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China","award":["32402120"],"award-info":[{"award-number":["32402120"]}]},{"name":"Natural Science Foundation of Fujian Province, China","award":["2023J05029"],"award-info":[{"award-number":["2023J05029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Abalone viscera is a discarded seafood by-product that contains a wealth of protein and is a good source of collagen peptides which have proven to have great potential in ameliorating host inflammation. The present study was conducted to evaluate the anti-inflammatory capacity of collagen peptide extracted from abalone viscera. Methods: Low, medium, and high dosages (300, 600, and 900 mg\/kg\/d) of abalone viscera collagen peptide (AVCP) were orally administered to DSS-induced acute colitis mice. The inflammatory mediators and oxidative stress factors were assessed using the ELISA method, and gut microbiota was widely studied by 16S rRNA sequencing technology. Results: The results showed that oral administration of AVCP led to a significant alleviation of weight loss, colon length shortening, and DAI escalation in colitis mice. AVCP could also alleviate the pathological damage of colon tissue; inhibit splenic edema and thymic atrophy; reduce the serum level of inflammatory mediators (IL-1\u03b2, IL-6, TNF-\u03b1, IL-17A, and myeloperoxidase (MPO)); and improved antioxidant capacity (the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) increased and malondialdehyde (MDA) level decreased). Moreover, AVCP restored the balance of the gut microbiota, such as Escherichia-Shigella, Bacteroides, norank_f_Muribaculaceae, Rikenellaceae_RC9_gut_group, and Parasutterella. Conclusions: Collectively, our observations elucidated the potential use of AVCP as a prebiotic for ulcerative colitis alleviation.<\/jats:p>","DOI":"10.3390\/nu17111926","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:00:49Z","timestamp":1749016849000},"page":"1926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Alleviating Effect of Abalone Viscera Collagen Peptide in DSS-Induced Colitis Mice: Effect on Inflammatory Cytokines, Oxidative Stress, and Gut Microbiota"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5207-8553","authenticated-orcid":false,"given":"Binxiong","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjiang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengming","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changcheng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"National R&D Center for Vegetable Processing, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"National R&D Center for Vegetable Processing, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"National R&D Center for Vegetable Processing, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tips.2024.08.003","article-title":"Ulcerative colitis: Clinical biomarkers, therapeutic targets, and emerging treatments","volume":"45","author":"Wangchuk","year":"2024","journal-title":"Trends Pharmacol. 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