{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:25Z","timestamp":1787029285004,"version":"build-2736575974"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014NextGenerationEU","award":["BG-RRP-2.004-0009-C02"],"award-info":[{"award-number":["BG-RRP-2.004-0009-C02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background\/Objectives: Iron plays an important role in cognitive, behavioral, and motor development. This study aims to assess the iron nutritional status of Bulgarian children with cerebral palsy (CP) and autism spectrum disorder (ASD), focusing on iron deficiency (ID) and its impact on children\u2019s development. We hypothesized that children with CP and ASD suffer from iron deficiency. Methods: The cross-sectional study includes 95 children from northeastern Bulgaria. Data were collected in two periods (2017\u20132018 and 2023\u20132024). Demographic questionnaires, food frequency questionnaires, and laboratory tests for hemoglobin, serum iron, serum ferritin, serum albumin, and CRP were conducted. Anthropometric measurements were evaluated. The Gross Motor Function Classification System scale was used to assess motor function in children with CP. Statistical analysis was performed using Jamovi software, ver. 2.6.44, with a significance level of p &lt; 0.05. Results: Of the 95 children, 62.1% had CP and 37.9% had ASD. Most children had normal hemoglobin and serum iron levels, but 62.7% of those with CP and 36.8% of those with ASD had low serum ferritin levels, indicating latent ID. A higher proportion of children with CP than those with ASD consumed meat daily, while fish was more commonly consumed by children with ASD. Anthropometric data showed delayed growth and lower height-for-age scores in children with CP. Conclusions: The study identifies latent ID in children with CP and ASD. An evaluation of dietary habits highlights the need for interventions to improve nutritional status and development. The observed deficiencies emphasize the need for regular monitoring and targeted dietary programs for children in these groups.<\/jats:p>","DOI":"10.3390\/nu17121969","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T09:59:14Z","timestamp":1749549554000},"page":"1969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Iron Deficiency Prevalence in Bulgarian Children with Cerebral Palsy and Autism: A Call for Nutritional Interventions to Support Development"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1782-8475","authenticated-orcid":false,"given":"Rositsa","family":"Chamova","sequence":"first","affiliation":[{"name":"Department of Hygiene and Epidemiology, Medical University, 9002 Varna, Bulgaria"},{"name":"NutriLect Research Group, Department of Neurosciences, Research Institute, Medical University, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7325-0110","authenticated-orcid":false,"given":"Silviya","family":"Nikolova","sequence":"additional","affiliation":[{"name":"NutriLect Research Group, Department of Neurosciences, Research Institute, Medical University, 9002 Varna, Bulgaria"},{"name":"Department of Social Medicine and Healthcare Organization, Medical University, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-5703","authenticated-orcid":false,"given":"Albena","family":"Toneva","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Medical University, 9002 Varna, Bulgaria"},{"name":"NutriLect Research Group, Department of Neurosciences, Research Institute, Medical University, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-2725","authenticated-orcid":false,"given":"Rozalina","family":"Braykova","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Medical University, 9002 Varna, Bulgaria"},{"name":"NutriLect Research Group, Department of Neurosciences, Research Institute, Medical University, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislava","family":"Hadzhieva","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Medical University, 9002 Varna, Bulgaria"},{"name":"NutriLect Research Group, Department of Neurosciences, Research Institute, Medical University, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-5713","authenticated-orcid":false,"given":"Yana","family":"Bocheva","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Faculty of Medicine, Medical University, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-3923","authenticated-orcid":false,"given":"Rouzha","family":"Pancheva","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Medical University, 9002 Varna, Bulgaria"},{"name":"NutriLect Research Group, Department of Neurosciences, Research Institute, Medical University, 9002 Varna, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chen, M.H., Su, T.P., Chen, Y.S., Hsu, J.W., Huang, K.L., Chang, W.H., Chen, T.J., and Bai, Y.M. (2013). Association between psychiatric disorders and iron deficiency anemia among children and adolescents: A nationwide population-based study. BMC Psychiatry, 13.","DOI":"10.1186\/1471-244X-13-161"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0091-3057(01)00563-9","article-title":"Iron deficiency decreases dopamine D1 and D2 receptors in rat brain","volume":"69","author":"Erikson","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4274\/buchd.galenos.2022.79027","article-title":"Iron, vitamin D, and B12 levels of young children with autism spectrum disorder at diagnosis","volume":"12","author":"Yakut","year":"2022","journal-title":"J. Dr. Behcet Uz Child. Hosp."