{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:28:56Z","timestamp":1784042936827,"version":"3.55.0"},"reference-count":117,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"start-up funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Menopause is associated with significant hormonal and reproductive changes in women. Evidence documents interindividual differences in the signs and symptoms associated with menopause, including cognitive decline. Hypothesized reasons for the cognitive decline include changes in hormone levels, especially estrogen, but study findings have been inconsistent. Hormone replacement therapies (HRTs) are often recommended to alleviate menopause-related symptoms in both peri- and postmenopausal women. However, the North American Menopause Society does not recommend the use of HRT for the management of cognitive complaints in perimenopausal women due to lack of evidence. Additionally, there are many women for which the use of HRT is contraindicated. As such, it would be helpful to have an alternative method for alleviating symptoms, including declines in cognition, during the menopause transition. Iron supplementation may be a promising candidate as it has been associated with improved cognitive performance in premenopausal women with iron deficiency and iron deficiency anemia. Because many women will experience heavy blood losses during perimenopause, they are at risk of becoming iron deficient and\/or anemic. The use of iron supplementation in women with iron deficiency may serve to not only improve iron status but also to alleviate many of the signs and symptoms associated with perimenopause (lethargy, depressed affect, etc.), including cognitive decline. However, evidence to inform treatment protocols is lacking. Well-designed studies of iron supplementation in perimenopausal women are needed in order to understand the potential of such supplementation to alleviate the cognitive decline associated with perimenopause.<\/jats:p>","DOI":"10.3390\/nu17111762","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:35:09Z","timestamp":1747982109000},"page":"1762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6638-4906","authenticated-orcid":false,"given":"Mun","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Nutrition Science, Purdue University, 700 Mitch Daniels Blvd., Stone Hall Rm. 214, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-8353","authenticated-orcid":false,"given":"Emily","family":"Seiger","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science, Purdue University, 700 Mitch Daniels Blvd., Stone Hall Rm. 214, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Murray-Kolb","sequence":"additional","affiliation":[{"name":"Department of Nutrition Science, Purdue University, 700 Mitch Daniels Blvd., Stone Hall Rm. 214, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref_1","unstructured":"(2024, June 16). The Global Strategy and Action Plan on Ageing and Health 2016\u20132020: Towards a World in Which Everyone Can Live a Long and Healthy Life. Available online: https:\/\/apps.who.int\/gb\/ebwha\/pdf_files\/WHA73\/A73_INF2-en.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2471\/BLT.17.203745","article-title":"Healthy Ageing: Moving Forward","volume":"95","author":"Beard","year":"2017","journal-title":"Bull. World Health Organ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/s43587-023-00509-8","article-title":"Female Aging: When Translational Models Don\u2019t Translate","volume":"3","author":"Gilmer","year":"2023","journal-title":"Nat. Aging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ecl.2015.05.010","article-title":"Endocrinology of the Menopause","volume":"44","author":"Hall","year":"2015","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/jama.2022.24140","article-title":"Management of Menopausal Symptoms: A Review","volume":"329","author":"Crandall","year":"2023","journal-title":"JAMA"},{"key":"ref_6","unstructured":"Peacock, K., Carlson, K., and Ketvertis, K.M. (2024). Menopause. StatPearls, StatPearls Publishing."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0378-5122(95)00968-X","article-title":"The Demography of Menopause","volume":"23","author":"Hill","year":"1996","journal-title":"Maturitas"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"US Preventive Services Task Force, Mangione, C.M., Barry, M.J., Nicholson, W.K., Cabana, M., Caughey, A.B., Chelmow, D., Coker, T.R., Davis, E.M., and Donahue, K.E. (2022). Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: US Preventive Services Task Force Recommendation Statement. JAMA, 328, 1740.","DOI":"10.1001\/jama.2022.18625"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.mayocp.2023.02.025","article-title":"Impact of Menopause Symptoms on Women in the Workplace","volume":"98","author":"Faubion","year":"2023","journal-title":"Mayo Clin. Proc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/GRF.0000000000000389","article-title":"Management of the Perimenopause","volume":"61","author":"Delamater","year":"2018","journal-title":"Clin. Obs. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/gme.0b013e31824d8f40","article-title":"Executive Summary of the Stages of Reproductive Aging Workshop+10: Addressing the Unfinished Agenda of Staging Reproductive Aging","volume":"19","author":"Harlow","year":"2012","journal-title":"Menopause"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1089\/jwh.2015.5556","article-title":"Perimenopause: From Research to Practice","volume":"25","author":"Santoro","year":"2016","journal-title":"J. Women\u2019s Health"},{"key":"ref_13","unstructured":"Dhakal, A., and Bobrin, B.D. (2024). Cognitive Deficits. StatPearls, StatPearls Publishing."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-0035-1555115","article-title":"The Impact of Age on Cognition","volume":"36","author":"Murman","year":"2015","journal-title":"Semin. Hear."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1017\/S1092852900023166","article-title":"Perimenopausal Mental Disorders: Epidemiology and Phenomenology","volume":"10","author":"Rasgon","year":"2005","journal-title":"CNS Spectr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1210\/jc.2012-1422","article-title":"Trajectory Clustering of Estradiol and Follicle-Stimulating Hormone during the Menopausal Transition among Women in the Study of Women\u2019s Health across the Nation (SWAN)","volume":"97","author":"Tepper","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/clinem\/dgaa764","article-title":"The Menopause Transition: Signs, Symptoms, and Management Options","volume":"106","author":"Santoro","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s11920-023-01447-3","article-title":"Cognitive Problems in Perimenopause: A Review of Recent Evidence","volume":"25","author":"Metcalf","year":"2023","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrendo.2015.82","article-title":"Perimenopause as a Neurological Transition State","volume":"11","author":"Brinton","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archneurol.2011.31","article-title":"Cognitive Decline in Prodromal Alzheimer Disease and Mild Cognitive Impairment","volume":"68","author":"Wilson","year":"2011","journal-title":"Arch. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2018-05-815944","article-title":"Iron Deficiency","volume":"133","author":"Camaschella","year":"2019","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gaskell, H., Derry, S., Andrew Moore, R., and McQuay, H.J. (2008). Prevalence of Anaemia in Older Persons: Systematic Review. BMC Geriatr., 8.","DOI":"10.1186\/1471-2318-8-1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/1028415X.2017.1360559","article-title":"Effect of Iron Deficiency on Simultaneous Measures of Behavior, Brain Activity, and Energy Expenditure in the Performance of a Cognitive Task","volume":"22","author":"Wenger","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The Role of Iron in Brain Ageing and Neurodegenerative Disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.nutr.23.020102.075739","article-title":"Iron Status and Neural Functioning","volume":"23","author":"Beard","year":"2003","journal-title":"Annu. Rev. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJM199109053251004","article-title":"Long-Term Developmental Outcome of Infants with Iron Deficiency","volume":"325","author":"Lozoff","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/312162a0","article-title":"Transferrin Receptor on Endothelium of Brain Capillaries","volume":"312","author":"Jefferies","year":"1984","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","article-title":"Blood\u2013Brain Barrier: Ageing and Microvascular Disease\u2014Systematic Review and Meta-Analysis","volume":"30","author":"Farrall","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/01.jnen.0000202887.22082.63","article-title":"Microglia in the Aging Brain","volume":"65","author":"Conde","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-nutr-071812-161205","article-title":"Iron Nutrition and Premenopausal Women: Effects of Poor Iron Status on Physical and Neuropsychological Performance","volume":"33","author":"McClung","year":"2013","journal-title":"Annu. Rev. