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Andaluc\u00eda","award":["FI22\/00294"],"award-info":[{"award-number":["FI22\/00294"]}]},{"name":"Consejer\u00eda de Salud, Junta de Andaluc\u00eda","award":["IHMC22-00011"],"award-info":[{"award-number":["IHMC22-00011"]}]},{"name":"Consejer\u00eda de Salud, Junta de Andaluc\u00eda","award":["C1-0005-2020"],"award-info":[{"award-number":["C1-0005-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Extra virgin olive oil (EVOO), an essential element of the Mediterranean diet (MedDiet), has demonstrated considerable potential in improving mitochondrial health and protecting against chronic diseases. This narrative review aims to explore how the main phenolic compounds found in EVOO\u2014hydroxytyrosol, oleuropein, and oleocanthal\u2014contribute to mitochondrial health by reducing oxidative stress and inflammation. Methods: A search for scientific evidence was carried out between October 2024 and March 2025 in different bibliographic databases such as PubMed, Web of Science, Embase, SciSpace, and ResearchRabbit databases. The search strategy included combinations of terms such as \u201cextra virgin olive oil\u201d, \u201cEVOO polyphenols\u201d, \u201cmitochondrial function\u201d, \u201coxidative stress\u201d, \u201cinflammation\u201d, \u201cmitophagy\u201d, and \u201cchronic diseases\u201d. Preclinical, clinical, and mechanistic studies were included, giving priority to peer-reviewed publications. Results: This narrative review shows how some bioactive components of EVOO activate cellular pathways, such as mTOR, AMPK and sirtuins, which promote mitochondrial biogenesis, improve the efficiency of the electron transport chain, and protect mitochondrial DNA integrity. Furthermore, EVOO improves mitochondrial membrane fluidity and integrity, ensuring its functionality and efficiency. On the other hand, nutrition literacy, an important component of health, is a critical determinant of people\u2019s eating behaviors. Conclusions: Although recent scientific evidence supports the metabolic benefits of EVOO components on mitochondrial metabolism and function, further nutritional intervention studies with these components are recommended to confirm their clinical relevance as a dietary tool aimed at preventing and\/or delaying age-related metabolic diseases.<\/jats:p>","DOI":"10.3390\/nu17091443","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T06:10:13Z","timestamp":1745561413000},"page":"1443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Extra Virgin Olive Oil Phenolic Compounds: Modulating Mitochondrial Function and Protecting Against Chronic Diseases\u2014A Narrative Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Mar\u00eda","family":"Silva-Soto","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Regional University Hospital of M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA-Plataforma Bionand), University of M\u00e1laga, Avda. Hospital Civil s\/n, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-4469","authenticated-orcid":false,"given":"Paloma","family":"Carrillo-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"UCM Digestive Diseases, Virgen del Roc\u00edo University Hospital, Instituto de Biomedicina de Sevilla (HUVR\/CSIC\/US), Department of Medicine, University of Seville, 41004 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-6482","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Saez Lancellotti","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Regional University Hospital of M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA-Plataforma Bionand), University of M\u00e1laga, Avda. Hospital Civil s\/n, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Medina-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Regional University Hospital of M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA-Plataforma Bionand), University of M\u00e1laga, Avda. Hospital Civil s\/n, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9012-4289","authenticated-orcid":false,"given":"Juan","family":"Mogaburo Alba","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Regional University Hospital of M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA-Plataforma Bionand), University of M\u00e1laga, Avda. Hospital Civil s\/n, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Catena-Granados","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Regional University Hospital of M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA-Plataforma Bionand), University of M\u00e1laga, Avda. Hospital Civil s\/n, 29009 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-076X","authenticated-orcid":false,"given":"Mar\u00eda","family":"L\u00f3pez-Carmona","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Regional University Hospital of M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA-Plataforma Bionand), University of M\u00e1laga, Avda. 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