{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:49:01Z","timestamp":1789728541429,"version":"4.0.1"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australasian Gastrointestinal Research Foundation (AGIRF)"},{"name":"The Yencken Family"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Exclusive Enteral Nutrition (EEN) and the Crohn\u2019s Disease Exclusion Diet (CDED) have been shown to induce remission in Crohn\u2019s disease. Low-sulphur, plant-based diets are being explored for ulcerative colitis, and wholefood, low-additive approaches are emerging as significant. Although Inflammatory Bowel Disease (IBD) patients modify their diet, evidence for tolerability and benefit outside clinical trials is limited. The DELECTABLE program aimed to assess satisfaction, adherence, and efficacy of dietary therapies as part of IBD care. Methods: In this dietitian-led, open-label, prospective study, patients with Crohn\u2019s disease were offered the CDED or a whole-food, additive-free diet (WFD), and patients with ulcerative colitis were offered a low-sulphur, plant-based diet (UCD) or WFD. Primary outcomes were 12-week diet satisfaction (modified DSAT-28) and diet adherence, including food additive intake. Secondary outcomes were quality of life (QoL) (IBDQ-9), disease activity (CDAI for Crohn\u2019s disease, partial Mayo score for ulcerative colitis), and biochemical markers (CRP, faecal calprotectin). Analyses were conducted within, rather than between, diet arms due to the non-random nature of the study. Diet adherence and disease activity change across time points (baseline, week 6, week 12) were assessed using repeated measures ANOVA or Friedman\u2019s test, with pairwise paired t-test or Wilcoxon Signed-Rank test. Diet satisfaction and quality of life changes across time (baseline\/week 1, week 12) were assessed using a paired t-test or Wilcoxon Signed-Rank test. Results: Of 165 referrals, 76 patients enrolled, with 64 completing the 12-week program (CDED: n = 15, WFD: n = 42, UCD: n = 7). Diet satisfaction was initially high and remained stable over time on CDED (p = 0.212) and improved on WFD (p = 0.03). Patient- and dietitian-rated adherence was high at baseline and did not significantly decrease on any diet arm (p &gt; 0.349). Food additive intake decreased on WFD (p = 0.009). QoL improved on CDED and WFD (p &lt; 0.001). CRP, calprotectin, and CDAI were reduced on CDED (p &lt; 0.045), and CDAI and partial Mayo were reduced on WFD (p &lt; 0.027). Conclusions: Well-balanced therapeutic diets are feasible and well-accepted by patients with IBD, with a promising impact on disease activity.<\/jats:p>","DOI":"10.3390\/nu17091592","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T09:08:56Z","timestamp":1746522536000},"page":"1592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Practical Application of Evidence-Based Dietary Therapy in Inflammatory Bowel Disease: The DELECTABLE Program"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2483-0899","authenticated-orcid":false,"given":"Gina","family":"Trakman","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Vincent\u2019s Hospital, Melbourne 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne, Melbourne 3065, Australia"},{"name":"Discipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Science, La Trobe University, Melbourne 3086, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent\u2019s Hospital, Melbourne 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne, Melbourne 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-2057","authenticated-orcid":false,"given":"Amy","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent\u2019s Hospital, Melbourne 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne, Melbourne 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wilson-O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent\u2019s Hospital, Melbourne 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne, Melbourne 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4609-001X","authenticated-orcid":false,"given":"Emily","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, St Vincent\u2019s Hospital, Melbourne 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6075-1557","authenticated-orcid":false,"given":"Natalie","family":"Simmance","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, St Vincent\u2019s Hospital, Melbourne 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Niewiadomski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent\u2019s