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"747S","DOI":"10.3945\/jn.110.130658","article-title":"Iron Status and Neuropsychological Consequences in Women of Reproductive Age: What Do We Know and Where Are We Headed?","volume":"141","year":"2011","journal-title":"J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3945\/jn.115.223586","article-title":"Iron Status Is Associated with Performance on Executive Functioning Tasks in Nonanemic Young Women","volume":"146","author":"Scott","year":"2016","journal-title":"J. Nutr."},{"key":"ref_33","first-page":"2087","article-title":"Iron Deficiency and Cognitive Functions","volume":"10","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"946S","DOI":"10.3945\/ajcn.2008.26692D","article-title":"Iron Deficiency and Child and Maternal Health","volume":"89","author":"Beard","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12603-011-0351-7","article-title":"Iron Deficiency Can Cause Cognitive Impairment in Geriatric Patients","volume":"16","author":"Yavuz","year":"2012","journal-title":"J. Nutr. Health Aging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2009.12.013","article-title":"Inpatient Hospitalization for Gynecologic Disorders in the United States","volume":"202","author":"Whiteman","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1089\/jwh.2012.3719","article-title":"The Impact of Menopausal Symptoms on Quality of Life, Productivity, and Economic Outcomes","volume":"22","author":"Whiteley","year":"2013","journal-title":"J. Women\u2019s Health"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/09513590.2017.1306736","article-title":"Forty to Fifty-Five-Year-Old Women and Iron Deficiency: Clinical Considerations and Quality of Life","volume":"33","author":"Firquet","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mosconi, L., Berti, V., Dyke, J., Schelbaum, E., Jett, S., Loughlin, L., Jang, G., Rahman, A., Hristov, H., and Pahlajani, S. (2021). Menopause Impacts Human Brain Structure, Connectivity, Energy Metabolism, and Amyloid-Beta Deposition. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-90084-y"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrendo.2017.180","article-title":"Symptoms of Menopause\u2014Global Prevalence, Physiology and Implications","volume":"14","author":"Monteleone","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/152460901750269670","article-title":"Midlife Women\u2019s Attributions about Perceived Memory Changes: Observations from the Seattle Midlife Women\u2019s Health Study","volume":"10","year":"2001","journal-title":"J. Women\u2019s Health Gend. Based Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/GME.0000000000001424","article-title":"The Menopause Transition and Women\u2019s Health at Midlife: A Progress Report from the Study of Women\u2019s Health Across the Nation (SWAN)","volume":"26","author":"Greendale","year":"2019","journal-title":"Menopause"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/gme.0b013e31827655e5","article-title":"Cognition in Perimenopause: The Effect of Transition Stage","volume":"20","author":"Weber","year":"2013","journal-title":"Menopause"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.brainres.2010.11.030","article-title":"Perimenopausal Use of Hormone Therapy Is Associated with Enhanced Memory and Hippocampal Function Later in Life","volume":"1379","author":"Maki","year":"2011","journal-title":"Brain Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/GME.0000000000002028","article-title":"The 2022 Hormone Therapy Position Statement of The North American Menopause Society","volume":"29","author":"Faubion","year":"2022","journal-title":"Menopause"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Alsugeir, D., Wei, L., Adesuyan, M., Cook, S., Panay, N., and Brauer, R. (2022). Hormone Replacement Therapy Prescribing in Menopausal Women in the UK: A Descriptive Study. BJGP Open, 6.","DOI":"10.3399\/BJGPO.2022.0126"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e763","DOI":"10.1136\/bmj.e763","article-title":"Hormone Replacement Therapy","volume":"344","author":"Hickey","year":"2012","journal-title":"BMJ"},{"key":"ref_48","unstructured":"Nguyen, M., and Tadi, P. (2024). Iron Supplementation. StatPearls, StatPearls Publishing."