{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:49:28Z","timestamp":1788997768999,"version":"build-2803163510"},"reference-count":86,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Melbourne School of Psychological Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Research on eating disorders (EDs) in individuals with multiple sclerosis (MS) is limited. In ED populations, neuroticism has been linked to ED symptoms through lower self-esteem and greater body dissatisfaction, but these relationships remain unexplored in MS. This study aimed to examine whether self-esteem and body dissatisfaction mediate the link between neuroticism and ED symptoms in individuals with MS. Methods: The current sample consisted of 275 participants who reported a neurologist-confirmed diagnosis of MS (Mage = 43.0, SD = 12.9) with the majority being female (218\/275; 79.3%). Participants completed an online questionnaire measuring neuroticism (Big Five Inventory), self-esteem (Rosenberg Self-esteem Scale), body dissatisfaction (Body Shape Questionnaire), and ED symptoms (Eating Attitudes Test-26). Results: A serial mediation analysis controlling for age, sex, and level of ambulation revealed that the association between neuroticism and ED symptoms is respectively and serially explained by self-esteem and body dissatisfaction in individuals with MS. The total model accounted for 43% of the variance in ED symptoms. Conclusions: Findings suggest that self-esteem and body dissatisfaction are important in understanding the relationship between neuroticism and ED symptoms. Neuroticism, self-esteem, and body dissatisfaction may be important targets for assessing and treating EDs in individuals with MS. Future longitudinal research is needed to examine causal relationships.<\/jats:p>","DOI":"10.3390\/nu17101609","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:47:15Z","timestamp":1746686835000},"page":"1609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eating Disorder Symptoms in Multiple Sclerosis: Relationships Between Neuroticism, Body Dissatisfaction, and Self-Esteem"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-5904","authenticated-orcid":false,"given":"Litza","family":"Kiropoulos","sequence":"first","affiliation":[{"name":"Mood and Anxiety Disorders Lab, Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-3595","authenticated-orcid":false,"given":"Isabel","family":"Krug","sequence":"additional","affiliation":[{"name":"Eating Disorders Lab, Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-2396","authenticated-orcid":false,"given":"Phuong Linh","family":"Dang","sequence":"additional","affiliation":[{"name":"Mood and Anxiety Disorders Lab, Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC 3010, Australia"},{"name":"Eating Disorders Lab, Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref_1","first-page":"988","article-title":"Epidemiology and pathophysiology of multiple sclerosis","volume":"28","author":"Ward","year":"2022","journal-title":"Continuum"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.7224\/1537-2073.2018-066","article-title":"Prevalence and correlates of body image dissatisfaction in patients with multiple sclerosis","volume":"21","author":"Stevens","year":"2019","journal-title":"Int. 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