{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:21:59Z","timestamp":1760059319884,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The European Commission\u2019s 7th Framework Program EarlyNutrition Project (FP7-289346-EarlyNutrition)","award":["FP7-289346-EarlyNutrition","633595"],"award-info":[{"award-number":["FP7-289346-EarlyNutrition","633595"]}]},{"name":"Abbott Nutrition","award":["FP7-289346-EarlyNutrition","633595"],"award-info":[{"award-number":["FP7-289346-EarlyNutrition","633595"]}]},{"name":"Horizon 2020 DynaHEALTH EU Project","award":["FP7-289346-EarlyNutrition","633595"],"award-info":[{"award-number":["FP7-289346-EarlyNutrition","633595"]}]},{"name":"PREcisE JPI-ERA-HDHL-Epigenetics","award":["FP7-289346-EarlyNutrition","633595"],"award-info":[{"award-number":["FP7-289346-EarlyNutrition","633595"]}]},{"name":"Else Kr\u00f6ner-Fresenius-Foundation","award":["FP7-289346-EarlyNutrition","633595"],"award-info":[{"award-number":["FP7-289346-EarlyNutrition","633595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Obesity during pregnancy is strongly related to increased insulin resistance, and subsequent development of metabolic syndrome-like disorders, such as glucose intolerance, pre-eclampsia, as well as preterm birth, and cesarean delivery. Nutrition can influence the evolution of glycemic response and may help improve adverse pregnancy outcomes and long-term complications. The main objective of the Nutritional Intervention during Gestation and Offspring Health (NIGOHealth) randomized clinical trial (ClinicalTrials.gov Identifier: NCT02285764) was to investigate the potential effects of a low glycemic index\/slow digesting (LGI\/SD) carbohydrate product on maternal glycemia (glucose AUC at 27+0\u201328+6 weeks; maternal fasting blood glucose (MFBG) at 34+0\u201336+0 weeks), and neonatal body composition. Methods: Obese pregnant women were randomized: 230 in the intervention group (IG), who consumed two servings of an LGI\/SD study product daily from 15 weeks of pregnancy until delivery, and 102 participants in the Standard of Care (SOC) group. Results: When analyzing baseline characteristics, significant differences were found in glucose metabolic parameters with higher values for IG than for the SOC group, compromising the group\u2019s comparability. Despite this, a statistical analysis was conducted (intention-to-treat analysis\/evaluable cohort): no differences were detected regarding maternal blood glucose AUC at 27+0\u201328+6 weeks, nor for MFBG at 34+0\u201336+0 weeks. Nonetheless, HbA1c (%) at 34+0\u201336+0 weeks was significantly lower in the IG vs. the SOC group (5.26 \u00b1 0.03, 5.31 \u00b1 0.04, p = 0.007) after adjusting for baseline conditions. Conclusion: This result might suggest a potential effect of the intervention on Evaluable participants. However, it should be taken with caution, due to the limitations of the study. More RCTs should be carried out to explore the effects of LGI\/SD products on glycemic response in obese pregnant women.<\/jats:p>","DOI":"10.3390\/nu17111942","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T11:04:06Z","timestamp":1749121446000},"page":"1942","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Low Glycemic Index\/Slow Digesting (LGI\/SD) Carbohydrate Product on Maternal Glycemia and Neonatal Body Composition in Obese Pregnant Women: The NIGOHealth Randomized Clinical Trial"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-5956","authenticated-orcid":false,"given":"Mercedes","family":"G. Berm\u00fadez","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Granada, Avda. de la Investigaci\u00f3n 11, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda-Ricobaraza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Granada, Avda. de la Investigaci\u00f3n 11, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Garc\u00eda-Santos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Granada, Avda. de la Investigaci\u00f3n 11, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Teresa","family":"Segura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Granada, Avda. de la Investigaci\u00f3n 11, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-040X","authenticated-orcid":false,"given":"Alberto","family":"Puertas-Prieto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s\/n, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Gallo-Vallejo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s\/n, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Padilla-Vinuesa","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics Unit, Hospital Universitario Cl\u00ednico San Cecilio, Avda. Conocimiento, s\/n, 18016 Granada, Spain"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Granada, Avda. Investigaci\u00f3n 11, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, LMU\u2014Ludwig Maximilians Universitaet Munich, Dr. von Hauner Children\u2019s LMU University Hospital, 80337 Munich, Germany"},{"name":"German Center for Child and Adolescent Health, 80337 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-7040","authenticated-orcid":false,"given":"Geraldine E.","family":"Baggs","sequence":"additional","affiliation":[{"name":"Abbott Nutrition R&D, Columbus, OH 43219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Oliveros","sequence":"additional","affiliation":[{"name":"Abbott Nutrition R&D, Abbott Laboratories, 18004 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-3190","authenticated-orcid":false,"given":"Ricardo","family":"Rueda","sequence":"additional","affiliation":[{"name":"Abbott Nutrition R&D, Abbott Laboratories, 18004 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-6785","authenticated-orcid":false,"given":"Cristina","family":"Campoy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Granada, Avda. de la Investigaci\u00f3n 11, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Health Sciences Technological Park, 18012 Granada, Spain"},{"name":"Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP) (Granada\u2019s Node), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000439487","article-title":"Interrupting Intergenerational Cycles of Maternal Obesity","volume":"Volume 85","author":"Fewtrell","year":"2016","journal-title":"Nestl\u00e9 Nutrition Institute Workshop Series"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"NCD Risk Factor Collaboration (NCD-RisC) (2016). 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