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3945\/jn.113.177089","article-title":"Midlife Iron Status Is Inversely Associated with Subsequent Cognitive Performance, Particularly in Perimenopausal Women","volume":"143","author":"Pilar","year":"2013","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Barnett, A.L., Wenger, M.J., Miles, P., Wu, D., Isingizwe, Z.R., Benbrook, D.M., and Yuan, H. (2025). Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause. Nutrients, 17.","DOI":"10.1101\/2025.01.28.25321122"},{"key":"ref_51","unstructured":"Koothirezhi, R., and Ranganathan, S. (2024). Postmenopausal Syndrome. StatPearls, StatPearls Publishing."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Von Holle, A., O\u2019Brien, K.M., Sandler, D.P., Janicek, R., Karagas, M.R., White, A.J., Niehoff, N.M., Levine, K.E., Jackson, B.P., and Weinberg, C.R. (2024). Toenail and Serum Levels as Biomarkers of Iron Status in Pre- and Postmenopausal Women: Correlations and Stability over Eight-Year Follow-Up. Sci. Rep., 14.","DOI":"10.1038\/s41598-023-50506-5"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1089\/ars.2009.2576","article-title":"Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women?","volume":"11","author":"Jian","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1067\/mhj.2000.106646","article-title":"Association of Age, Sex, and Race with Body Iron Stores in Adults: Analysis of NHANES III Data","volume":"140","author":"Zacharski","year":"2000","journal-title":"Am. Heart J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.clnu.2024.03.026","article-title":"The Complementary Roles of Iron and Estrogen in Menopausal Differences in Cardiometabolic Outcomes","volume":"43","author":"Ahanchi","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/ajcn\/73.3.638","article-title":"Iron Status of the Free-Living, Elderly Framingham Heart Study Cohort: An Iron-Replete Population with a High Prevalence of Elevated Iron Stores","volume":"73","author":"Fleming","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_57","unstructured":"Sung, S., Carlson, K., and Abramovitz, A. (2024). Postmenopausal Bleeding. StatPearls, StatPearls Publishing."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"304","DOI":"10.12669\/pjms.312.6462","article-title":"Malabsorption of Iron as a Cause of Iron Deficiency Anemia in Postmenopausal Women","volume":"31","author":"Saboor","year":"2015","journal-title":"Pak. J. Med. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1080\/13685538.2019.1595571","article-title":"General Characteristics of Anemia in Postmenopausal Women and Elderly Men","volume":"23","author":"Duman","year":"2020","journal-title":"Aging Male"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1212\/WNL.48.5_Suppl_7.8S","article-title":"Ovarian Steroids and the Brain: Implications for Cognition and Aging","volume":"48","author":"McEwen","year":"1997","journal-title":"Neurology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Comasco, E., Frokjaer, V.G., and Sundstr\u00f6m-Poromaa, I. (2014). Functional and Molecular Neuroimaging of Menopause and Hormone Replacement Therapy. Front. Neurosci., 8.","DOI":"10.3389\/fnins.2014.00388"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1016\/S0002-9343(97)00259-3","article-title":"Estrogen Replacement Therapy and Cognitive Function in Postmenopausal Women Without Dementia","volume":"103","author":"Rice","year":"1997","journal-title":"Am. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1001\/jama.281.13.1197","article-title":"Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks","volume":"281","author":"Shaywitz","year":"1999","journal-title":"JAMA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bbagen.2010.06.002","article-title":"Decline in Mitochondrial Bioenergetics and Shift to Ketogenic Profile in Brain during Reproductive Senescence","volume":"1800","author":"Yao","year":"2010","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Gen. Subj."