Hospital, Melbourne 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne, Melbourne 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kamm","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Vincent\u2019s Hospital, Melbourne 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne, Melbourne 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology and Risk Factors for IBD","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bpg.2010.01.002","article-title":"Adverse Effects of Biologics Used for Treating IBD","volume":"24","author":"Stallmach","year":"2010","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.5217\/ir.2017.15.4.434","article-title":"Medication Adherence in Inflammatory Bowel Disease","volume":"15","author":"Chan","year":"2017","journal-title":"Intest. Res."},{"key":"ref_4","first-page":"246","article-title":"Exclusive Enteral Nutrition Induces Early Clinical, Mucosal and Transmural Remission in Paediatric Crohn\u2019s Disease","volume":"18","author":"Grover","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.3748\/wjg.v19.i43.7652","article-title":"Use of Exclusive Enteral Nutrition in Adults with Crohn\u2019s Disease: A Review","volume":"19","author":"Wall","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2023.11.303","article-title":"AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review","volume":"166","author":"Hashash","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/flgastro-2022-102173","article-title":"Lessons from an Audit of Exclusive Enteral Nutrition in Adult Inpatients and Outpatients with ACTIVE Crohn\u2019s disease: A Single-Centre Experience","volume":"14","author":"Melton","year":"2023","journal-title":"Front. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jgh3.12256","article-title":"An Optimal Care Pathway for Use in Adult Patients with Active Crohn\u2019s Disease","volume":"4","author":"Day","year":"2020","journal-title":"JGH Open"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.clnu.2018.01.020","article-title":"Exclusive Enteral Nutrition in Crohn\u2019s Disease: Evidence and Practicalities","volume":"38","author":"Ashton","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000494022","article-title":"Patient\u2019s Dietary Beliefs and Behaviours in Inflammatory Bowel Disease","volume":"37","author":"Dijkhuizen","year":"2019","journal-title":"Dig. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/MIB.0000000000000585","article-title":"Dietary Practices and Beliefs in Patients with Inflammatory Bowel Disease","volume":"22","author":"Limdi","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/jhn.12400","article-title":"Patients with Inflammatory Bowel Disease and Their Treating Clinicians Have Different Views Regarding Diet","volume":"30","author":"Holt","year":"2017","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"105650","DOI":"10.1016\/j.appet.2021.105650","article-title":"Food Avoidance, Restrictive Eating Behaviour and Association with Quality of Life in Adults with Inflammatory Bowel Disease: A Systematic Scoping Review","volume":"167","author":"Day","year":"2021","journal-title":"Appetite"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41575-022-00619-5","article-title":"Dietary Management of Adults with IBD\u2014The Emerging Role of Dietary Therapy","volume":"19","author":"Fitzpatrick","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1136\/gutjnl-2017-315866","article-title":"Evolving Role of Diet in the Pathogenesis and Treatment of Inflammatory BOWEL diseases","volume":"67","author":"Levine","year":"2018","journal-title":"Gut"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature14232","article-title":"Dietary Emulsifiers Impact the Mouse Gut Microbiota Promoting Colitis and Metabolic Syndrome","volume":"519","author":"Chassaing","year":"2015","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1136\/gutjnl-2016-313099","article-title":"Dietary Emulsifiers Directly Alter Human Microbiota Composition and Gene Expression ex vivo Potentiating Intestinal Inflammation","volume":"66","author":"Chassaing","year":"2017","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.toxlet.2012.04.012","article-title":"Pro-Inflammatory NF-\u03baB and Early Growth Response Gene 1 Regulate Epithelial Barrier Disruption by Food Additive Carrageenan in Human Intestinal Epithelial Cells","volume":"211","author":"Choi","year":"2012","journal-title":"Toxicol. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ibd.20763","article-title":"Bacterial Overgrowth and Inflammation of Small Intestine After Carboxymethylcellulose Ingestion in Genetically Susceptible Mice","volume":"15","author":"Swidsinski","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S542","DOI":"10.1093\/ecco-jcc\/jjy222.961","article-title":"P837 The Common Food Additives Sodium Sulfite and Polysorbate 80 Have a Profound Inhibitory Effect on the Commensal, Anti-Inflammatory Bacterium Faecalibacterium Prausnitzii: The Enigma Study","volume":"13","author":"Berendsen","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sandall, A.M., Cox, S.R., Lindsay, J.O., Gewirtz, A.T., Chassaing, B., Rossi, M., and Whelan, K. (2020). Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn\u2019s Disease. Nutrients, 12.","DOI":"10.3390\/nu12092827"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Marion-Letellier, R., Amamou, A., Savoye, G., and Ghosh, S. (2019). Inflammatory Bowel Diseases and Food Additives: To Add Fuel on the Flames!. Nutrients, 11.","DOI":"10.3390\/nu11051111"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/ecco-jcc\/jjaa254","article-title":"Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation: Mechanistic Insights in Inflammatory Bowel Disease","volume":"15","author":"Bancil","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.cgh.2020.01.046","article-title":"Dietary Guidance From the International Organization for the Study of Inflammatory Bowel Diseases","volume":"18","author":"Levine","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"440.e8","DOI":"10.1053\/j.gastro.2019.04.021","article-title":"Crohn\u2019s Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial","volume":"157","author":"Levine","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S2468-1253(21)00299-5","article-title":"The Crohn\u2019s Disease Exclusion Diet for Induction and Maintenance of Remission in Adults with Mild-to-Moderate Crohn\u2019s Disease (CDED-AD): An Open-Label, Pilot, Randomised Trial","volume":"7","author":"Yanai","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Szczube\u0142ek, M., Pomorska, K., Kor\u00f3lczyk-Kowalczyk, M., Lewandowski, K., Kaniewska, M., and Rydzewska, G. (2021). Effectiveness of Crohn\u2019s Disease Exclusion Diet for Induction of Remission in Crohn\u2019s Disease Adult Patients. Nutrients, 13.","DOI":"10.3390\/nu13114112"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/jgh.16414","article-title":"Practical Application of the Crohn\u2019s Disease Exclusion Diet as Therapy in an Adult Australian Population","volume":"39","author":"Russell","year":"2023","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1053\/j.gastro.2021.05.047","article-title":"A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn\u2019s Disease","volume":"161","author":"Lewis","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Nitescu, M., Istratescu, D., Preda, C.M., Manuc, T.E., Louis, E., Manuc, M., Stroie, T., Catrinoiu, M., Tieranu, C.G., and Badea, L.E. (2023). Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults. Medicina, 59.","DOI":"10.3390\/medicina59020329"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/ibd\/izaa018","article-title":"Dietary Patterns, Ultra-processed Food, and the Risk of Inflammatory Bowel Diseases in the NutriNet-Sant\u00e9 Cohort","volume":"27","author":"Vasseur","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Trakman, G.L., Lin, W.Y.Y., Hamilton, A.L., Wilson-O\u2019brien, A.L., Stanley, A., Ching, J.Y., Yu, J., Mak, J.W.Y., Sun, Y., and Niu, J. (2022). Processed Food as a Risk Factor for the Development and Perpetuation of Crohn\u2019s Disease\u2014The ENIGMA Study. Nutrients, 14.","DOI":"10.3390\/nu14173627"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"i1228","DOI":"10.1093\/ecco-jcc\/jjae190.0796","article-title":"P0622 Total Emulsifier Intake, but not Ultra-Processed Food Consumption Is Higher in Patients with Inflammatory Bowel Disease Compared to Healthy Controls","volume":"19","author":"Wellens","year":"2025","journal-title":"J. Crohns Colitis"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41430-024-01487-9","article-title":"A Pilot Randomized Controlled Trial Investigating the Effects of an Anti-Inflammatory Dietary Pattern on Disease Activity, Symptoms and Microbiota Profile in Adults with Inflammatory Bowel Disease","volume":"78","author":"Marsh","year":"2024","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/ejcn.2016.130","article-title":"The