{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:18:10Z","timestamp":1794071890448,"version":"4.8.0"},"reference-count":100,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T00:00:00Z","timestamp":1747526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"North Denmark Region Health Science Research Fund","award":["2023-0054"],"award-info":[{"award-number":["2023-0054"]}],"id":[{"id":"https:\/\/ror.org\/003gkfx86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Department of Clinical Medicine, Aalborg University","award":["2023-0054"],"award-info":[{"award-number":["2023-0054"]}],"id":[{"id":"https:\/\/ror.org\/04m5j1k67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Department of Obstetrics and Gynecology, Aalborg University Hospital","award":["2023-0054"],"award-info":[{"award-number":["2023-0054"]}],"id":[{"id":"https:\/\/ror.org\/02jk5qe80","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: The aim of this systematic review and meta-analysis was to investigate the effect of dietary supplements on male infertility. Methods: PubMed, Embase, and CENTRAL were searched from inception to May 2024. Randomized controlled trials with treatment durations of \u226512 weeks investigating the effect of dietary supplements on male infertility compared to placebo were included. Primary outcomes were pregnancy and live birth, while secondary outcomes were sperm concentration, sperm count, total motility, progressive motility, normal morphology, and DNA Fragmentation Index. Risk of bias was assessed using the revised Cochrane risk of bias (RoB2) tool. Data were meta-analyzed using random effects-restricted maximum likelihood models. Certainty of evidence was evaluated using the grading of recommendations, assessment, development and evaluation (GRADE) approach. Results: Of the 3137 articles identified, 50 were included. No effect on pregnancy and live birth was found. Different supplements improved single sperm parameters: Zinc and folic acid and \u22653 substance dietary supplements improved sperm concentration, selenium, carnitine, and coenzyme Q10 improved motility and alpha-lipoic acid improved normal morphology. Vitamin D, vitamin E, and omega-3 fatty acids showed no improvement in sperm parameters. The majority of studies had some concerns or high risk of bias, and certainty of evidence was generally low or very low. Conclusions: This study found no convincing evidence of an effect of any dietary supplements on male infertility. Larger and more well-conducted randomized controlled trials focusing on specific supplements and considering pregnancy outcomes are needed.<\/jats:p>","DOI":"10.3390\/nu17101710","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:37:13Z","timestamp":1747633033000},"page":"1710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2799-2855","authenticated-orcid":false,"given":"Mette","family":"Michaelsen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9335-0111","authenticated-orcid":false,"given":"Michelle","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-5292","authenticated-orcid":false,"given":"Anne","family":"Bjerregaard","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark"},{"name":"Department of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Borgstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Herlev and Gentofte University Hospital, 2730 Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chortsen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahra","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Kesmodel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,18]]},"reference":[{"key":"ref_1","first-page":"1443","article-title":"Infertility Affects 1 in 6 People Globally","volume":"329","author":"Harris","year":"2023","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0974-1208.170370","article-title":"Trends of male factor infertility, an important cause of infertility: A review of literature","volume":"8","author":"Kumar","year":"2015","journal-title":"J. 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