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tips.2008.12.006","article-title":"Estrogen-Induced Plasticity from Cells to Circuits: Predictions for Cognitive Function","volume":"30","author":"Brinton","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6","article-title":"Comparative Distribution of Estrogen Receptor-\u03b1 And -\u03b2 mRNA in the Rat Central Nervous System","volume":"388","author":"Shughrue","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/GME.0000000000001725","article-title":"Cognitive Changes during the Menopausal Transition: A Longitudinal Study in Women with and without HIV","volume":"28","author":"Maki","year":"2021","journal-title":"Menopause"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1212\/WNL.0b013e3181a71193","article-title":"Effects of the Menopause Transition and Hormone Use on Cognitive Performance in Midlife Women","volume":"72","author":"Greendale","year":"2009","journal-title":"Neurology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.maturitas.2005.07.009","article-title":"A Longitudinal Study of Cognition Change during Early Menopausal Transition in a Rural Community","volume":"53","author":"Fuh","year":"2006","journal-title":"Maturitas"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/09513590701228034","article-title":"Menopause-Specific Quality of Life Satisfaction in Community-Dwelling Menopausal Women in China","volume":"23","author":"Chen","year":"2007","journal-title":"Gynecol. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5498\/wjp.v11.i8.412","article-title":"Menopause and Cognitive Impairment: A Narrative Review of Current Knowledge","volume":"11","author":"Conde","year":"2021","journal-title":"World J. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/aje\/kwq067","article-title":"Menopause-Associated Symptoms and Cognitive Performance: Results From the Study of Women\u2019s Health Across the Nation","volume":"171","author":"Greendale","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1212\/01.WNL.0000079051.91602.E2","article-title":"A Population-Based Longitudinal Study of Cognitive Functioning in the Menopausal Transition","volume":"61","author":"Meyer","year":"2003","journal-title":"Neurology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"102","DOI":"10.33314\/jnhrc.v20i01.3891","article-title":"Health Problems Experienced by Peri-Menopausal Women and Their Perception towards Menopause","volume":"20","author":"Chalise","year":"2022","journal-title":"J. Nepal. Health Res. Counc."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/GME.0000000000001805","article-title":"Symptom Experience during the Late Reproductive Stage and the Menopausal Transition: Observations from the Women Living Better Survey","volume":"28","author":"Coslov","year":"2021","journal-title":"Menopause"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"24","DOI":"10.6118\/jmm.19022","article-title":"Morbidity Patterns among Menopausal Women in Rural Uttar Pradesh, India: A Cross-Sectional Study","volume":"27","author":"Mathew","year":"2021","journal-title":"J. Menopausal Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/09513590.2020.1832070","article-title":"Menopausal Symptoms among Chinese Peri- and Postmenopausal Women: A Large Prospective Single-Center Cohort Study","volume":"37","author":"Zhang","year":"2021","journal-title":"Gynecol. Endocrinol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"He, L., Guo, W., Qiu, J., An, X., and Lu, W. (2021). Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.652512"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Zhang, S., Fan, W., Hu, H., Wen, L., Gong, M., Liu, B., Hu, J., Li, G., and Zhang, D. (2021). Subcortical Volume Changes in Early Menopausal Women and Correlation With Neuropsychological Tests. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.738679"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/13697137.2021.2014808","article-title":"Alterations of Regional Homogeneity in Perimenopause: A Resting-State Functional MRI Study","volume":"25","author":"Zhang","year":"2022","journal-title":"Climacteric"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e17962","DOI":"10.1097\/MD.0000000000017962","article-title":"Regional Homogeneity and Functional Connectivity Analysis of Resting-State Magnetic Resonance in Patients with Bipolar II Disorder","volume":"98","author":"Xu","year":"2019","journal-title":"Medicine"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"E1686","DOI":"10.1210\/jc.2012-1365","article-title":"Hormonal Environment Affects Cognition Independent of Age during the Menopause Transition","volume":"97","author":"Persad","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jsbmb.2013.06.001","article-title":"Cognition and Mood in Perimenopause: A Systematic Review and Meta-Analysis","volume":"142","author":"Weber","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.neurobiolaging.2012.04.011","article-title":"Hormone Levels and Cognitive Function in Postmenopausal Midlife Women","volume":"33","author":"Ryan","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/jwh.2006.0057","article-title":"Menopause Transition Stage and Endogenous Estradiol and Follicle-Stimulating