{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:41:42Z","timestamp":1792806102252,"version":"4.5.0"},"reference-count":255,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Semmelweis University","award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}],"id":[{"id":"https:\/\/ror.org\/01g9ty582","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Semmelweis University","award":["RRF-2.3.1\u201321-2022\u201300003"],"award-info":[{"award-number":["RRF-2.3.1\u201321-2022\u201300003"]}],"id":[{"id":"https:\/\/ror.org\/01g9ty582","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Semmelweis University","award":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"],"award-info":[{"award-number":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"]}],"id":[{"id":"https:\/\/ror.org\/01g9ty582","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002332","name":"Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002332","name":"Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["RRF-2.3.1\u201321-2022\u201300003"],"award-info":[{"award-number":["RRF-2.3.1\u201321-2022\u201300003"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002332","name":"Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund","doi-asserted-by":"publisher","award":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"],"award-info":[{"award-number":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Cardiovascular Laboratory Program","award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}]},{"name":"National Cardiovascular Laboratory Program","award":["RRF-2.3.1\u201321-2022\u201300003"],"award-info":[{"award-number":["RRF-2.3.1\u201321-2022\u201300003"]}]},{"name":"National Cardiovascular Laboratory Program","award":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"],"award-info":[{"award-number":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"]}]},{"name":"European University for Well-Being (EUniWell) program","award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}]},{"name":"European University for Well-Being (EUniWell) program","award":["RRF-2.3.1\u201321-2022\u201300003"],"award-info":[{"award-number":["RRF-2.3.1\u201321-2022\u201300003"]}]},{"name":"European University for Well-Being (EUniWell) program","award":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"],"award-info":[{"award-number":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"]}]},{"name":"EK\u00d6P-2024-9 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["TKP2021-NKTA-47"],"award-info":[{"award-number":["TKP2021-NKTA-47"]}]},{"name":"EK\u00d6P-2024-9 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["RRF-2.3.1\u201321-2022\u201300003"],"award-info":[{"award-number":["RRF-2.3.1\u201321-2022\u201300003"]}]},{"name":"EK\u00d6P-2024-9 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund","award":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"],"award-info":[{"award-number":["101004093\/EUniWell\/EAC-A02-2019\/EAC-A02-2019\u20131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D plays a crucial role in the regulation of the immune system, with immunomodulatory effects that are key in the prevention of colorectal cancer (CRC). Over the past decades, research has shown that this steroid hormone impacts much more than bone health, significantly influencing immune responses. Vitamin D enhances immune organ functions such as the spleen and lymph nodes, and boosts T-cell activity, which is essential in defending the body against tumors. Additionally, vitamin D mitigates inflammatory responses closely linked to cancer development, reducing the inflammation that contributes to CRC. It acts via vitamin D receptors (VDRs) expressed on immune cells, modulating immune responses. Adequate vitamin D levels influence gene expression related to inflammation and cell proliferation, inhibiting tumor development. Vitamin D also activates mechanisms that suppress cancer cell survival, proliferation, migration, and metastasis. Low levels of vitamin D have been associated with an increased risk of CRC, with deficiency correlating with higher disease incidence. Lifestyle factors, such as a diet high in red meat and calories but low in fiber, fruits, and vegetables, as well as physical inactivity, contribute significantly to CRC risk. Insufficient calcium and vitamin D intake are also linked to disease occurrence and poorer clinical outcomes. Maintaining optimal vitamin D levels and adequate dietary intake is crucial in preventing CRC and improving patient prognosis. This review explores the role of vitamin D in immune regulation and summarizes findings from randomized clinical trials assessing the effects of vitamin D supplementation on CRC outcomes.<\/jats:p>","DOI":"10.3390\/nu17081351","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T06:50:27Z","timestamp":1744699827000},"page":"1351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-2120","authenticated-orcid":false,"given":"M\u00f3nika","family":"Fekete","sequence":"first","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-7518","authenticated-orcid":false,"given":"Andrea","family":"Lehoczki","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"},{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Szappanos","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"},{"name":"Department of Rheumatology and Clinical Immunology, Semmelweis University, 1023 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vir\u00e1g","family":"Z\u00e1b\u00f3","sequence":"additional","affiliation":[{"name":"Health Sciences Division, Doctoral College, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-1067","authenticated-orcid":false,"given":"Csilla","family":"Kaposv\u00e1ri","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp\u00e1r","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Pulmonology Center of the Reformed Church in Hungary, 2045 T\u00f6r\u00f6kb\u00e1lint, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1rp\u00e1d","family":"Farkas","sequence":"additional","affiliation":[{"name":"HUN-REN Centre for Energy Research, 1121 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-4003","authenticated-orcid":false,"given":"Vince","family":"Fazekas-Pongor","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-9745","authenticated-orcid":false,"given":"D\u00e1vid","family":"Major","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Lip\u00e9cz","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Cs\u00edp\u0151","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-1336","authenticated-orcid":false,"given":"J\u00e1nos Tam\u00e1s","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-pharmtox-010510-100611","article-title":"Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D","volume":"51","author":"Krishnan","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz, A., and Grant, W.B. (2022). Vitamin D and cancer: An historical overview of the epidemiology and mechanisms. Nutrients, 14.","DOI":"10.3390\/nu14071448"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0955-2863(02)00183-3","article-title":"Vitamin D and cancer","volume":"13","author":"Mehta","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"ref_4","first-page":"400","article-title":"Metabolizmus vitaminu D [Vitamin D metabolism]","volume":"58","author":"Kulda","year":"2012","journal-title":"Vnitrni Lekarstvi"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kemeny, L.V., and Fisher, D.E. (2020). Hormones and Hormone Precursors of the Skin. Hormonal Signaling in Biology and Medicine, Elsevier.","DOI":"10.1016\/B978-0-12-813814-4.00023-7"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Carlberg, C., Raczyk, M., and Zawrotna, N. (2023). Vitamin D: A master example of nutrigenomics. Redox Biol., 62.","DOI":"10.1016\/j.redox.2023.102695"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dwivedi, S., Singh, V., Sen, A., Yadav, D., Agrawal, R., Kishore, S., Misra, S., and Sharma, P. (2024). Vitamin D in Disease Prevention and Cure-Part I: An Update on Molecular Mechanism and Significance on Human Health. Indian J. Clin. Biochem., 1\u201343.","DOI":"10.1007\/s12291-024-01251-7"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Roseland, J.M., Phillips, K.M., Patterson, K.Y., Pehrsson, P.R., and Taylor, C.L. (2018). Vitamin D in Foods: An Evolution of Knowledge. Vitamin D, Elsevier.","DOI":"10.1016\/B978-0-12-809963-6.00060-2"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s11154-021-09693-7","article-title":"Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?","volume":"22","author":"Bilezikian","year":"2021","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/kisup.2011.30","article-title":"Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation","volume":"1","author":"Dusso","year":"2011","journal-title":"Kidney Int. Suppl."