{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:26:34Z","timestamp":1787239594024,"version":"build-2736575974"},"reference-count":109,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Orthopedic surgery and the corresponding events (i.e., immobilization and muscle disuse) result in a cascade of biological events to promote healing but can come with the loss of skeletal muscle mass and strength. A good nutritional status of patients is associated with positive post-surgical outcomes, with macronutrients receiving the majority of emphasis in the research literature. However, beyond the surgical literature, there are other nutrients and nutritional supplements that have been established or postulated to improve skeletal muscle mass and strength. Objective: The purpose of this narrative review is to provide evidence for the utility of using creatine, vitamin D, omega-3 fatty acids, glutamine, essential amino acids-branched chain amino acids (EAA-BCAA) and beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the role they may play in minimizing muscle atrophy and strength loss following orthopedic surgery. The review will also highlight areas of future research to support a better understanding of the efficacy of supplementing with these substances pre- and\/or post-surgery.<\/jats:p>","DOI":"10.3390\/nu17071273","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T03:23:07Z","timestamp":1743996187000},"page":"1273","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Selected Nutrients to Oppose Muscle Disuse Following Arthroscopic Orthopedic Surgery: A Narrative Review"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-8370","authenticated-orcid":false,"given":"Dean M.","family":"Cordingley","sequence":"first","affiliation":[{"name":"Applied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Pan Am Clinic Foundation, 75 Poseidon Bay, Winnipeg, MB R3M 3E4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-4529","authenticated-orcid":false,"given":"Maryam","family":"Taheri","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Faculty of Sport Science and Health, Shahid Beheshti University, Tehran 19839 69411, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-0393","authenticated-orcid":false,"given":"Moein","family":"Fasihiyan","sequence":"additional","affiliation":[{"name":"Faculty of Sport Science and Health, Shahid Beheshti University, Tehran 19839 69411, Iran"},{"name":"Department of Kinesiology and Physical Education, McGill University, Montr\u00e9al, QC H2W 1S4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarret M.","family":"Woodmass","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery, Pan Am Clinic, 75 Poseidon Bay, Winnipeg, MB R3M 3E4, Canada"},{"name":"Division of Orthopaedics, Department of Surgery, University of Manitoba, Winnipeg, MB R3A 1R9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-6707","authenticated-orcid":false,"given":"Stephen M.","family":"Cornish","sequence":"additional","affiliation":[{"name":"Applied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"},{"name":"Centre for Aging, University of Manitoba, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"ref_1","first-page":"e9","article-title":"Nutrition, Anabolism, and the Wound Healing Process: An Overview","volume":"9","author":"Demling","year":"2009","journal-title":"Eplasty"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.14336\/AD.2022.0404","article-title":"Acute Sarcopenia after Elective and Emergency Surgery","volume":"13","author":"Shrestha","year":"2022","journal-title":"Aging Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00221-019-05499-x","article-title":"Quadriceps Muscle Function Following Anterior Cruciate Ligament Reconstruction: Systemic Differences in Neural and Morphological Characteristics","volume":"237","author":"Lepley","year":"2019","journal-title":"Exp. 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