Association between the Intake of Specific Dietary Components and Lifestyle Factors and Microscopic Colitis","volume":"70","author":"Larsson","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/apt.16085","article-title":"Review Article: The Impact of Diet on Ileoanal Pouch Function and on the Pathogenesis of Pouchitis","volume":"52","author":"Ardalan","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/jn\/nxac093","article-title":"Therapeutic Potential of the 4 Strategies to SUlfide-REduction (4-SURE) Diet in Adults with Mild to Moderately Active Ulcerative Colitis: An Open-Label Feasibility Study","volume":"152","author":"Day","year":"2022","journal-title":"J. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-Fat-Induced Taurocholic Acid Promotes Pathobiont Expansion and Colitis in Il10\u2212\/\u2212 Mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Teigen, L.M., Geng, Z., Sadowsky, M.J., Vaughn, B.P., Hamilton, M.J., and Khoruts, A. (2019). Dietary Factors in Sulfur Metabolism and Pathogenesis of Ulcerative Colitis. Nutrients, 11.","DOI":"10.3390\/nu11040931"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.39.1.1","article-title":"Hydrogen Sulphide: A Bacterial Toxin in Ulcerative Colitis?","volume":"39","author":"Pitcher","year":"1996","journal-title":"Gut"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000371687","article-title":"Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases","volume":"33","author":"Devkota","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/ibd\/izae037","article-title":"Dietary Interventions and Supplementation in Patients with an Ileal Pouch\u2013Anal Anastomosis: A Systematic Review","volume":"31","author":"Gold","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_43","unstructured":"National Health and Medical Research Council (2013). Australian Dietary Guidelines."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Nickerson, K.P., and McDonald, C. (2012). Crohn\u2019s Disease-Associated Adherent-Invasive Escherichia coli Adhesion Is Enhanced by Exposure to the Ubiquitous Dietary Polysaccharide Maltodextrin. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052132"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., and Lu, K. (2017). The Artificial Sweetener Acesulfame Potassium Affects the Gut Microbiome and Body Weight Gain in CD-1 Mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178426"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature13793","article-title":"Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota","volume":"514","author":"Suez","year":"2014","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/MPG.0b013e3182464b0e","article-title":"Food Additives: Possible Cause for Recent Remarkable Increase of Inflammatory Bowel Disease in Children","volume":"54","author":"Qin","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41575-024-00893-5","article-title":"Ultra-Processed Foods and Food Additives in Gut Health and Disease","volume":"21","author":"Whelan","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/apt.13248","article-title":"Dietary Fibre\u2013Microbiota Interactions","volume":"42","author":"Simpson","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.micpath.2016.02.005","article-title":"Akkermansia Muciniphila and Its Role in Regulating Host Functions","volume":"106","author":"Derrien","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.molmed.2016.01.002","article-title":"Sulfide as a Mucus Barrier-Breaker in Inflammatory Bowel Disease?","volume":"22","author":"Ijssennagger","year":"2016","journal-title":"Trends Mol. Med."},{"key":"ref_52","unstructured":"(2016). Nutrient Reference Values for Australia and New Zealand."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research Electronic Data Capture (REDCap)\u2014A Metadata-Driven Methodology and Workflow Process for Providing Translational Research Informatics Support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Harris, P.A., Taylor, R., Minor, B.L., Elliott, V., Fernandez, M., O\u2019Neal, L., McLeod, L., Delacqua, G., Delacqua, F., and Kirby, J. (2019). The REDCap Consortium: Building an International Community of Software Platform Partners. J. Biomed. Inform., 95.","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1185\/03007995.2013.851075","article-title":"Revision and validation of Medication Adherence Reasons Scale (MAR-Scale)","volume":"30","author":"Unni","year":"2014","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Trakman, G.L., Lin, W., Wilson-O\u2019brien, A.L., Stanley, A., Hamilton, A.L., Tang, W., Or, L., Ching, J., Morrison, M., and Yu, J. (2020). Development and Validation of Surveys to Estimate Food Additive Intake. Nutrients, 12.","DOI":"10.3390\/nu12030812"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/osp4.299","article-title":"Validation of the Diet Satisfaction Questionnaire: A new measure of satisfaction with diets for weight management","volume":"4","author":"James","year":"2018","journal-title":"Obes. Sci. Pract."