},{"key":"ref_11","unstructured":"Bikle, D.D. (2015). Vitamin D: Production, Metabolism and Mechanisms of Action, MDText.com, Inc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2011.05.010","article-title":"Vitamin D receptor (VDR)-mediated actions of 1\u03b1,25(OH)2vitamin D3: Genomic and non-genomic mechanisms","volume":"25","author":"Haussler","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"\u017bmijewski, M.A. (2022). Nongenomic Activities of Vitamin D. Nutrients, 14.","DOI":"10.3390\/nu14235104"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.14336\/AD.2016.1021","article-title":"Vitamin D and chronic diseases","volume":"8","author":"Wang","year":"2017","journal-title":"Aging Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100616","DOI":"10.1016\/j.ctarc.2022.100616","article-title":"Vitamin D and colorectal cancer\u2013A practical review of the literature","volume":"32","author":"Peixoto","year":"2022","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_17","first-page":"e10734","article-title":"Role of vitamin D in colorectal cancer: A holistic approach and review of the clinical utility","volume":"12","author":"Javed","year":"2020","journal-title":"Cureus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3109\/13880209.2014.988274","article-title":"Vitamin D in cancer chemoprevention","volume":"53","author":"Giammanco","year":"2015","journal-title":"Pharm. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cui, A., Zhang, T., Xiao, P., Fan, Z., Wang, H., and Zhuang, Y. (2023). Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: A pooled analysis of 7.9 million participants. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1070808"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s43465-023-01089-w","article-title":"The Global Prevalence of Vitamin D Deficiency in the Elderly: A Meta-analysis","volume":"58","author":"Meshkin","year":"2024","journal-title":"Indian J. Orthop."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2340\/00015555-0980","article-title":"Factors influencing vitamin D status","volume":"91","author":"Tsiaras","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.115.120873","article-title":"Vitamin D deficiency in Europe: Pandemic?","volume":"103","author":"Cashman","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3322\/caac.21601","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Rebecca","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_24","unstructured":"Horv\u00e1thn\u00e9, K.Z. (2021). A Vastagb\u00e9lsz\u0171r\u00e9si Pilot Program \u00c9rt\u00e9kel\u00e9se \u00e9s a Vastagb\u00e9ldaganatb\u00f3l Ered\u0151 Betegs\u00e9gteher Vizsg\u00e1lata, University of P\u00e9cs."},{"key":"ref_25","first-page":"89","article-title":"Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz. Gastroenterol."},{"key":"ref_26","first-page":"175","article-title":"A rosszindulat\u00fa daganatok hazai epidemiol\u00f3giai helyzete a XXI. sz\u00e1zad m\u00e1sodik \u00e9vtized\u00e9ben","volume":"66","author":"Kenessey","year":"2022","journal-title":"Magy. Onkol\u00f3gia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.21037\/jgo-24-318","article-title":"Colorectal cancer: Local results and significance in Hungary","volume":"15","author":"Longobardi","year":"2024","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global burden of colorectal cancer in 2020 and 2040: Incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Morgan","year":"2023","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Murata, S., Schmidt-Mende, K., Ebeling, M., and Modig, K. (2024). Do people reach 100 by surviving, delaying, or avoiding diseases? A life course comparison of centenarians and non-centenarians from the same birth cohorts. GeroScience.","DOI":"10.1007\/s11357-024-01330-w"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s11357-024-01425-4","article-title":"Centenarians of the Basque Country are resilient to cancer","volume":"47","author":"Larranaga","year":"2024","journal-title":"GeroScience"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11357-024-01364-0","article-title":"Inflammation and aging-related disease: A transdisciplinary inflammaging framework","volume":"47","author":"Andonian","year":"2024","journal-title":"GeroScience"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1007\/s11357-024-01164-6","article-title":"Prognostic significance of a signature based on senescence-related genes in colorectal cancer","volume":"46","author":"Ungvari","year":"2024","journal-title":"GeroScience"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Cummings, S.R., Lui, L.-Y., Zaira, A., Mau, T., Fielding, R.A., Atkinson, E.J., Patel, S., and LeBrasseur, N. (2024). Biomarkers of cellular senescence and major health outcomes in older adults. GeroScience.","DOI":"10.1007\/s11357-024-01474-9"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1611623","DOI":"10.3389\/pore.2024.1611623","article-title":"Geroscience and pathology: A new frontier in understanding age-related diseases","volume":"30","author":"Fekete","year":"2024","journal-title":"Pathol. Oncol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1007\/s11357-023-00913-3","article-title":"Exposome and unhealthy aging: Environmental drivers from air pollution to occupational exposures","volume":"45","author":"Pandics","year":"2023","journal-title":"Geroscience"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s11357-024-01411-w","article-title":"Plasma proteomics-based organ-specific aging for all-cause mortality and cause-specific mortality: A prospective cohort study","volume":"47","author":"Zhao","year":"2024","journal-title":"GeroScience"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s11357-023-00891-6","article-title":"Associations of healthy aging index and all-cause and cause-specific mortality: A prospective cohort study of UK Biobank participants","volume":"46","author":"Zhuang","year":"2024","journal-title":"GeroScience"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1007\/s11357-024-01408-5","article-title":"Physical activity and DNA methylation-based markers of ageing in 6208 middle-aged and older Australians: Cross-sectional and longitudinal analyses","volume":"47","author":"Zheng","year":"2024","journal-title":"GeroScience"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Maugeri, A., Barchitta, M., Magnano San Lio, R., Li Destri, G., Agodi, A., and Basile, G. (2020). Epigenetic Aging and Colorectal Cancer: State of the Art and Perspectives for Future Research. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010200"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bardelcikova, A., Soltys, J., and Mojzis, J. (2023). Oxidative Stress, Inflammation and Colorectal Cancer: An Overview. Antioxidants, 12.","DOI":"10.3390\/antiox12040901"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11357-024-01374-y","article-title":"Genomic instability and genetic heterogeneity in aging: Insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL)","volume":"47","author":"Kallai","year":"2024","journal-title":"GeroScience"},{"key":"ref_42","first-page":"275","article-title":"Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention","volume":"17","author":"Song","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s11357-024-01332-8","article-title":"Coffee consumption, cancer, and healthy aging: Epidemiological evidence and underlying mechanisms","volume":"47","author":"Kunutsor","year":"2024","journal-title":"GeroScience"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1007\/s11357-024-01222-z","article-title":"Unraveling the link between cardiorespiratory fitness and cancer: A state-of-the-art review","volume":"46","author":"Kunutsor","year":"2024","journal-title":"GeroScience"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kunutsor, S.K., Jassal, D.S., Ravandi, A., and Lehoczki, A. (2025). Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging. GeroScience.","DOI":"10.1007\/s11357-025-01512-0"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"d6617","DOI":"10.1136\/bmj.d6617","article-title":"Dietary fibre, whole grains, and risk of colorectal cancer: Systematic review and dose-response meta-analysis of prospective studies","volume":"343","author":"Aune","year":"2011","journal-title":"BMJ"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1007\/s11357-024-01064-9","article-title":"Aging induces changes in cancer formation and microbial content in a murine model of bladder cancer","volume":"46","author":"Woolbright","year":"2024","journal-title":"GeroScience"},{"key":"ref_48","first-page":"1477","article-title":"Signs of aging in midlife: Physical function and sex differences in microbiota","volume":"46","author":"Turjeman","year":"2024","journal-title":"GeroScience"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s11357-024-01419-2","article-title":"Characterizing the oral and gastrointestinal microbiome associated with healthy aging: Insights from long-lived populations in Northeastern China","volume":"47","author":"Ji","year":"2024","journal-title":"GeroScience"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-0042-1760679","article-title":"Role of Bacteria in the Development of Colorectal Cancer","volume":"36","author":"Thomas","year":"2023","journal-title":"Clin. Colon. Rectal Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1007\/s11357-024-01255-4","article-title":"Guideline for designing microbiome studies in neoplastic diseases","volume":"46","author":"Sipos","year":"2024","journal-title":"GeroScience"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ungvari, Z., Fekete, M., Varga, P., Lehoczki, A., Fekete, J.T., Ungvari, A., and Gy\u0151rffy, B. (2024). Overweight and obesity significantly increase colorectal cancer risk: A meta-analysis of 66 studies revealing a 25-57% elevation in risk. GeroScience.","DOI":"10.1007\/s11357-024-01375-x"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/endrev\/bnz014","article-title":"Review: Diabetes, Obesity, and Cancer-Pathophysiology and Clinical Implications","volume":"41","author":"Lega","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Socol, C.T., Chira, A., Martinez-Sanchez, M.A., Nu\u00f1ez-Sanchez, M.A., Maerescu, C.M., Mierlita, D., Rusu, A.V., Ruiz-Alcaraz, A.J., Trif, M., and Ramos-Molina, B. (2022). Leptin Signaling in Obesity and Colorectal Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094713"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s11357-023-00783-9","article-title":"Can frailty scores predict the incidence of cancer? Results from two large population-based studies","volume":"45","author":"Mak","year":"2023","journal-title":"GeroScience"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Melia, F., Udomjarumanee, P., Zinovkin, D., Arghiani, N., and Pranjol, M.Z.I. (2022). Pro-tumorigenic role of type 2 diabetes-induced cellular senescence in colorectal cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.975644"},{"key":"ref_57","first-page":"575","article-title":"Hungarian consensus recommendation on the role of vitamin D in disease prevention and treatment","volume":"163","author":"Dank","year":"2022","journal-title":"Orvosi Hetil."},{"key":"ref_58","unstructured":"Bhattoa, H.P. (2023). A Csontanyagcsere \u00e9s a D-Vitaminh\u00e1ztart\u00e1s Biok\u00e9miai Markerei, DE \u00c1OK. Analitikai kih\u00edv\u00e1sok, klinikai alkalmaz\u00e1sok."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jsbmb.2015.01.011","article-title":"Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation","volume":"148","author":"Li","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"bvz038","DOI":"10.1210\/jendso\/bvz038","article-title":"Vitamin D: Newer concepts of its metabolism and function at the basic and clinical level","volume":"4","author":"Bikle","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11357-015-9755-3","article-title":"Motor imagery of gait in non-demented older community-dwellers: Performance depends on serum 25-hydroxyvitamin D concentrations","volume":"37","author":"Beauchet","year":"2015","journal-title":"AGE"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2024). Physiology of vitamin D\u2014Focusing on disease prevention. Nutrients, 16.","DOI":"10.3390\/nu16111666"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_64","first-page":"324","article-title":"Considera\u00e7\u00f5es atuais sobre a vitamina D","volume":"50","author":"Reis","year":"2013","journal-title":"Bras\u00edlia Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"S\u00eerbe, C., Rednic, S., Grama, A., and Pop, T.L. (2022). An update on the effects of vitamin D on the immune system and autoimmune diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179784"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1111\/j.1753-4887.2008.00094.x","article-title":"Vitamin D\u2019s role in cell proliferation and differentiation","volume":"66","author":"Samuel","year":"2008","journal-title":"Nutr. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Liu, W., Zhang, L., Xu, H.-J., Li, Y., Hu, C.-M., Yang, J.-Y., and Sun, M.-Y. (2018). The anti-inflammatory effects of vitamin D in tumorigenesis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092736"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1017\/S0007114516000696","article-title":"Vitamin D and colorectal cancer: Molecular, epidemiological and clinical evidence","volume":"115","author":"Dou","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1007\/s11357-024-01138-8","article-title":"A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age","volume":"46","author":"McGee","year":"2024","journal-title":"GeroScience"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11357-022-00637-w","article-title":"Vitamin D(3) promotes longevity in Caenorhabditis elegans","volume":"45","author":"Huggins","year":"2023","journal-title":"GeroScience"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s11357-022-00581-9","article-title":"Vitamin D supplementation is associated with slower epigenetic aging","volume":"44","author":"Vetter","year":"2022","journal-title":"GeroScience"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.3390\/nu7065020","article-title":"Mechanistic Effects of Calcitriol in Cancer Biology","volume":"7","year":"2015","journal-title":"Nutrients"},{"key":"ref_73","first-page":"28","article-title":"Vitamin D, vitamin D receptor and the importance of its activation in patients with chronic kidney disease","volume":"35","author":"Bover","year":"2015","journal-title":"Nefrolog\u00eda"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6","DOI":"10.36553\/wm.55","article-title":"Vitamin D, infections and immunity","volume":"2","author":"Misiorowski","year":"2020","journal-title":"Wiedza Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"132","DOI":"10.46903\/gjms\/18.03.841","article-title":"Immunomodulatory role of vitamin D: Clinical implications in infections and autoimmune disorders","volume":"18","author":"Alswailmi","year":"2020","journal-title":"Gomal J. Med. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s11357-023-00805-6","article-title":"Combining exercise with cognitive training and vitamin D3 to improve functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI). Results from the SYNERGIC trial","volume":"45","author":"Bray","year":"2023","journal-title":"GeroScience"},{"key":"ref_77","first-page":"192747","article-title":"Vitamin D and Alzheimer\u2019s disease: Neurocognition to therapeutics","volume":"2015","author":"Banerjee","year":"2015","journal-title":"Int. J. Alzheimer\u2019s Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s40263-019-00640-4","article-title":"Potential role of vitamin D for the management of depression and anxiety","volume":"33","author":"Casseb","year":"2019","journal-title":"CNS Drugs"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.amjcard.2010.04.042","article-title":"Role of vitamin D in cardiovascular health","volume":"106","author":"Vanga","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.1007\/s11357-024-01193-1","article-title":"Association of vitamin D and bisphenol A levels with cardiovascular risk in an elderly Italian population: Results from the InCHIANTI study","volume":"46","author":"Brandi","year":"2024","journal-title":"GeroScience"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"47","DOI":"10.55289\/jnutres\/v11i2_23.16","article-title":"Vitamin D Deficiency and Heart Health: A Narrative Review","volume":"11","author":"Gupta","year":"2023","journal-title":"J. Nutr. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/nutrit\/nuz037","article-title":"Effect of vitamin D supplementation on serum lipid profiles: A systematic review and meta-analysis","volume":"77","author":"Dibaba","year":"2019","journal-title":"Nutr. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1017\/S0950268814000193","article-title":"Does vitamin D protect against respiratory viral infections?","volume":"142","author":"Bryson","year":"2014","journal-title":"Epidemiol. Infect."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.vaccine.2022.11.020","article-title":"COVID-19 vaccination coverage in patients with chronic obstructive pulmonary disease\u2014A cross-sectional study in Hungary","volume":"41","author":"Fekete","year":"2023","journal-title":"Vaccine"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s10787-023-01190-4","article-title":"Fatigue, sleepiness and sleep quality are SARS-CoV-2 variant independent in patients with long COVID symptoms","volume":"31","author":"Percze","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1556\/2060.2022.00172","article-title":"COVID-19 infection in patients with chronic obstructive pulmonary disease: From pathophysiology to therapy","volume":"109","author":"Fekete","year":"2022","journal-title":"Mini-Rev. Physiol. Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/1753465813503029","article-title":"Beneficial role of vitamin D3 in the prevention of certain respiratory diseases","volume":"7","year":"2013","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Banerjee, A., and Panettieri, R.A. (2012). Vitamin D modulates airway smooth muscle function. Vitamin D Lung Mech. Dis. Assoc., 127\u2013150.","DOI":"10.1007\/978-1-61779-888-7_7"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1152\/physiolgenomics.00134.2006","article-title":"1\u03b1, 25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes","volume":"29","author":"Maghni","year":"2007","journal-title":"Physiol. Genom."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF02432515","article-title":"Age and immunity to respiratory tract infections","volume":"12","author":"Ganguly","year":"1989","journal-title":"AGE"},{"key":"ref_91","first-page":"PA704","article-title":"Optimizing Cardiopulmonary Rehabilitation Duration for Long COVID Patients: An Exercise Physiology Monitoring Approach","volume":"64","author":"Szarvas","year":"2025","journal-title":"Eur. Respir. J."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Abidi, Y., Kovats, Z., Bohacs, A., Fekete, M., Naas, S., Madurka, I., Torok, K., Bogyo, L., and Varga, J.T. (2023). Lung Transplant Rehabilitation\u2014A Review. Life, 13.","DOI":"10.3390\/life13020506"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1267\/ahc.20011","article-title":"Vitamin D and the host-gut microbiome: A brief overview","volume":"53","author":"Akimbekov","year":"2020","journal-title":"Acta Histochem. Cytochem."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Marfil-S\u00e1nchez, A., Seelbinder, B., Ni, Y., Varga, J., Berta, J., Hollosi, V., Dome, B., Megyesfalvi, Z., Dulka, E., and Galffy, G. (2021). Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0259898"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/apt.12553","article-title":"vitamin D and inflammatory bowel diseases","volume":"39","author":"Mouli","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/j.2040-4603.2016.tb00690.x","article-title":"PTH and Vitamin D","volume":"6","author":"Khundmiri","year":"2016","journal-title":"Compr. Physiol."},{"key":"ref_97","unstructured":"DeLuca, H.F. (2012). Vitamin D: Metabolism and Function, Springer."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.nut.2007.11.006","article-title":"Vitamin D, glucose, insulin, and insulin sensitivity","volume":"24","author":"Tai","year":"2008","journal-title":"Nutrition"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Bi, Y., Xia, H., Li, L., Lee, R.J., Xie, J., Liu, Z., Qiu, Z., and Teng, L. (2019). Liposomal vitamin D3 as an anti-aging agent for the skin. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11070311"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"59","DOI":"10.56543\/aaeeu.2024.3.2.01","article-title":"Anti-aging nutrition therapy","volume":"3","author":"Kocyigit","year":"2024","journal-title":"Anti-Aging East. Eur."},{"key":"ref_101","first-page":"76112","article-title":"Eg\u00e9szs\u00e9g\u00fcgyi szakmai ir\u00e1nyelv a kr\u00f3nikus obstrukt\u00edv t\u00fcd\u0151betegs\u00e9g (COPD) diagnosztik\u00e1j\u00e1r\u00f3l \u00e9s kezel\u00e9s\u00e9r\u0151l, az alap, a szak \u00e9s a s\u00fcrg\u0151ss\u00e9gi ell\u00e1t\u00e1s ter\u00fclet\u00e9n","volume":"67","author":"Gy","year":"2014","journal-title":"Med. Thor."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1556\/650.2020.31824","article-title":"[Significance of nutritional status in chronic obstructive pulmonary disease: A survey]","volume":"161","author":"Fekete","year":"2020","journal-title":"Orv. Hetil."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398.2021.1939649","article-title":"Circulating vitamin D levels and colorectal cancer risk: A meta-analysis and systematic review of case-control and prospective cohort studies","volume":"63","author":"Boughanem","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0140-6736(89)91789-3","article-title":"Serum 25-hydroxyvitamin D and colon cancer: Eight-year prospective study","volume":"334","author":"Garland","year":"1989","journal-title":"Lancet"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrc2196","article-title":"Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics","volume":"7","author":"Deeb","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2005.06.005","article-title":"The vitamin D endocrine system of the gut\u2014Its possible role in colorectal cancer prevention","volume":"97","author":"Cross","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1200\/JCO.2011.35.7566","article-title":"Association between vitamin D and risk of colorectal cancer: A systematic review of prospective studies","volume":"29","author":"Ma","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2018.07.002","article-title":"Mechanisms of action of vitamin D in colon cancer","volume":"185","author":"Larriba","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jgh.14949","article-title":"Effect and mechanism of vitamin D on the development of colorectal cancer based on intestinal flora disorder","volume":"35","author":"Zhou","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Bellerba, F., Muzio, V., Gnagnarella, P., Facciotti, F., Chiocca, S., Bossi, P., Cortinovis, D., Chiaradonna, F., Serrano, D., and Raimondi, S. (2021). The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies. Nutrients, 13.","DOI":"10.3390\/nu13103378"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1158\/0008-5472.CAN-13-2820","article-title":"Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer","volume":"74","author":"Meeker","year":"2014","journal-title":"Cancer Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"31","DOI":"10.24365\/ef.v62i4.6928","article-title":"Az emberi szervezetben \u00e9l\u0151 bakt\u00e9riumok klinikai jelent\u0151s\u00e9ge a gyakorlatban","volume":"62","author":"Fekete","year":"2021","journal-title":"Eg\u00e9szs\u00e9gfejleszt\u00e9s"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"G864","DOI":"10.1152\/ajpgi.00524.2001","article-title":"Transforming growth factor-beta 1 signaling contributes to Caco-2 cell growth inhibition induced by 1,25(OH)(2)D(3)","volume":"283","author":"Chen","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.3748\/wjg.v19.i17.2621","article-title":"CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells","volume":"19","author":"Balla","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/j.gastro.2014.12.035","article-title":"Nutrients, foods, and colorectal cancer prevention","volume":"148","author":"Song","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"147","DOI":"10.15430\/JCP.2022.27.3.147","article-title":"Vitamin D and Colorectal Cancer: Current Perspectives and Future Directions","volume":"27","author":"Na","year":"2022","journal-title":"J. Cancer Prev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2310\/JIM.0b013e31821b8755","article-title":"Vitamin D and the immune system","volume":"59","author":"Aranow","year":"2011","journal-title":"J. Investig. Med."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"El-Sharkawy, A., and Malki, A. (2020). Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications. Molecules, 25.","DOI":"10.3390\/molecules25143219"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2567.2011.03482.x","article-title":"Vitamin D3: A helpful immuno-modulator","volume":"134","author":"Malaguarnera","year":"2011","journal-title":"Immunology"},{"key":"ref_120","first-page":"77","article-title":"Role of inflammation in the development of colorectal cancer","volume":"21","author":"Muthusami","year":"2021","journal-title":"Endocr. Metab. Immune Disord.-Drug Targets (Former. Curr. Drug Targets-Immune Endocr. Metab. Disord.)"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1111\/febs.16955","article-title":"From molecular basis to clinical insights: A challenging future for the vitamin D endocrine system in colorectal cancer","volume":"291","author":"Pereira","year":"2024","journal-title":"FEBS J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11914-009-0011-6","article-title":"Vitamin D and immune function: Understanding common pathways","volume":"7","author":"Bikle","year":"2009","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.2174\/1568026615666150915111557","article-title":"The roles of vitamin D and its analogs in inflammatory diseases","volume":"16","author":"Lin","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Burgos-Molina, A.M., T\u00e9llez Santana, T., Redondo, M., and Bravo Romero, M.J. (2024). The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25116188"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.4049\/jimmunol.164.9.4443","article-title":"Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells","volume":"164","author":"Piemonti","year":"2000","journal-title":"J. