{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:04:59Z","timestamp":1791608699888,"version":"4.3.4"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>By conducting a narrative review of the scientific literature, the authors of this study sought to verify whether there were sufficient data to answer the following question: \u201cCan wine positively or negatively influence the incidence and severity of disorders associated with gastrointestinal (GI) diseases?\u201d. In this review, most of the studies considered tested different alcoholic beverages (other than wine), not always reporting in the conclusions the possible difference in the extent of symptoms. Although alcohol certainly plays a central role in influencing the oesophageal and gastric environment, no studies evaluating the role of alcohol as such were included, since the aim of the review was to understand whether wine can be moderately consumed by patients with gastrointestinal diseases. The analysis of studies selected from the main reference databases indicates that even moderate wine consumption can be a source of discomfort in subjects with the GI diseases included in this review (gastritis and gastroesophageal disease, gastrointestinal motility, inflammatory bowel disease, irritable bowel syndrome, and microscopic colitis). This does not mean that a certain percentage of patients cannot tolerate moderate amounts of alcoholic beverages; however, discussion with the family doctor or specialist is essential to identify the correct diet in which to include or exclude the consumption of wine. One of the limitations of this review is the low number of studies available, at least for some of the pathologies considered. It is important to emphasise, however, that some selected epidemiological studies, which include many subjects (even over 100,000), can provide useful information from a scientific point of view.<\/jats:p>","DOI":"10.3390\/nu17101608","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:47:15Z","timestamp":1746686835000},"page":"1608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Moderate Wine Consumption and Gastrointestinal Diseases"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-5987","authenticated-orcid":false,"given":"Patrizia","family":"Restani","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e0 degli Studi di Milano, 20133 Milano, Italy"},{"name":"CRC \u201cInnovation for Well-Being and Environment\u201d, Universit\u00e0 degli Studi di Milano, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-8720","authenticated-orcid":false,"given":"Chiara","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"CRC \u201cInnovation for Well-Being and Environment\u201d, Universit\u00e0 degli Studi di Milano, 20122 Milano, Italy"},{"name":"Department of Pharmacological and Biomolecular Sciences, Universit\u00e0 degli Studi di Milano, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-1741","authenticated-orcid":false,"given":"Arina Oana","family":"Antoce","sequence":"additional","affiliation":[{"name":"Department of Bioengineering of Horti-Viticultural Systems, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 011464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Araujo","sequence":"additional","affiliation":[{"name":"OIV\u2014International Organisation of Vine and Wine, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-8746","authenticated-orcid":false,"given":"Corinne","family":"Bani","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences, Universit\u00e0 degli Studi di Milano, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-0437","authenticated-orcid":false,"given":"Francesca","family":"Mercogliano","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences, Universit\u00e0 degli Studi di Milano, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Ruf","sequence":"additional","affiliation":[{"name":"OIV\u2014International Organisation of Vine and Wine, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-6064","authenticated-orcid":false,"given":"Rena I.","family":"Kosti","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Physical Education, Sports and Dietetics, University of Thessaly, 42132 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-5456","authenticated-orcid":false,"given":"Pierre-Louis","family":"Teissedre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux, Bordeaux INP, INRAE, OENO, UMR 1366, ISVV, F-33140 Villenave d\u2019Ornon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1039\/C9FO01490J","article-title":"Habitual animal fat consumption in shaping gut microbiota and microbial metabolites","volume":"10","author":"Wan","year":"2019","journal-title":"Food Funct."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.cgh.2021.12.011","article-title":"Sugars and Gastrointestinal Health","volume":"20","author":"Arnone","year":"2022","journal-title":"Clin. 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