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of a Crohn\u2019s disease activity index. National Cooperative Crohn\u2019s Disease Study","volume":"70","author":"Best","year":"1976","journal-title":"Gastroenterology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/ibd.20520","article-title":"Use of the Noninvasive Components of the Mayo Score to Assess Clinical Response in Ulcerative Colitis","volume":"14","author":"Lewis","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1572-0241.2004.04071.x","article-title":"Assessment of the Influence of Disease Activity on the Quality of Life of Patients with Inflammatory Bowel Disease Using a Short Questionnaire","volume":"99","author":"Casellas","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wall, C.L., Bensley, R., Glyn, T., Haines, M., Rowbotham, D., Bissett, I., Eglinton, T., and Gearry, R.B. (2024). Preoperative Crohn\u2019s Disease Exclusion Diet and Exclusive Enteral Nutrition in Adults with Crohn\u2019s Disease: A Feasibility Randomised Controlled Trial. Nutrients, 16.","DOI":"10.3390\/nu16132105"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"i4","DOI":"10.1093\/ecco-jcc\/jjae190.0002","article-title":"OP02 Tasty & Healthy Flexible Diet Induces clinical and biological Remission in Children and Young Adults with Mild-Moderate Crohn\u2019s Disease similar to EEN: Results from the \u201cTASTI-MM\u201d randomized, physician-blinded, controlled trial","volume":"19","author":"Frutkoff","year":"2025","journal-title":"J. Crohns Colitis"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/ibd\/izad318","article-title":"Dietary Emulsifier Exposure in People with Inflammatory Bowel Disease Compared with Healthy Controls: Is There a Cause for Concern?","volume":"30","author":"Katsoudas","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Landry, M.J., Crimarco, A., Perelman, D., Durand, L.R., Petlura, C., Aronica, L., Robinson, J.L., Kim, S.H., and Gardner, C.D. (2021). Adherence to Ketogenic and Mediterranean Study Diets in a Crossover Trial: The Keto\u2013Med Randomized Trial. Nutrients, 13.","DOI":"10.3390\/nu13030967"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/ecco-jcc\/jjac145","article-title":"What are the Unmet Needs and Most Relevant Treatment Outcomes According to Patients with Inflammatory Bowel Disease? A Qualitative Patient Preference Study","volume":"17","author":"Schoefs","year":"2023","journal-title":"J. Crohns Colitis"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"i262","DOI":"10.1093\/ecco-jcc\/jjae190.0136","article-title":"Dop097 Emulsifier Restriction Is an Effective Therapy for Active Crohn\u2019s Disease: The Addapt Trial\u2014A Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Re-Supplementation Trial in 154 Patients","volume":"19","author":"Bancil","year":"2025","journal-title":"J. Crohns Colitis"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ibd\/izx100","article-title":"Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses\u2014Part I","volume":"24","author":"Knowles","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"otz019","DOI":"10.1093\/crocol\/otz019","article-title":"An Autoimmune Protocol Diet Improves Patient-Reported Quality of Life in Inflammatory Bowel Disease","volume":"1","author":"Chandrasekaran","year":"2019","journal-title":"Crohn\u2019s Colitis 360"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cgh.2020.05.026","article-title":"Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis","volume":"19","author":"Fritsch","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"i1460","DOI":"10.1093\/ecco-jcc\/jjae190.0931","article-title":"P0757 Emulsifier Restriction Does not Impair Nutrient Intake and Improves Food-Related Quality of Life in Active Crohn\u2019s Disease: Dietary Analysis of the ADDapt Randomised Controlled Trial","volume":"19","author":"Buckley","year":"2025","journal-title":"J. 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