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/imm.12610","article-title":"Vitamin D immunoregulation through dendritic cells","volume":"148","author":"Bscheider","year":"2016","journal-title":"Immunology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: Modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cellimm.2012.10.009","article-title":"Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages","volume":"280","author":"Malaguarnera","year":"2012","journal-title":"Cell. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Skrobot, A., Demkow, U., and Wachowska, M. (2018). Immunomodulatory role of vitamin D: A review. Current Trends in Immunity and Respiratory Infections, Springer.","DOI":"10.1007\/5584_2018_246"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3748\/wjg.v22.i3.933","article-title":"Protective links between vitamin D, inflammatory bowel disease and colon cancer","volume":"22","author":"Meeker","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/1756283X10377820","article-title":"Vitamin D and gastrointestinal diseases: Inflammatory bowel disease and colorectal cancer","volume":"4","author":"Raman","year":"2011","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2174\/187152013804487443","article-title":"The anti-cancer actions of vitamin D","volume":"13","author":"Chiang","year":"2013","journal-title":"Anti-Cancer Agents Med. Chem.-Anti-Cancer Agents"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Starska-Kowarska, K. (2023). Role of vitamin D in head and neck cancer\u2014Immune function, anti-tumour effect, and its impact on patient prognosis. Nutrients, 15.","DOI":"10.3390\/nu15112592"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4772134","DOI":"10.1155\/2023\/4772134","article-title":"Vitamin D promotes ferroptosis in colorectal cancer stem cells via SLC7A11 downregulation","volume":"2023","author":"Guo","year":"2023","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Guo, S., Zhao, W., Zhang, T., Li, S., Guo, J., and Liu, L. (2023). Identification of a ferroptosis-related gene signature for prognosis prediction in colorectal cancer patients and relationship with vitamin D. J. Steroid Biochem. Mol. Biol., 227.","DOI":"10.1016\/j.jsbmb.2022.106234"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Nemeth, Z., Patonai, A., Simon-Szab\u00f3, L., and Tak\u00e1cs, I. (2023). Interplay of vitamin D and SIRT1 in tissue-specific metabolism\u2014Potential roles in prevention and treatment of non-communicable diseases including cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076154"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"18210","DOI":"10.1074\/jbc.M109.000034","article-title":"SirT1 is an inhibitor of proliferation and tumor formation in colon cancer","volume":"284","author":"Kabra","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Singh, P.K., and Campbell, M.J. (2012). 2 Vitamin D Receptor: Genomic and Epigenomic Effects. Vitamin D: Oxidative Stress, Immunity, and Aging, CRC Press.","DOI":"10.1201\/b13714-4"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"RP86913","DOI":"10.7554\/eLife.86913.3","article-title":"Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer","volume":"12","author":"Fiuza","year":"2023","journal-title":"eLife"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2174\/0929867324666171107103114","article-title":"SIRT1 as a therapeutic target in diabetic complications","volume":"25","author":"Strycharz","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., and Fuchs, C. (2008). The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002020"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jsbmb.2017.06.010","article-title":"SIRT1 enzymatically potentiates 1, 25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation","volume":"172","author":"Sabir","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1755563","DOI":"10.1155\/2022\/1755563","article-title":"Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2\/Akt Signaling","volume":"2022","author":"Yuan","year":"2022","journal-title":"J. Diabetes Res."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Borojevi\u0107, A., Jaukovi\u0107, A., Kukolj, T., Mojsilovi\u0107, S., Obradovi\u0107, H., Trivanovi\u0107, D., \u017divanovi\u0107, M., Ze\u010devi\u0107, \u017d., Simi\u0107, M., and Gobelji\u0107, B. (2022). Vitamin D3 stimulates proliferation capacity, expression of pluripotency markers, and osteogenesis of human bone marrow mesenchymal stromal\/stem cells, partly through SIRT1 signaling. Biomolecules, 12.","DOI":"10.3390\/biom12020323"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Carafa, V., Altucci, L., and Nebbioso, A. (2019). Dual tumor suppressor and tumor promoter action of sirtuins in determining malignant phenotype. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00038"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cub.2016.12.047","article-title":"Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development","volume":"27","author":"Ren","year":"2017","journal-title":"Curr. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/infdis\/jiu235","article-title":"Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation","volume":"210","author":"Assa","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jcmgh.2020.05.010","article-title":"Vitamin D receptor protects against dysbiosis and tumorigenesis via the JAK\/STAT pathway in intestine","volume":"10","author":"Zhang","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Naderpoor, N., Mousa, A., Fernanda Gomez Arango, L., Barrett, H.L., Dekker Nitert, M., and de Courten, B. (2019). Effect of Vitamin D Supplementation on Faecal Microbiota: A Randomised Clinical Trial. Nutrients, 11.","DOI":"10.3390\/nu11122888"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e00083-24","DOI":"10.1128\/spectrum.00083-24","article-title":"Randomized control trial of moderate dose vitamin D alters microbiota stability and metabolite networks in healthy adults","volume":"12","author":"Wyatt","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1007\/s00432-022-04552-7","article-title":"Combined effects of vitamin D and neferine on the progression and metastasis of colorectal cancer","volume":"149","author":"Yang","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1002\/ptr.6687","article-title":"Neferine, an alkaloid from lotus seed embryo targets HELA and SIHA cervical cancer cells via pro-oxidant anticancer mechanism","volume":"34","author":"Dasari","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Ungvari, Z., Fekete, M., Varga, P., Fekete, J.T., Buda, A., Szappanos, \u00c1., Lehoczki, A., M\u00f3zes, N., Grosso, G., and Menyhart, O. (2025). Impact of adherence to the Mediterranean diet on stroke risk. GeroScience.","DOI":"10.1007\/s11357-024-01491-8"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Ungvari, Z., Fekete, M., Varga, P., Lehoczki, A., Munk\u00e1csy, G., Fekete, J.T., Bianchini, G., Ocana, A., Buda, A., and Ungvari, A. (2025). Association between red and processed meat consumption and colorectal cancer risk: A comprehensive meta-analysis of prospective studies. GeroScience.","DOI":"10.1007\/s11357-025-01646-1"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zhao, W., Chen, Q., Zhang, Q., Li, S., Zhao, J., Chen, W., Yang, J., Xia, M., and Liu, Y. (2024). Association of adherence to the EAT-Lancet diet with risk of dementia according to social economic status: A prospective cohort in UK Biobank. GeroScience.","DOI":"10.1007\/s11357-024-01333-7"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s11357-024-01361-3","article-title":"Association of a DASH diet and magnetoencephalography in dementia-free adults with different risk levels of Alzheimer\u2019s disease","volume":"47","author":"Aparicio","year":"2024","journal-title":"GeroScience"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Ungvari, Z., Fekete, M., Lehoczki, A., Munk\u00e1csy, G., Fekete, J.T., Z\u00e1b\u00f3, V., Purebl, G., Varga, P., Ungvari, A., and Gy\u0151rffy, B. (2025). Sleep disorders increase the risk of dementia, Alzheimer\u2019s disease, and cognitive decline: A meta-analysis. GeroScience.","DOI":"10.1007\/s11357-025-01637-2"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s11357-024-01296-9","article-title":"Adherence to the Mediterranean diet and its protective effects against colorectal cancer: A meta-analysis of 26 studies with 2,217,404 participants","volume":"47","author":"Ungvari","year":"2024","journal-title":"GeroScience"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Fekete, M., Cs\u00edp\u0151, T., Fazekas-Pongor, V., B\u00e1lint, M., Csizmadia, Z., Tarantini, S., and Varga, J.T. (2023). The Possible Role of Food and Diet in the Quality of Life in Patients with COPD-A State-of-the-Art Review. Nutrients, 