author":"Liakou","year":"2015","journal-title":"Psoriasis (Auckl.)"},{"key":"ref_153","first-page":"121","article-title":"Obesity: A key component of psoriasis","volume":"86","author":"Correia","year":"2015","journal-title":"Acta Biomed."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.jid.2021.02.755","article-title":"Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells","volume":"141","author":"Simard","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Morin, S., Simard, M., Flamand, N., and Pouliot, R. (2021). Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1866.","DOI":"10.1016\/j.bbalip.2021.159032"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jdermsci.2019.05.003","article-title":"Current understanding of the role of dietary lipids in the pathophysiology of psoriasis","volume":"94","author":"Honda","year":"2019","journal-title":"J. Dermatol. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"100428","DOI":"10.1016\/j.jlr.2023.100428","article-title":"Eicosapentaenoic acid reduces the proportion of IL-17A-producing T cells in a 3D psoriatic skin model","volume":"64","author":"Morin","year":"2023","journal-title":"J. Lipid Res."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Son, S.-E., Koh, J.-M., and Im, D.-S. (2022). Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094482"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/1099800415621617","article-title":"Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120","volume":"18","author":"Arantes","year":"2016","journal-title":"Biol. Res. Nurs."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Sawada, Y., Honda, T., Nakamizo, S., Otsuka, A., Ogawa, N., Kobayashi, Y., Nakamura, M., and Kabashima, K. (2018). Resolvin E1 attenuates murine psoriatic dermatitis. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-30373-1"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jacl.2018.03.091","article-title":"Identification of proresolving and inflammatory lipid mediators in human psoriasis","volume":"12","author":"Sorokin","year":"2018","journal-title":"J. Clin. Lipidol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Sorokin, A.V., Arnardottir, H., Svirydava, M., Ng, Q., Baumer, Y., Berg, A., Pantoja, C.J., Florida, E.M., Teague, H.L., and Yang, Z.-H. (2023). Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction. J. Nutr. Biochem., 117.","DOI":"10.1016\/j.jnutbio.2023.109348"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/nutrit\/nuz098","article-title":"Efficacy of fish oil and its components in the management of psoriasis: A systematic review of 18 randomized controlled trials","volume":"78","author":"Chen","year":"2020","journal-title":"Nutr. Rev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s10067-019-04456-x","article-title":"Efficacy of \u03c9-3 supplementation in patients with psoriasis: A meta-analysis of randomized controlled trials","volume":"38","author":"Clark","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1136\/annrheumdis-2013-205012","article-title":"The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: The NEO study","volume":"74","author":"Visser","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.joca.2014.10.002","article-title":"Metabolic triggered inflammation in osteoarthritis","volume":"23","author":"Wang","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/rheumatology\/keu464","article-title":"Obesity and osteoarthritis, more than just wear and tear: Pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis","volume":"54","author":"Thijssen","year":"2015","journal-title":"Rheumatology"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/bcpt.12109","article-title":"Adiponectin and leptin: New targets in inflammation","volume":"114","author":"Scotece","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"R207","DOI":"10.1186\/ar3183","article-title":"Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1\u03b2-mediated cartilage degradation","volume":"12","author":"Wann","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prostaglandins.2019.02.007","article-title":"Omega-3 fatty acids and docosahexaenoic acid oxymetabolites modulate the inflammatory response of equine recombinant interleukin1\u03b2-stimulated equine synoviocytes","volume":"142","author":"Caron","year":"2019","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"3711371","DOI":"10.1155\/2022\/3711371","article-title":"Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4\/NF-\u03baB Signaling Pathway Affects Chondrocyte Pyroptosis","volume":"2022","author":"Jin","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1136\/annrheumdis-2014-205601","article-title":"Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury","volume":"74","author":"Wu","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s13018-023-03855-w","article-title":"Effect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: A meta-analysis","volume":"18","author":"Deng","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Shi, W., Xu, C., Xu, Q., Zhang, H., Li, Z., and Li, H. (2025). Polyunsaturated fatty acids may not be helpful for people with osteoarthritis: A two-sample Mendelian randomization analysis. Sci. Rep., 15.","DOI":"10.1038\/s41598-024-84506-w"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jbm.a.37512","article-title":"Sustained release resolvin D1 liposomes are effective in the treatment of osteoarthritis in obese mice","volume":"111","author":"Dravid","year":"2023","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_176","first-page":"1079","article-title":"A meta-analysis of the relationship between body mass index and risk of rheumatoid arthritis","volume":"17","author":"Zhou","year":"2018","journal-title":"EXCLI J."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e007568","DOI":"10.1136\/bmjopen-2014-007568","article-title":"Body mass index and risk of knee osteoarthritis: Systematic review and meta-analysis of prospective studies","volume":"5","author":"Zheng","year":"2015","journal-title":"BMJ Open"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/rheumatology\/41.10.1155","article-title":"Influence of obesity on the development of osteoarthritis of the hip: A systematic review","volume":"41","author":"Lievense","year":"2002","journal-title":"Rheumatology"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e004227","DOI":"10.1136\/rmdopen-2024-004227","article-title":"Obesity is a risk factor for poor response to treatment in early rheumatoid arthritis: A NORD-STAR study","volume":"10","author":"Dubovyk","year":"2024","journal-title":"RMD Open"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11926-015-0550-z","article-title":"The Obesity Epidemic and Consequences for Rheumatoid Arthritis Care","volume":"18","author":"George","year":"2016","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrrheum.2009.179","article-title":"IL-17 as a future therapeutic target for rheumatoid arthritis","volume":"5","author":"Miossec","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1002\/art.34391","article-title":"Bone marrow-derived and synovium-derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: Contribution to the chronicity of rheumatoid arthritis","volume":"64","author":"Eljaafari","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Kim, J.Y., Lim, K., Kim, K.H., Kim, J.H., Choi, J.S., and Shim, S.