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Thompson, B., and Amoroso, L. (2011). Combating iron deficiency:food-based approaches. Combating Micronutrient Deficiencies: Food-Based Approaches, FAO.","DOI":"10.1079\/9781845937140.0000"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Yanagimoto, Y., Ishizaki, Y., and Kaneko, K. (2020). Iron deficiency anemia, stunted growth, and developmental delay due to avoidant\/restrictive food intake disorder by restricted eating in autism spectrum disorder. Biopsychosoc. Med., 14.","DOI":"10.1186\/s13030-020-00182-y"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3945\/ajcn.114.103366","article-title":"Guidelines on the diagnosis and treatment of iron deficiency across indications: A systematic review","volume":"102","author":"Williet","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(13)60937-X","article-title":"Maternal and child undernutrition and overweight in low-income and middle-income countries","volume":"382","author":"Black","year":"2013","journal-title":"Lancet"},{"key":"ref_8","first-page":"11","article-title":"Hematologic disorders: Anemia","volume":"433","author":"Baltierra","year":"2015","journal-title":"FP Essent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jpc.12483","article-title":"Iron deficiency in children with global developmental delay and autism spectrum disorder","volume":"50","author":"Sidrak","year":"2014","journal-title":"J. Paediatr. Child. Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00431-011-1506-6","article-title":"Ferritin and iron levels in children with autistic disorder","volume":"171","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"McWilliams, S., Singh, I., Leung, W., Stockler, S., and Ipsiroglu, O.S. (2022). Iron deficiency and common neurodevelopmental disorders-A scoping review. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0273819"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1362361302006001008","article-title":"Iron deficiency in autism and asperger syndrome","volume":"6","author":"Latif","year":"2002","journal-title":"Autism"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/aur.239","article-title":"Global prevalence of autism and other pervasive developmental disorders","volume":"5","author":"Elsabbagh","year":"2012","journal-title":"Autism Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pediatrneurol.2006.11.004","article-title":"Children with autism: Effect of iron supplementation on sleep and ferritin","volume":"36","author":"Dosman","year":"2007","journal-title":"Pediatr. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.2147\/NDT.S224779","article-title":"Eating and mealtime behaviors in patients with autism spectrum disorder: Current perspectives","volume":"16","author":"Margari","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.rasd.2009.12.008","article-title":"Iron deficiency in preschool children with autistic spectrum disorders","volume":"4","author":"Uslu","year":"2010","journal-title":"Res. Autism Spectr. Disord."},{"key":"ref_17","first-page":"6","article-title":"Assessment of biometal profile in children with autism spectrum disorder, with attention deficit hyperactivity disorder, or with other psychiatric diagnoses: A comparative outpatient study","volume":"4","author":"Pakyurek","year":"2018","journal-title":"Acta Psychol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/aam.aam_17_17","article-title":"Iron and vitamin D levels among autism spectrum disorders children","volume":"16","author":"Bener","year":"2017","journal-title":"Ann. Afr. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2017.02.003","article-title":"Risk factors for malnutrition among children with cerebral palsy in Botswana","volume":"70","author":"Johnson","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12098-014-1543-z","article-title":"Comparison of micronutrient levels in children with cerebral palsy and neurologically normal controls","volume":"82","author":"Kalra","year":"2015","journal-title":"Indian J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.earlhumdev.2007.12.009","article-title":"Effects of iron deficiency in infancy on patterns of motor development over time","volume":"84","author":"Shafir","year":"2008","journal-title":"Early Hum. Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1001\/archpedi.1995.02170190068012","article-title":"Use of segmental measures to estimate stature in children with cerebral palsy","volume":"149","author":"Stevenson","year":"1995","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.2471\/BLT.07.043497","article-title":"Development of a WHO growth reference for school-aged children and adolescents","volume":"85","author":"Onyango","year":"2007","journal-title":"Bull. World Health Organ."},{"key":"ref_24","first-page":"112","article-title":"Vitamin D and iron deficiencies in children and adolescents with cerebral palsy","volume":"36","author":"Barja","year":"2021","journal-title":"Neurolog\u00eda"},{"key":"ref_25","first-page":"9394060","article-title":"Limitations of serum ferritin in diagnosing ID in inflammatory conditions","volume":"2018","author":"Dignass","year":"2018","journal-title":"Int. J. Chronic Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13052-017-0407-3","article-title":"Iron deficiency parameters in autism spectrum disorder: Clinical correlates and associated factors","volume":"43","author":"Gunes","year":"2017","journal-title":"Ital. J. Pediatr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jor.2018.11.002","article-title":"Is ferritin estimation and optimisation important in cerebral palsy children undergoing single event multilevel surgery?","volume":"16","author":"Mohan","year":"2018","journal-title":"J. Orthop."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000431330","article-title":"Cerebral palsy in children as a risk factor for malnutrition","volume":"66","author":"Perenc","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.mehy.2014.08.007","article-title":"Autism prevalence and meat consumption\u2014A hypothesis that needs to be tested","volume":"83","author":"Pisula","year":"2014","journal-title":"Med. Hypotheses"},{"key":"ref_30","first-page":"50","article-title":"Nutrition in children and adults in Bulgaria: Food frequency consumption","volume":"15","author":"Duleva","year":"2023","journal-title":"BJPH"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ahumada, D., Guzm\u00e1n, B., Rebolledo, S., Opazo, K., Marileo, L., Parra-Soto, S., and Viscardi, S. (2022). Eating patterns in children with autism spectrum disorder. Healthcare, 10.","DOI":"10.3390\/healthcare10101829"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1002\/eat.23631","article-title":"Food selectivity, nutritional inadequacies, and mealtime behavioral problems in children with autism spectrum disorder compared to neurotypical children","volume":"54","author":"Planells","year":"2021","journal-title":"Int. J. Eat. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1753-4887.2010.00342.x","article-title":"Micronutrient adequacy and morbidity: Paucity of information in children with cerebral palsy","volume":"68","author":"Schoendorfer","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000516987","article-title":"1.2.4 Use of Laboratory Measurements in Nutritional Assessment","volume":"124","author":"Gerasimidis","year":"2022","journal-title":"World Rev. Nutr. Diet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1067\/mpd.2002.129888","article-title":"Relationship of nutritional status to health and societal participation in children with cerebral palsy","volume":"141","author":"Fung","year":"2002","journal-title":"J. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10803-014-2205-8","article-title":"Nutritional status of children with autism spectrum disorders (ASDs): A case-control study","volume":"45","year":"2015","journal-title":"J. Autism Dev. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Rhoten, S., Wenger, M.J., and De Stefano, L. (2024). Iron deficiency negatively affects behavioral measures of learning, indirect neural measures of dopamine, and neural efficiency. PsyArXiv.","DOI":"10.31234\/osf.io\/qv8bc"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"103089","DOI":"10.1016\/j.nicl.2022.103089","article-title":"Cognitive control inhibition networks in adulthood are impaired by early iron deficiency in infancy","volume":"35","author":"Cecilia","year":"2022","journal-title":"NeuroImage Clin."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1984-0462\/2025\/43\/2024017","article-title":"Iron deficiency and changes in sleep: Two conditions that compromise child growth and development","volume":"43","author":"Ciampo","year":"2025","journal-title":"Rev. Paul. De Pediatr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/12\/1969\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:49:29Z","timestamp":1760032169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/17\/12\/1969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["nu17121969"],"URL":"https:\/\/doi.org\/10.3390\/nu17121969","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}