15.","DOI":"10.3390\/nu15183902"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Fekete, M., Varga, P., Ungvari, Z., Fekete, J.T., Buda, A., Szappanos, \u00c1., Lehoczki, A., M\u00f3zes, N., Grosso, G., and Godos, J. (2025). The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer\u2019s disease: A meta-analysis. GeroSscience, 1\u201320.","DOI":"10.1007\/s11357-024-01488-3"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1007\/s11357-024-01247-4","article-title":"A systematic review of diet and medication use among centenarians and near-centenarians worldwide","volume":"46","author":"Dai","year":"2024","journal-title":"GeroScience"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11357-024-01290-1","article-title":"The role of atrial fibrillation in vascular cognitive impairment and dementia: Epidemiology, pathophysiology, and preventive strategies","volume":"47","author":"Fekete","year":"2025","journal-title":"GeroScience"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1007\/s11357-022-00615-2","article-title":"Which components of the Mediterranean diet are associated with dementia? A UK Biobank cohort study","volume":"44","author":"Dobreva","year":"2022","journal-title":"Geroscience"},{"key":"ref_164","first-page":"3801","article-title":"Survival and longevity of European rulers: Geographical influences and exploring potential factors, including the Mediterranean diet\u2014A historical analysis from 1354 to the twentieth century","volume":"46","author":"Szarvas","year":"2024","journal-title":"GeroScience"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s11357-024-01365-z","article-title":"Nut consumption is associated with a lower risk of all-cause dementia in adults: A community-based cohort study from the UK Biobank","volume":"47","author":"Beneit","year":"2024","journal-title":"Geroscience"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s40520-024-02823-6","article-title":"Fish consumption, cognitive impairment and dementia: An updated dose-response meta-analysis of observational studies","volume":"36","author":"Godos","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s11357-019-00149-0","article-title":"One-year Mediterranean diet promotes epigenetic rejuvenation with country-and sex-specific effects: A pilot study from the NU-AGE project","volume":"42","author":"Gensous","year":"2020","journal-title":"Geroscience"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s11357-023-00882-7","article-title":"Personalization matters: The effect of sex in multivitamin-multimineral-based cancer prevention","volume":"46","author":"Selb","year":"2024","journal-title":"Geroscience"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1038\/s41467-023-42523-9","article-title":"Healthy dietary patterns and the risk of individual chronic diseases in community-dwelling adults","volume":"14","author":"Shang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41416-023-02306-x","article-title":"Consumption of olive oil and risk of breast cancer in U.S. women: Results from the Nurses\u2019 Health Studies","volume":"129","author":"Willett","year":"2023","journal-title":"Br. J. Cancer"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1556\/650.2021.31973","article-title":"Az \u00f3mega-3 zs\u00edrsavak p\u00f3tl\u00e1s\u00e1nak klinikai \u00e9rt\u00e9ke kr\u00f3nikus obstrukt\u00edv t\u00fcd\u0151betegs\u00e9gben","volume":"162","author":"Fekete","year":"2021","journal-title":"Orvosi Hetil."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11357-015-9758-0","article-title":"Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population","volume":"37","author":"GGu","year":"2015","journal-title":"Age"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s11357-011-9305-6","article-title":"Mediterranean diet reduces senescence-associated stress in endothelial cells","volume":"34","author":"Marin","year":"2012","journal-title":"Age"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11357-010-9193-1","article-title":"Does the Mediterranean diet predict longevity in the elderly? A Swedish perspective","volume":"33","author":"Tognon","year":"2011","journal-title":"Age"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Papadopoulou, S.K., Detopoulou, P., Voulgaridou, G., Tsoumana, D., Spanoudaki, M., Sadikou, F., Papadopoulou, V.G., Zidrou, C., Chatziprodromidou, I.P., and Giaginis, C. (2023). Mediterranean Diet and Sarcopenia Features in Apparently Healthy Adults over 65 Years: A Systematic Review. Nutrients, 15.","DOI":"10.3390\/nu15051104"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"112110","DOI":"10.1016\/j.exger.2023.112110","article-title":"The role of nutrition and the Mediterranean diet on the trajectories of cognitive decline","volume":"173","author":"Maggi","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"155594","DOI":"10.1016\/j.metabol.2023.155594","article-title":"A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: The DIRECT PLUS randomized controlled trial","volume":"145","author":"Hoffmann","year":"2023","journal-title":"Metabolism"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Z\u00e1b\u00f3, V., Lehoczki, A., Fekete, M., Szappanos, \u00c1., Varga, P., Moizs, M., Giovannetti, G., Loscalzo, Y., Giannini, M., and Polidori, M.C. (GeroScience, 2025). The role of purpose in life in healthy aging: Implications for the Semmelweis Study and the Semmelweis-EUniWell Workplace Health Promotion Model Program, GeroScience, Advance online publication.","DOI":"10.1007\/s11357-025-01625-6"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"112143","DOI":"10.1016\/j.exger.2023.112143","article-title":"Mediterranean diet, mental health, cognitive status, quality of life, and successful aging in southern Italian older adults","volume":"175","author":"Godos","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1001\/jamapsychiatry.2023.0800","article-title":"Association of the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet with the Risk of Dementia","volume":"80","author":"Chen","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1017\/S0007114521003251","article-title":"The role of a Mediterranean diet and physical activity in decreasing age-related inflammation through modulation of the gut microbiota composition","volume":"128","author":"Clark","year":"2022","journal-title":"Br. J. Nutr."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41430-020-00841-x","article-title":"Mediterranean diet and the hallmarks of ageing","volume":"75","author":"Shannon","year":"2021","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s11357-024-01457-w","article-title":"Exploring the global impact of obesity and diet on dementia burden: The role of national policies and sex differences","volume":"47","author":"Cao","year":"2025","journal-title":"GeroScience"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Fekete, M., Szarvas, Z., Fazekas-Pongor, V., Feher, A., Csipo, T., Forrai, J., Dosa, N., Peterfi, A., Lehoczki, A., and Tarantini, S. (2022). Nutrition strategies promoting healthy aging: From improvement of cardiovascular and brain health to prevention of age-associated diseases. Nutrients, 15.","DOI":"10.3390\/nu15010047"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Fekete, M., Lehoczki, A., Tarantini, S., Fazekas-Pongor, V., Cs\u00edp\u0151, T., Csizmadia, Z., and Varga, J.T. (2023). Improving Cognitive Function with Nutritional Supplements in Aging: A Comprehensive Narrative Review of Clinical Studies Investigating the Effects of Vitamins, Minerals, Antioxidants, and Other Dietary Supplements. Nutrients, 15.","DOI":"10.3390\/nu15245116"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Saketkoo, L.A., Escorpizo, R., Varga, J., Keen, K.J., Fligelstone, K., Birring, S.S., Alexanderson, H., Pettersson, H., Chaudhry, H.A., and Poole, J.L. (2022). World Health Organization (WHO) international classification of functioning, disability and health (ICF) core set development for interstitial lung disease. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.979788"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Patai, R., Patel, K., Csik, B., Gulej, R., Nagaraja, R.Y., Nagy, D., Chandragiri, S.S., Shanmugarama, S., Kordestan, K.V., and Nagykaldi, M. (2025). Aging, mitochondrial dysfunction, and cerebral microhemorrhages: A preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening. GeroScience.","DOI":"10.1007\/s11357-025-01634-5"},{"key":"ref_188","first-page":"1357","article-title":"Mediterranean lifestyle index and 24-h systolic blood pressure and heart rate in community-dwelling older adults","volume":"46","author":"Banegas","year":"2024","journal-title":"GeroScience"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Fekete, M., Cs\u00edp\u0151, T., Fazekas-Pongor, V., Feh\u00e9r, \u00c1., Szarvas, Z., Kaposv\u00e1ri, C., Horv\u00e1th, K., Lehoczki, A., Tarantini, S., and Varga, J.T. (2023). The Effectiveness of Supplementation with Key Vitamins, Minerals, Antioxidants and Specific Nutritional Supplements in COPD-A Review. Nutrients, 15.","DOI":"10.3390\/nu15122741"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s11357-023-00753-1","article-title":"Ultra-processed food consumption and nutritional frailty in older age","volume":"45","author":"Zupo","year":"2023","journal-title":"GeroScience"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11357-022-00614-3","article-title":"Plant-based diets and risk of frailty in community-dwelling older adults: The Seniors-ENRICA-1 cohort","volume":"45","year":"2023","journal-title":"GeroScience"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"40214","DOI":"10.18632\/oncotarget.16597","article-title":"Prognostic value of circulating vitamin D binding protein, total, free and bioavailable 25-hydroxy vitamin D in patients with colorectal cancer","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/jgh.13326","article-title":"Prognostic role of 25-hydroxyvitamin D in patients with liver metastases from colorectal cancer treated with radiofrequency ablation","volume":"31","author":"Facciorusso","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10654-017-0298-z","article-title":"Relationship of very low serum 25-hydroxyvitamin D 3 levels with long-term survival in a large cohort of colorectal cancer patients from Germany","volume":"32","author":"Maalmi","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10552-011-9885-6","article-title":"Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: A population-based study","volume":"23","author":"Tretli","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1200\/JCO.2013.54.5947","article-title":"Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer","volume":"32","author":"Zgaga","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1200\/JCO.2010.31.7255","article-title":"Vitamin D status in patients with stage IV colorectal cancer: Findings from Intergroup trial N9741","volume":"29","author":"Ng","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Mezawa, H., Sugiura, T., Watanabe, M., Norizoe, C., Takahashi, D., Shimojima, A., Tamez, S., Tsutsumi, Y., Yanaga, K., and Urashima, M. (2010). Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study. BMC Cancer, 10.","DOI":"10.1186\/1471-2407-10-347"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1158\/1055-9965.EPI-11-1065","article-title":"Prediagnostic 25-hydroxyvitamin D, VDR and CASR polymorphisms, and survival in patients with colorectal cancer in western European populations","volume":"21","author":"Fedirko","year":"2012","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1158\/1078-0432.CCR-19-0877","article-title":"Plasma 25-hydroxyvitamin D levels and survival in patients with advanced or metastatic colorectal cancer: Findings from CALGB\/SWOG 80405 (Alliance)","volume":"25","author":"Yuan","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/annonc\/mdx109","article-title":"Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance)","volume":"28","author":"Fuchs","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.nutres.2019.03.010","article-title":"Lower serum 25-hydroxyvitamin D is associated with colorectal and breast cancer, but not overall cancer risk: A 20-year cohort study","volume":"67","author":"Zhu","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Heath, A.K., Hodge, A.M., Ebeling, P.R., Kvaskoff, D., Eyles, D.W., Giles, G.G., English, D.R., and Williamson, E.J. (2020). Circulating 25-hydroxyvitamin D concentration and cause-specific mortality in the Melbourne Collaborative Cohort Study. J. Steroid Biochem. Mol. Biol., 198.","DOI":"10.1016\/j.jsbmb.2020.105612"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/ijc.32105","article-title":"Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark","volume":"145","author":"Vojdeman","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10654-015-0040-7","article-title":"Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: An analysis of cohorts participating in the CHANCES consortium","volume":"31","author":"Fedirko","year":"2016","journal-title":"Eur. J. Epidemiol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1158\/1055-9965.EPI-12-1332","article-title":"Serum 25-hydroxyvitamin d and cancer risk in older adults: Results from a large German prospective cohort study","volume":"22","author":"Haug","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1158\/1055-9965.EPI-14-0007","article-title":"Prospective population-based study of the association between serum 25-hydroxyvitamin-D levels and the incidence of specific types of cancer","volume":"23","author":"Skaaby","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Wong, Y.Y.E., Hyde, Z., McCaul, K.A., Yeap, B.B., Golledge, J., Hankey, G.J., and Flicker, L. (2014). In older men, lower plasma 25-hydroxyvitamin D is associated with reduced incidence of prostate, but not colorectal or lung cancer. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099954"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1158\/1055-9965.EPI-13-0199","article-title":"C-reactive protein, lipid-soluble micronutrients, and survival in colorectal cancer patients","volume":"22","author":"Cooney","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1200\/JCO.2007.15.1027","article-title":"Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer","volume":"26","author":"Ng","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cgh.2013.10.011","article-title":"Association between reduced plasma 25-hydroxy vitamin D and increased risk of cancer in patients with inflammatory bowel diseases","volume":"12","author":"Ananthakrishnan","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000485512","article-title":"The Association between Serum 25-Hydroxyvitamin D and Cancer Risk: Results from the Prospective KORA F4 Study","volume":"41","author":"Cheney","year":"2018","journal-title":"Oncol. Res. Treat."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Boughanem, H., Canudas, S., Hernandez-Alonso, P., Becerra-Tom\u00e1s, N., Babio, N., Salas-Salvad\u00f3, J., and Macias-Gonzalez, M. (2021). Vitamin D intake and the risk of colorectal cancer: An updated meta-analysis and systematic review of case-control and prospective cohort studies. Cancers, 13.","DOI":"10.3390\/cancers13112814"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1022591007673","article-title":"Calcium, vitamin D, dairy products, and risk of colorectal cancer in the Cancer Prevention Study II Nutrition Cohort (United States)","volume":"14","author":"McCullough","year":"2003","journal-title":"Cancer Causes Control"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/jnci\/88.19.1375","article-title":"Calcium, vitamin D, and the occurrence of colorectal cancer among women","volume":"88","author":"Giovannucci","year":"1996","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/oxfordjournals.aje.a116640","article-title":"Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women. The Iowa Women\u2019s Health Study","volume":"137","author":"Bostick","year":"1993","journal-title":"Am. J. Epidemiol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/oxfordjournals.aje.a008834","article-title":"Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men","volume":"143","author":"Keamey","year":"1996","journal-title":"Am. J. Epidemiol."},{"key":"ref_218","first-page":"221","article-title":"A prospective cohort study of intake of calcium, vitamin D, and other micronutrients in relation to incidence of rectal cancer among postmenopausal women","volume":"7","author":"Zheng","year":"1998","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1007\/s00394-021-02585-1","article-title":"Dietary vitamin D intake and colorectal cancer risk: A longitudinal approach within the PREDIMED study","volume":"60","author":"Canudas","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Kopp, T.I., Vogel, U., and Andersen, V. (2020). Associations between common polymorphisms in CYP2R1 and GC, Vitamin D intake and risk of colorectal cancer in a prospective case-cohort study in Danes. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228635"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ijc.21148","article-title":"Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study","volume":"117","author":"Kesse","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00535-024-02129-4","article-title":"Dietary vitamin D intake and risk of colorectal cancer according to vitamin D receptor expression in tumors and their surrounding stroma","volume":"59","author":"Nakano","year":"2024","journal-title":"J. Gastroenterol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(85)91082-7","article-title":"Dietary vitamin D and calcium and risk of colorectal cancer: A 19-year prospective study in men","volume":"325","author":"Garland","year":"1985","journal-title":"Lancet"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3945\/ajcn.2008.26195","article-title":"Dietary calcium, vitamin D, and the risk of colorectal cancer","volume":"88","author":"Ishihara","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/sj.ejcn.1601260","article-title":"Prospective study on milk products, calcium and cancers of the colon and rectum","volume":"55","author":"Knekt","year":"2001","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1207\/S15327914NC431_4","article-title":"Dietary calcium and vitamin D intake and risk of colorectal cancer: A prospective cohort study in women","volume":"43","author":"Terry","year":"2002","journal-title":"Nutr. Cancer"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1024\/0300-9831\/a000733","article-title":"Sources of vitamin D for humans","volume":"92","author":"Benedik","year":"2022","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Clemente-Su\u00e1rez, V.J., Beltr\u00e1n-Velasco, A.I., Redondo-Fl\u00f3rez, L., Mart\u00edn-Rodr\u00edguez, A., and Tornero-Aguilera, J.F. (2023). Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15122749"},{"key":"ref_229","unstructured":"Erem, S., and Razzaque, M.S. (2021). Benefits of safe sunlight exposure: Vitamin D and beyond. J. Steroid Biochem. Mol. Biol., 27."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Morgado-Diaz, J.A. (2022). The Role of Diet and Lifestyle in Colorectal Cancer Incidence and Survival. Gastrointestinal Cancers, Exon Publications.","DOI":"10.36255\/exon-publications-gastrointestinal-cancers"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"304","DOI":"10.12968\/johv.2014.2.6.304","article-title":"Identifying vitamin D deficiency and recommendations for at-risk groups","volume":"2","author":"Cowbrough","year":"2014","journal-title":"J. Health Visit."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1542\/peds.2007-1894","article-title":"Vitamin D deficiency in children and its management: Review of current knowledge and recommendations","volume":"122","author":"Misra","year":"2008","journal-title":"Pediatrics"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10552-021-01512-3","article-title":"The role of calcium and vitamin D dietary intake on risk of colorectal cancer: Systematic review and meta-analysis of case-control studies","volume":"33","author":"Molina","year":"2022","journal-title":"Cancer Causes Control"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00384-021-03879-w","article-title":"The effect of vitamin D on the occurrence and development of colorectal cancer: A systematic review and meta-analysis","volume":"36","author":"Xu","year":"2021","journal-title":"Int. J. Color. Dis."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1001\/jama.2019.2402","article-title":"Effect of high-dose vs standard-dose vitamin D3 supplementation on progression-free survival among patients with advanced or metastatic colorectal cancer: The SUNSHINE randomized clinical trial","volume":"321","author":"Ng","year":"2019","journal-title":"Jama"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/01635581.2018.1539188","article-title":"Associations of Calcium, Vitamin D, and Dairy Product Intakes with Colorectal Cancer Risk among Older Women: The Iowa Women\u2019s Health Study","volume":"71","author":"Um","year":"2019","journal-title":"Nutr. Cancer"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/aje\/kwk069","article-title":"Calcium and vitamin D intake and risk of colorectal cancer: The Multiethnic Cohort Study","volume":"165","author":"Park","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1809944","article-title":"Vitamin D supplements and prevention of cancer and cardiovascular disease","volume":"380","author":"Manson","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1056\/NEJMoa055222","article-title":"Calcium plus vitamin D supplementation and the risk of colorectal cancer","volume":"354","author":"Kotchen","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1001\/jama.2019.2210","article-title":"Effect of vitamin D supplementation on relapse-free survival among patients with digestive tract cancers: The AMATERASU randomized clinical trial","volume":"321","author":"Urashima","year":"2019","journal-title":"JAMA"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/01635581.2018.1445766","article-title":"Vitamin D supplementation and survival in metastatic colorectal cancer","volume":"70","author":"Librenjak","year":"2018","journal-title":"Nutr. Cancer"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/aje\/kwi101","article-title":"Intakes of calcium and vitamin D and risk of colorectal cancer in women","volume":"161","author":"Lin","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Serrano, D., Bellerba, F., Johansson, H., Macis, D., Aristarco, V., Accornero, C.A., Guerrieri-Gonzaga, A., Trovato, C.M., Zampino, M.G., and Sal\u00e8, E.O. (2023). Vitamin D Supplementation and Adherence to World Cancer Research Fund (WCRF) Diet Recommendations for Colorectal Cancer Prevention: A Nested Prospective Cohort Study of a Phase II Randomized Trial. Biomedicines, 11.","DOI":"10.3390\/biomedicines11061766"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1017\/S0007114523000077","article-title":"Pre-diagnostic intake of vitamin D and incidence of colorectal cancer by anatomical subsites: The Norwegian Women and Cancer Cohort Study (NOWAC)","volume":"130","author":"Paulsen","year":"2023","journal-title":"Br. J. Nutr."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1556\/650.2021.32332","article-title":"Ambul\u00e1ns rehabilit\u00e1ci\u00f3s programok COVID\u201319-betegek sz\u00e1m\u00e1ra","volume":"162","author":"Fekete","year":"2021","journal-title":"Orvosi Hetil."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Pludowski, P., Grant, W.B., Karras, S.N., Zittermann, A., and Pilz, S. (2024). Vitamin D supplementation: A review of the evidence arguing for a daily dose of 2000 international units (50 \u00b5g) of vitamin D for adults in the general population. Nutrients, 16.","DOI":"10.3390\/nu16030391"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/ajcn\/77.1.204","article-title":"Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol","volume":"77","author":"Heaney","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Wimalawansa, S.J. (2022). Rapidly Increasing Serum 25 (OH) D Boosts the Immune System, against Infections\u2014Sepsis and COVID-19. Nutrients, 14.","DOI":"10.3390\/nu14142997"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/j.gastro.2018.04.019","article-title":"Association between risk factors for colorectal cancer and risk of serrated polyps and conventional adenomas","volume":"155","author":"He","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"106072","DOI":"10.1016\/j.ypmed.2020.106072","article-title":"Vitamin D supplementation reduces the occurrence of colorectal polyps in high-latitude locations","volume":"135","author":"Sutherland","year":"2020","journal-title":"Prev. Med."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1158\/1940-6207.CAPR-12-0292","article-title":"A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on the APC\/\u03b2-catenin pathway in the normal mucosa of colorectal adenoma patients","volume":"5","author":"Ahearn","year":"2012","journal-title":"Cancer Prev. Res."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/mc.22945","article-title":"Effects of vitamin D and calcium on expression of MSH2 and transforming growth factors in normal-appearing colorectal mucosa of sporadic colorectal adenoma patients: A randomized clinical trial","volume":"58","author":"Kwan","year":"2019","journal-title":"Mol. Carcinog."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/gutjnl-2017-315242","article-title":"Calcium and vitamin D supplementation and increased risk of serrated polyps: Results from a randomised clinical trial","volume":"68","author":"Crockett","year":"2019","journal-title":"Gut"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1056\/NEJMoa1500409","article-title":"A trial of calcium and vitamin D for the prevention of colorectal adenomas","volume":"373","author":"Baron","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cgh.2020.02.013","article-title":"No association between vitamin D supplementation and risk of colorectal adenomas or serrated polyps in a randomized trial","volume":"19","author":"Song","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/8\/1351\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:14:48Z","timestamp":1760030088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/8\/1351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":255,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["nu17081351"],"URL":"https:\/\/doi.org\/10.3390\/nu17081351","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]}}}