Hormone Levels Are Not Related to Cognitive Performance: Cross-Sectional Results from the Study of Women\u2019s Health across the Nation (SWAN)","volume":"16","author":"Luetters","year":"2007","journal-title":"J. Women\u2019s Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/01.gme.0000247019.86748.e3","article-title":"Endogenous Estrogen Is Not Associated with Cognitive Performance before, during, or after Menopause","volume":"14","author":"Herlitz","year":"2007","journal-title":"Menopause"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1210\/jc.2013-1808","article-title":"Menopause Effects on Verbal Memory: Findings From a Longitudinal Community Cohort","volume":"98","author":"Epperson","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neurobiolaging.2024.05.017","article-title":"Menopause Status- and Sex-Related Differences in Age Associations with Spatial Context Memory and White Matter Microstructure at Midlife","volume":"141","author":"Lissaman","year":"2024","journal-title":"Neurobiol. Aging"},{"key":"ref_89","first-page":"2857","article-title":"Reorganization of Functional Networks in Verbal Working Memory Circuitry in Early Midlife: The Impact of Sex and Menopausal Status","volume":"27","author":"Jacobs","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1523\/JNEUROSCI.0951-16.2016","article-title":"Impact of Sex and Menopausal Status on Episodic Memory Circuitry in Early Midlife","volume":"36","author":"Jacobs","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, S., Hu, J., Fan, W., Liu, B., Wen, L., Wang, G., Gong, M., Yang, C., and Zhang, D. (2018). Aberrant Cerebral Activity in Early Postmenopausal Women: A Resting-State Functional Magnetic Resonance Imaging Study. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00454"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/hbm.24441","article-title":"Impact of Sex and Reproductive Status on Memory Circuitry Structure and Function in Early Midlife Using Structural Covariance Analysis","volume":"40","author":"Seitz","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"bhae088","DOI":"10.1093\/cercor\/bhae088","article-title":"Impact of Sex and Reproductive Status on the Default Mode Network in Early Midlife: Implications for Aging of Memory Circuitry and Function","volume":"34","author":"Spets","year":"2024","journal-title":"Cereb. Cortex"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/13697137.2021.1892626","article-title":"Cognitive Profiles in Perimenopause: Hormonal and Menopausal Symptom Correlates","volume":"24","author":"Weber","year":"2021","journal-title":"Climacteric"},{"key":"ref_95","first-page":"1318","article-title":"Oestrogen Receptor \u03b1 Gene Polymorphisms, Insomnia, and Cognitive Functions in Perimenopausal and Postmenopausal Women in Non-Manual Employment","volume":"18","author":"Bojar","year":"2020","journal-title":"Arch. Med. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"107804","DOI":"10.1016\/j.maturitas.2023.107804","article-title":"Within-Person Changes in Reproductive Hormones and Cognition in the Menopause Transition","volume":"177","author":"Grummisch","year":"2023","journal-title":"Maturitas"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"zsae188","DOI":"10.1093\/sleep\/zsae188","article-title":"Deciphering the Impairment of Perimenopausal Insomnia on Visual Search from a Neurocognitive Processing Perspective","volume":"47","author":"Yu","year":"2024","journal-title":"SLEEP"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1258\/mi.2008.008013","article-title":"Sleep and the Menopause\u2014Do Postmenopausal Women Experience Worse Sleep than Premenopausal Women?","volume":"14","author":"Kalleinen","year":"2008","journal-title":"Menopause Int."},{"key":"ref_99","first-page":"269","article-title":"Cognitive Functions and Serum Cortisol Concentration in Perimenopausal and Postmenopausal Women Working Non-Manually","volume":"38","author":"Raczkiewicz","year":"2017","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/13697137.2016.1193137","article-title":"The Intensity of Menopausal Symptoms Is Associated with Episodic Memory in Postmenopausal Women","volume":"19","author":"Triantafyllou","year":"2016","journal-title":"Climacteric"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/gme.0b013e318196a0c9","article-title":"Memory Complaints and Memory Performance in the Menopausal Transition","volume":"16","author":"Weber","year":"2009","journal-title":"Menopause"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/13697137.2019.1646719","article-title":"Menopausal Symptoms, Menopausal Stage and Cognitive Functioning in Black Urban African Women","volume":"23","author":"Jaff","year":"2020","journal-title":"Climacteric"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Raczkiewicz, D., Gujski, M., Sarecka-Hujar, B., Suski, K., Pedrycz-Wieczorska, A., Wdowiak, A., and Bojar, I. (2024). Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopausal Polish Women. Med. Sci. Monit., 30.","DOI":"10.12659\/MSM.943249"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3109\/13697130903009187","article-title":"Subjective Cognitive Complaints at Menopause Associated with Declines in Performance of Verbal Memory and Attentional Processes","volume":"13","author":"Schaafsma","year":"2010","journal-title":"Climacteric"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/gme.0b013e318241fd22","article-title":"Reconciling Subjective Memory Complaints with Objective Memory Performance in the Menopausal Transition","volume":"19","author":"Weber","year":"2012","journal-title":"Menopause"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/GME.0000000000000705","article-title":"Understanding Women\u2019s Experience of Memory over the Menopausal Transition: Subjective and Objective Memory in Pre-, Peri-, and Postmenopausal Women","volume":"23","author":"Unkenstein","year":"2016","journal-title":"Menopause"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1111\/jgs.14658","article-title":"Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life","volume":"64","author":"Karim","year":"2016","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e1673","DOI":"10.1212\/WNL.0000000000005486","article-title":"Age at Menopause and Lifetime Cognition: Findings from a British Birth Cohort Study","volume":"90","author":"Kuh","year":"2018","journal-title":"Neurology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3233\/JAD-122062","article-title":"Lifelong Estrogen Exposure and Memory in Older Postmenopausal Women","volume":"34","author":"Tierney","year":"2013","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"455","DOI":"10.29252\/ijrm.16.7.455","article-title":"The Association between Estradiol Levels and Cognitive Function in Postmenopausal Women","volume":"16","author":"Gholizadeh","year":"2018","journal-title":"Int. J. Reprod. Biomed. (IJRM)"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1017\/S0033291720005127","article-title":"Causal Inference with Observational Data: The Need for Triangulation of Evidence","volume":"51","author":"Hammerton","year":"2021","journal-title":"Psychol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1210\/rp.57.1.257","article-title":"Hormonal Changes in the Menopause Transition","volume":"57","author":"Burger","year":"2002","journal-title":"Recent. Prog. Horm. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1111\/j.1532-5415.2004.52575.x","article-title":"Black and White Differences in Cognitive Function Test Scores: What Explains the Difference?","volume":"52","author":"Mehta","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"100411","DOI":"10.1016\/j.bbih.2022.100411","article-title":"Adverse Childhood Experiences Interact with Inflammation and Menopause Transition Stage to Predict Verbal Memory in Women","volume":"20","author":"Metcalf","year":"2022","journal-title":"Brain Behav. Immun. Health"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"deLeyer-Tiarks, J.M., Caemmerer, J.M., Bray, M.A., and Kaufman, A.S. (2024). Assessment of Human Intelligence\u2014The State of the Art in the 2020s. J. Intell., 12.","DOI":"10.3390\/jintelligence12080072"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Holden, L.R., and Tanenbaum, G.J. (2023). Modern Assessments of Intelligence Must Be Fair and Equitable. J. Intell., 11.","DOI":"10.31234\/osf.io\/6aqhp"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"117447","DOI":"10.1016\/j.socscimed.2024.117447","article-title":"Racial Discrimination and Cognitive Function: An Instrumental Variable Analysis","volume":"363","author":"Lawrence","year":"2024","journal-title":"Soc. Sci. Med."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/11\/1762\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:39:05Z","timestamp":1760031545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/11\/1762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":117,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["nu17111762"],"URL":"https:\/\/doi.org\/10.3390\/nu17111762","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}