-C. (2018). N-3 polyunsaturated fatty acids restore Th17 and Treg balance in collagen antibody-induced arthritis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194331"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Lee, J.-E., Lee, J.-H., Koh, J.-M., and Im, D.-S. (2024). Free Fatty Acid 4 Receptor Activation Attenuates Collagen-Induced Arthritis by Rebalancing Th1\/Th17 and Treg Cells. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115866"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbalip.2014.08.010","article-title":"Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance","volume":"1851","author":"Calder","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Dong, Y., Greenwood, D.C., Webster, J., Uzokwe, C., Tao, J., Hardie, L.J., and Cade, J.E. (2024). Dose-Response Associations Between Diet and Risk of Rheumatoid Arthritis: A Meta-Analysis of Prospective Cohort Studies. Nutrients, 16.","DOI":"10.3390\/nu16234050"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00296-002-0234-7","article-title":"Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis","volume":"23","author":"Adam","year":"2003","journal-title":"Rheumatol. Int."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.nut.2017.06.023","article-title":"Intake of \u03c9-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis","volume":"45","author":"Gioxari","year":"2018","journal-title":"Nutrition"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.autrev.2014.07.001","article-title":"Obesity in autoimmune diseases: Not a passive bystander","volume":"13","author":"Versini","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.neuint.2009.04.018","article-title":"Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study","volume":"55","author":"Ouellet","year":"2009","journal-title":"Neurochem. Int."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Dyall, S.C. (2015). Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA. Front. Aging Neurosci., 7.","DOI":"10.3389\/fnagi.2015.00052"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.plefa.2008.12.001","article-title":"Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis","volume":"80","author":"Shinto","year":"2009","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Ceccarini, M.R., Ceccarelli, V., Codini, M., Fettucciari, K., Calvitti, M., Cataldi, S., Albi, E., Vecchini, A., and Beccari, T. (2022). The Polyunsaturated Fatty Acid EPA, but Not DHA, Enhances Neurotrophic Factor Expression through Epigenetic Mechanisms and Protects against Parkinsonian Neuronal Cell Death. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232416176"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/ocl\/2023030","article-title":"DHA (omega-3 fatty acid) increases the action of brain-derived neurotrophic factor (BDNF)","volume":"31","author":"Majou","year":"2024","journal-title":"OCL"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1172\/JCI58649","article-title":"Multiple sclerosis","volume":"122","author":"Nylander","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jneuroim.2012.12.003","article-title":"Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis","volume":"256","author":"Unoda","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1034\/j.1600-0404.2000.102003143.x","article-title":"Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients","volume":"102","author":"Nordvik","year":"2000","journal-title":"Acta Neurol. Scand."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/1028415X.2019.1659560","article-title":"Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: A systematic review","volume":"24","author":"AlAmmar","year":"2021","journal-title":"Nutr. Neurosci."},{"key":"ref_201","first-page":"709493","article-title":"Efficacy of fish oil on serum of TNF\u03b1, IL-1\u03b2, and IL-6 oxidative stress markers in multiple sclerosis treated with interferon beta-1b","volume":"2013","author":"Ortiz","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1001\/archneurol.2012.283","article-title":"\u03c9-3 fatty acid treatment in multiple sclerosis (OFAMS Study): A randomized, double-blind, placebo-controlled trial","volume":"69","author":"Torkildsen","year":"2012","journal-title":"Arch. Neurol."},{"key":"ref_203","first-page":"CD004192","article-title":"Dietary interventions for multiple sclerosis","volume":"12","author":"Farinotti","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1136\/annrheumdis-2018-213511","article-title":"Maresin 1 improves the Treg\/Th17 imbalance in rheumatoid arthritis through miR-21","volume":"77","author":"Jin","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1046\/j.1365-2249.1997.4351455.x","article-title":"N-3 polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes and inhibit antigen-presentation in vitro","volume":"110","author":"Hughes","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Cl\u00e0ria, J., Gonz\u00e1lez-P\u00e9riz, A., L\u00f3pez-Vicario, C., Rius, B., and Titos, E. (2011). New insights into the role of macrophages in adipose tissue inflammation and Fatty liver disease: Modulation by endogenous omega-3 Fatty Acid-derived lipid mediators. Front. Immunol., 2.","DOI":"10.3389\/fimmu.2011.00049"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"108753","DOI":"10.1016\/j.pharmthera.2024.108753","article-title":"Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation","volume":"265","author":"Peh","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"101605","DOI":"10.1016\/j.smim.2022.101605","article-title":"Specialized pro-resolving mediators as modulators of immune responses","volume":"59","author":"Julliard","year":"2022","journal-title":"Semin. Immunol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/7\/1253\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:09:26Z","timestamp":1760029766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/7\/1253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":208,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["nu17071253"],"URL":"https:\/\/doi.org\/10.3390\/nu17071253","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]}}}